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Protein

Probable histone deacetylase HOS2

Gene

HOS2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). It is apparently involved in transcriptional activation.1 Publication

Miscellaneous

Present with 4890 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

Hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei197By similarity1

GO - Molecular functioni

GO - Biological processi

  • chromatin organization Source: SGD
  • histone deacetylation Source: SGD
  • negative regulation of meiotic nuclear division Source: SGD
  • positive regulation of stress-activated MAPK cascade Source: SGD
  • regulation of transcription, DNA-templated Source: SGD
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, Chromatin regulator, Hydrolase
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-30675-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable histone deacetylase HOS2 (EC:3.5.1.98)
Gene namesi
Name:HOS2
Ordered Locus Names:YGL194C
ORF Names:G1330
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGL194C
SGDiS000003162 HOS2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi196 – 197HH → AA: Leads to hyperacetylation. 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001147231 – 452Probable histone deacetylase HOS2Add BLAST452

Proteomic databases

MaxQBiP53096
PaxDbiP53096
PRIDEiP53096

Interactioni

Subunit structurei

Identified in a Set3C complex with SET3, HST1, SNT1, SIF2, CPR1 and HOS4/YIL112W.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi33063, 382 interactors
DIPiDIP-6828N
IntActiP53096, 37 interactors
STRINGi4932.YGL194C

Structurei

3D structure databases

ProteinModelPortaliP53096
SMRiP53096
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni26 – 340Histone deacetylaseAdd BLAST315

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00910000145730
HOGENOMiHOG000225180
InParanoidiP53096
KOiK11483
OMAiPRAWTHL
OrthoDBiEOG092C1END

Family and domain databases

Gene3Di3.40.800.20, 1 hit
InterProiView protein in InterPro
IPR000286 His_deacetylse
IPR003084 His_deacetylse_1
IPR023801 His_deacetylse_dom
IPR037138 His_deacetylse_dom_sf
IPR023696 Ureohydrolase_dom_sf
PANTHERiPTHR10625 PTHR10625, 1 hit
PfamiView protein in Pfam
PF00850 Hist_deacetyl, 1 hit
PIRSFiPIRSF037913 His_deacetylse_1, 1 hit
PRINTSiPR01270 HDASUPER
PR01271 HISDACETLASE
SUPFAMiSSF52768 SSF52768, 1 hit

Sequencei

Sequence statusi: Complete.

P53096-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGTFSYDVK TKENEPLFEF NSAYSPRVSY HFNSKVSHYH YGVKHPMKPF
60 70 80 90 100
RLMLTDHLVS SYGLHKIMDL YETRSATRDE LLQFHSEDYV NFLSKVSPEN
110 120 130 140 150
ANKLPRGTLE NFNIGDDCPI FQNLYDYTTL YTGASLDATR KLINNQSDIA
160 170 180 190 200
INWSGGLHHA KKNSPSGFCY VNDIVLSILN LLRYHPRILY IDIDLHHGDG
210 220 230 240 250
VQEAFYTTDR VFTLSFHKYN GEFFPGTGDL TEIGCDKGKH FALNVPLEDG
260 270 280 290 300
IDDDSYINLF KSIVDPLIMT FKPTLIVQQC GADSLGHDRL GCFNLNIKAH
310 320 330 340 350
GECVKFVKSF GLPMLVVGGG GYTPRNVSRL WTYETGILND VLLPEDIPED
360 370 380 390 400
IPFRDSFGPD YSLYPMLDDL YENKNSKKLL EDIRIRCLEN IRYLQGAPSV
410 420 430 440 450
RMDAECIPTQ DISALTEEED KIIQEMNEET EADSSNRLEE MEKENSGLIA

FS
Length:452
Mass (Da):51,455
Last modified:October 1, 1996 - v1
Checksum:i024E8AEA0A445A08
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti352 – 364PFRDS…DYSLY → HSGTHSGRIIHFI (PubMed:9046087).CuratedAdd BLAST13

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91837 Genomic DNA Translation: CAA62950.1
Z72716 Genomic DNA Translation: CAA96906.1
BK006941 Genomic DNA Translation: DAA07921.1
PIRiS64211
RefSeqiNP_011321.1, NM_001181059.1

Genome annotation databases

EnsemblFungiiYGL194C; YGL194C; YGL194C
GeneIDi852681
KEGGisce:YGL194C

Similar proteinsi

Entry informationi

Entry nameiHOS2_YEAST
AccessioniPrimary (citable) accession number: P53096
Secondary accession number(s): D6VTW0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health