Reviewed, UniProtKB/Swiss-Prot P53061 (ZIP2_YEAST)

Names and origin

Protein names

Recommended name:
    Protein ZIP2
Alternative name(s):
    Zipping up meiotic chromosomes protein 2

Gene names

Name:	ZIP2
Ordered Locus Names:	YGL249W
ORF Names:	NRC704

Organism

Saccharomyces cerevisiae (Baker's yeast) [Complete proteome]

Taxonomic identifier

4932 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	704 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Required for initiation of meiotic chromosome synapsis. Involved in synaptonemal complex formation, a structure that tethers a pair of homologous chromosomes along their lengths and plays a central role in recombination and homolog segregation during meiosis. Required for the normal localization of MSH4 to chromosomes. Ref.3 Ref.4 Ref.5 Ref.6 Ref.7 Ref.9 Ref.10
Subunit structure	Interacts with ZIP3. Ref.5
Subcellular location	Nucleus. Note: localizes to a meiosis specific chromosomal structure called the synaptonemal complex (SC) formed during meiotic prophase. Ref.3 Ref.7 Ref.10 Ref.8
Induction	During meiosis. Ref.3
Sequence similarities	Belongs to the ZIP2 family.

Ontologies

Keywords
Biological process	Cell cycle Chromosome partition Meiosis
Cellular component	Chromosomal protein Nucleus
Coding sequence diversity	Chromosomal rearrangement
Ligand	DNA-binding Nucleotide-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	chromosome segregation Inferred from electronic annotation. Source: UniProtKB-KW synaptonemal complex assembly Ref.3 Inferred from mutant phenotype. Source: SGD
Cellular component	synaptonemal complex Ref.3 Inferred from direct assay. Source: SGD
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW nucleotide binding Inferred from electronic annotation. Source: UniProtKB-KW protein binding Ref.5 Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CDC53	Q12018	2	EBI-24222,EBI-4321
CST9	Q06032	1	EBI-24222,EBI-30044

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 704	704	Protein ZIP2		PRO_0000202706

Sequences

	Sequence		Length	Mass (Da)
	P53061-1 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 171387494869B56E	FASTA	704	82,816
	10 20 30 40 50 60 MIIERWEVKL SKCNQNVGGY SVLSGNLKEN IKLGRRAQKY LKELRNLQLK PLKIGGYENC 70 80 90 100 110 120 GTINGEEYFL EVIHITSGRQ KIDVAVGKTW NVTNIENDNK EELQYELFKE KLKVGKQDML 130 140 150 160 170 180 FFSWMKSLSV QLNAPLHQKM TEHGLADDNT RLEWFNIPLL RRSQYRKKVP YPSLRQMSSV 190 200 210 220 230 240 LEVQCSTLTE EKLNFCVGFS DKPLSEWKPQ IFEQTYNRYR LQRISPEKSF KYKSRCSKYN 250 260 270 280 290 300 FKTSSQSWVV KVPEHDQQLN TFEKRYDELF DAQFNKLEFF KIRMKKLKKN KPIEKKNYKI 310 320 330 340 350 360 WCLEKEDLKD LVWDPLKRIC NHSRYAIFEH VTINREAYSI KPLRLTFQKL DSGSLDLIDN 370 380 390 400 410 420 QKKTFGSIKL AMSMPDVKKT ENQSIEESER HDETAIETQE FDENDCLSSK ADINTSLAPQ 430 440 450 460 470 480 KRSFIDNELM SMLVTKKKIK KDKDVSDTGI SSTSYLINSG TYANSHIEIP TSNSVYNGKE 490 500 510 520 530 540 DCSFNNYSVK HSILEEDIEN KCIAVNENKV IENQKVIQSL CKNSHLDLIE QSYFGECDFI 550 560 570 580 590 600 INHSTCVYKI QASRFMQLRN NGSLHYDKAV NDLLTEFQRV IIIVEFSEII QDVDPDLFWK 610 620 630 640 650 660 IKLYLLNSRV DVFFIHETTD FFIDWMKYFI ARWAFSYNDE KEKNIANADI LLDLGFNILL 670 680 690 700 VRKIFQTYSL EEFFMAIIKE ESKAVKMLTV SQMTRLKKLL TLEW

