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P53096

- HOS2_YEAST

UniProt

P53096 - HOS2_YEAST

Protein

Probable histone deacetylase HOS2

Gene

HOS2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 129 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). It is apparently involved in transcriptional activation.1 Publication

    Catalytic activityi

    Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei197 – 1971By similarity

    GO - Molecular functioni

    1. NAD-dependent histone deacetylase activity Source: SGD
    2. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
    3. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
    4. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
    5. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC
    6. NAD-independent histone deacetylase activity Source: SGD
    7. protein binding Source: IntAct

    GO - Biological processi

    1. chromatin organization Source: SGD
    2. histone deacetylation Source: SGD
    3. negative regulation of meiosis Source: SGD
    4. positive regulation of stress-activated MAPK cascade Source: SGD
    5. regulation of transcription, DNA-templated Source: SGD
    6. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Chromatin regulator, Hydrolase

    Keywords - Biological processi

    Transcription, Transcription regulation

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30675-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable histone deacetylase HOS2 (EC:3.5.1.98)
    Gene namesi
    Name:HOS2
    Ordered Locus Names:YGL194C
    ORF Names:G1330
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VII

    Organism-specific databases

    CYGDiYGL194c.
    SGDiS000003162. HOS2.

    Subcellular locationi

    GO - Cellular componenti

    1. Set3 complex Source: SGD

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi196 – 1972HH → AA: Leads to hyperacetylation. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 452452Probable histone deacetylase HOS2PRO_0000114723Add
    BLAST

    Proteomic databases

    MaxQBiP53096.
    PaxDbiP53096.

    Expressioni

    Gene expression databases

    GenevestigatoriP53096.

    Interactioni

    Subunit structurei

    Identified in a Set3C complex with SET3, HST1, SNT1, SIF2, CPR1 and HOS4/YIL112W.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CYC8P149224EBI-8475,EBI-18215
    HHT2P618302EBI-8475,EBI-8098

    Protein-protein interaction databases

    BioGridi33063. 238 interactions.
    DIPiDIP-6828N.
    IntActiP53096. 37 interactions.
    MINTiMINT-629670.
    STRINGi4932.YGL194C.

    Structurei

    3D structure databases

    ProteinModelPortaliP53096.
    SMRiP53096. Positions 28-394.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni26 – 340315Histone deacetylaseAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0123.
    GeneTreeiENSGT00390000003411.
    HOGENOMiHOG000225180.
    KOiK11483.
    OMAiDKQIHHI.
    OrthoDBiEOG78M0B2.

    Family and domain databases

    Gene3Di3.40.800.20. 1 hit.
    InterProiIPR000286. His_deacetylse.
    IPR003084. His_deacetylse_1.
    IPR023801. His_deacetylse_dom.
    [Graphical view]
    PANTHERiPTHR10625. PTHR10625. 1 hit.
    PfamiPF00850. Hist_deacetyl. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
    PRINTSiPR01270. HDASUPER.
    PR01271. HISDACETLASE.

    Sequencei

    Sequence statusi: Complete.

    P53096-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGTFSYDVK TKENEPLFEF NSAYSPRVSY HFNSKVSHYH YGVKHPMKPF    50
    RLMLTDHLVS SYGLHKIMDL YETRSATRDE LLQFHSEDYV NFLSKVSPEN 100
    ANKLPRGTLE NFNIGDDCPI FQNLYDYTTL YTGASLDATR KLINNQSDIA 150
    INWSGGLHHA KKNSPSGFCY VNDIVLSILN LLRYHPRILY IDIDLHHGDG 200
    VQEAFYTTDR VFTLSFHKYN GEFFPGTGDL TEIGCDKGKH FALNVPLEDG 250
    IDDDSYINLF KSIVDPLIMT FKPTLIVQQC GADSLGHDRL GCFNLNIKAH 300
    GECVKFVKSF GLPMLVVGGG GYTPRNVSRL WTYETGILND VLLPEDIPED 350
    IPFRDSFGPD YSLYPMLDDL YENKNSKKLL EDIRIRCLEN IRYLQGAPSV 400
    RMDAECIPTQ DISALTEEED KIIQEMNEET EADSSNRLEE MEKENSGLIA 450
    FS 452
    Length:452
    Mass (Da):51,455
    Last modified:October 1, 1996 - v1
    Checksum:i024E8AEA0A445A08
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti352 – 36413PFRDS…DYSLY → HSGTHSGRIIHFI(PubMed:9046087)CuratedAdd
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X91837 Genomic DNA. Translation: CAA62950.1.
    Z72716 Genomic DNA. Translation: CAA96906.1.
    BK006941 Genomic DNA. Translation: DAA07921.1.
    PIRiS64211.
    RefSeqiNP_011321.1. NM_001181059.1.

