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Protein

Cystathionine beta-lyase

Gene

STR3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-cystathionine + H2O = L-homocysteine + NH3 + pyruvate.

Cofactori

Pathwayi: L-methionine biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes L-homocysteine from L-cystathionine.
Proteins known to be involved in this subpathway in this organism are:
  1. Putative cystathionine beta-lyase (IRC7), Cystathionine beta-lyase (STR3)
This subpathway is part of the pathway L-methionine biosynthesis via de novo pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-homocysteine from L-cystathionine, the pathway L-methionine biosynthesis via de novo pathway and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

  • 'de novo' L-methionine biosynthetic process Source: GO_Central
  • cysteine biosynthetic process via cystathionine Source: GO_Central
  • methionine biosynthetic process Source: SGD
  • transsulfuration Source: SGD

Keywordsi

Molecular functionLyase
Biological processAmino-acid biosynthesis, Methionine biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciMetaCyc:YGL184C-MONOMER
YEAST:YGL184C-MONOMER
UniPathwayiUPA00051; UER00078

Names & Taxonomyi

Protein namesi
Recommended name:
Cystathionine beta-lyase (EC:4.4.1.8)
Short name:
CBL
Alternative name(s):
Beta-cystathionase
Cysteine lyase
Sulfur transfer protein 3
Gene namesi
Name:STR3
Ordered Locus Names:YGL184C
ORF Names:G1601
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi

Organism-specific databases

EuPathDBiFungiDB:YGL184C
SGDiS000003152 STR3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001147641 – 465Cystathionine beta-lyaseAdd BLAST465

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei213N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

MaxQBiP53101
PaxDbiP53101
PRIDEiP53101

PTM databases

iPTMnetiP53101

Interactioni

Protein-protein interaction databases

BioGridi33071, 58 interactors
DIPiDIP-4518N
IntActiP53101, 4 interactors
STRINGi4932.YGL184C

Structurei

3D structure databases

ProteinModelPortaliP53101
SMRiP53101
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the trans-sulfuration enzymes family.Curated

Phylogenomic databases

GeneTreeiENSGT00550000075611
HOGENOMiHOG000246415
InParanoidiP53101
KOiK01760
OMAiAVDNCFC
OrthoDBiEOG092C2AJE

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 1 hit
InterProiView protein in InterPro
IPR000277 Cys/Met-Metab_PyrdxlP-dep_enz
IPR006238 Cys_b_lyase_euk
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR11808 PTHR11808, 1 hit
PfamiView protein in Pfam
PF01053 Cys_Met_Meta_PP, 1 hit
PIRSFiPIRSF001434 CGS, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR01329 cysta_beta_ly_E, 1 hit
PROSITEiView protein in PROSITE
PS00868 CYS_MET_METAB_PP, 1 hit

Sequencei

Sequence statusi: Complete.

P53101-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPIKRLDTVV VNTGSQNDQH SASVPPVYLS TTFKVDLNNE DAQNYDYSRS
60 70 80 90 100
GNPTRSVLQH QIGKLYRVPQ ENVLAVSSGM TALDVILRGL VLLNGTDNHT
110 120 130 140 150
PTIIAGDDLY GGTQRLLNFF KQQSHAVSVH VDTSDFEKFK TVFQSLDKVD
160 170 180 190 200
CVLLESPTNP LCKVVDIPRI LRFVKCISPD TTVVVDNTMM SGLNCNPLQL
210 220 230 240 250
NPGCDVVYES ATKYLNGHHD LMGGVIISKT PEIASKLYFV INSTGAGLSP
260 270 280 290 300
MDSWLLVRGL KTLGVRLYQQ QRNAMILAHW LENSCGFKPT RTNKATKTRF
310 320 330 340 350
VGLRSNPDFK LHKSFNNGPG AVLSFETGSF EHSKRLVSSK KLSIWAVTVS
360 370 380 390 400
FGCVNSLLSM PCKMSHASID PELRKERDFP EDLVRLCCGI ENIVDLKKDL
410 420 430 440 450
LAAMVDADII EVRENGKYLF NKLNKNLAVN TTIDDLHKPL SIYEEFYNQD
460
LIRKDSELNI KSSKL
Length:465
Mass (Da):51,828
Last modified:October 1, 1996 - v1
Checksum:i50957D6A2D7EDB43
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91489 Genomic DNA Translation: CAA62790.1
Z72706 Genomic DNA Translation: CAA96896.1
BK006941 Genomic DNA Translation: DAA07931.1
PIRiS61133
RefSeqiNP_011331.3, NM_001181049.3

Genome annotation databases

EnsemblFungiiYGL184C; YGL184C; YGL184C
GeneIDi852691
KEGGisce:YGL184C

Entry informationi

Entry nameiSTR3_YEAST
AccessioniPrimary (citable) accession number: P53101
Secondary accession number(s): D6VTX0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

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