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P53053 (COS12_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Protein COS12
Gene names
Name:COS12
Ordered Locus Names:YGL263W
ORF Names:NRC380
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length380 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the DUP/COS family.

Ontologies

Keywords
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

YHR080CP388001EBI-5002,EBI-24597

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 380380Protein COS12
PRO_0000207522

Regions

Topological domain1 – 7070Cytoplasmic Potential
Transmembrane71 – 9121Helical; Potential
Topological domain92 – 231140Extracellular Potential
Transmembrane232 – 25221Helical; Potential
Topological domain253 – 2575Cytoplasmic Potential
Transmembrane258 – 27821Helical; Potential
Topological domain279 – 380102Extracellular Potential

Sequences

Sequence LengthMass (Da)Tools
P53053 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 52F58F4E400CA596

FASTA38044,804
        10         20         30         40         50         60 
MDGAKFENTV AFLPSEIFDC YNSTLPKNVF RSFVTWSCYE KFNSLEFRTW LLMWLPLIIA 

        70         80         90        100        110        120 
WKIRGKRHYL VIVTALMFEV LYFLWTYSYI FRERTLGKQV SQFAKEIITN TPGIDTEDWE 

       130        140        150        160        170        180 
RVAVNFNSYL YENKLWNTEY FFFDGSSCQE AFRKMLLEPF SLKKNDFANA KVPDGSVCYT 

       190        200        210        220        230        240 
EKALQVYFTQ IERKWHWINS EGFLHNKTTQ SVQFSKHGYG SKLLWAFKEV TIMNSRFAFF 

       250        260        270        280        290        300 
SIAYLNGLLT IPRLRNSLHI LYVCAVLSSM IIEYLIGIDK FRFKSMNLIH KLQFLSYITC 

       310        320        330        340        350        360 
GHEKSDATNW SQIAKRTNTY MFEQKIWNSP ILFSDGIDCE KFFKWYFSTP VSSQASLSVG 

       370        380 
STDFELWPYI KEAQSACNDV

« Hide

References

« Hide 'large scale' references
[1]"Sequence of a 39,411 bp DNA fragment covering the left end of chromosome VII of Saccharomyces cerevisiae."
Coissac E., Maillier E., Robineau S., Netter P.
Yeast 12:1555-1562(1996) [PubMed: 8972578] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 96604 / S288c / FY1679.
[2]"The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E. expand/collapse author list , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
Nature 387:81-84(1997) [PubMed: 9169869] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 96604 / S288c / FY1679.
[3]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"A global topology map of the Saccharomyces cerevisiae membrane proteome."
Kim H., Melen K., Oesterberg M., von Heijne G.
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed: 16847258] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
Strain: ATCC 208353 / W303-1A.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X94357 Genomic DNA. Translation: CAA64124.1.
Z72785 Genomic DNA. Translation: CAA96983.1.
BK006941 Genomic DNA. Translation: DAA07855.1.
PIRS61598.
RefSeqNP_011251.1. NM_001181129.1.

3D structure databases

ProteinModelPortalP53053.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-5034N.
IntActP53053. 1 interaction.
MINTMINT-482433.
STRINGP53053.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYGL263W; YGL263W; YGL263W.
GeneID852628.
KEGGsce:YGL263W.
NMPDRfig|4932.3.peg.2353.

Organism-specific databases

CYGDYGL263w.
SGDS000003232. COS12.

Phylogenomic databases

GeneTreeEFGT00050000008557.
HOGENOMHBG204451.

Gene expression databases

ArrayExpressP53053.
GenevestigatorP53053.
GermOnlineYGL263W. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR001142. DUP.
[Graphical view]
PfamPF00674. DUP. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio971855.

Entry information

Entry nameCOS12_YEAST
AccessionPrimary (citable) accession number: P53053
Secondary accession number(s): D6VV71
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: December 14, 2011
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome VII

Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents