P53062 (BRR6_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nucleus export protein BRR6

Alternative name(s):
Bad response to refrigeration protein 6

Gene names

Name:	BRR6
Ordered Locus Names:	YGL247W
ORF Names:	NRA197

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	197 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Required for mRNA nuclear export. Involved in the nuclear pore complex (NPC) distribution and nuclear envelope morphology. Ref.5 Ref.8
Subunit structure	Interacts with BRL1. Ref.8
Subcellular location	Nucleus membrane; Multi-pass membrane protein Ref.5 Ref.6.
Miscellaneous	Present with 125 molecules/cell in log phase SD medium. Ref.7
Sequence similarities	Belongs to the BRL1/BRR6 family.

Ontologies

Keywords
Biological process	Transport mRNA transport
Cellular component	Membrane Nucleus
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	mRNA export from nucleus Inferred from mutant phenotype Ref.5. Source: SGD nuclear envelope organization Inferred from mutant phenotype. Source: SGD protein export from nucleus Inferred from mutant phenotype Ref.5. Source: SGD
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW nuclear membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 197	197	Nucleus export protein BRR6		PRO_0000202707
Regions
	Transmembrane	54 – 74	21	Helical; Potential
	Transmembrane	161 – 181	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	P53062 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 92326642C0C9439E	FASTA	197	22,807
	10 20 30 40 50 60 MELRSFSRQP DGILANPRLG REEVLEGEHP QDARLARQSI WLSPSLIAEY IQLFFNFIIG 70 80 90 100 110 120 TIGLSLAIKF ILMIRNDVNL KLEHNVREEL DKIATCKSRY FENQCEPHMR VPALEVRCNE 130 140 150 160 170 180 WSKCMNKEIV SGSDYQWAKA WARTLAEVIN AFFEAFSIRS FLFILISIIG IIFVTNTSFG 190 SYRVYLNNKD TKSVRHA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence of a 39,411 bp DNA fragment covering the left end of chromosome VII of Saccharomyces cerevisiae." Coissac E., Maillier E., Robineau S., Netter P. Yeast 12:1555-1562(1996) [PubMed: 8972578] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[2]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome VII." Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E. , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K. Nature 387:81-84(1997) [PubMed: 9169869] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[4]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed: 17322287] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[5]	"An essential nuclear envelope integral membrane protein, Brr6p, required for nuclear transport." de Bruyn Kops A., Guthrie C. EMBO J. 20:4183-4193(2001) [PubMed: 11483521] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, TOPOLOGY.
[6]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed: 14562095] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[7]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[8]	"Brl1p - a novel nuclear envelope protein required for nuclear transport." Saitoh Y.-H., Ogawa K., Nishimoto T. Traffic 6:502-517(2005) [PubMed: 15882446] [Abstract] Cited for: FUNCTION, INTERACTION WITH BRL1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X94357 Genomic DNA. Translation: CAA64140.1. Z72769 Genomic DNA. Translation: CAA96967.1. AY693171 Genomic DNA. Translation: AAT93190.1. BK006941 Genomic DNA. Translation: DAA07872.1.
PIR	S61614.
RefSeq	NP_011267.1. NM_001181113.1.
3D structure databases
ProteinModelPortal	P53062.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-7322N.
IntAct	P53062. 1 interaction.
STRING	P53062.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YGL247W; YGL247W; YGL247W.
GeneID	852645.
KEGG	sce:YGL247W.
NMPDR	fig|4932.3.peg.2370.
Organism-specific databases
CYGD	YGL247w.
SGD	S000003216. BRR6.
Phylogenomic databases
eggNOG	fuNOG11565.
GeneTree	EFGT00050000004422.
OMA	ILMIRND.
OrthoDB	EOG49S9H7.
Gene expression databases
ArrayExpress	P53062.
Genevestigator	P53062.
GermOnline	YGL247W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR018767. Brl1/Brr6_dom. [Graphical view]
Pfam	PF10104. Brr6_like_C_C. 1 hit. [Graphical view]
SMART	SM01042. Brr6_like_C_C. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	971906.

Entry information

Entry name

BRR6_YEAST

Accession

Primary (citable) accession number: P53062
Secondary accession number(s): D6VV88

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	January 25, 2012
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program