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P53075

- SHE10_YEAST

UniProt

P53075 - SHE10_YEAST

Protein

Sensitivity to high expression protein 10

Gene

SHE10

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Component of the mitochondrial RNase MRP (MtMRP), a ribonucleoprotein endoribonuclease involved in the cleaving RNA transcripts to generate primers for DNA replication in mitochondria. Absent in the nucleus-localized RNase MRP (NuMRP). Causes growth arrest when highly overexpressed.1 Publication

    GO - Biological processi

    1. ascospore wall assembly Source: SGD

    Keywords - Molecular functioni

    Ribonucleoprotein

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30702-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sensitivity to high expression protein 10
    Gene namesi
    Name:SHE10
    Ordered Locus Names:YGL228W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VII

    Organism-specific databases

    CYGDiYGL228w.
    SGDiS000003197. SHE10.

    Subcellular locationi

    Mitochondrion 1 Publication

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB-SubCell
    2. ribonucleoprotein complex Source: UniProtKB-KW

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 577577Sensitivity to high expression protein 10PRO_0000202713Add
    BLAST

    Proteomic databases

    MaxQBiP53075.
    PaxDbiP53075.
    PeptideAtlasiP53075.

    Expressioni

    Gene expression databases

    GenevestigatoriP53075.

    Interactioni

    Subunit structurei

    Component of the mitochondria-localized RNase mitochondrial RNA-processing (RNase MRP) composed of one single RNA encoded by the NME1 gene and at least 31 proteins.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    YHR080CP388001EBI-24178,EBI-24597

    Protein-protein interaction databases

    BioGridi33011. 34 interactions.
    IntActiP53075. 2 interactions.
    STRINGi4932.YGL228W.

    Structurei

    3D structure databases

    ProteinModelPortaliP53075.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili379 – 41638Sequence AnalysisAdd
    BLAST
    Coiled coili513 – 56250Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the SHE10 family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG43738.
    GeneTreeiENSGT00530000067862.
    OMAiGSISCER.
    OrthoDBiEOG7H4F68.

    Sequencei

    Sequence statusi: Complete.

    P53075-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGKLIKLITT LTVLVSLLQY CCEFNSGSIS CERTQTLCHY TNPRVWNTYF    50
    SRNCELYKNK VSPGFDIVAR KYDTAVKPVI DDATVKVNKV AIQPAFKVIH 100
    SQCKKWNCGK YYQLVRSPMV KTRRFFFAKY NAFVKPNLDK FFTAEFRSHL 150
    KERILKYKNI GHYYFTITSR CIKSKYDFIV GNTEEKLMGK FKNKDTHGIH 200
    GSVTREPSSE DMVLTVSTME SDEEELTTTS TQTVVETITL DQEEASAVAN 250
    HAHDDEASTD VEGSTDVNVN EQALLQEDFD MWSETILQKT QDVIQLFEKD 300
    VSKYINGKLV EEANHFKAKF QSLDDKSKKF FSKISLAIND IECVEGIDSE 350
    TGKKIFFDKS GSTEISQYIT RELVREYFNE TRSTLDELTN AMEKDLSEIT 400
    DEIEKKVNAI REENVEVFEE WGDIIVNEWS KRMAYVDVIN AHMGADDDTT 450
    LDEEKAKSSV NWKKFLKGKK QIIESRDKLA HHSADLSRVN AFRQKVQKKI 500
    LSFTQESGEF LYILRSKANL QFQERERKER ERKEREKAAA EEFQRQQELL 550
    RQQEEEDEED VSYTSTSTIT TTITMTL 577
    Length:577
    Mass (Da):66,862
    Last modified:October 1, 1996 - v1
    Checksum:iEF4CA95FA3157660
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z72750 Genomic DNA. Translation: CAA96945.1.
    BK006941 Genomic DNA. Translation: DAA07890.1.
    PIRiS64250.
    RefSeqiNP_011286.1. NM_001181094.1.

    Genome annotation databases

    EnsemblFungiiYGL228W; YGL228W; YGL228W.
    GeneIDi852623.
    KEGGisce:YGL228W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z72750 Genomic DNA. Translation: CAA96945.1 .
    BK006941 Genomic DNA. Translation: DAA07890.1 .
    PIRi S64250.
    RefSeqi NP_011286.1. NM_001181094.1.

    3D structure databases

    ProteinModelPortali P53075.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33011. 34 interactions.
    IntActi P53075. 2 interactions.
    STRINGi 4932.YGL228W.

    Proteomic databases

    MaxQBi P53075.
    PaxDbi P53075.
    PeptideAtlasi P53075.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YGL228W ; YGL228W ; YGL228W .
    GeneIDi 852623.
    KEGGi sce:YGL228W.

    Organism-specific databases

    CYGDi YGL228w.
    SGDi S000003197. SHE10.

    Phylogenomic databases

    eggNOGi NOG43738.
    GeneTreei ENSGT00530000067862.
    OMAi GSISCER.
    OrthoDBi EOG7H4F68.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30702-MONOMER.

    Miscellaneous databases

    NextBioi 971841.

    Gene expression databases

    Genevestigatori P53075.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
      Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
      , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
      Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "An efficient method to isolate yeast genes causing overexpression-mediated growth arrest."
      Espinet C., de la Torre M.A., Aldea M., Herrero E.
      Yeast 11:25-32(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    5. "Comparison of mitochondrial and nucleolar RNase MRP reveals identical RNA components with distinct enzymatic activities and protein components."
      Lu Q., Wierzbicki S., Krasilnikov A.S., Schmitt M.E.
      RNA 16:529-537(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN MITOCHONDRIAL RNASE MRP, SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.

    Entry informationi

    Entry nameiSHE10_YEAST
    AccessioniPrimary (citable) accession number: P53075
    Secondary accession number(s): D6VVA6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 8640 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome VII
      Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

    External Data

    Dasty 3