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Protein

Alpha-1,3-mannosyltransferase MNT2

Gene

MNT2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mannosyltransferase involved in adding the 4th and 5th mannose residues of O-linked glycans.

Miscellaneous

Present with 1170 molecules/cell in log phase SD medium.1 Publication

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

  • alpha-1,3-mannosyltransferase activity Source: SGD

GO - Biological processi

  • protein O-linked glycosylation Source: SGD

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciMetaCyc:G3O-30725-MONOMER
YEAST:G3O-30725-MONOMER
UniPathwayiUPA00378

Protein family/group databases

CAZyiGT71 Glycosyltransferase Family 71

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-1,3-mannosyltransferase MNT2 (EC:2.4.1.-)
Gene namesi
Name:MNT2
Ordered Locus Names:YGL257C
ORF Names:NRD558
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGL257C
SGDiS000003226 MNT2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 6CytoplasmicSequence analysis6
Transmembranei7 – 27Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini28 – 558LumenalSequence analysisAdd BLAST531

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000805591 – 558Alpha-1,3-mannosyltransferase MNT2Add BLAST558

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi187N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP53059
PaxDbiP53059
PRIDEiP53059

Interactioni

Protein-protein interaction databases

BioGridi33022, 81 interactors
STRINGi4932.YGL257C

Structurei

3D structure databases

ProteinModelPortaliP53059
SMRiP53059
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MNN1/MNT family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000003622
HOGENOMiHOG000113620
InParanoidiP53059
KOiK10968
OMAiLMERWRI
OrthoDBiEOG092C553O

Family and domain databases

InterProiView protein in InterPro
IPR022751 Alpha_mannosyltransferase
IPR029044 Nucleotide-diphossugar_trans
PfamiView protein in Pfam
PF11051 Mannosyl_trans3, 1 hit
SUPFAMiSSF53448 SSF53448, 2 hits

Sequencei

Sequence statusi: Complete.

P53059-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRKNRLFIL VVLLGIVLVV YYSQLNSLDL VEPVQSSSSG NGGCWSYYEG
60 70 80 90 100
LTPGWLNDFY DVNQITPNPA KDVIELVTRI KIFFNCLQQV DGHNIQRLRD
110 120 130 140 150
IEKKLFPYIN FEKLETDESA FWHTTTRWNG EVYHASMLEF DPKNHQFLRS
160 170 180 190 200
KPINFDTGLS FWENWLHTVT QSGSKGIVIS ASDVQLNETI RLLKVLRFIK
210 220 230 240 250
NDYPIQIVHN ADLSQDSMKS IIKYARSLDT AEYPAQELWF LNVHSLLNPK
260 270 280 290 300
YSKKFTTYSN KWLALTFSSF EIPILMDSDT VPFVSIEKFY ELEEFQKTGV
310 320 330 340 350
LFFKDRVISD DLFESSELKI LREIVYGCIG LDLEDESKIH EQVEDPVVAQ
360 370 380 390 400
VLENMFIKKY KHHLESGLVI LHKGKHLFSM LTSIALQFSP IAEYFHGDKD
410 420 430 440 450
FFWLGELLSN NRFTFHPVDA SNIGQLGNVV SKESTGEFYQ ICSVQLSHTD
460 470 480 490 500
RDGSLLWLNG GLNICKKTSW EYDYEHRQRL NDMFQNADEL REYYASPVKL
510 520 530 540 550
EGIIIPDTSI SGWINSGECF LFNYCTLFKE GEFGKLIKFK EDEKLRLSQI

VDIWNKDI
Length:558
Mass (Da):64,853
Last modified:October 1, 1996 - v1
Checksum:i3E58ED62B4E291B6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94357 Genomic DNA Translation: CAA64130.1
Z72779 Genomic DNA Translation: CAA96977.1
BK006941 Genomic DNA Translation: DAA07862.1
PIRiS61604
RefSeqiNP_011257.1, NM_001181123.1

Genome annotation databases

EnsemblFungiiYGL257C; YGL257C; YGL257C
GeneIDi852635
KEGGisce:YGL257C

Similar proteinsi

Entry informationi

Entry nameiMNT2_YEAST
AccessioniPrimary (citable) accession number: P53059
Secondary accession number(s): D6VV78
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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