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P53052

- CPDB_YEREN

UniProt

P53052 - CPDB_YEREN

Protein

2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase

Gene

cpdB

Organism
Yersinia enterocolitica
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    This bifunctional enzyme catalyzes two consecutive reactions during ribonucleic acid degradation. Converts a 2',3'-cyclic nucleotide to a 3'-nucleotide and then the 3'-nucleotide to the corresponding nucleoside and phosphate By similarity.By similarity

    Catalytic activityi

    Nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 3'-phosphate.
    A 3'-ribonucleotide + H2O = a ribonucleoside + phosphate.

    Cofactori

    Divalent cations.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi36 – 361Divalent metal cation 1By similarity
    Metal bindingi38 – 381Divalent metal cation 1By similarity
    Metal bindingi81 – 811Divalent metal cation 1By similarity
    Metal bindingi81 – 811Divalent metal cation 2By similarity
    Metal bindingi121 – 1211Divalent metal cation 2By similarity
    Metal bindingi230 – 2301Divalent metal cation 2By similarity
    Metal bindingi262 – 2621Divalent metal cation 2By similarity
    Metal bindingi264 – 2641Divalent metal cation 1By similarity
    Binding sitei445 – 4451SubstrateBy similarity

    GO - Molecular functioni

    1. 2',3'-cyclic-nucleotide 2'-phosphodiesterase activity Source: UniProtKB-EC
    2. 3'-nucleotidase activity Source: UniProtKB-EC
    3. metal ion binding Source: UniProtKB-KW
    4. nucleotide binding Source: UniProtKB-KW

    GO - Biological processi

    1. nucleotide catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi3.1.4.16. 6741.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase (EC:3.1.3.6, EC:3.1.4.16)
    Gene namesi
    Name:cpdB
    OrganismiYersinia enterocolitica
    Taxonomic identifieri630 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia

    Subcellular locationi

    GO - Cellular componenti

    1. periplasmic space Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Periplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 6526282',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidasePRO_0000000038Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP53052.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni549 – 5557Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the 5'-nucleotidase family.Curated

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3Di3.60.21.10. 1 hit.
    3.90.780.10. 1 hit.
    InterProiIPR008334. 5'-Nucleotdase_C.
    IPR006146. 5'-Nucleotdase_CS.
    IPR006179. 5_nucleotidase/apyrase.
    IPR004843. Calcineurin-like_PHP_apaH.
    IPR006294. Cyc_nuc_PDE_nucleotidase.
    IPR029052. Metallo-depent_PP-like.
    [Graphical view]
    PANTHERiPTHR11575. PTHR11575. 1 hit.
    PfamiPF02872. 5_nucleotid_C. 1 hit.
    PF00149. Metallophos. 1 hit.
    [Graphical view]
    PRINTSiPR01607. APYRASEFAMLY.
    SUPFAMiSSF55816. SSF55816. 1 hit.
    SSF56300. SSF56300. 1 hit.
    TIGRFAMsiTIGR01390. CycNucDiestase. 1 hit.
    PROSITEiPS00785. 5_NUCLEOTIDASE_1. 1 hit.
    PS00786. 5_NUCLEOTIDASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P53052-1 [UniParc]FASTAAdd to Basket

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    MFKRPLTLSL LASLIALTTS TAQAATVDLR VLETTDLHSN MMDFDYYKDK    50
    PTEKFGLVRT ASLIEAARQQ ATNSVLVDNG DLIQGSPLGD YMAAKGLKAG 100
    EIHPVYKAMN TLDYAVGNIG NHEFNYGLDY LKKSLAGAKF PYVNANVIDV 150
    KTGKPLFQPY LIVDTPVKDR DGKNHNLRIG YIGFGPPQVM IWDKANLTGK 200
    VTVDDITETA KKWVPEMRKQ GANLVVAIPH SGLSSDPYKT MAENSVYYLS 250
    QVPGIDAIMF GHAHAVFPSK DFATIKGADI AQGTLNGIPA VMPGQWGDHL 300
    GVVDFVLNND QGQWQVTQAK AEARPIFDKA TQKSLAAENA NLMKVLAADH 350
    QGTRDFVSQP IGTASDNMYS YLSLIQDDPT VQIVNNAQRA YTEHFIQGDP 400
    DLADLPVLSA AAPFKAGGRK NDPASFVEVE KGELTFRNAA DLYLYPNTLV 450
    VVKASGADVK QWLECSAAQF NQIDVNSSKP QSLINWDSFR TYNFDVIDGV 500
    NYEIDVSQPA RYDGECALIN DKAERIKNLT FNGKPIDPQA TFLIGTNNYR 550
    AYSGKFAGTG DSHIAFASPD ENRAVLSAYI SAETKKHGQV TPQADNNWRL 600
    ATLNSQQPLD IRFETSPSTK AAEFIKQKAQ YPMKAMGTDE IGFAVFKIDL 650
    QK 652
    Length:652
    Mass (Da):71,492
    Last modified:October 1, 1996 - v1
    Checksum:i8781369575794E17
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X85742 Genomic DNA. Translation: CAA59745.1.
    PIRiS52695.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X85742 Genomic DNA. Translation: CAA59745.1 .
    PIRi S52695.

    3D structure databases

    ProteinModelPortali P53052.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    BRENDAi 3.1.4.16. 6741.

    Family and domain databases

    Gene3Di 3.60.21.10. 1 hit.
    3.90.780.10. 1 hit.
    InterProi IPR008334. 5'-Nucleotdase_C.
    IPR006146. 5'-Nucleotdase_CS.
    IPR006179. 5_nucleotidase/apyrase.
    IPR004843. Calcineurin-like_PHP_apaH.
    IPR006294. Cyc_nuc_PDE_nucleotidase.
    IPR029052. Metallo-depent_PP-like.
    [Graphical view ]
    PANTHERi PTHR11575. PTHR11575. 1 hit.
    Pfami PF02872. 5_nucleotid_C. 1 hit.
    PF00149. Metallophos. 1 hit.
    [Graphical view ]
    PRINTSi PR01607. APYRASEFAMLY.
    SUPFAMi SSF55816. SSF55816. 1 hit.
    SSF56300. SSF56300. 1 hit.
    TIGRFAMsi TIGR01390. CycNucDiestase. 1 hit.
    PROSITEi PS00785. 5_NUCLEOTIDASE_1. 1 hit.
    PS00786. 5_NUCLEOTIDASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Truelzsch K.S.
      Submitted (MAR-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 51871 / WA-314 / Serotype O:8.

    Entry informationi

    Entry nameiCPDB_YEREN
    AccessioniPrimary (citable) accession number: P53052
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Multifunctional enzyme

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3