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P53111

- ARI1_YEAST

UniProt

P53111 - ARI1_YEAST

Protein

NADPH-dependent aldehyde reductase ARI1

Gene

ARI1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    NADPH-dependent aldehyde reductase involved in the detoxification of aldehyde inhibitors derived from lignocellulosic biomass conversion. Reduces commonly detected inhibitors in biomass conversion hydrolysates such as furfural, 5-hydroxymethylfurfural (HMF), cinnamic aldehyde, benzaldehyde, phenylacetaldehyde, and anisaldehyde.3 Publications

    Cofactori

    NADPH.2 Publications

    pH dependencei

    Optimum pH is 7.0.1 Publication

    Temperature dependencei

    Optimum temperature is 25 degrees Celsius.1 Publication

    GO - Molecular functioni

    1. carbonyl reductase (NADPH) activity Source: SGD
    2. coenzyme binding Source: InterPro
    3. oxidoreductase activity Source: SGD

    GO - Biological processi

    1. cellular metabolic process Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30646-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADPH-dependent aldehyde reductase ARI1 (EC:1.1.1.-)
    Gene namesi
    Name:ARI1
    Ordered Locus Names:YGL157W
    ORF Names:G1857
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VII

    Organism-specific databases

    CYGDiYGL157w.
    SGDiS000003125. ARI1.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 347347NADPH-dependent aldehyde reductase ARI1PRO_0000215578Add
    BLAST

    Proteomic databases

    MaxQBiP53111.
    PaxDbiP53111.
    PeptideAtlasiP53111.

    Expressioni

    Inductioni

    By furfural and 5-hydroxymethylfurfural (HMF).1 Publication

    Gene expression databases

    GenevestigatoriP53111.

    Interactioni

    Protein-protein interaction databases

    BioGridi33097. 13 interactions.
    DIPiDIP-5112N.
    IntActiP53111. 8 interactions.
    MINTiMINT-513533.
    STRINGi4932.YGL157W.

    Structurei

    3D structure databases

    ProteinModelPortaliP53111.
    SMRiP53111. Positions 6-331.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0451.
    GeneTreeiENSGT00390000002618.
    OMAiFIALHIM.
    OrthoDBiEOG77M8ZW.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR001509. Epimerase_deHydtase.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF01370. Epimerase. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P53111-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTTDTTVFVS GATGFIALHI MNDLLKAGYT VIGSGRSQEK NDGLLKKFNN    50
    NPKLSMEIVE DIAAPNAFDE VFKKHGKEIK IVLHTASPFH FETTNFEKDL 100
    LTPAVNGTKS ILEAIKKYAA DTVEKVIVTS STAALVTPTD MNKGDLVITE 150
    ESWNKDTWDS CQANAVAAYC GSKKFAEKTA WEFLKENKSS VKFTLSTINP 200
    GFVFGPQMFA DSLKHGINTS SGIVSELIHS KVGGEFYNYC GPFIDVRDVS 250
    KAHLVAIEKP ECTGQRLVLS EGLFCCQEIV DILNEEFPQL KGKIATGEPA 300
    TGPSFLEKNS CKFDNSKTKK LLGFQFYNLK DCIVDTAAQM LEVQNEA 347
    Length:347
    Mass (Da):38,083
    Last modified:October 1, 1996 - v1
    Checksum:i51035AD526E418AD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z48618 Genomic DNA. No translation available.
    Z72679 Genomic DNA. Translation: CAA96869.1.
    BK006941 Genomic DNA. Translation: DAA07955.1.
    PIRiS60428.
    RefSeqiNP_011358.3. NM_001181022.3.

    Genome annotation databases

    EnsemblFungiiYGL157W; YGL157W; YGL157W.
    GeneIDi852720.
    KEGGisce:YGL157W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z48618 Genomic DNA. No translation available.
    Z72679 Genomic DNA. Translation: CAA96869.1 .
    BK006941 Genomic DNA. Translation: DAA07955.1 .
    PIRi S60428.
    RefSeqi NP_011358.3. NM_001181022.3.

    3D structure databases

    ProteinModelPortali P53111.
    SMRi P53111. Positions 6-331.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33097. 13 interactions.
    DIPi DIP-5112N.
    IntActi P53111. 8 interactions.
    MINTi MINT-513533.
    STRINGi 4932.YGL157W.

    Proteomic databases

    MaxQBi P53111.
    PaxDbi P53111.
    PeptideAtlasi P53111.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YGL157W ; YGL157W ; YGL157W .
    GeneIDi 852720.
    KEGGi sce:YGL157W.

    Organism-specific databases

    CYGDi YGL157w.
    SGDi S000003125. ARI1.

    Phylogenomic databases

    eggNOGi COG0451.
    GeneTreei ENSGT00390000002618.
    OMAi FIALHIM.
    OrthoDBi EOG77M8ZW.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30646-MONOMER.

    Miscellaneous databases

    NextBioi 972099.

    Gene expression databases

    Genevestigatori P53111.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR001509. Epimerase_deHydtase.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF01370. Epimerase. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "DNA sequence analysis of a 35 kb segment from Saccharomyces cerevisiae chromosome VII reveals 19 open reading frames including RAD54, ACE1/CUP2, PMR1, RCK1, AMS1 and CAL1/CDC43."
      James C.M., Indge K.J., Oliver S.G.
      Yeast 11:1413-1419(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
      Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
      , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
      Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. "Efficient anaerobic whole cell stereoselective bioreduction with recombinant Saccharomyces cerevisiae."
      Katz M., Frejd T., Hahn-Hagerdal B., Gorwa-Grauslund M.F.
      Biotechnol. Bioeng. 84:573-582(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    7. "A novel NADPH-dependent aldehyde reductase gene from Saccharomyces cerevisiae NRRL Y-12632 involved in the detoxification of aldehyde inhibitors derived from lignocellulosic biomass conversion."
      Liu Z.L., Moon J.
      Gene 446:1-10(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION, FUNCTION, COFACTOR, BIOPHYSICOCHEMICAL PROPERTIES.
    8. "Stereochemistry of furfural reduction by a Saccharomyces cerevisiae aldehyde reductase that contributes to in situ furfural detoxification."
      Bowman M.J., Jordan D.B., Vermillion K.E., Braker J.D., Moon J., Liu Z.L.
      Appl. Environ. Microbiol. 76:4926-4932(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, COFACTOR.

    Entry informationi

    Entry nameiARI1_YEAST
    AccessioniPrimary (citable) accession number: P53111
    Secondary accession number(s): D6VTZ4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome VII
      Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

    External Data

    Dasty 3