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Protein

NADPH-dependent aldehyde reductase ARI1

Gene

ARI1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

NADPH-dependent aldehyde reductase involved in the detoxification of aldehyde inhibitors derived from lignocellulosic biomass conversion. Reduces commonly detected inhibitors in biomass conversion hydrolysates such as furfural, 5-hydroxymethylfurfural (HMF), cinnamic aldehyde, benzaldehyde, phenylacetaldehyde, and anisaldehyde.3 Publications

Cofactori

NADPH2 Publications

pH dependencei

Optimum pH is 7.0.1 Publication

Temperature dependencei

Optimum temperature is 25 degrees Celsius.1 Publication

GO - Molecular functioni

  • carbonyl reductase (NADPH) activity Source: SGD
  • coenzyme binding Source: InterPro
  • oxidoreductase activity Source: SGD

Keywordsi

Molecular functionOxidoreductase
LigandNADP

Enzyme and pathway databases

BioCyciYEAST:G3O-30646-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
NADPH-dependent aldehyde reductase ARI1 (EC:1.1.1.-)
Gene namesi
Name:ARI1
Ordered Locus Names:YGL157W
ORF Names:G1857
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGL157W
SGDiS000003125 ARI1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002155781 – 347NADPH-dependent aldehyde reductase ARI1Add BLAST347

Proteomic databases

MaxQBiP53111
PaxDbiP53111
PRIDEiP53111

Expressioni

Inductioni

By furfural and 5-hydroxymethylfurfural (HMF).1 Publication

Interactioni

Protein-protein interaction databases

BioGridi33097, 51 interactors
DIPiDIP-5112N
IntActiP53111, 8 interactors
MINTiP53111
STRINGi4932.YGL157W

Structurei

3D structure databases

ProteinModelPortaliP53111
SMRiP53111
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000002618
InParanoidiP53111
OMAiKYIPLEV
OrthoDBiEOG092C3RD2

Family and domain databases

InterProiView protein in InterPro
IPR001509 Epimerase_deHydtase
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF01370 Epimerase, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit

Sequencei

Sequence statusi: Complete.

P53111-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTDTTVFVS GATGFIALHI MNDLLKAGYT VIGSGRSQEK NDGLLKKFNN
60 70 80 90 100
NPKLSMEIVE DIAAPNAFDE VFKKHGKEIK IVLHTASPFH FETTNFEKDL
110 120 130 140 150
LTPAVNGTKS ILEAIKKYAA DTVEKVIVTS STAALVTPTD MNKGDLVITE
160 170 180 190 200
ESWNKDTWDS CQANAVAAYC GSKKFAEKTA WEFLKENKSS VKFTLSTINP
210 220 230 240 250
GFVFGPQMFA DSLKHGINTS SGIVSELIHS KVGGEFYNYC GPFIDVRDVS
260 270 280 290 300
KAHLVAIEKP ECTGQRLVLS EGLFCCQEIV DILNEEFPQL KGKIATGEPA
310 320 330 340
TGPSFLEKNS CKFDNSKTKK LLGFQFYNLK DCIVDTAAQM LEVQNEA
Length:347
Mass (Da):38,083
Last modified:October 1, 1996 - v1
Checksum:i51035AD526E418AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48618 Genomic DNA No translation available.
Z72679 Genomic DNA Translation: CAA96869.1
BK006941 Genomic DNA Translation: DAA07955.1
PIRiS60428
RefSeqiNP_011358.3, NM_001181022.3

Genome annotation databases

EnsemblFungiiYGL157W; YGL157W; YGL157W
GeneIDi852720
KEGGisce:YGL157W

Similar proteinsi

Entry informationi

Entry nameiARI1_YEAST
AccessioniPrimary (citable) accession number: P53111
Secondary accession number(s): D6VTZ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

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