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P53073

- EMC4_YEAST

UniProt

P53073 - EMC4_YEAST

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Protein

ER membrane protein complex subunit 4

Gene

EMC4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER).

GO - Biological processi

  1. protein folding in endoplasmic reticulum Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-30705-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
ER membrane protein complex subunit 4
Gene namesi
Name:EMC4
Ordered Locus Names:YGL231C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VII

Organism-specific databases

CYGDiYGL231c.
SGDiS000003200. EMC4.

Subcellular locationi

Endoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei98 – 11821HelicalSequence AnalysisAdd
BLAST
Transmembranei136 – 15621HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. ER membrane protein complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 190190ER membrane protein complex subunit 4PRO_0000202711Add
BLAST

Proteomic databases

MaxQBiP53073.
PaxDbiP53073.

Expressioni

Gene expression databases

GenevestigatoriP53073.

Interactioni

Subunit structurei

Component of the ER membrane protein complex (EMC), which is composed of EMC1, EMC2, EMC3, EMC4, EMC5 and EMC6.1 Publication

Protein-protein interaction databases

BioGridi33008. 45 interactions.
MINTiMINT-4486491.
STRINGi4932.YGL231C.

Structurei

3D structure databases

ProteinModelPortaliP53073.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the EMC4 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG308755.
GeneTreeiENSGT00390000006970.
HOGENOMiHOG000163282.
InParanoidiP53073.
OMAiFAKFDTE.
OrthoDBiEOG75B8HW.

Family and domain databases

InterProiIPR009445. DUF1077_TMEM85.
[Graphical view]
PANTHERiPTHR19315. PTHR19315. 1 hit.
PfamiPF06417. DUF1077. 1 hit.
[Graphical view]
PIRSFiPIRSF017207. UCP017207_TM-p85. 1 hit.

Sequencei

Sequence statusi: Complete.

P53073-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSEQEPYEWA KHLLDTKYIE KYNIQNSNTL PSPPGFEGNS SKGNVTRKQQ
60 70 80 90 100
DATSQTTSLA QKNQITVLQV QKAWQIALQP AKSIPMNIFM SYMSGTSLQI
110 120 130 140 150
IPIMTALMLL SGPIKAIFST RSAFKPVLGN KATQSQVQTA MFMYIVFQGV
160 170 180 190
LMYIGYRKLN SMGLIPNAKG DWLPWERIAH YNNGLQWFSD
Length:190
Mass (Da):21,460
Last modified:October 1, 1996 - v1
Checksum:i062AE1EAB05360EE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72753 Genomic DNA. Translation: CAA96949.1.
AY558267 Genomic DNA. Translation: AAS56593.1.
BK006941 Genomic DNA. Translation: DAA07887.1.
PIRiS64253.
RefSeqiNP_011283.1. NM_001181097.1.

Genome annotation databases

EnsemblFungiiYGL231C; YGL231C; YGL231C.
GeneIDi852620.
KEGGisce:YGL231C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72753 Genomic DNA. Translation: CAA96949.1 .
AY558267 Genomic DNA. Translation: AAS56593.1 .
BK006941 Genomic DNA. Translation: DAA07887.1 .
PIRi S64253.
RefSeqi NP_011283.1. NM_001181097.1.

3D structure databases

ProteinModelPortali P53073.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 33008. 45 interactions.
MINTi MINT-4486491.
STRINGi 4932.YGL231C.

Proteomic databases

MaxQBi P53073.
PaxDbi P53073.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YGL231C ; YGL231C ; YGL231C .
GeneIDi 852620.
KEGGi sce:YGL231C.

Organism-specific databases

CYGDi YGL231c.
SGDi S000003200. EMC4.

Phylogenomic databases

eggNOGi NOG308755.
GeneTreei ENSGT00390000006970.
HOGENOMi HOG000163282.
InParanoidi P53073.
OMAi FAKFDTE.
OrthoDBi EOG75B8HW.

Enzyme and pathway databases

BioCyci YEAST:G3O-30705-MONOMER.

Miscellaneous databases

NextBioi 971832.
PROi P53073.

Gene expression databases

Genevestigatori P53073.

Family and domain databases

InterProi IPR009445. DUF1077_TMEM85.
[Graphical view ]
PANTHERi PTHR19315. PTHR19315. 1 hit.
Pfami PF06417. DUF1077. 1 hit.
[Graphical view ]
PIRSFi PIRSF017207. UCP017207_TM-p85. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
    Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
    , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
    Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. "Comprehensive characterization of genes required for protein folding in the endoplasmic reticulum."
    Jonikas M.C., Collins S.R., Denic V., Oh E., Quan E.M., Schmid V., Weibezahn J., Schwappach B., Walter P., Weissman J.S., Schuldiner M.
    Science 323:1693-1697(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN EMC COMPLEX.

Entry informationi

Entry nameiEMC4_YEAST
AccessioniPrimary (citable) accession number: P53073
Secondary accession number(s): D6VVA3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1320 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

External Data

Dasty 3