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Protein

Probable metalloreductase AIM14

Gene

AIM14

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probable cell surface metalloreductase. May be involved in iron or copper homeostasis (By similarity).By similarity

GO - Molecular functioni

  • oxidoreductase activity, oxidizing metal ions Source: SGD
  • superoxide-generating NADPH oxidase activity Source: SGD

GO - Biological processi

  • apoptotic process Source: SGD
  • ion transport Source: UniProtKB-KW
  • regulation of actin cytoskeleton organization Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Ion transport, Transport

Keywords - Ligandi

FAD, Flavoprotein, NADP

Enzyme and pathway databases

BioCyciYEAST:G3O-30649-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable metalloreductase AIM14 (EC:1.16.1.-)
Alternative name(s):
Altered inheritance of mitochondria protein 14
Gene namesi
Name:AIM14
Ordered Locus Names:YGL160W
ORF Names:G1837
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGL160W.
SGDiS000003128. AIM14.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 20ExtracellularSequence analysisAdd BLAST20
Transmembranei21 – 41HelicalSequence analysisAdd BLAST21
Topological domaini42 – 69CytoplasmicSequence analysisAdd BLAST28
Transmembranei70 – 90HelicalSequence analysisAdd BLAST21
Topological domaini91 – 141ExtracellularSequence analysisAdd BLAST51
Transmembranei142 – 162HelicalSequence analysisAdd BLAST21
Topological domaini163 – 176CytoplasmicSequence analysisAdd BLAST14
Transmembranei177 – 197HelicalSequence analysisAdd BLAST21
Topological domaini198 – 373ExtracellularSequence analysisAdd BLAST176
Transmembranei374 – 394HelicalSequence analysisAdd BLAST21
Topological domaini395 – 570CytoplasmicSequence analysisAdd BLAST176

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • perinuclear endoplasmic reticulum Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

Increases frequency of mitochondrial genome loss.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002027311 – 570Probable metalloreductase AIM14Add BLAST570

Proteomic databases

MaxQBiP53109.
PRIDEiP53109.

Interactioni

Subunit structurei

Interacts with ribosomes.

Protein-protein interaction databases

BioGridi33093. 20 interactors.

Structurei

3D structure databases

ProteinModelPortaliP53109.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini101 – 219Ferric oxidoreductaseAdd BLAST119
Domaini250 – 388FAD-binding FR-typeAdd BLAST139

Sequence similaritiesi

Contains 1 FAD-binding FR-type domain.Curated
Contains 1 ferric oxidoreductase domain.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00530000068386.
InParanoidiP53109.
OMAiVNIICGG.
OrthoDBiEOG092C1K3T.

Family and domain databases

InterProiIPR013112. FAD-bd_8.
IPR013130. Fe3_Rdtase_TM_dom.
IPR013121. Fe_red_NAD-bd_6.
[Graphical view]
PfamiPF08022. FAD_binding_8. 1 hit.
PF01794. Ferric_reduct. 1 hit.
PF08030. NAD_binding_6. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53109-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKESPLITLV KRHSETHFAN IKYGYYVLII SLVYLIGLAL LRAFGRRTPS
60 70 80 90 100
RSSSAFKNKI IYRLYDIDPA IHLGILFFAV LIPFYYHYSL TTQSTVYLKR
110 120 130 140 150
LGRLSYALIP LNLFLTLRPN WFLRKNCTYT DFIPFHKWFS RIITVIGLLH
160 170 180 190 200
GIFFIIKWAI DDNVSLKQKL ILKTFNFAGF IISILVLFLL ICSIGPMRRY
210 220 230 240 250
NYRLFYIVHN LVNVAFILLT PIHSRPGVKF PFLLLNCTLL FIHIINRIVF
260 270 280 290 300
AKSLMILNKN ANYSKTNLVH VRLPRAILPD YFEPGSHIRI SPYRRINPLY
310 320 330 340 350
WLLPSHPYTI ASLAEDNSID LIIKETSTAE PGSQIESLRS NPKSFHLDQE
360 370 380 390 400
KTYTLINSYP PSVPEECYSQ GTNIAIICGG SGISFALPLF RHFFNKENVK
410 420 430 440 450
YLKMIWLIKD YSEYELVLDY LKTNGLTFEK KLSNNKRISV FISGEYTAET
460 470 480 490 500
RLDEITTNID DENSEYEMGS FNNEDEDLSI SNFNSENADS NDNTPETSHS
510 520 530 540 550
PTKENGSMIE VKSKHSFTLS NELKSFNNES AQVNQNETWL FSCGPPSLLQ
560 570
LSKKYCNDER INFVCETYGL
Length:570
Mass (Da):65,840
Last modified:October 1, 1996 - v1
Checksum:iD2534C1404A04FB8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72682 Genomic DNA. Translation: CAA96872.1.
BK006941 Genomic DNA. Translation: DAA07952.1.
PIRiS60426.
RefSeqiNP_011355.1. NM_001181025.1.

Genome annotation databases

EnsemblFungiiYGL160W; YGL160W; YGL160W.
GeneIDi852716.
KEGGisce:YGL160W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72682 Genomic DNA. Translation: CAA96872.1.
BK006941 Genomic DNA. Translation: DAA07952.1.
PIRiS60426.
RefSeqiNP_011355.1. NM_001181025.1.

3D structure databases

ProteinModelPortaliP53109.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33093. 20 interactors.

Proteomic databases

MaxQBiP53109.
PRIDEiP53109.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGL160W; YGL160W; YGL160W.
GeneIDi852716.
KEGGisce:YGL160W.

Organism-specific databases

EuPathDBiFungiDB:YGL160W.
SGDiS000003128. AIM14.

Phylogenomic databases

GeneTreeiENSGT00530000068386.
InParanoidiP53109.
OMAiVNIICGG.
OrthoDBiEOG092C1K3T.

Enzyme and pathway databases

BioCyciYEAST:G3O-30649-MONOMER.

Miscellaneous databases

PROiP53109.

Family and domain databases

InterProiIPR013112. FAD-bd_8.
IPR013130. Fe3_Rdtase_TM_dom.
IPR013121. Fe_red_NAD-bd_6.
[Graphical view]
PfamiPF08022. FAD_binding_8. 1 hit.
PF01794. Ferric_reduct. 1 hit.
PF08030. NAD_binding_6. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAIM14_YEAST
AccessioniPrimary (citable) accession number: P53109
Secondary accession number(s): D6VTZ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.