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Protein

ER membrane protein complex subunit 4

Gene

EMC4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER).

Miscellaneous

Present with 1320 molecules/cell in log phase SD medium.1 Publication

GO - Biological processi

  • protein folding in endoplasmic reticulum Source: SGD

Enzyme and pathway databases

BioCyciYEAST:G3O-30705-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
ER membrane protein complex subunit 4
Gene namesi
Name:EMC4
Ordered Locus Names:YGL231C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGL231C
SGDiS000003200 EMC4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei98 – 118HelicalSequence analysisAdd BLAST21
Transmembranei136 – 156HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002027111 – 190ER membrane protein complex subunit 4Add BLAST190

Proteomic databases

MaxQBiP53073
PaxDbiP53073
PRIDEiP53073

PTM databases

iPTMnetiP53073

Interactioni

Subunit structurei

Component of the ER membrane protein complex (EMC), which is composed of EMC1, EMC2, EMC3, EMC4, EMC5 and EMC6.1 Publication

Protein-protein interaction databases

BioGridi33008, 81 interactors
DIPiDIP-7920N
IntActiP53073, 5 interactors
STRINGi4932.YGL231C

Structurei

3D structure databases

ProteinModelPortaliP53073
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the EMC4 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000006970
HOGENOMiHOG000163282
InParanoidiP53073
OMAiPMTAIMM
OrthoDBiEOG092C4OT5

Family and domain databases

InterProiView protein in InterPro
IPR009445 TMEM85/Emc4
PANTHERiPTHR19315 PTHR19315, 1 hit
PfamiView protein in Pfam
PF06417 DUF1077, 1 hit
PIRSFiPIRSF017207 UCP017207_TM-p85, 1 hit

Sequencei

Sequence statusi: Complete.

P53073-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEQEPYEWA KHLLDTKYIE KYNIQNSNTL PSPPGFEGNS SKGNVTRKQQ
60 70 80 90 100
DATSQTTSLA QKNQITVLQV QKAWQIALQP AKSIPMNIFM SYMSGTSLQI
110 120 130 140 150
IPIMTALMLL SGPIKAIFST RSAFKPVLGN KATQSQVQTA MFMYIVFQGV
160 170 180 190
LMYIGYRKLN SMGLIPNAKG DWLPWERIAH YNNGLQWFSD
Length:190
Mass (Da):21,460
Last modified:October 1, 1996 - v1
Checksum:i062AE1EAB05360EE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72753 Genomic DNA Translation: CAA96949.1
AY558267 Genomic DNA Translation: AAS56593.1
BK006941 Genomic DNA Translation: DAA07887.1
PIRiS64253
RefSeqiNP_011283.1, NM_001181097.1

Genome annotation databases

EnsemblFungiiYGL231C; YGL231C; YGL231C
GeneIDi852620
KEGGisce:YGL231C

Similar proteinsi

Entry informationi

Entry nameiEMC4_YEAST
AccessioniPrimary (citable) accession number: P53073
Secondary accession number(s): D6VVA3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

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