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P53109

- AIM14_YEAST

UniProt

P53109 - AIM14_YEAST

Protein

Probable metalloreductase AIM14

Gene

AIM14

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Probable cell surface metalloreductase. May be involved in iron or copper homeostasis By similarity.By similarity

    GO - Molecular functioni

    1. oxidoreductase activity, oxidizing metal ions Source: SGD
    2. superoxide-generating NADPH oxidase activity Source: SGD

    GO - Biological processi

    1. apoptotic process Source: SGD
    2. ion transport Source: UniProtKB-KW
    3. regulation of actin cytoskeleton organization Source: SGD

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Ion transport, Transport

    Keywords - Ligandi

    FAD, Flavoprotein, NADP

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30649-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable metalloreductase AIM14 (EC:1.16.1.-)
    Alternative name(s):
    Altered inheritance of mitochondria protein 14
    Gene namesi
    Name:AIM14
    Ordered Locus Names:YGL160W
    ORF Names:G1837
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VII

    Organism-specific databases

    CYGDiYGL160w.
    SGDiS000003128. AIM14.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. perinuclear endoplasmic reticulum Source: SGD

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Disruption phenotypei

    Increases frequency of mitochondrial genome loss.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 570570Probable metalloreductase AIM14PRO_0000202731Add
    BLAST

    Proteomic databases

    MaxQBiP53109.
    PaxDbiP53109.

    Expressioni

    Gene expression databases

    GenevestigatoriP53109.

    Interactioni

    Subunit structurei

    Interacts with ribosomes.

    Protein-protein interaction databases

    BioGridi33093. 20 interactions.
    STRINGi4932.YGL160W.

    Structurei

    3D structure databases

    ProteinModelPortaliP53109.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2020ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini42 – 6928CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini91 – 14151ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini163 – 17614CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini198 – 373176ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini395 – 570176CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei21 – 4121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei70 – 9021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei142 – 16221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei177 – 19721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei374 – 39421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini101 – 219119Ferric oxidoreductaseAdd
    BLAST
    Domaini250 – 388139FAD-binding FR-typeAdd
    BLAST

    Sequence similaritiesi

    Contains 1 FAD-binding FR-type domain.Curated
    Contains 1 ferric oxidoreductase domain.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG267494.
    GeneTreeiENSGT00530000068386.
    OMAiNIICGGS.
    OrthoDBiEOG7N37NK.

    Family and domain databases

    InterProiIPR013112. FAD-bd_8.
    IPR013130. Fe3_Rdtase_TM_dom.
    IPR013121. Fe_red_NAD-bd_6.
    [Graphical view]
    PfamiPF08022. FAD_binding_8. 1 hit.
    PF01794. Ferric_reduct. 1 hit.
    PF08030. NAD_binding_6. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P53109-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKESPLITLV KRHSETHFAN IKYGYYVLII SLVYLIGLAL LRAFGRRTPS    50
    RSSSAFKNKI IYRLYDIDPA IHLGILFFAV LIPFYYHYSL TTQSTVYLKR 100
    LGRLSYALIP LNLFLTLRPN WFLRKNCTYT DFIPFHKWFS RIITVIGLLH 150
    GIFFIIKWAI DDNVSLKQKL ILKTFNFAGF IISILVLFLL ICSIGPMRRY 200
    NYRLFYIVHN LVNVAFILLT PIHSRPGVKF PFLLLNCTLL FIHIINRIVF 250
    AKSLMILNKN ANYSKTNLVH VRLPRAILPD YFEPGSHIRI SPYRRINPLY 300
    WLLPSHPYTI ASLAEDNSID LIIKETSTAE PGSQIESLRS NPKSFHLDQE 350
    KTYTLINSYP PSVPEECYSQ GTNIAIICGG SGISFALPLF RHFFNKENVK 400
    YLKMIWLIKD YSEYELVLDY LKTNGLTFEK KLSNNKRISV FISGEYTAET 450
    RLDEITTNID DENSEYEMGS FNNEDEDLSI SNFNSENADS NDNTPETSHS 500
    PTKENGSMIE VKSKHSFTLS NELKSFNNES AQVNQNETWL FSCGPPSLLQ 550
    LSKKYCNDER INFVCETYGL 570
    Length:570
    Mass (Da):65,840
    Last modified:October 1, 1996 - v1
    Checksum:iD2534C1404A04FB8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z72682 Genomic DNA. Translation: CAA96872.1.
    BK006941 Genomic DNA. Translation: DAA07952.1.
    PIRiS60426.
    RefSeqiNP_011355.1. NM_001181025.1.

    Genome annotation databases

    EnsemblFungiiYGL160W; YGL160W; YGL160W.
    GeneIDi852716.
    KEGGisce:YGL160W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z72682 Genomic DNA. Translation: CAA96872.1 .
    BK006941 Genomic DNA. Translation: DAA07952.1 .
    PIRi S60426.
    RefSeqi NP_011355.1. NM_001181025.1.

    3D structure databases

    ProteinModelPortali P53109.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33093. 20 interactions.
    STRINGi 4932.YGL160W.

    Proteomic databases

    MaxQBi P53109.
    PaxDbi P53109.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YGL160W ; YGL160W ; YGL160W .
    GeneIDi 852716.
    KEGGi sce:YGL160W.

    Organism-specific databases

    CYGDi YGL160w.
    SGDi S000003128. AIM14.

    Phylogenomic databases

    eggNOGi NOG267494.
    GeneTreei ENSGT00530000068386.
    OMAi NIICGGS.
    OrthoDBi EOG7N37NK.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30649-MONOMER.

    Miscellaneous databases

    NextBioi 972088.

    Gene expression databases

    Genevestigatori P53109.

    Family and domain databases

    InterProi IPR013112. FAD-bd_8.
    IPR013130. Fe3_Rdtase_TM_dom.
    IPR013121. Fe_red_NAD-bd_6.
    [Graphical view ]
    Pfami PF08022. FAD_binding_8. 1 hit.
    PF01794. Ferric_reduct. 1 hit.
    PF08030. NAD_binding_6. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "DNA sequence analysis of a 35 kb segment from Saccharomyces cerevisiae chromosome VII reveals 19 open reading frames including RAD54, ACE1/CUP2, PMR1, RCK1, AMS1 and CAL1/CDC43."
      James C.M., Indge K.J., Oliver S.G.
      Yeast 11:1413-1419(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
      Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
      , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
      Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. "Systematic identification and functional screens of uncharacterized proteins associated with eukaryotic ribosomal complexes."
      Fleischer T.C., Weaver C.M., McAfee K.J., Jennings J.L., Link A.J.
      Genes Dev. 20:1294-1307(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: COPURIFICATION WITH RIBOSOMAL COMPLEXES, IDENTIFICATION BY MASS SPECTROMETRY.
    5. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
      Kim H., Melen K., Oesterberg M., von Heijne G.
      Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
      Strain: ATCC 208353 / W303-1A.
    6. "Computationally driven, quantitative experiments discover genes required for mitochondrial biogenesis."
      Hess D.C., Myers C.L., Huttenhower C., Hibbs M.A., Hayes A.P., Paw J., Clore J.J., Mendoza R.M., Luis B.S., Nislow C., Giaever G., Costanzo M., Troyanskaya O.G., Caudy A.A.
      PLoS Genet. 5:E1000407-E1000407(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiAIM14_YEAST
    AccessioniPrimary (citable) accession number: P53109
    Secondary accession number(s): D6VTZ1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome VII
      Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

    External Data

    Dasty 3