Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable metalloreductase AIM14

Gene

AIM14

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable cell surface metalloreductase. May be involved in iron or copper homeostasis (By similarity).By similarity

GO - Molecular functioni

  • oxidoreductase activity, oxidizing metal ions Source: SGD
  • superoxide-generating NADPH oxidase activity Source: SGD

GO - Biological processi

  • apoptotic process Source: SGD
  • ion transport Source: UniProtKB-KW
  • regulation of actin cytoskeleton organization Source: SGD

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Ion transport, Transport
LigandFAD, Flavoprotein, NADP

Enzyme and pathway databases

BioCyciYEAST:G3O-30649-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable metalloreductase AIM14 (EC:1.16.1.-)
Alternative name(s):
Altered inheritance of mitochondria protein 14
Gene namesi
Name:AIM14
Ordered Locus Names:YGL160W
ORF Names:G1837
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGL160W
SGDiS000003128 AIM14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 20ExtracellularSequence analysisAdd BLAST20
Transmembranei21 – 41HelicalSequence analysisAdd BLAST21
Topological domaini42 – 69CytoplasmicSequence analysisAdd BLAST28
Transmembranei70 – 90HelicalSequence analysisAdd BLAST21
Topological domaini91 – 141ExtracellularSequence analysisAdd BLAST51
Transmembranei142 – 162HelicalSequence analysisAdd BLAST21
Topological domaini163 – 176CytoplasmicSequence analysisAdd BLAST14
Transmembranei177 – 197HelicalSequence analysisAdd BLAST21
Topological domaini198 – 373ExtracellularSequence analysisAdd BLAST176
Transmembranei374 – 394HelicalSequence analysisAdd BLAST21
Topological domaini395 – 570CytoplasmicSequence analysisAdd BLAST176

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

Increases frequency of mitochondrial genome loss.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002027311 – 570Probable metalloreductase AIM14Add BLAST570

Proteomic databases

MaxQBiP53109
PaxDbiP53109
PRIDEiP53109

Interactioni

Subunit structurei

Interacts with ribosomes.

Protein-protein interaction databases

BioGridi33093, 49 interactors
STRINGi4932.YGL160W

Structurei

3D structure databases

ProteinModelPortaliP53109
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini101 – 219Ferric oxidoreductaseAdd BLAST119
Domaini250 – 388FAD-binding FR-typeAdd BLAST139

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00530000068386
InParanoidiP53109
OMAiGRMAYCL
OrthoDBiEOG092C1K3T

Family and domain databases

InterProiView protein in InterPro
IPR013112 FAD-bd_8
IPR013130 Fe3_Rdtase_TM_dom
IPR013121 Fe_red_NAD-bd_6
PfamiView protein in Pfam
PF08022 FAD_binding_8, 1 hit
PF01794 Ferric_reduct, 1 hit
PF08030 NAD_binding_6, 1 hit

Sequencei

Sequence statusi: Complete.

P53109-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKESPLITLV KRHSETHFAN IKYGYYVLII SLVYLIGLAL LRAFGRRTPS
60 70 80 90 100
RSSSAFKNKI IYRLYDIDPA IHLGILFFAV LIPFYYHYSL TTQSTVYLKR
110 120 130 140 150
LGRLSYALIP LNLFLTLRPN WFLRKNCTYT DFIPFHKWFS RIITVIGLLH
160 170 180 190 200
GIFFIIKWAI DDNVSLKQKL ILKTFNFAGF IISILVLFLL ICSIGPMRRY
210 220 230 240 250
NYRLFYIVHN LVNVAFILLT PIHSRPGVKF PFLLLNCTLL FIHIINRIVF
260 270 280 290 300
AKSLMILNKN ANYSKTNLVH VRLPRAILPD YFEPGSHIRI SPYRRINPLY
310 320 330 340 350
WLLPSHPYTI ASLAEDNSID LIIKETSTAE PGSQIESLRS NPKSFHLDQE
360 370 380 390 400
KTYTLINSYP PSVPEECYSQ GTNIAIICGG SGISFALPLF RHFFNKENVK
410 420 430 440 450
YLKMIWLIKD YSEYELVLDY LKTNGLTFEK KLSNNKRISV FISGEYTAET
460 470 480 490 500
RLDEITTNID DENSEYEMGS FNNEDEDLSI SNFNSENADS NDNTPETSHS
510 520 530 540 550
PTKENGSMIE VKSKHSFTLS NELKSFNNES AQVNQNETWL FSCGPPSLLQ
560 570
LSKKYCNDER INFVCETYGL
Length:570
Mass (Da):65,840
Last modified:October 1, 1996 - v1
Checksum:iD2534C1404A04FB8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72682 Genomic DNA Translation: CAA96872.1
BK006941 Genomic DNA Translation: DAA07952.1
PIRiS60426
RefSeqiNP_011355.1, NM_001181025.1

Genome annotation databases

EnsemblFungiiYGL160W; YGL160W; YGL160W
GeneIDi852716
KEGGisce:YGL160W

Similar proteinsi

Entry informationi

Entry nameiAIM14_YEAST
AccessioniPrimary (citable) accession number: P53109
Secondary accession number(s): D6VTZ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health