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Protein

Probable histone deacetylase HOS2

Gene

HOS2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). It is apparently involved in transcriptional activation.1 Publication

Catalytic activityi

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei197 – 1971By similarity

GO - Molecular functioni

  1. NAD-dependent histone deacetylase activity Source: SGD
  2. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
  3. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
  4. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
  5. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC
  6. NAD-independent histone deacetylase activity Source: SGD

GO - Biological processi

  1. chromatin organization Source: SGD
  2. histone deacetylation Source: SGD
  3. negative regulation of meiosis Source: SGD
  4. positive regulation of stress-activated MAPK cascade Source: SGD
  5. regulation of transcription, DNA-templated Source: SGD
  6. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Chromatin regulator, Hydrolase

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-30675-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable histone deacetylase HOS2 (EC:3.5.1.98)
Gene namesi
Name:HOS2
Ordered Locus Names:YGL194C
ORF Names:G1330
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VII

Organism-specific databases

CYGDiYGL194c.
SGDiS000003162. HOS2.

Subcellular locationi

GO - Cellular componenti

  1. Set3 complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi196 – 1972HH → AA: Leads to hyperacetylation.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 452452Probable histone deacetylase HOS2PRO_0000114723Add
BLAST

Proteomic databases

MaxQBiP53096.
PaxDbiP53096.

Expressioni

Gene expression databases

GenevestigatoriP53096.

Interactioni

Subunit structurei

Identified in a Set3C complex with SET3, HST1, SNT1, SIF2, CPR1 and HOS4/YIL112W.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CYC8P149224EBI-8475,EBI-18215
HHT2P618302EBI-8475,EBI-8098

Protein-protein interaction databases

BioGridi33063. 239 interactions.
DIPiDIP-6828N.
IntActiP53096. 37 interactions.
MINTiMINT-629670.
STRINGi4932.YGL194C.

Structurei

3D structure databases

ProteinModelPortaliP53096.
SMRiP53096. Positions 28-394.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni26 – 340315Histone deacetylaseAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0123.
GeneTreeiENSGT00390000003411.
HOGENOMiHOG000225180.
InParanoidiP53096.
KOiK11483.
OMAiDFGPTHP.
OrthoDBiEOG78M0B2.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.

Sequencei

Sequence statusi: Complete.

P53096-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSGTFSYDVK TKENEPLFEF NSAYSPRVSY HFNSKVSHYH YGVKHPMKPF
60 70 80 90 100
RLMLTDHLVS SYGLHKIMDL YETRSATRDE LLQFHSEDYV NFLSKVSPEN
110 120 130 140 150
ANKLPRGTLE NFNIGDDCPI FQNLYDYTTL YTGASLDATR KLINNQSDIA
160 170 180 190 200
INWSGGLHHA KKNSPSGFCY VNDIVLSILN LLRYHPRILY IDIDLHHGDG
210 220 230 240 250
VQEAFYTTDR VFTLSFHKYN GEFFPGTGDL TEIGCDKGKH FALNVPLEDG
260 270 280 290 300
IDDDSYINLF KSIVDPLIMT FKPTLIVQQC GADSLGHDRL GCFNLNIKAH
310 320 330 340 350
GECVKFVKSF GLPMLVVGGG GYTPRNVSRL WTYETGILND VLLPEDIPED
360 370 380 390 400
IPFRDSFGPD YSLYPMLDDL YENKNSKKLL EDIRIRCLEN IRYLQGAPSV
410 420 430 440 450
RMDAECIPTQ DISALTEEED KIIQEMNEET EADSSNRLEE MEKENSGLIA

FS
Length:452
Mass (Da):51,455
Last modified:October 1, 1996 - v1
Checksum:i024E8AEA0A445A08
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti352 – 36413PFRDS…DYSLY → HSGTHSGRIIHFI(PubMed:9046087)CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91837 Genomic DNA. Translation: CAA62950.1.
Z72716 Genomic DNA. Translation: CAA96906.1.
BK006941 Genomic DNA. Translation: DAA07921.1.
PIRiS64211.
RefSeqiNP_011321.1. NM_001181059.1.

Genome annotation databases

EnsemblFungiiYGL194C; YGL194C; YGL194C.
GeneIDi852681.
KEGGisce:YGL194C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91837 Genomic DNA. Translation: CAA62950.1.
Z72716 Genomic DNA. Translation: CAA96906.1.
BK006941 Genomic DNA. Translation: DAA07921.1.
PIRiS64211.
RefSeqiNP_011321.1. NM_001181059.1.

3D structure databases

ProteinModelPortaliP53096.
SMRiP53096. Positions 28-394.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33063. 239 interactions.
DIPiDIP-6828N.
IntActiP53096. 37 interactions.
MINTiMINT-629670.
STRINGi4932.YGL194C.

Proteomic databases

MaxQBiP53096.
PaxDbiP53096.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGL194C; YGL194C; YGL194C.
GeneIDi852681.
KEGGisce:YGL194C.

Organism-specific databases

CYGDiYGL194c.
SGDiS000003162. HOS2.

Phylogenomic databases

eggNOGiCOG0123.
GeneTreeiENSGT00390000003411.
HOGENOMiHOG000225180.
InParanoidiP53096.
KOiK11483.
OMAiDFGPTHP.
OrthoDBiEOG78M0B2.

Enzyme and pathway databases

BioCyciYEAST:G3O-30675-MONOMER.

Miscellaneous databases

NextBioi971996.

Gene expression databases

GenevestigatoriP53096.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequencing of a 40.5 kb fragment located on the left arm of chromosome VII from Saccharomyces cerevisiae."
    Coglievina M., Klima R., Bertani I., Delneri D., Zaccaria P., Bruschi C.V.
    Yeast 13:55-64(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 96604 / S288c / FY1679.
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
    Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
    , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
    Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription."
    Rundlett S.E., Carmen A.A., Kobayashi R., Bavykin S., Turner B.M., Grunstein M.
    Proc. Natl. Acad. Sci. U.S.A. 93:14503-14508(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE NAME.
  5. "The S. cerevisiae SET3 complex includes two histone deacetylases, Hos2 and Hst1, and is a meiotic-specific repressor of the sporulation gene program."
    Pijnappel W.W.M.P., Schaft D., Roguev A., Shevchenko A., Tekotte H., Wilm M., Rigaut G., Seraphin B., Aasland R., Stewart A.F.
    Genes Dev. 15:2991-3004(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN A COMPLEX WITH SET3; HST1; SNT1; SIF2; CPR1 AND YIL112W.
  6. "Requirement of Hos2 histone deacetylase for gene activity in yeast."
    Wang A., Kurdistani S.K., Grunstein M.
    Science 298:1412-1414(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, MUTAGENESIS OF 195-HIS-HIS-196.
  7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiHOS2_YEAST
AccessioniPrimary (citable) accession number: P53096
Secondary accession number(s): D6VTW0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: January 7, 2015
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 4890 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.