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P53109

- AIM14_YEAST

UniProt

P53109 - AIM14_YEAST

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Protein

Probable metalloreductase AIM14

Gene
AIM14, YGL160W, G1837
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Probable cell surface metalloreductase. May be involved in iron or copper homeostasis By similarity.

GO - Molecular functioni

  1. oxidoreductase activity, oxidizing metal ions Source: SGD
  2. superoxide-generating NADPH oxidase activity Source: SGD

GO - Biological processi

  1. apoptotic process Source: SGD
  2. ion transport Source: UniProtKB-KW
  3. regulation of actin cytoskeleton organization Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Ion transport, Transport

Keywords - Ligandi

FAD, Flavoprotein, NADP

Enzyme and pathway databases

BioCyciYEAST:G3O-30649-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable metalloreductase AIM14 (EC:1.16.1.-)
Alternative name(s):
Altered inheritance of mitochondria protein 14
Gene namesi
Name:AIM14
Ordered Locus Names:YGL160W
ORF Names:G1837
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VII

Organism-specific databases

CYGDiYGL160w.
SGDiS000003128. AIM14.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2020Extracellular Reviewed predictionAdd
BLAST
Transmembranei21 – 4121Helical; Reviewed predictionAdd
BLAST
Topological domaini42 – 6928Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei70 – 9021Helical; Reviewed predictionAdd
BLAST
Topological domaini91 – 14151Extracellular Reviewed predictionAdd
BLAST
Transmembranei142 – 16221Helical; Reviewed predictionAdd
BLAST
Topological domaini163 – 17614Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei177 – 19721Helical; Reviewed predictionAdd
BLAST
Topological domaini198 – 373176Extracellular Reviewed predictionAdd
BLAST
Transmembranei374 – 39421Helical; Reviewed predictionAdd
BLAST
Topological domaini395 – 570176Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. perinuclear endoplasmic reticulum Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

Increases frequency of mitochondrial genome loss.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 570570Probable metalloreductase AIM14PRO_0000202731Add
BLAST

Proteomic databases

MaxQBiP53109.
PaxDbiP53109.

Expressioni

Gene expression databases

GenevestigatoriP53109.

Interactioni

Subunit structurei

Interacts with ribosomes.

Protein-protein interaction databases

BioGridi33093. 20 interactions.
STRINGi4932.YGL160W.

Structurei

3D structure databases

ProteinModelPortaliP53109.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini101 – 219119Ferric oxidoreductaseAdd
BLAST
Domaini250 – 388139FAD-binding FR-typeAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG267494.
GeneTreeiENSGT00530000068386.
OMAiNIICGGS.
OrthoDBiEOG7N37NK.

Family and domain databases

InterProiIPR013112. FAD-bd_8.
IPR013130. Fe3_Rdtase_TM_dom.
IPR013121. Fe_red_NAD-bd_6.
[Graphical view]
PfamiPF08022. FAD_binding_8. 1 hit.
PF01794. Ferric_reduct. 1 hit.
PF08030. NAD_binding_6. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53109-1 [UniParc]FASTAAdd to Basket

« Hide

MKESPLITLV KRHSETHFAN IKYGYYVLII SLVYLIGLAL LRAFGRRTPS    50
RSSSAFKNKI IYRLYDIDPA IHLGILFFAV LIPFYYHYSL TTQSTVYLKR 100
LGRLSYALIP LNLFLTLRPN WFLRKNCTYT DFIPFHKWFS RIITVIGLLH 150
GIFFIIKWAI DDNVSLKQKL ILKTFNFAGF IISILVLFLL ICSIGPMRRY 200
NYRLFYIVHN LVNVAFILLT PIHSRPGVKF PFLLLNCTLL FIHIINRIVF 250
AKSLMILNKN ANYSKTNLVH VRLPRAILPD YFEPGSHIRI SPYRRINPLY 300
WLLPSHPYTI ASLAEDNSID LIIKETSTAE PGSQIESLRS NPKSFHLDQE 350
KTYTLINSYP PSVPEECYSQ GTNIAIICGG SGISFALPLF RHFFNKENVK 400
YLKMIWLIKD YSEYELVLDY LKTNGLTFEK KLSNNKRISV FISGEYTAET 450
RLDEITTNID DENSEYEMGS FNNEDEDLSI SNFNSENADS NDNTPETSHS 500
PTKENGSMIE VKSKHSFTLS NELKSFNNES AQVNQNETWL FSCGPPSLLQ 550
LSKKYCNDER INFVCETYGL 570
Length:570
Mass (Da):65,840
Last modified:October 1, 1996 - v1
Checksum:iD2534C1404A04FB8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z72682 Genomic DNA. Translation: CAA96872.1.
BK006941 Genomic DNA. Translation: DAA07952.1.
PIRiS60426.
RefSeqiNP_011355.1. NM_001181025.1.

Genome annotation databases

EnsemblFungiiYGL160W; YGL160W; YGL160W.
GeneIDi852716.
KEGGisce:YGL160W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z72682 Genomic DNA. Translation: CAA96872.1 .
BK006941 Genomic DNA. Translation: DAA07952.1 .
PIRi S60426.
RefSeqi NP_011355.1. NM_001181025.1.

3D structure databases

ProteinModelPortali P53109.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 33093. 20 interactions.
STRINGi 4932.YGL160W.

Proteomic databases

MaxQBi P53109.
PaxDbi P53109.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YGL160W ; YGL160W ; YGL160W .
GeneIDi 852716.
KEGGi sce:YGL160W.

Organism-specific databases

CYGDi YGL160w.
SGDi S000003128. AIM14.

Phylogenomic databases

eggNOGi NOG267494.
GeneTreei ENSGT00530000068386.
OMAi NIICGGS.
OrthoDBi EOG7N37NK.

Enzyme and pathway databases

BioCyci YEAST:G3O-30649-MONOMER.

Miscellaneous databases

NextBioi 972088.

Gene expression databases

Genevestigatori P53109.

Family and domain databases

InterProi IPR013112. FAD-bd_8.
IPR013130. Fe3_Rdtase_TM_dom.
IPR013121. Fe_red_NAD-bd_6.
[Graphical view ]
Pfami PF08022. FAD_binding_8. 1 hit.
PF01794. Ferric_reduct. 1 hit.
PF08030. NAD_binding_6. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "DNA sequence analysis of a 35 kb segment from Saccharomyces cerevisiae chromosome VII reveals 19 open reading frames including RAD54, ACE1/CUP2, PMR1, RCK1, AMS1 and CAL1/CDC43."
    James C.M., Indge K.J., Oliver S.G.
    Yeast 11:1413-1419(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
    Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
    , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
    Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "Systematic identification and functional screens of uncharacterized proteins associated with eukaryotic ribosomal complexes."
    Fleischer T.C., Weaver C.M., McAfee K.J., Jennings J.L., Link A.J.
    Genes Dev. 20:1294-1307(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: COPURIFICATION WITH RIBOSOMAL COMPLEXES, IDENTIFICATION BY MASS SPECTROMETRY.
  5. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.
  6. "Computationally driven, quantitative experiments discover genes required for mitochondrial biogenesis."
    Hess D.C., Myers C.L., Huttenhower C., Hibbs M.A., Hayes A.P., Paw J., Clore J.J., Mendoza R.M., Luis B.S., Nislow C., Giaever G., Costanzo M., Troyanskaya O.G., Caudy A.A.
    PLoS Genet. 5:E1000407-E1000407(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiAIM14_YEAST
AccessioniPrimary (citable) accession number: P53109
Secondary accession number(s): D6VTZ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 14, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

External Data

Dasty 3

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