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Protein

Cystathionine beta-lyase

Gene

STR3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-cystathionine + H2O = L-homocysteine + NH3 + pyruvate.

Cofactori

Pathwayi: L-methionine biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes L-homocysteine from L-cystathionine.
Proteins known to be involved in this subpathway in this organism are:
  1. Putative cystathionine beta-lyase (IRC7), Cystathionine beta-lyase (STR3)
This subpathway is part of the pathway L-methionine biosynthesis via de novo pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-homocysteine from L-cystathionine, the pathway L-methionine biosynthesis via de novo pathway and in Amino-acid biosynthesis.

GO - Molecular functioni

  • cystathionine beta-lyase activity Source: SGD
  • pyridoxal phosphate binding Source: GO_Central

GO - Biological processi

  • 'de novo' L-methionine biosynthetic process Source: GO_Central
  • cysteine biosynthetic process via cystathionine Source: GO_Central
  • methionine biosynthetic process Source: SGD
  • transsulfuration Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Methionine biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciMetaCyc:YGL184C-MONOMER.
YEAST:YGL184C-MONOMER.
UniPathwayiUPA00051; UER00078.

Names & Taxonomyi

Protein namesi
Recommended name:
Cystathionine beta-lyase (EC:4.4.1.8)
Short name:
CBL
Alternative name(s):
Beta-cystathionase
Cysteine lyase
Sulfur transfer protein 3
Gene namesi
Name:STR3
Ordered Locus Names:YGL184C
ORF Names:G1601
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGL184C.
SGDiS000003152. STR3.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB-SubCell
  • peroxisome Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001147641 – 465Cystathionine beta-lyaseAdd BLAST465

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei213N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

MaxQBiP53101.
PRIDEiP53101.

PTM databases

iPTMnetiP53101.

Interactioni

Protein-protein interaction databases

BioGridi33071. 31 interactors.
DIPiDIP-4518N.
IntActiP53101. 4 interactors.
MINTiMINT-502903.

Structurei

3D structure databases

ProteinModelPortaliP53101.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the trans-sulfuration enzymes family.Curated

Phylogenomic databases

GeneTreeiENSGT00550000075611.
HOGENOMiHOG000246415.
InParanoidiP53101.
KOiK01760.
OMAiHLAKIMN.
OrthoDBiEOG092C2AJE.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR000277. Cys/Met-Metab_PyrdxlP-dep_enz.
IPR006238. Cys_b_lyase_euk.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11808. PTHR11808. 1 hit.
PfamiPF01053. Cys_Met_Meta_PP. 1 hit.
[Graphical view]
PIRSFiPIRSF001434. CGS. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01329. cysta_beta_ly_E. 1 hit.
PROSITEiPS00868. CYS_MET_METAB_PP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53101-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPIKRLDTVV VNTGSQNDQH SASVPPVYLS TTFKVDLNNE DAQNYDYSRS
60 70 80 90 100
GNPTRSVLQH QIGKLYRVPQ ENVLAVSSGM TALDVILRGL VLLNGTDNHT
110 120 130 140 150
PTIIAGDDLY GGTQRLLNFF KQQSHAVSVH VDTSDFEKFK TVFQSLDKVD
160 170 180 190 200
CVLLESPTNP LCKVVDIPRI LRFVKCISPD TTVVVDNTMM SGLNCNPLQL
210 220 230 240 250
NPGCDVVYES ATKYLNGHHD LMGGVIISKT PEIASKLYFV INSTGAGLSP
260 270 280 290 300
MDSWLLVRGL KTLGVRLYQQ QRNAMILAHW LENSCGFKPT RTNKATKTRF
310 320 330 340 350
VGLRSNPDFK LHKSFNNGPG AVLSFETGSF EHSKRLVSSK KLSIWAVTVS
360 370 380 390 400
FGCVNSLLSM PCKMSHASID PELRKERDFP EDLVRLCCGI ENIVDLKKDL
410 420 430 440 450
LAAMVDADII EVRENGKYLF NKLNKNLAVN TTIDDLHKPL SIYEEFYNQD
460
LIRKDSELNI KSSKL
Length:465
Mass (Da):51,828
Last modified:October 1, 1996 - v1
Checksum:i50957D6A2D7EDB43
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91489 Genomic DNA. Translation: CAA62790.1.
Z72706 Genomic DNA. Translation: CAA96896.1.
BK006941 Genomic DNA. Translation: DAA07931.1.
PIRiS61133.
RefSeqiNP_011331.3. NM_001181049.3.

Genome annotation databases

EnsemblFungiiYGL184C; YGL184C; YGL184C.
GeneIDi852691.
KEGGisce:YGL184C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91489 Genomic DNA. Translation: CAA62790.1.
Z72706 Genomic DNA. Translation: CAA96896.1.
BK006941 Genomic DNA. Translation: DAA07931.1.
PIRiS61133.
RefSeqiNP_011331.3. NM_001181049.3.

3D structure databases

ProteinModelPortaliP53101.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33071. 31 interactors.
DIPiDIP-4518N.
IntActiP53101. 4 interactors.
MINTiMINT-502903.

PTM databases

iPTMnetiP53101.

Proteomic databases

MaxQBiP53101.
PRIDEiP53101.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGL184C; YGL184C; YGL184C.
GeneIDi852691.
KEGGisce:YGL184C.

Organism-specific databases

EuPathDBiFungiDB:YGL184C.
SGDiS000003152. STR3.

Phylogenomic databases

GeneTreeiENSGT00550000075611.
HOGENOMiHOG000246415.
InParanoidiP53101.
KOiK01760.
OMAiHLAKIMN.
OrthoDBiEOG092C2AJE.

Enzyme and pathway databases

UniPathwayiUPA00051; UER00078.
BioCyciMetaCyc:YGL184C-MONOMER.
YEAST:YGL184C-MONOMER.

Miscellaneous databases

PROiP53101.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR000277. Cys/Met-Metab_PyrdxlP-dep_enz.
IPR006238. Cys_b_lyase_euk.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11808. PTHR11808. 1 hit.
PfamiPF01053. Cys_Met_Meta_PP. 1 hit.
[Graphical view]
PIRSFiPIRSF001434. CGS. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01329. cysta_beta_ly_E. 1 hit.
PROSITEiPS00868. CYS_MET_METAB_PP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSTR3_YEAST
AccessioniPrimary (citable) accession number: P53101
Secondary accession number(s): D6VTX0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.