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Protein

Mitochondrial translation optimization protein 1

Gene

MTO1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the 5-carboxymethylaminomethyl modification (mnm5s2U34) of the wobble uridine base in mitochondrial tRNAs.

Cofactori

FADBy similarity

GO - Molecular functioni

GO - Biological processi

  • mitochondrial tRNA wobble uridine modification Source: SGD
  • tRNA methylation Source: GO_Central
  • tRNA modification Source: Reactome

Keywordsi

Biological processtRNA processing
LigandFAD, Flavoprotein

Enzyme and pathway databases

BioCyciMetaCyc:G3O-30709-MONOMER
YEAST:G3O-30709-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial translation optimization protein 1
Gene namesi
Name:MTO1
Synonyms:IPS1
Ordered Locus Names:YGL236C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGL236C
SGDiS000003205 MTO1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi431A → T: Does not completely restore mitochondrial DNA-dependent respiratory chain activities in respiration-defective mutant cells. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 59MitochondrionSequence analysisAdd BLAST59
ChainiPRO_000004268760 – 669Mitochondrial translation optimization protein 1Add BLAST610

Proteomic databases

MaxQBiP53070
PaxDbiP53070
PRIDEiP53070

Interactioni

Subunit structurei

Forms a heterodimer with MSS1.

Protein-protein interaction databases

BioGridi33004, 196 interactors
DIPiDIP-4488N
IntActiP53070, 4 interactors
STRINGi4932.YGL236C

Structurei

3D structure databases

ProteinModelPortaliP53070
SMRiP53070
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MnmG family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

GeneTreeiENSGT00390000011297
HOGENOMiHOG000201059
InParanoidiP53070
KOiK03495
OMAiFRPGYAI
OrthoDBiEOG092C1TLA

Family and domain databases

Gene3Di3.50.50.60, 2 hits
HAMAPiMF_00129 MnmG_GidA, 1 hit
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR026904 GidA-assoc_3
IPR004416 MnmG
IPR002218 MnmG-rel
IPR020595 MnmG-rel_CS
PANTHERiPTHR11806 PTHR11806, 1 hit
PTHR11806:SF0 PTHR11806:SF0, 1 hit
PfamiView protein in Pfam
PF01134 GIDA, 1 hit
PF13932 GIDA_assoc, 1 hit
SUPFAMiSSF51905 SSF51905, 2 hits
TIGRFAMsiTIGR00136 gidA, 1 hit
PROSITEiView protein in PROSITE
PS01280 GIDA_1, 1 hit
PS01281 GIDA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P53070-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRVTTLASS CTSFPLQVLR RRLTISSLTS FQPTTKTQVV VIGAGHAGCE
60 70 80 90 100
AAAASSRTGA HTTLITPSLT DIGKCSCNPS IGGVGKGILV KEIDALDGLM
110 120 130 140 150
GKVTDLAGVQ FKMLNRSKGP AVWGPRAQID RELYKKYMQR ELSDKKAHPN
160 170 180 190 200
LSLLQNKVAD LILYDPGCGH KVIKGVVLDD GTQVGADQVI ITTGTFLSAE
210 220 230 240 250
IHIGDKRIAA GRIGEQPTYG ISNTLQNEVG FQLGRLKTGT PARLAKESID
260 270 280 290 300
FSALEVQKGD ALPVPMSFLN ETVSVEPTKQ LDCFGTHTTP QMHDFLRNNL
310 320 330 340 350
HQSIHIQDTT IKGPRYCPSI EAKILRFPDR SSHKIWLEPE GFNSDVIYPN
360 370 380 390 400
GISNSMPEDV QLQMMRLIPG MANVEILQPA YGVEYDYVDP RQLKPSLETK
410 420 430 440 450
LVDGLFLAGQ INGTTGYEEA AAQGIIAGIN AGLLSRQERE QLVLKRSEAY
460 470 480 490 500
IGVLIDDLIN NGVIEPYRMF TSRSEFRISV RADNADFRLT PIGAQLGIIS
510 520 530 540 550
PVRLSQYSRD KHLYDETIRA LQNFKLSSQK WSSLLQANIA PQAENRSAWE
560 570 580 590 600
IFRFKDMDLH KLYECIPDLP INLLDIPMHV VTKINIQGKY EPYIVKQNQF
610 620 630 640 650
VKAFQADENM LLPQDYDYRQ LPTLSTECKL LLNRVQPLTI GQARRIQGIT
660
AAALFELYRV ARKPSQPVM
Length:669
Mass (Da):74,215
Last modified:October 3, 2006 - v2
Checksum:i917F22AE324F1B87
GO

Sequence cautioni

The sequence CAA96953 differs from that shown. Reason: Frameshift at position 663.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72758 Genomic DNA Translation: CAA96953.1 Frameshift.
BK006941 Genomic DNA Translation: DAA07882.1
PIRiS64258
RefSeqiNP_011278.2, NM_001181102.1

Genome annotation databases

EnsemblFungiiYGL236C; YGL236C; YGL236C
GeneIDi852616
KEGGisce:YGL236C

Similar proteinsi

Entry informationi

Entry nameiMTO1_YEAST
AccessioniPrimary (citable) accession number: P53070
Secondary accession number(s): D6VV98
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 3, 2006
Last modified: March 28, 2018
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health