P53082 (FRA2_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Fe repressor of activation 2

Alternative name(s):
Altered inheritance rate of mitochondria protein 15

Gene names

Name:	FRA2
Synonyms:	AIM15
Ordered Locus Names:	YGL220W

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	120 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in the regulation of the iron regulon in response to decreased mitochondrial iron-sulfur cluster synthesis. May be involved in mitochondrial organization and biogenesis. Ref.7 Ref.8
Subunit structure	Interacts with FRA1, GRX3 and GRX4. Ref.7
Subcellular location	Cytoplasm. Nucleus Ref.5 Ref.7.
Miscellaneous	Present with 2050 molecules/cell in log phase SD medium. Ref.6
Sequence similarities	Belongs to the bolA/yrbA family.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	negative regulation of transcription from RNA polymerase II promoter in response to iron Inferred from mutant phenotype Ref.7. Source: SGD
Cellular component	cytosol Inferred from direct assay Ref.7. Source: SGD nucleus Inferred from direct assay Ref.5. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 120	120	Fe repressor of activation 2		PRO_0000201232

Sequences

	Sequence		Length	Mass (Da)
	P53082 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 9111F95A839235A8	FASTA	120	14,102
	10 20 30 40 50 60 MTGERIEKVK INDEFAKSHF LTTQWRETKR QRHYKMPVTE QGLRERIESA IPQVYHIIVT 70 80 90 100 110 120 DLSYGCGQSF DIVVVSDFFQ GKSKLMRSRA VNKAVKEELQ EIHAFSCKCY TEEEWSKIVV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence analysis of 203 kilobases from Saccharomyces cerevisiae chromosome VII." Rieger M., Brueckner M., Schaefer M., Mueller-Auer S. Yeast 13:1077-1090(1997) [PubMed: 9290212] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[2]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome VII." Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E. , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K. Nature 387:81-84(1997) [PubMed: 9169869] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[4]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed: 17322287] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[5]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed: 14562095] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[6]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[7]	"Identification of FRA1 and FRA2 as genes involved in regulating the yeast iron regulon in response to decreased mitochondrial iron-sulfur cluster synthesis." Kumanovics A., Chen O.S., Li L., Bagley D., Adkins E.M., Lin H., Dingra N.N., Outten C.E., Keller G., Winge D., Ward D.M., Kaplan J. J. Biol. Chem. 283:10276-10286(2008) [PubMed: 18281282] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH FRA1; GRX3 AND GRX4.
[8]	"Computationally driven, quantitative experiments discover genes required for mitochondrial biogenesis." Hess D.C., Myers C.L., Huttenhower C., Hibbs M.A., Hayes A.P., Paw J., Clore J.J., Mendoza R.M., Luis B.S., Nislow C., Giaever G., Costanzo M., Troyanskaya O.G., Caudy A.A. PLoS Genet. 5:E1000407-E1000407(2009) [PubMed: 19300474] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z72742 Genomic DNA. Translation: CAA96936.1. AY558390 Genomic DNA. Translation: AAS56716.1. BK006941 Genomic DNA. Translation: DAA07899.1.
PIR	S64242.
RefSeq	NP_011295.1. NM_001181085.1.
3D structure databases
ProteinModelPortal	P53082.
SMR	P53082. Positions 38-118.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-2048N.
IntAct	P53082. 5 interactions.
MINT	MINT-522906.
STRING	P53082.
Proteomic databases
PeptideAtlas	P53082.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YGL220W; YGL220W; YGL220W.
GeneID	852652.
KEGG	sce:YGL220W.
NMPDR	fig|4932.3.peg.2398.
Organism-specific databases
CYGD	YGL220w.
SGD	S000003188. FRA2.
Phylogenomic databases
eggNOG	fuNOG11922.
GeneTree	EFGT00050000004040.
HOGENOM	HBG739421.
OrthoDB	EOG43R6XH.
Gene expression databases
ArrayExpress	P53082.
Genevestigator	P53082.
GermOnline	YGL220W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR002634. BolA. [Graphical view]
Gene3D	G3DSA:3.30.300.90. BolA. 1 hit.
PANTHER	PTHR12735. BolA. 1 hit.
Pfam	PF01722. BolA. 1 hit. [Graphical view]
SUPFAM	SSF82657. BolA. 1 hit.
ProtoNet	Search...
Other
NextBio	971927.

Entry information

Entry name

FRA2_YEAST

Accession

Primary (citable) accession number: P53082
Secondary accession number(s): D6VVB5

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	December 14, 2011
This is version 85 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program