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Protein

Importin subunit beta-5

Gene

KAP114

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins. Serves a receptor for nuclear localization signals. Mediates the nuclear import of TATA-binding protein (TBP) and of histones H2A and H2B.2 Publications

Miscellaneous

Present with 2940 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • protein transporter activity Source: SGD
  • Ran GTPase binding Source: InterPro

GO - Biological processi

  • mRNA transport Source: UniProtKB-KW
  • protein import into nucleus Source: SGD

Keywordsi

Biological processmRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-30713-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Importin subunit beta-5
Alternative name(s):
114 kDa karyopherin
Karyopherin subunit beta-5
Karyopherin-114
Gene namesi
Name:KAP114
Ordered Locus Names:YGL241W
ORF Names:HRC1004
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGL241W
SGDiS000003210 KAP114

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nuclear pore complex, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001207781 – 1004Importin subunit beta-5Add BLAST1004

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP53067
PaxDbiP53067
PRIDEiP53067

PTM databases

iPTMnetiP53067

Interactioni

Subunit structurei

Interacts with NAP1.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi32999, 78 interactors
DIPiDIP-5881N
IntActiP53067, 24 interactors
MINTiP53067
STRINGi4932.YGL241W

Structurei

3D structure databases

ProteinModelPortaliP53067
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 100Importin N-terminalPROSITE-ProRule annotationAdd BLAST80

Sequence similaritiesi

Belongs to the importin beta family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000008224
HOGENOMiHOG000113058
InParanoidiP53067
KOiK20224
OMAiTMALCKL
OrthoDBiEOG092C0J3Z

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR001494 Importin-beta_N
PfamiView protein in Pfam
PF03810 IBN_N, 1 hit
SMARTiView protein in SMART
SM00913 IBN_N, 1 hit
SUPFAMiSSF48371 SSF48371, 3 hits
PROSITEiView protein in PROSITE
PS50166 IMPORTIN_B_NT, 1 hit

Sequencei

Sequence statusi: Complete.

P53067-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDINELIIGA QSADKHTREV AETQLLQWCD SDASQVFKAL ANVALQHEAS
60 70 80 90 100
LESRQFALLS LRKLITMYWS PGFESYRSTS NVEIDVKDFI REVLLKLCLN
110 120 130 140 150
DNENTKIKNG ASYCIVQISA VDFPDQWPQL LTVIYDAISH QHSLNAMSLL
160 170 180 190 200
NEIYDDVVSE EMFFEGGIGL ATMEIVFKVL NTETSTLIAK IAALKLLKAC
210 220 230 240 250
LLQMSSHNEY DEASRKSFVS QCLATSLQIL GQLLTLNFGN VDVISQLKFK
260 270 280 290 300
SIIYENLVFI KNDFSRKHFS SELQKQFKIM AIQDLENVTH INANVETTES
310 320 330 340 350
EPLLETVHDC SIYIVEFLTS VCTLQFSVEE MNKIITSLTI LCQLSSETRE
360 370 380 390 400
IWTSDFNTFV SKETGLAASY NVRDQANEFF TSLPNPQLSL IFKVVSNDIE
410 420 430 440 450
HSTCNYSTLE SLLYLLQCIL LNDDEITGEN IDQSLQILIK TLENILVSQE
460 470 480 490 500
IPELILARAI LTIPRVLDKF IDALPDIKPL TSAFLAKSLN LALKSDKELI
510 520 530 540 550
KSATLIAFTY YCYFAELDSV LGPEVCSETQ EKVIRIINQV SSDAEEDTNG
560 570 580 590 600
ALMEVLSQVI SYNPKEPHSR KEILQAEFHL VFTISSEDPA NVQVVVQSQE
610 620 630 640 650
CLEKLLDNIN MDNYKNYIEL CLPSFINVLD SNNANNYRYS PLLSLVLEFI
660 670 680 690 700
TVFLKKKPND GFLPDEINQY LFEPLAKVLA FSTEDETLQL ATEAFSYLIF
710 720 730 740 750
NTDTRAMEPR LMDIMKVLER LLSLEVSDSA AMNVGPLVVA IFTRFSKEIQ
760 770 780 790 800
PLIGRILEAV VVRLIKTQNI STEQNLLSVL CFLTCNDPKQ TVDFLSSFQI
810 820 830 840 850
DNTDALTLVM RKWIEAFEVI RGEKRIKENI VALSNLFFLN DKRLQKVVVN
860 870 880 890 900
GNLIPYEGDL IITRSMAKKM PDRYVQVPLY TKIIKLFVSE LSFQSKQPNP
910 920 930 940 950
EQLITSDIKQ EVVNANKDDD NDDWEDVDDV LDYDKLKEYI DDDVDEEADD
960 970 980 990 1000
DSDDITGLMD VKESVVQLLV RFFKEVASKD VSGFHCIYET LSDSERKVLS

EALL
Length:1,004
Mass (Da):113,921
Last modified:October 1, 1996 - v1
Checksum:i1F4C02AA6AB2FF39
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49149 Genomic DNA Translation: CAA89014.1
Z72763 Genomic DNA Translation: CAA96960.1
BK006941 Genomic DNA Translation: DAA07878.1
PIRiS53939
RefSeqiNP_011273.1, NM_001181107.1

Genome annotation databases

EnsemblFungiiYGL241W; YGL241W; YGL241W
GeneIDi852610
KEGGisce:YGL241W

Similar proteinsi

Entry informationi

Entry nameiIMB5_YEAST
AccessioniPrimary (citable) accession number: P53067
Secondary accession number(s): D6VV94
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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