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Protein

Peroxisomal membrane protein PEX14

Gene

PEX14

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the peroxisomal translocation machinery with PEX13 and PEX17. Interacts with both the PTS1 and PTS2 receptors. Binds directly to PEX17.

Miscellaneous

Present with 2570 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • protein binding, bridging Source: SGD
  • signaling receptor binding Source: GO_Central

GO - Biological processi

  • protein import into peroxisome matrix, docking Source: SGD

Keywordsi

Biological processProtein transport, Translocation, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-30644-MONOMER
ReactomeiR-SCE-8866654 E3 ubiquitin ligases ubiquitinate target proteins
R-SCE-9033241 Peroxisomal protein import

Protein family/group databases

TCDBi3.A.20.1.5 the peroxisomal protein importer (ppi) family

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal membrane protein PEX14
Alternative name(s):
Peroxin-14
Gene namesi
Name:PEX14
Ordered Locus Names:YGL153W
ORF Names:G1870
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGL153W
SGDiS000003121 PEX14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Peroxisome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi87 – 90PTLP → ATLA: Loss of interaction with SH3 domain of PEX13. No effect on membrane association. 1 Publication4

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000583292 – 341Peroxisomal membrane protein PEX14Add BLAST340

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei313PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP53112
PaxDbiP53112
PRIDEiP53112

PTM databases

iPTMnetiP53112

Interactioni

Subunit structurei

Interacts with the SH3 domain of PEX13.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • protein binding, bridging Source: SGD
  • signaling receptor binding Source: GO_Central

Protein-protein interaction databases

BioGridi33101, 207 interactors
DIPiDIP-1749N
ELMiP53112
IntActiP53112, 31 interactors
MINTiP53112
STRINGi4932.YGL153W

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1N5ZX-ray2.70P/Q83-96[»]
2V1RX-ray2.10P/Q/R83-96[»]
ProteinModelPortaliP53112
SMRiP53112
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP53112

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi86 – 94SH3-binding9

Sequence similaritiesi

Belongs to the peroxin-14 family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000015047
HOGENOMiHOG000000921
InParanoidiP53112
KOiK13343
OMAiASIPAWQ
OrthoDBiEOG092C470X

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR025655 PEX14
IPR006785 Pex14_N
IPR036388 WH-like_DNA-bd_sf
PANTHERiPTHR23058 PTHR23058, 1 hit
PfamiView protein in Pfam
PF04695 Pex14_N, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P53112-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDVVSKDRK ALFDSAVSFL KDESIKDAPL LKKIEFLKSK GLTEKEIEIA
60 70 80 90 100
MKEPKKDGIV GDEVSKKIGS TENRASQDMY LYEAMPPTLP HRDWKDYFVM
110 120 130 140 150
ATATAGLLYG AYEVTRRYVI PNILPEAKSK LEGDKKEIDD QFSKIDTVLN
160 170 180 190 200
AIEAEQAEFR KKESETLKEL SDTIAELKQA LVQTTRSREK IEDEFRIVKL
210 220 230 240 250
EVVNMQNTID KFVSDNDGMQ ELNNIQKEME SLKSLMNNRM ESGNAQDNRL
260 270 280 290 300
FSISPNGIPG IDTIPSASEI LAKMGMQEES DKEKENGSDA NKDDNAVPAW
310 320 330 340
KKAREQTIDS NASIPEWQKN TAANEISVPD WQNGQVEDSI P
Length:341
Mass (Da):38,420
Last modified:October 1, 1996 - v1
Checksum:iB714D7DA045E2DCB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48618 Genomic DNA No translation available.
Z72675 Genomic DNA Translation: CAA96864.1
AY558503 Genomic DNA Translation: AAS56829.1
BK006941 Genomic DNA Translation: DAA07959.1
PIRiS60431
RefSeqiNP_011362.3, NM_001181018.3

Genome annotation databases

EnsemblFungiiYGL153W; YGL153W; YGL153W
GeneIDi852724
KEGGisce:YGL153W

Similar proteinsi

Entry informationi

Entry nameiPEX14_YEAST
AccessioniPrimary (citable) accession number: P53112
Secondary accession number(s): D6VTZ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names
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