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Protein

ER membrane protein complex subunit 4

Gene

EMC4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER).

GO - Biological processi

  • protein folding in endoplasmic reticulum Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-30705-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
ER membrane protein complex subunit 4
Gene namesi
Name:EMC4
Ordered Locus Names:YGL231C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome VII

Organism-specific databases

CYGDiYGL231c.
EuPathDBiFungiDB:YGL231C.
SGDiS000003200. EMC4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei98 – 11821HelicalSequence AnalysisAdd
BLAST
Transmembranei136 – 15621HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • ER membrane protein complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 190190ER membrane protein complex subunit 4PRO_0000202711Add
BLAST

Proteomic databases

MaxQBiP53073.
PaxDbiP53073.

Interactioni

Subunit structurei

Component of the ER membrane protein complex (EMC), which is composed of EMC1, EMC2, EMC3, EMC4, EMC5 and EMC6.1 Publication

Protein-protein interaction databases

BioGridi33008. 44 interactions.
DIPiDIP-7920N.
MINTiMINT-4486491.

Structurei

3D structure databases

ProteinModelPortaliP53073.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the EMC4 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG308755.
GeneTreeiENSGT00390000006970.
HOGENOMiHOG000163282.
InParanoidiP53073.
OMAiFAKFDTE.
OrthoDBiEOG75B8HW.

Family and domain databases

InterProiIPR009445. DUF1077_TMEM85.
[Graphical view]
PANTHERiPTHR19315. PTHR19315. 1 hit.
PfamiPF06417. DUF1077. 1 hit.
[Graphical view]
PIRSFiPIRSF017207. UCP017207_TM-p85. 1 hit.

Sequencei

Sequence statusi: Complete.

P53073-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEQEPYEWA KHLLDTKYIE KYNIQNSNTL PSPPGFEGNS SKGNVTRKQQ
60 70 80 90 100
DATSQTTSLA QKNQITVLQV QKAWQIALQP AKSIPMNIFM SYMSGTSLQI
110 120 130 140 150
IPIMTALMLL SGPIKAIFST RSAFKPVLGN KATQSQVQTA MFMYIVFQGV
160 170 180 190
LMYIGYRKLN SMGLIPNAKG DWLPWERIAH YNNGLQWFSD
Length:190
Mass (Da):21,460
Last modified:October 1, 1996 - v1
Checksum:i062AE1EAB05360EE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72753 Genomic DNA. Translation: CAA96949.1.
AY558267 Genomic DNA. Translation: AAS56593.1.
BK006941 Genomic DNA. Translation: DAA07887.1.
PIRiS64253.
RefSeqiNP_011283.1. NM_001181097.1.

Genome annotation databases

EnsemblFungiiYGL231C; YGL231C; YGL231C.
GeneIDi852620.
KEGGisce:YGL231C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72753 Genomic DNA. Translation: CAA96949.1.
AY558267 Genomic DNA. Translation: AAS56593.1.
BK006941 Genomic DNA. Translation: DAA07887.1.
PIRiS64253.
RefSeqiNP_011283.1. NM_001181097.1.

3D structure databases

ProteinModelPortaliP53073.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33008. 44 interactions.
DIPiDIP-7920N.
MINTiMINT-4486491.

Proteomic databases

MaxQBiP53073.
PaxDbiP53073.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGL231C; YGL231C; YGL231C.
GeneIDi852620.
KEGGisce:YGL231C.

Organism-specific databases

CYGDiYGL231c.
EuPathDBiFungiDB:YGL231C.
SGDiS000003200. EMC4.

Phylogenomic databases

eggNOGiNOG308755.
GeneTreeiENSGT00390000006970.
HOGENOMiHOG000163282.
InParanoidiP53073.
OMAiFAKFDTE.
OrthoDBiEOG75B8HW.

Enzyme and pathway databases

BioCyciYEAST:G3O-30705-MONOMER.

Miscellaneous databases

NextBioi971832.
PROiP53073.

Family and domain databases

InterProiIPR009445. DUF1077_TMEM85.
[Graphical view]
PANTHERiPTHR19315. PTHR19315. 1 hit.
PfamiPF06417. DUF1077. 1 hit.
[Graphical view]
PIRSFiPIRSF017207. UCP017207_TM-p85. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
    Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
    , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
    Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. "Comprehensive characterization of genes required for protein folding in the endoplasmic reticulum."
    Jonikas M.C., Collins S.R., Denic V., Oh E., Quan E.M., Schmid V., Weibezahn J., Schwappach B., Walter P., Weissman J.S., Schuldiner M.
    Science 323:1693-1697(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN EMC COMPLEX.

Entry informationi

Entry nameiEMC4_YEAST
AccessioniPrimary (citable) accession number: P53073
Secondary accession number(s): D6VVA3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 22, 2015
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1320 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.