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P53075

- SHE10_YEAST

UniProt

P53075 - SHE10_YEAST

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Protein

Outer spore wall assembly protein SHE10

Gene

SHE10

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Involved in spore wall assembly (PubMed:23966878). May be a component of the mitochondrial RNase MRP (MtMRP), a ribonucleoprotein endoribonuclease involved in the cleaving RNA transcripts to generate primers for DNA replication in mitochondria (PubMed:20086051). Causes growth arrest when highly overexpressed (PubMed:7762298).3 Publications

GO - Biological processi

  1. ascospore wall assembly Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

Sporulation

Enzyme and pathway databases

BioCyciYEAST:G3O-30702-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Outer spore wall assembly protein SHE101 Publication
Alternative name(s):
Sensitivity to high expression protein 101 Publication
Gene namesi
Name:SHE101 Publication
Ordered Locus Names:YGL228WImported
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VII

Organism-specific databases

CYGDiYGL228w.
SGDiS000003197. SHE10.

Subcellular locationi

Mitochondrion 1 Publication

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
  2. ribonucleoprotein complex Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Disruption phenotypei

A combined deletion of the OSW7 and SHE10 has reduced dityrosine incorporation in the outer spore wall.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 577554Outer spore wall assembly protein SHE10PRO_0000202713Add
BLAST

Proteomic databases

MaxQBiP53075.
PaxDbiP53075.
PeptideAtlasiP53075.

Expressioni

Gene expression databases

GenevestigatoriP53075.

Interactioni

Subunit structurei

Component of the mitochondria-localized RNase mitochondrial RNA-processing (RNase MRP) composed of one single RNA encoded by the NME1 gene and at least 31 proteins. Absent in the nucleus-localized RNase MRP (NuMRP).1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
YHR080CP388001EBI-24178,EBI-24597

Protein-protein interaction databases

BioGridi33011. 35 interactions.
IntActiP53075. 2 interactions.
STRINGi4932.YGL228W.

Structurei

3D structure databases

ProteinModelPortaliP53075.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili379 – 41638Sequence AnalysisAdd
BLAST
Coiled coili513 – 56250Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the OSW/SHE family.Curated

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiNOG43738.
GeneTreeiENSGT00530000067862.
InParanoidiP53075.
OMAiGSISCER.
OrthoDBiEOG7H4F68.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P53075-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGKLIKLITT LTVLVSLLQY CCEFNSGSIS CERTQTLCHY TNPRVWNTYF
60 70 80 90 100
SRNCELYKNK VSPGFDIVAR KYDTAVKPVI DDATVKVNKV AIQPAFKVIH
110 120 130 140 150
SQCKKWNCGK YYQLVRSPMV KTRRFFFAKY NAFVKPNLDK FFTAEFRSHL
160 170 180 190 200
KERILKYKNI GHYYFTITSR CIKSKYDFIV GNTEEKLMGK FKNKDTHGIH
210 220 230 240 250
GSVTREPSSE DMVLTVSTME SDEEELTTTS TQTVVETITL DQEEASAVAN
260 270 280 290 300
HAHDDEASTD VEGSTDVNVN EQALLQEDFD MWSETILQKT QDVIQLFEKD
310 320 330 340 350
VSKYINGKLV EEANHFKAKF QSLDDKSKKF FSKISLAIND IECVEGIDSE
360 370 380 390 400
TGKKIFFDKS GSTEISQYIT RELVREYFNE TRSTLDELTN AMEKDLSEIT
410 420 430 440 450
DEIEKKVNAI REENVEVFEE WGDIIVNEWS KRMAYVDVIN AHMGADDDTT
460 470 480 490 500
LDEEKAKSSV NWKKFLKGKK QIIESRDKLA HHSADLSRVN AFRQKVQKKI
510 520 530 540 550
LSFTQESGEF LYILRSKANL QFQERERKER ERKEREKAAA EEFQRQQELL
560 570
RQQEEEDEED VSYTSTSTIT TTITMTL
Length:577
Mass (Da):66,862
Last modified:October 1, 1996 - v1
Checksum:iEF4CA95FA3157660
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z72750 Genomic DNA. Translation: CAA96945.1.
BK006941 Genomic DNA. Translation: DAA07890.1.
PIRiS64250.
RefSeqiNP_011286.1. NM_001181094.1.

Genome annotation databases

EnsemblFungiiYGL228W; YGL228W; YGL228W.
GeneIDi852623.
KEGGisce:YGL228W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z72750 Genomic DNA. Translation: CAA96945.1 .
BK006941 Genomic DNA. Translation: DAA07890.1 .
PIRi S64250.
RefSeqi NP_011286.1. NM_001181094.1.

3D structure databases

ProteinModelPortali P53075.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 33011. 35 interactions.
IntActi P53075. 2 interactions.
STRINGi 4932.YGL228W.

Proteomic databases

MaxQBi P53075.
PaxDbi P53075.
PeptideAtlasi P53075.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YGL228W ; YGL228W ; YGL228W .
GeneIDi 852623.
KEGGi sce:YGL228W.

Organism-specific databases

CYGDi YGL228w.
SGDi S000003197. SHE10.

Phylogenomic databases

eggNOGi NOG43738.
GeneTreei ENSGT00530000067862.
InParanoidi P53075.
OMAi GSISCER.
OrthoDBi EOG7H4F68.

Enzyme and pathway databases

BioCyci YEAST:G3O-30702-MONOMER.

Miscellaneous databases

NextBioi 971841.

Gene expression databases

Genevestigatori P53075.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
    Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
    , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
    Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "An efficient method to isolate yeast genes causing overexpression-mediated growth arrest."
    Espinet C., de la Torre M.A., Aldea M., Herrero E.
    Yeast 11:25-32(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  5. "Comparison of mitochondrial and nucleolar RNase MRP reveals identical RNA components with distinct enzymatic activities and protein components."
    Lu Q., Wierzbicki S., Krasilnikov A.S., Schmitt M.E.
    RNA 16:529-537(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN MITOCHONDRIAL RNASE MRP, SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.
  6. "A highly redundant gene network controls assembly of the outer spore wall in S. cerevisiae."
    Lin C.P., Kim C., Smith S.O., Neiman A.M.
    PLoS Genet. 9:E1003700-E1003700(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiSHE10_YEAST
AccessioniPrimary (citable) accession number: P53075
Secondary accession number(s): D6VVA6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 8640 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

External Data

Dasty 3