P53060 (RMR1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Reduced meiotic recombination protein 1

Gene names

Name:	RMR1
Ordered Locus Names:	YGL250W
ORF Names:	NRC245

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	241 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Required for normal levels of gene conversion events during meiosis. Ref.8
Subcellular location	Cytoplasm. Nucleus Ref.5.
Post-translational modification	Sumoylated. Ref.7
Miscellaneous	Present with 1820 molecules/cell in log phase SD medium. Ref.6
Sequence similarities	Belongs to the RMR1 family.
Sequence caution	The sequence CAA64137.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence CAA96970.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Biological process	Meiosis
Cellular component	Cytoplasm Nucleus
PTM	Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	meiotic gene conversion Inferred from mutant phenotype Ref.8. Source: SGD reciprocal meiotic recombination Inferred from mutant phenotype Ref.8. Source: SGD
Cellular component	cytoplasm Inferred from direct assay Ref.5. Source: SGD nucleus Inferred from direct assay Ref.5. Source: SGD
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
AVO2	Q04749	1	EBI-24228,EBI-28131

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 241	241	Reduced meiotic recombination protein 1		PRO_0000202705

Sequences

	Sequence		Length	Mass (Da)
	P53060 [UniParc]. Last modified August 16, 2005. Version 2. Checksum: E77D9C8D241CA99A	FASTA	241	27,709
	10 20 30 40 50 60 MSEEEAHKTV EVDDVGVQLD EGDEEDLLEY DDELVEEQPS DARIRNVAET LMKSELPKVT 70 80 90 100 110 120 VEYKDTTFLL FTSDDKNESN NPIICENAAL YQRPMGEFME SIRKFMGNRF GRLAFATKEL 130 140 150 160 170 180 VLQLKSLDLT LFEDNVYNNH ISFSDVYTIF KILKERSESN FETDIPTHLA IELSTRPRFV 190 200 210 220 230 240 SRYNALVELT ESSATLKNIK PFSNDETHPL IVDDNDQYTH QNTSEVIVMD IDDDVGEDSE D

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence of a 39,411 bp DNA fragment covering the left end of chromosome VII of Saccharomyces cerevisiae." Coissac E., Maillier E., Robineau S., Netter P. Yeast 12:1555-1562(1996) [PubMed: 8972578] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[2]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome VII." Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E. , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K. Nature 387:81-84(1997) [PubMed: 9169869] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[4]	"Sequencing and comparison of yeast species to identify genes and regulatory elements." Kellis M., Patterson N., Endrizzi M., Birren B.W., Lander E.S. Nature 423:241-254(2003) [PubMed: 12748633] [Abstract] Cited for: IDENTIFICATION OF PROBABLE INITIATION SITE.
[5]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed: 14562095] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[6]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[7]	"Defining the SUMO-modified proteome by multiple approaches in Saccharomyces cerevisiae." Hannich J.T., Lewis A., Kroetz M.B., Li S.J., Heide H., Emili A., Hochstrasser M. J. Biol. Chem. 280:4102-4110(2005) [PubMed: 15590687] [Abstract] Cited for: SUMOYLATION.
[8]	"Novel roles for selected genes in meiotic DNA processing." Jordan P.W., Klein F., Leach D.R. PLoS Genet. 3:E222-E222(2007) [PubMed: 18069899] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X94357 Genomic DNA. Translation: CAA64137.1. Different initiation. Z72772 Genomic DNA. Translation: CAA96970.1. Different initiation. BK006941 Genomic DNA. Translation: DAA07869.1.
PIR	S61611.
RefSeq	NP_011264.2. NM_001181116.1.
3D structure databases
ProteinModelPortal	P53060.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-4375N.
IntAct	P53060. 6 interactions.
MINT	MINT-477238.
STRING	P53060.
Proteomic databases
PeptideAtlas	P53060.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YGL250W; YGL250W; YGL250W.
GeneID	852642.
KEGG	sce:YGL250W.
NMPDR	fig|4932.3.peg.2367.
Organism-specific databases
CYGD	YGL250w.
SGD	S000003219. RMR1.
Phylogenomic databases
eggNOG	fuNOG10883.
HOGENOM	HBG204290.
OMA	PRFVSRY.
OrthoDB	EOG4WWVVF.
Gene expression databases
ArrayExpress	P53060.
Genevestigator	P53060.
GermOnline	YGL250W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR018822. UPF0646. [Graphical view]
Pfam	PF10336. DUF2420. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	971897.

Entry information

Entry name

RMR1_YEAST

Accession

Primary (citable) accession number: P53060
Secondary accession number(s): D6VV85

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	August 16, 2005
Last modified:	December 14, 2011
This is version 74 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program