    Genome annotation databases

    EnsemblFungiiYGL194C; YGL194C; YGL194C.
    GeneIDi852681.
    KEGGisce:YGL194C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X91837 Genomic DNA. Translation: CAA62950.1 .
    Z72716 Genomic DNA. Translation: CAA96906.1 .
    BK006941 Genomic DNA. Translation: DAA07921.1 .
    PIRi S64211.
    RefSeqi NP_011321.1. NM_001181059.1.

    3D structure databases

    ProteinModelPortali P53096.
    SMRi P53096. Positions 28-394.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33063. 238 interactions.
    DIPi DIP-6828N.
    IntActi P53096. 37 interactions.
    MINTi MINT-629670.
    STRINGi 4932.YGL194C.

    Proteomic databases

    MaxQBi P53096.
    PaxDbi P53096.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YGL194C ; YGL194C ; YGL194C .
    GeneIDi 852681.
    KEGGi sce:YGL194C.

    Organism-specific databases

    CYGDi YGL194c.
    SGDi S000003162. HOS2.

    Phylogenomic databases

    eggNOGi COG0123.
    GeneTreei ENSGT00390000003411.
    HOGENOMi HOG000225180.
    KOi K11483.
    OMAi DKQIHHI.
    OrthoDBi EOG78M0B2.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30675-MONOMER.

    Miscellaneous databases

    NextBioi 971996.

    Gene expression databases

    Genevestigatori P53096.

    Family and domain databases

    Gene3Di 3.40.800.20. 1 hit.
    InterProi IPR000286. His_deacetylse.
    IPR003084. His_deacetylse_1.
    IPR023801. His_deacetylse_dom.
    [Graphical view ]
    PANTHERi PTHR10625. PTHR10625. 1 hit.
    Pfami PF00850. Hist_deacetyl. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037913. His_deacetylse_1. 1 hit.
    PRINTSi PR01270. HDASUPER.
    PR01271. HISDACETLASE.
    ProtoNeti Search...

    Publicationsi

    1. "Sequencing of a 40.5 kb fragment located on the left arm of chromosome VII from Saccharomyces cerevisiae."
      Coglievina M., Klima R., Bertani I., Delneri D., Zaccaria P., Bruschi C.V.
      Yeast 13:55-64(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 96604 / S288c / FY1679.
    2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
      Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
      , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
      Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. "HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription."
      Rundlett S.E., Carmen A.A., Kobayashi R., Bavykin S., Turner B.M., Grunstein M.
      Proc. Natl. Acad. Sci. U.S.A. 93:14503-14508(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE NAME.
    5. "The S. cerevisiae SET3 complex includes two histone deacetylases, Hos2 and Hst1, and is a meiotic-specific repressor of the sporulation gene program."
      Pijnappel W.W.M.P., Schaft D., Roguev A., Shevchenko A., Tekotte H., Wilm M., Rigaut G., Seraphin B., Aasland R., Stewart A.F.
      Genes Dev. 15:2991-3004(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN A COMPLEX WITH SET3; HST1; SNT1; SIF2; CPR1 AND YIL112W.
    6. "Requirement of Hos2 histone deacetylase for gene activity in yeast."
      Wang A., Kurdistani S.K., Grunstein M.
      Science 298:1412-1414(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, MUTAGENESIS OF 195-HIS-HIS-196.
    7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiHOS2_YEAST
    AccessioniPrimary (citable) accession number: P53096
    Secondary accession number(s): D6VTW0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 129 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 4890 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome VII
      Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

    External Data

    Dasty 3