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P53109 (AIM14_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable metalloreductase AIM14
EC=1.16.1.-
Alternative name(s):
Altered inheritance of mitochondria protein 14
Gene names
Name:AIM14
Ordered Locus Names:YGL160W
ORF Names:G1837
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›

Protein attributes

Sequence length570 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Probable cell surface metalloreductase. May be involved in iron or copper homeostasis By similarity.

Subunit structure

Interacts with ribosomes.

Subcellular location

Membrane; Multi-pass membrane protein.

Disruption phenotype

Increases frequency of mitochondrial genome loss. Ref.6

Sequence similarities

Belongs to the ferric reductase (FRE) family. AIM14 subfamily.

Contains 1 FAD-binding FR-type domain.

Contains 1 ferric oxidoreductase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 570570Probable metalloreductase AIM14
PRO_0000202731

Regions

Topological domain1 – 2020Extracellular Potential
Transmembrane21 – 4121Helical; Potential
Topological domain42 – 6928Cytoplasmic Potential
Transmembrane70 – 9021Helical; Potential
Topological domain91 – 14151Extracellular Potential
Transmembrane142 – 16221Helical; Potential
Topological domain163 – 17614Cytoplasmic Potential
Transmembrane177 – 19721Helical; Potential
Topological domain198 – 373176Extracellular Potential
Transmembrane374 – 39421Helical; Potential
Topological domain395 – 570176Cytoplasmic Potential
Domain101 – 219119Ferric oxidoreductase
Domain250 – 388139FAD-binding FR-type

Sequences

Sequence LengthMass (Da)Tools
P53109 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: D2534C1404A04FB8

FASTA57065,840
        10         20         30         40         50         60 
MKESPLITLV KRHSETHFAN IKYGYYVLII SLVYLIGLAL LRAFGRRTPS RSSSAFKNKI 

        70         80         90        100        110        120 
IYRLYDIDPA IHLGILFFAV LIPFYYHYSL TTQSTVYLKR LGRLSYALIP LNLFLTLRPN 

       130        140        150        160        170        180 
WFLRKNCTYT DFIPFHKWFS RIITVIGLLH GIFFIIKWAI DDNVSLKQKL ILKTFNFAGF 

       190        200        210        220        230        240 
IISILVLFLL ICSIGPMRRY NYRLFYIVHN LVNVAFILLT PIHSRPGVKF PFLLLNCTLL 

       250        260        270        280        290        300 
FIHIINRIVF AKSLMILNKN ANYSKTNLVH VRLPRAILPD YFEPGSHIRI SPYRRINPLY 

       310        320        330        340        350        360 
WLLPSHPYTI ASLAEDNSID LIIKETSTAE PGSQIESLRS NPKSFHLDQE KTYTLINSYP 

       370        380        390        400        410        420 
PSVPEECYSQ GTNIAIICGG SGISFALPLF RHFFNKENVK YLKMIWLIKD YSEYELVLDY 

       430        440        450        460        470        480 
LKTNGLTFEK KLSNNKRISV FISGEYTAET RLDEITTNID DENSEYEMGS FNNEDEDLSI 

       490        500        510        520        530        540 
SNFNSENADS NDNTPETSHS PTKENGSMIE VKSKHSFTLS NELKSFNNES AQVNQNETWL 

       550        560        570 
FSCGPPSLLQ LSKKYCNDER INFVCETYGL

« Hide

References

« Hide 'large scale' references
[1]"DNA sequence analysis of a 35 kb segment from Saccharomyces cerevisiae chromosome VII reveals 19 open reading frames including RAD54, ACE1/CUP2, PMR1, RCK1, AMS1 and CAL1/CDC43."
James C.M., Indge K.J., Oliver S.G.
Yeast 11:1413-1419(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E. expand/collapse author list , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 96604 / S288c / FY1679.
[3]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Systematic identification and functional screens of uncharacterized proteins associated with eukaryotic ribosomal complexes."
Fleischer T.C., Weaver C.M., McAfee K.J., Jennings J.L., Link A.J.
Genes Dev. 20:1294-1307(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: COPURIFICATION WITH RIBOSOMAL COMPLEXES, MASS SPECTROMETRY.
[5]"A global topology map of the Saccharomyces cerevisiae membrane proteome."
Kim H., Melen K., Oesterberg M., von Heijne G.
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
Strain: ATCC 208353 / W303-1A.
[6]"Computationally driven, quantitative experiments discover genes required for mitochondrial biogenesis."
Hess D.C., Myers C.L., Huttenhower C., Hibbs M.A., Hayes A.P., Paw J., Clore J.J., Mendoza R.M., Luis B.S., Nislow C., Giaever G., Costanzo M., Troyanskaya O.G., Caudy A.A.
PLoS Genet. 5:E1000407-E1000407(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: DISRUPTION PHENOTYPE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		Z72682 Genomic DNA. Translation: CAA96872.1.
BK006941 Genomic DNA. Translation: DAA07952.1.
PIRS60426.
RefSeqNP_011355.1. NM_001181025.1.

3D structure databases

ProteinModelPortalP53109.
ModBaseSearch...

Protein-protein interaction databases

STRING4932.YGL160W.

Proteomic databases

PaxDbP53109.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYGL160W; YGL160W; YGL160W.
GeneID852716.
KEGGsce:YGL160W.

Organism-specific databases

CYGDYGL160w.
SGDS000003128. AIM14.

Phylogenomic databases

eggNOGNOG267494.
GeneTreeENSGT00530000068386.
OMAGRMAYCL.
OrthoDBEOG444PVG.

Gene expression databases

GenevestigatorP53109.
GermOnlineYGL160W. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR013112. FAD-bd_8.
IPR013130. Fe3_Rdtase_TM_dom.
IPR013121. Fe_red_NAD-bd_6.
[Graphical view]
PfamPF08022. FAD_binding_8. 1 hit.
PF01794. Ferric_reduct. 1 hit.
PF08030. NAD_binding_6. 1 hit.
[Graphical view]
PROSITEPS51384. FAD_FR. False negative.
[Graphical view]
ProtoNetSearch...

Other

NextBio972088.

Entry information

Entry nameAIM14_YEAST
AccessionPrimary (citable) accession number: P53109
Secondary accession number(s): D6VTZ1
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 1, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome VII

Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents