Reviewed, UniProtKB/Swiss-Prot P53060 (YGZA_YEAST)

Names and origin

Protein names

Recommended name:
    UPF0646 protein YGL250W

Gene names

Ordered Locus Names:	YGL250W
ORF Names:	NRC245

Organism

Saccharomyces cerevisiae (Baker's yeast) [Complete proteome]

Taxonomic identifier

4932 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	241 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subcellular location	Cytoplasm. Nucleus.
Miscellaneous	Present with 1820 molecules/cell in log phase SD medium. Ref.5
Sequence similarities	Belongs to the UPF0646 family.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	meiotic gene conversion Inferred from mutant phenotype. Source: SGD reciprocal meiotic recombination Inferred from mutant phenotype. Source: SGD
Cellular component	cytoplasm Ref.4 Inferred from direct assay. Source: SGD nucleus Ref.4 Inferred from direct assay. Source: SGD
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
AVO2	Q04749	1	EBI-24228,EBI-28131

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 241	241	UPF0646 protein YGL250W		PRO_0000202705

Sequences

	Sequence		Length	Mass (Da)
	P53060-1 [UniParc]. Last modified August 16, 2005. Version 2. Checksum: E77D9C8D241CA99A	FASTA	241	27,709
	10 20 30 40 50 60 MSEEEAHKTV EVDDVGVQLD EGDEEDLLEY DDELVEEQPS DARIRNVAET LMKSELPKVT 70 80 90 100 110 120 VEYKDTTFLL FTSDDKNESN NPIICENAAL YQRPMGEFME SIRKFMGNRF GRLAFATKEL 130 140 150 160 170 180 VLQLKSLDLT LFEDNVYNNH ISFSDVYTIF KILKERSESN FETDIPTHLA IELSTRPRFV 190 200 210 220 230 240 SRYNALVELT ESSATLKNIK PFSNDETHPL IVDDNDQYTH QNTSEVIVMD IDDDVGEDSE D

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence of a 39,411 bp DNA fragment covering the left end of chromosome VII of Saccharomyces cerevisiae." Coissac E., Maillier E., Robineau S., Netter P. Yeast 12:1555-1562(1996) [PubMed: 8972578] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[2]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome VII." Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E. , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K. Nature 387:81-84(1997) [PubMed: 9169869] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[3]	"Sequencing and comparison of yeast species to identify genes and regulatory elements." Kellis M., Patterson N., Endrizzi M., Birren B.W., Lander E.S. Nature 423:241-254(2003) [PubMed: 12748633] [Abstract] Cited for: IDENTIFICATION OF PROBABLE INITIATION SITE.
[4]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed: 14562095] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[5]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X94357 Genomic DNA. Translation: CAA64137.1. Different initiation. Z72772 Genomic DNA. Translation: CAA96970.1. Different initiation.
PIR	S61611.
RefSeq	NP_011264.2.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:4375N.
IntAct	P53060. 10 interactions.
STRING	P53060.
Proteomic databases
PeptideAtlas	P53060.
Genome annotation databases
Ensembl	YGL250W; YGL250W; YGL250W; Saccharomyces cerevisiae. [Genome view]
GeneID	852642.
KEGG	sce:YGL250W.
NMPDR	fig|4932.3.peg.2367.
Organism-specific databases
CYGD	YGL250w.
SGD	S000003219. YGL250W.
Phylogenomic databases
OMA	PRFVSRY
OrthoDB	EOG9JDJPW
Gene expression databases
ArrayExpress	P53060.
Genevestigator	P53060.
GermOnline	YGL250W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR018822. DUF2420. [Graphical view]
Pfam	PF10336. DUF2420. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	971897.

Entry information

Entry name

YGZA_YEAST

Accession

Primary (citable) accession number: P53060

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	August 16, 2005
Last modified:	November 24, 2009
This is version 57 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)