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence of a 39,411 bp DNA fragment covering the left end of chromosome VII of Saccharomyces cerevisiae." Coissac E., Maillier E., Robineau S., Netter P. Yeast 12:1555-1562(1996) [PubMed: 8972578] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[2]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome VII." Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E. , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K. Nature 387:81-84(1997) [PubMed: 9169869] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[3]	"Zip2, a meiosis-specific protein required for the initiation of chromosome synapsis." Chua P.R., Roeder G.S. Cell 93:349-359(1998) [PubMed: 9590170] [Abstract] Cited for: FUNCTION, INDUCTION, SUBCELLULAR LOCATION.
[4]	"Pch2 links chromatin silencing to meiotic checkpoint control." San-Segundo P.A., Roeder G.S. Cell 97:313-324(1999) [PubMed: 10319812] [Abstract] Cited for: FUNCTION.
[5]	"Zip3 provides a link between recombination enzymes and synaptonemal complex proteins." Agarwal S., Roeder G.S. Cell 102:245-255(2000) [PubMed: 10943844] [Abstract] Cited for: FUNCTION, SUBELLULAR LOCATION, INTERACTION WITH ZIP3.
[6]	"Bypass of a meiotic checkpoint by overproduction of meiotic chromosomal proteins." Bailis J.M., Smith A.V., Roeder G.S. Mol. Cell. Biol. 20:4838-4848(2000) [PubMed: 10848609] [Abstract] Cited for: FUNCTION.
[7]	"The budding yeast Msh4 protein functions in chromosome synapsis and the regulation of crossover distribution." Novak J.E., Ross-Macdonald P.B., Roeder G.S. Genetics 158:1013-1025(2001) [PubMed: 11454751] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.
[8]	"Imposition of crossover interference through the nonrandom distribution of synapsis initiation complexes." Fung J.C., Rockmill B., Odell M., Roeder G.S. Cell 116:795-802(2004) [PubMed: 15035982] [Abstract] Cited for: SUBCELLULAR LOCATION.
[9]	"Multiple branches of the meiotic recombination pathway contribute independently to homolog pairing and stable juxtaposition during meiosis in budding yeast." Peoples-Holst T.L., Burgess S.M. Genes Dev. 19:863-874(2005) [PubMed: 15805472] [Abstract] Cited for: FUNCTION.
[10]	"The meiosis-specific zip4 protein regulates crossover distribution by promoting synaptonemal complex formation together with zip2." Tsubouchi T., Zhao H., Roeder G.S. Dev. Cell 10:809-819(2006) [PubMed: 16740482] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X94357 Genomic DNA. Translation: CAA64138.1. Z72771 Genomic DNA. Translation: CAA96969.1.
PIR	S61612.
RefSeq	NP_011265.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:1241N.
IntAct	P53061. 4 interactions.
Genome annotation databases
Ensembl	YGL249W. Saccharomyces cerevisiae. [Contig view]
GeneID	852643.
GenomeReviews	Gene locus YGL249W in contig Y13135_GR.
KEGG	sce:YGL249W.
NMPDR	fig|4932.3.peg.2368.
Organism-specific databases
CYGD	YGL249w.
SGD	S000003218. ZIP2.
Yeast-GFP	Search...
Phylogenomic databases
HOGENOM	P53061.
OMA	P53061. TSICEES.
Gene expression databases
ArrayExpress	P53061.
GermOnline	YGL249W. Saccharomyces cerevisiae.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	971900.

Entry information

Entry name

ZIP2_YEAST

Accession

Primary (citable) accession number: P53061

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	June 16, 2009
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)