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Protein

Kinesin-like protein KIP3

Gene

KIP3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Miscellaneous

Present with 736 molecules/cell in log phase SD medium.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi192 – 199ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • ATP-dependent microtubule motor activity, plus-end-directed Source: SGD
  • microtubule binding Source: InterPro
  • tubulin-dependent ATPase activity Source: SGD

GO - Biological processi

  • establishment of mitotic spindle orientation Source: SGD
  • mitotic spindle assembly Source: SGD
  • mitotic spindle disassembly Source: SGD
  • mitotic spindle organization in nucleus Source: SGD
  • negative regulation of microtubule polymerization Source: SGD
  • nuclear migration along microtubule Source: SGD
  • plus-end specific microtubule depolymerization Source: SGD
  • regulation of mitotic spindle elongation Source: SGD

Keywordsi

Molecular functionMotor protein
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-30692-MONOMER.
ReactomeiR-SCE-5610787. Hedgehog 'off' state.
R-SCE-6811434. COPI-dependent Golgi-to-ER retrograde traffic.
R-SCE-983189. Kinesins.

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIP3
Gene namesi
Name:KIP3
Ordered Locus Names:YGL216W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGL216W.
SGDiS000003184. KIP3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001254041 – 805Kinesin-like protein KIP3Add BLAST805

Proteomic databases

MaxQBiP53086.
PRIDEiP53086.

PTM databases

iPTMnetiP53086.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi33041. 202 interactors.
DIPiDIP-6383N.
IntActiP53086. 8 interactors.
MINTiMINT-688270.
STRINGi4932.YGL216W.

Structurei

3D structure databases

ProteinModelPortaliP53086.
SMRiP53086.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 438Kinesin motorPROSITE-ProRule annotationAdd BLAST429

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili449 – 481Sequence analysisAdd BLAST33

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

GeneTreeiENSGT00890000139327.
HOGENOMiHOG000183905.
InParanoidiP53086.
KOiK10401.
OMAiCVDDKML.
OrthoDBiEOG092C2D4G.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiView protein in InterPro
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00225. Kinesin. 1 hit.
PRINTSiPR00380. KINESINHEAVY.
SMARTiView protein in SMART
SM00129. KISc. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P53086-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNVPETRQSS IVVAIRVRPF TSMEKTRLVN EASGAEANFP GLGDSSLILP
60 70 80 90 100
MSNNSDSDID IDAEEGSTRS KRNSLLRRKV IRPEGIRKIV DCVDDRMLIF
110 120 130 140 150
DPADRNPLNK VSDQVLNSMR ARATKATASS INNSNATNKF SSQRRRHGGE
160 170 180 190 200
IKFVFDKLFD ETSSQARVYK ETTSPLLDSV LDGFNSTVFA YGATGCGKTY
210 220 230 240 250
TVSGTPSQPG IIFLAMEELF NKITDLKDEK DFEISLSYLE IYNERIRDLL
260 270 280 290 300
KPETPSKRLV IREDTQNHIK VANLSYHHPN TVEDVMDLVV QGNINRTTSP
310 320 330 340 350
TEANEVSSRS HAVLQIHIMQ TNKLVDLTSQ HTFATLSIID LAGSERAAAT
360 370 380 390 400
RNRGIRLHEG ANINRSLLAL GNCINALCLN DGSRSCHIPY RDSKLTRLLK
410 420 430 440 450
FSLGGNCKTV MIVCISPSSS HYDETLNTLK YANRAKEIKT KIIRNQQSLS
460 470 480 490 500
RHVGSYLKMI TEQKRQIEEL REREEKMISL KLTKYKLNKE KIQLAINECV
510 520 530 540 550
NRVQQTYAGV ETYQVAKTLK SLILCKRRFL QMVKLEVDNL ILLFEREEST
560 570 580 590 600
AAEMQPVISN CRMISGQLYN KIHELEMKFD ETDTLSSVIH QVHSIDLNKL
610 620 630 640 650
REMEDWDETY DLVYLESCLN QISELQRNEI LVNSSIMTEK LMSDPGLNSR
660 670 680 690 700
FKFLSKWLMN RTPNIESIIQ DLVHIDEEFE SFARTFIANP DSNFTNTNIN
710 720 730 740 750
IINTTAADLA VPAETLQRQN FSQKKVKWTS PDLSPSPMIE PQPELEPELH
760 770 780 790 800
QDQDAIASEV DVSMQDTTFN EQGPSTPSAP TTAVPRRKMR SSLLTHQSLL

ATARK
Length:805
Mass (Da):91,090
Last modified:October 1, 1996 - v1
Checksum:i6049EF2C13D5C2C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72739 Genomic DNA. Translation: CAA96933.1.
BK006941 Genomic DNA. Translation: DAA07901.1.
PIRiS64238.
RefSeqiNP_011299.1. NM_001181081.1.

Genome annotation databases

EnsemblFungiiYGL216W; YGL216W; YGL216W.
GeneIDi852655.
KEGGisce:YGL216W.

Similar proteinsi

Entry informationi

Entry nameiKIP3_YEAST
AccessioniPrimary (citable) accession number: P53086
Secondary accession number(s): D6VTU0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 27, 2017
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names