Reviewed, UniProtKB/Swiss-Prot P53079 (COG1_YEAST)

Names and origin

Protein names

Recommended name:
    Conserved oligomeric Golgi complex subunit 1
      Short name=COG complex subunit 1
Alternative name(s):
    Component of oligomeric Golgi complex 1
    Complexed with DOR1 protein 3
    Protein SEC36

Gene names

Name:	COG1
Synonyms:	COD3, SEC36, TFI1
Ordered Locus Names:	YGL223C

Organism

Saccharomyces cerevisiae (Baker's yeast) [Complete proteome]

Taxonomic identifier

4932 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	417 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Acts as essential component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events. Ref.5 Ref.6
Subunit structure	Component of the conserved oligomeric Golgi (COG or Sec34/Sec35) complex which consists of eight different proteins COG1-COG8. Ref.4
Subcellular location	Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side By similarity.
Miscellaneous	Present with 2190 molecules/cell in log phase SD medium. Ref.7
Sequence similarities	Belongs to the COG1 family.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Golgi apparatus Membrane
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	protein transport Inferred from electronic annotation. Source: UniProtKB-KW retrograde transport, vesicle recycling within Golgi Ref.4 Inferred from mutant phenotype. Source: SGD
Cellular component	Golgi transport complex Ref.4 Inferred from physical interaction. Source: SGD membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 417	417	Conserved oligomeric Golgi complex subunit 1		PRO_0000213494
Amino acid modifications
	Modified residue	305	1	Phosphoserine Ref.9

Sequences

	Sequence		Length	Mass (Da)
	P53079-1 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 65F7EF5B5194D9AB	FASTA	417	48,337
	10 20 30 40 50 60 MDEVLPLFRD SHIPQIKDYQ LELQNDLTKT NEAFQKNLLK NYNKILSLTD SVNDLSLNLK 70 80 90 100 110 120 NVDQDFKSLC FNDEKFQLNK LTPLPYQTTT HISPPRDEEK VSIPSQNILV ISNWTISINN 130 140 150 160 170 180 FCNRIVTSTT PSRIFDELLL NFHELSLIPV PSKFEALVKD KCCRLQKFLV DSMKTLNLTL 190 200 210 220 230 240 LQWVKLYNLL NTEFSSKWDD DLLSIFNESL FETLFNDNVQ ALLISSANSK DHQYHSNQQY 250 260 270 280 290 300 KDAIVVDFVN SSTFRDHLIR RTVKEINTHL DTLSTLRAKL KEPETLHKLD IFHDNDTNLN 310 320 330 340 350 360 DGTVSPLDDD ALKQYIDTAV FYSKGLTNDT TLQIYQTVQP TIEILQNLEL YKCPQETLTD 370 380 390 400 410 LRNKLITQLQ EFKTQISSRL PSPLENSTSV VDDFITSYNN HNLLQLVIDQ ITQLRQQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence analysis of 203 kilobases from Saccharomyces cerevisiae chromosome VII." Rieger M., Brueckner M., Schaefer M., Mueller-Auer S. Yeast 13:1077-1090(1997) [PubMed: 9290212] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[2]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome VII." Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E. , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K. Nature 387:81-84(1997) [PubMed: 9169869] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[3]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed: 17322287] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[4]	"The Sec34/35 Golgi transport complex is related to the exocyst, defining a family of complexes involved in multiple steps of membrane traffic." Whyte J.R., Munro S. Dev. Cell 1:527-537(2001) [PubMed: 11703943] [Abstract] Cited for: SUBUNIT.
[5]	"The Sec34/Sec35p complex, a Ypt1p effector required for retrograde intra-Golgi trafficking, interacts with Golgi SNAREs and COPI vesicle coat proteins." Suvorova E.S., Duden R., Lupashin V.V. J. Cell Biol. 157:631-643(2002) [PubMed: 12011112] [Abstract] Cited for: IDENTIFICATION IN THE COG COMPLEX, FUNCTION OF THE COG COMPLEX.
[6]	"Identification of sec36p, sec37p, and sec38p: components of yeast complex that contains sec34p and sec35p." Ram R.J., Li B., Kaiser C.A. Mol. Biol. Cell 13:1484-1500(2002) [PubMed: 12006647] [Abstract] Cited for: FUNCTION, IDENTIFICATION IN THE COG COMPLEX.
[7]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[8]	"The binary interacting network of the conserved oligomeric Golgi tethering complex." Loh E., Hong W. J. Biol. Chem. 279:24640-24648(2004) [PubMed: 15047703] [Abstract] Cited for: COMPOSITION OF THE COG COMPLEX, INTERACTION WITH COG3 AND COG4.
[9]	"Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases." Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H. Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007) [PubMed: 17563356] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-305, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z72745 Genomic DNA. Translation: CAA96939.1. AY692796 Genomic DNA. Translation: AAT92815.1.
PIR	S64245.
RefSeq	NP_011292.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:4374N.
IntAct	P53079. 11 interactions.
STRING	P53079.
Proteomic databases
PRIDE	P53079.
Genome annotation databases
Ensembl	YGL223C; YGL223C; YGL223C; Saccharomyces cerevisiae. [Genome view]
GeneID	852649.
KEGG	sce:YGL223C.
NMPDR	fig|4932.3.peg.2395.
Organism-specific databases
CYGD	YGL223c.
SGD	S000003191. COG1.
Phylogenomic databases
HOGENOM	P53079.
OMA	HELSTIN
OrthoDB	EOG9J3Z0N
Gene expression databases
ArrayExpress	P53079.
Genevestigator	P53079.
GermOnline	YGL223C. Saccharomyces cerevisiae.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	971918.

Entry information

Entry name

COG1_YEAST

Accession

Primary (citable) accession number: P53079

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	November 24, 2009
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)