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P53073

- EMC4_YEAST

UniProt

P53073 - EMC4_YEAST

Protein

ER membrane protein complex subunit 4

Gene

EMC4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER).

    GO - Biological processi

    1. protein folding in endoplasmic reticulum Source: SGD

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30705-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ER membrane protein complex subunit 4
    Gene namesi
    Name:EMC4
    Ordered Locus Names:YGL231C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VII

    Organism-specific databases

    CYGDiYGL231c.
    SGDiS000003200. EMC4.

    Subcellular locationi

    Endoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. ER membrane protein complex Source: SGD

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 190190ER membrane protein complex subunit 4PRO_0000202711Add
    BLAST

    Proteomic databases

    MaxQBiP53073.
    PaxDbiP53073.

    Expressioni

    Gene expression databases

    GenevestigatoriP53073.

    Interactioni

    Subunit structurei

    Component of the ER membrane protein complex (EMC), which is composed of EMC1, EMC2, EMC3, EMC4, EMC5 and EMC6.1 Publication

    Protein-protein interaction databases

    BioGridi33008. 44 interactions.
    MINTiMINT-4486491.
    STRINGi4932.YGL231C.

    Structurei

    3D structure databases

    ProteinModelPortaliP53073.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei98 – 11821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei136 – 15621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the EMC4 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG308755.
    GeneTreeiENSGT00390000006970.
    HOGENOMiHOG000163282.
    OMAiFAKFDTE.
    OrthoDBiEOG75B8HW.

    Family and domain databases

    InterProiIPR009445. DUF1077_TMEM85.
    [Graphical view]
    PANTHERiPTHR19315. PTHR19315. 1 hit.
    PfamiPF06417. DUF1077. 1 hit.
    [Graphical view]
    PIRSFiPIRSF017207. UCP017207_TM-p85. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P53073-1 [UniParc]FASTAAdd to Basket

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    MSEQEPYEWA KHLLDTKYIE KYNIQNSNTL PSPPGFEGNS SKGNVTRKQQ    50
    DATSQTTSLA QKNQITVLQV QKAWQIALQP AKSIPMNIFM SYMSGTSLQI 100
    IPIMTALMLL SGPIKAIFST RSAFKPVLGN KATQSQVQTA MFMYIVFQGV 150
    LMYIGYRKLN SMGLIPNAKG DWLPWERIAH YNNGLQWFSD 190
    Length:190
    Mass (Da):21,460
    Last modified:October 1, 1996 - v1
    Checksum:i062AE1EAB05360EE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z72753 Genomic DNA. Translation: CAA96949.1.
    AY558267 Genomic DNA. Translation: AAS56593.1.
    BK006941 Genomic DNA. Translation: DAA07887.1.
    PIRiS64253.
    RefSeqiNP_011283.1. NM_001181097.1.

    Genome annotation databases

    EnsemblFungiiYGL231C; YGL231C; YGL231C.
    GeneIDi852620.
    KEGGisce:YGL231C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z72753 Genomic DNA. Translation: CAA96949.1 .
    AY558267 Genomic DNA. Translation: AAS56593.1 .
    BK006941 Genomic DNA. Translation: DAA07887.1 .
    PIRi S64253.
    RefSeqi NP_011283.1. NM_001181097.1.

    3D structure databases

    ProteinModelPortali P53073.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33008. 44 interactions.
    MINTi MINT-4486491.
    STRINGi 4932.YGL231C.

    Proteomic databases

    MaxQBi P53073.
    PaxDbi P53073.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YGL231C ; YGL231C ; YGL231C .
    GeneIDi 852620.
    KEGGi sce:YGL231C.

    Organism-specific databases

    CYGDi YGL231c.
    SGDi S000003200. EMC4.

    Phylogenomic databases

    eggNOGi NOG308755.
    GeneTreei ENSGT00390000006970.
    HOGENOMi HOG000163282.
    OMAi FAKFDTE.
    OrthoDBi EOG75B8HW.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30705-MONOMER.

    Miscellaneous databases

    NextBioi 971832.
    PROi P53073.

    Gene expression databases

    Genevestigatori P53073.

    Family and domain databases

    InterProi IPR009445. DUF1077_TMEM85.
    [Graphical view ]
    PANTHERi PTHR19315. PTHR19315. 1 hit.
    Pfami PF06417. DUF1077. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF017207. UCP017207_TM-p85. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
      Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
      , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
      Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    6. "Comprehensive characterization of genes required for protein folding in the endoplasmic reticulum."
      Jonikas M.C., Collins S.R., Denic V., Oh E., Quan E.M., Schmid V., Weibezahn J., Schwappach B., Walter P., Weissman J.S., Schuldiner M.
      Science 323:1693-1697(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN EMC COMPLEX.

    Entry informationi

    Entry nameiEMC4_YEAST
    AccessioniPrimary (citable) accession number: P53073
    Secondary accession number(s): D6VVA3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 1320 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome VII
      Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

    External Data

    Dasty 3