P53078 (SDT1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Suppressor of disruption of TFIIS

Gene names

Name:	SDT1
Synonyms:	SSM1
Ordered Locus Names:	YGL224C

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	280 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Could be an enzyme that inactivates 6-azauracil by modifying it.
Sequence similarities	Belongs to the SSM1 family.

Ontologies

Keywords
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	pyrimidine base metabolic process Inferred from mutant phenotype. Source: SGD
Molecular function	nucleotidase activity Inferred from direct assay. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 280

280

Suppressor of disruption of TFIIS

PRO_0000072213

Secondary structure

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280

Helix Strand Turn

Details...

Helix

6 – 29

24

Beta strand

57 – 60

4

Turn

63 – 65

3

Helix

71 – 87

17

Helix

93 – 106

14

Turn

116 – 118

3

Helix

122 – 129

8

Turn

130 – 132

3

Helix

135 – 137

3

Helix

143 – 154

12

Beta strand

159 – 164

6

Helix

169 – 178

10

Helix

205 – 214

10

Helix

220 – 222

3

Beta strand

223 – 227

5

Turn

232 – 234

3

Beta strand

243 – 247

5

Beta strand

264 – 268

5

Helix

269 – 274

6

Helix

277 – 279

3

Sequences

	Sequence		Length	Mass (Da)
	P53078 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 680F66359CD57B8B	FASTA	280	31,969
	10 20 30 40 50 60 MTVEYTASDL ATYQNEVNEQ IAKNKAHLES LTHPGSKVTF PIDQDISATP QNPNLKVFFF 70 80 90 100 110 120 DIDNCLYKSS TRIHDLMQQS ILRFFQTHLK LSPEDAHVLN NSYYKEYGLA IRGLVMFHKV 130 140 150 160 170 180 NALEYNRLVD DSLPLQDILK PDIPLRNMLL RLRQSGKIDK LWLFTNAYKN HAIRCLRLLG 190 200 210 220 230 240 IADLFDGLTY CDYSRTDTLV CKPHVKAFEK AMKESGLARY ENAYFIDDSG KNIETGIKLG 250 260 270 280 MKTCIHLVEN EVNEILGQTP EGAIVISDIL ELPHVVSDLF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Transcription elongation factor S-II confers yeast resistance to 6-azauracil by enhancing expression of the SSM1 gene." Shimoaraiso M., Nakanishi T., Kubo T., Natori S. J. Biol. Chem. 275:29623-29627(2000) [PubMed: 10858443] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Sequence analysis of 203 kilobases from Saccharomyces cerevisiae chromosome VII." Rieger M., Brueckner M., Schaefer M., Mueller-Auer S. Yeast 13:1077-1090(1997) [PubMed: 9290212] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[3]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome VII." Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E. , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K. Nature 387:81-84(1997) [PubMed: 9169869] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[4]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[5]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed: 17322287] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

D26043 Genomic DNA. Translation: BAB13723.1.
Z72746 Genomic DNA. Translation: CAA96940.1.
AY692802 Genomic DNA. Translation: AAT92821.1.
BK006941 Genomic DNA. Translation: DAA07895.1.

PIR

S64246.

RefSeq

NP_011291.1. NM_001181089.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3NUQ	X-ray	1.70	A	1-280	[»]
3ONN	X-ray	1.87	A	26-280	[»]
3OPX	X-ray	1.70	A	26-280	[»]

ProteinModelPortal

P53078.

SMR

P53078. Positions 1-280.

ModBase

Search...

Protein-protein interaction databases

MINT

MINT-597480.

STRING

P53078.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblFungi

YGL224C; YGL224C; YGL224C.

GeneID

852648.

KEGG

sce:YGL224C.

NMPDR

fig|4932.3.peg.2394.

Organism-specific databases

CYGD

YGL224c.

SGD

S000003192. SDT1.

Phylogenomic databases

eggNOG

fuNOG08726.

GeneTree

EFGT00050000005347.

HOGENOM

HBG502486.

OMA

FDYFWLV.

OrthoDB

EOG437VQ1.

Gene expression databases

ArrayExpress

P53078.

Genevestigator

P53078.

GermOnline

YGL224C. Saccharomyces cerevisiae.

Family and domain databases

InterPro

IPR005834. Dehalogen-like_hydro.
IPR023214. HAD-like_dom.
IPR006402. HAD-SF_hydro_IA_v3.
IPR010237. Pyr-5-nucltdase.
[Graphical view]

Gene3D

G3DSA:3.40.50.1000. HAD-like_dom. 2 hits.

KO

K07025.

Pfam

PF00702. Hydrolase. 1 hit.
[Graphical view]

SUPFAM

SSF56784. HAD-like_dom. 1 hit.

TIGRFAMs

TIGR01509. HAD-SF-IA-v3. 1 hit.
TIGR01993. Pyr-5-nucltdase. 1 hit.

ProtoNet

Search...

Other

NextBio

971915.

Entry information

Entry name

SDT1_YEAST

Accession

Primary (citable) accession number: P53078
Secondary accession number(s): D6VVB1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	December 14, 2011
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program