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Protein

tRNA-specific adenosine deaminase 1

Gene

TAD1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Deaminates adenosine-37 to inosine in tRNA-Ala.

Catalytic activityi

Adenine(37) in tRNA(Ala) + H2O = hypoxanthine(37) in tRNA(Ala) + NH3.1 Publication

Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi101ZincPROSITE-ProRule annotation1
Active sitei103Proton donorPROSITE-ProRule annotation1
Binding sitei108Inositol hexakisphosphateBy similarity1
Metal bindingi157ZincPROSITE-ProRule annotation1
Metal bindingi223ZincPROSITE-ProRule annotation1
Binding sitei226Inositol hexakisphosphateBy similarity1
Binding sitei232Inositol hexakisphosphateBy similarity1
Binding sitei369Inositol hexakisphosphateBy similarity1
Binding sitei375Inositol hexakisphosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

  • tRNA modification Source: SGD

Keywordsi

Molecular functionHydrolase
Biological processtRNA processing
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:YGL243W-MONOMER
BRENDAi3.5.4.34 984

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA-specific adenosine deaminase 1 (EC:3.5.4.34)
Alternative name(s):
tRNA-specific adenosine-37 deaminase
Gene namesi
Name:TAD1
Ordered Locus Names:YGL243W
ORF Names:HRA400
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGL243W
SGDiS000003212 TAD1

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001717771 – 400tRNA-specific adenosine deaminase 1Add BLAST400

Proteomic databases

MaxQBiP53065
PaxDbiP53065
PRIDEiP53065

Interactioni

Protein-protein interaction databases

BioGridi32997, 60 interactors
STRINGi4932.YGL243W

Structurei

3D structure databases

ProteinModelPortaliP53065
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini76 – 400A to I editasePROSITE-ProRule annotationAdd BLAST325

Sequence similaritiesi

Belongs to the ADAT1 family.Curated

Phylogenomic databases

HOGENOMiHOG000248878
InParanoidiP53065
KOiK15440
OMAiVHDMHAE
OrthoDBiEOG092C3ESZ

Family and domain databases

InterProiView protein in InterPro
IPR002466 A_deamin
PfamiView protein in Pfam
PF02137 A_deamin, 1 hit
SMARTiView protein in SMART
SM00552 ADEAMc, 1 hit
PROSITEiView protein in PROSITE
PS50141 A_DEAMIN_EDITASE, 1 hit

Sequencei

Sequence statusi: Complete.

P53065-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSCQGTRPC IVNLLTMPSE DKLGEEISTR VINEYSKLKS ACRPIIRPSG
60 70 80 90 100
IREWTILAGV AAINRDGGAN KIEILSIATG VKALPDSELQ RSEGKILHDC
110 120 130 140 150
HAEILALRGA NTVLLNRIQN YNPSSGDKFI QHNDEIPARF NLKENWELAL
160 170 180 190 200
YISRLPCGDA SMSFLNDNCK NDDFIKIEDS DEFQYVDRSV KTILRGRLNF
210 220 230 240 250
NRRNVVRTKP GRYDSNITLS KSCSDKLLMK QRSSVLNCLN YELFEKPVFL
260 270 280 290 300
KYIVIPNLED ETKHHLEQSF HTRLPNLDNE IKFLNCLKPF YDDKLDEEDV
310 320 330 340 350
PGLMCSVKLF MDDFSTEEAI LNGVRNGFYT KSSKPLRKHC QSQVSRFAQW
360 370 380 390 400
ELFKKIRPEY EGISYLEFKS RQKKRSQLII AIKNILSPDG WIPTRTDDVK
Length:400
Mass (Da):45,947
Last modified:October 1, 1996 - v1
Checksum:i2AA9304C549026FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ007297 Genomic DNA Translation: CAA07438.1
Z49149 Genomic DNA Translation: CAA89012.1
Z72765 Genomic DNA Translation: CAA96962.1
BK006941 Genomic DNA Translation: DAA07876.1
PIRiS53937
RefSeqiNP_011271.1, NM_001181109.1

Genome annotation databases

EnsemblFungiiYGL243W; YGL243W; YGL243W
GeneIDi852608
KEGGisce:YGL243W

Similar proteinsi

Entry informationi

Entry nameiTAD1_YEAST
AccessioniPrimary (citable) accession number: P53065
Secondary accession number(s): D6VV92
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

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