P53057 (YPS5_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Yapsin-5

Alternative name(s):
Aspartic proteinase-like protein YPS5

Gene names

Name:	YPS5
Ordered Locus Names:	YGL259W
ORF Names:	NRA165

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	165 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Uncertain

General annotation (Comments)

Sequence similarities	Belongs to the peptidase A1 family.
Caution	Could be the product of a pseudogene. Contains only the N-ter part of the functional aspartic proteinases.

Ontologies

Keywords
Domain	Signal
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: InterPro
Molecular function	aspartic-type endopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	Potential
	Chain	25 – 165	141	Yapsin-5		PRO_0000014320
Amino acid modifications
	Glycosylation	57	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	P53057 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 0B6445C18BE45EB3	FASTA	165	17,953
	10 20 30 40 50 60 MQLFSILSLL SSLMCSLTVL GSSASSYVKF PVQKFADIIN IGTQDVSTVF KRNEVLNTTV 70 80 90 100 110 120 INGIGVYVVK MEIGTPPQTV YLQLDTGSSD MIVNNADIAY CKSMSDGSDY ASTDNYELTA 130 140 150 160 TFTGPRSTTT SPELITLSAL IGVNSMQETH LLLRITRLSS MTYTY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence of a 39,411 bp DNA fragment covering the left end of chromosome VII of Saccharomyces cerevisiae." Coissac E., Maillier E., Robineau S., Netter P. Yeast 12:1555-1562(1996) [PubMed: 8972578] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[2]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome VII." Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E. , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K. Nature 387:81-84(1997) [PubMed: 9169869] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[4]	"Identification and characterization of Saccharomyces cerevisiae yapsin 3, a new member of the yapsin family of aspartic proteases encoded by the YPS3 gene." Olsen V., Cawley N.X., Brandt J., Egel-Mitani M., Loh Y.P. Biochem. J. 339:407-411(1999) [PubMed: 10191273] [Abstract] Cited for: GENE NAME.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X94357 Genomic DNA. Translation: CAA64128.1. Z72781 Genomic DNA. Translation: CAA96979.1. BK006941 Genomic DNA. Translation: DAA07859.1.
PIR	S61602.
RefSeq	NP_011255.1. NM_001181125.1.
3D structure databases
ProteinModelPortal	P53057.
SMR	P53057. Positions 55-163.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-4875N.
MINT	MINT-479387.
STRING	P53057.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YGL259W; YGL259W; YGL259W.
GeneID	852632.
KEGG	sce:YGL259W.
NMPDR	fig|4932.3.peg.2357.
Organism-specific databases
CYGD	YGL259w.
SGD	S000003228. YPS5.
Phylogenomic databases
eggNOG	KOG1339.
Gene expression databases
ArrayExpress	P53057.
Genevestigator	P53057.
GermOnline	YGL259W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR001461. Peptidase_A1. IPR021109. Peptidase_aspartic. IPR009007. Peptidase_aspartic_catalytic. [Graphical view]
Gene3D	G3DSA:2.40.70.10. Pept_Aspartc_cat. 1 hit.
PANTHER	PTHR13683. Peptidase_A1. 1 hit.
Pfam	PF00026. Asp. 1 hit. [Graphical view]
SUPFAM	SSF50630. Pept_Aspartic. 1 hit.
ProtoNet	Search...
Other
NextBio	971867.

Entry information

Entry name

YPS5_YEAST

Accession

Primary (citable) accession number: P53057
Secondary accession number(s): D6VV75

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	December 14, 2011
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program