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P53093 (YIP4_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein YIP4
Alternative name(s):
YPT-interacting protein 4
Gene names
Name:YIP4
Ordered Locus Names:YGL198W
ORF Names:G1304
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length235 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be involved in proper membrane localization of Rab GTPases. Ref.6

Subunit structure

Interacts with TVP18, TVP23, YIP1 and YIP5. Interacts with SEC4, YPT1, YPT6, YPT7, YPT10, YPT11, YPT31, YPT32 and YPT52; These proteins are all Rab GTPases. Ref.4 Ref.6

Subcellular location

Golgi apparatus membrane; Multi-pass membrane protein Ref.6.

Sequence similarities

Belongs to the YIP1 family.

Sequence caution

The sequence CAA62946.1 differs from that shown. Reason: Frameshift at positions 220, 226 and 230.

The sequence CAA96911.1 differs from that shown. Reason: Frameshift at positions 220, 226 and 230.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 235235Protein YIP4
PRO_0000202721

Regions

Transmembrane89 – 10921Helical; Potential
Transmembrane114 – 13421Helical; Potential
Transmembrane145 – 16521Helical; Potential
Transmembrane186 – 20621Helical; Potential
Transmembrane215 – 23521Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
P53093 [UniParc].

Last modified April 18, 2006. Version 2.
Checksum: 642B53FDCCDEA86A

FASTA23525,995
        10         20         30         40         50         60 
MSYGREDTTI EPDFIEPDAP LAASGGVADN IGGTMQNSGS RGTLDETVLQ TLKRDVVEIN 

        70         80         90        100        110        120 
SRLKQVVYPH FPSFFSPSDD GIGAADNDIS ANCDLWAPLA FIILYSLFVS HARSLFSSLF 

       130        140        150        160        170        180 
VSSWFILLVM ALHLRLTKPH QRVSLISYIS ISGYCLFPQV LNALVSQILL PLAYHIGKQN 

       190        200        210        220        230 
RWIVRVLSLV KLVVMALCLM WSVAAVSWVT KSKTIIEIYP LALCLFGMAW LSTIL

« Hide

References

« Hide 'large scale' references
[1]"Sequencing of a 40.5 kb fragment located on the left arm of chromosome VII from Saccharomyces cerevisiae."
Coglievina M., Klima R., Bertani I., Delneri D., Zaccaria P., Bruschi C.V.
Yeast 13:55-64(1997) [PubMed: 9046087] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 96604 / S288c / FY1679.
[2]"The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E. expand/collapse author list , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
Nature 387:81-84(1997) [PubMed: 9169869] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 96604 / S288c / FY1679.
[3]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Identification of the novel proteins Yip4p and Yip5p as Rab GTPase interacting factors."
Calero M., Winand N.J., Collins R.N.
FEBS Lett. 515:89-98(2002) [PubMed: 11943201] [Abstract]
Cited for: INTERACTION WITH SEC4; YIP1; YIP5; YPT1; YPT6; YPT7; YPT10; YPT11; YPT31; YPT32 AND YPT52.
[5]"Sequencing and comparison of yeast species to identify genes and regulatory elements."
Kellis M., Patterson N., Endrizzi M., Birren B.W., Lander E.S.
Nature 423:241-254(2003) [PubMed: 12748633] [Abstract]
Cited for: IDENTIFICATION OF FRAMESHIFTS.
[6]"Tvp38, Tvp23, Tvp18 and Tvp15: novel membrane proteins in the Tlg2-containing Golgi/endosome compartments of Saccharomyces cerevisiae."
Inadome H., Noda Y., Kamimura Y., Adachi H., Yoda K.
Exp. Cell Res. 313:688-697(2007) [PubMed: 17178117] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH TVP18; TVP23 AND YIP5.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X91837 Genomic DNA. Translation: CAA62946.1. Frameshift.
Z72721 Genomic DNA. Translation: CAA96911.1. Frameshift.
BK006941 Genomic DNA. Translation: DAA07916.1.
PIRS62047.
RefSeqNP_011317.2. NM_001181063.1.

3D structure databases

ProteinModelPortalP53093.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-1823N.
IntActP53093. 24 interactions.
MINTMINT-390715.
STRINGP53093.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYGL198W; YGL198W; YGL198W.
GeneID852676.
KEGGsce:YGL198W.
NMPDRfig|4932.3.peg.2420.

Organism-specific databases

CYGDYGL198w.
SGDS000003166. YIP4.

Phylogenomic databases

eggNOGfuNOG06254.
GeneTreeEFGT00050000003332.
HOGENOMHBG204454.
OMATIEPDFI.
OrthoDBEOG4N33Z4.

Gene expression databases

ArrayExpressP53093.
GenevestigatorP53093.
GermOnlineYGL198W. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR006977. Yip1.
[Graphical view]
PfamPF04893. Yip1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio971984.

Entry information

Entry nameYIP4_YEAST
AccessionPrimary (citable) accession number: P53093
Secondary accession number(s): D6VTV5
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: April 18, 2006
Last modified: December 14, 2011
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome VII

Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

SIMILARITY comments

Index of protein domains and families

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