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Protein

2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase

Gene

cpdB

Organism
Yersinia enterocolitica
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

This bifunctional enzyme catalyzes two consecutive reactions during ribonucleic acid degradation. Converts a 2',3'-cyclic nucleotide to a 3'-nucleotide and then the 3'-nucleotide to the corresponding nucleoside and phosphate (By similarity).By similarity

Catalytic activityi

Nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 3'-phosphate.
A 3'-ribonucleotide + H2O = a ribonucleoside + phosphate.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi36Divalent metal cation 1By similarity1
Metal bindingi38Divalent metal cation 1By similarity1
Metal bindingi81Divalent metal cation 1By similarity1
Metal bindingi81Divalent metal cation 2By similarity1
Metal bindingi121Divalent metal cation 2By similarity1
Metal bindingi230Divalent metal cation 2By similarity1
Metal bindingi262Divalent metal cation 2By similarity1
Metal bindingi264Divalent metal cation 1By similarity1
Binding sitei445SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Multifunctional enzyme
LigandMetal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi3.1.4.16 6741

Names & Taxonomyi

Protein namesi
Recommended name:
2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase (EC:3.1.3.6, EC:3.1.4.16)
Gene namesi
Name:cpdB
OrganismiYersinia enterocolitica
Taxonomic identifieri630 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000000003825 – 6522',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidaseAdd BLAST628

Structurei

3D structure databases

ProteinModelPortaliP53052
SMRiP53052
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni549 – 555Substrate bindingBy similarity7

Sequence similaritiesi

Belongs to the 5'-nucleotidase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4107RNS Bacteria
COG0737 LUCA

Family and domain databases

Gene3Di3.60.21.10, 1 hit
3.90.780.10, 1 hit
InterProiView protein in InterPro
IPR008334 5'-Nucleotdase_C
IPR036907 5'-Nucleotdase_C_sf
IPR006146 5'-Nucleotdase_CS
IPR006179 5_nucleotidase/apyrase
IPR004843 Calcineurin-like_PHP_ApaH
IPR006294 Cyc_nuc_PDE_nucleotidase
IPR029052 Metallo-depent_PP-like
PANTHERiPTHR11575 PTHR11575, 1 hit
PfamiView protein in Pfam
PF02872 5_nucleotid_C, 1 hit
PF00149 Metallophos, 1 hit
PRINTSiPR01607 APYRASEFAMLY
SUPFAMiSSF55816 SSF55816, 1 hit
TIGRFAMsiTIGR01390 CycNucDiestase, 1 hit
PROSITEiView protein in PROSITE
PS00785 5_NUCLEOTIDASE_1, 1 hit
PS00786 5_NUCLEOTIDASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P53052-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFKRPLTLSL LASLIALTTS TAQAATVDLR VLETTDLHSN MMDFDYYKDK
60 70 80 90 100
PTEKFGLVRT ASLIEAARQQ ATNSVLVDNG DLIQGSPLGD YMAAKGLKAG
110 120 130 140 150
EIHPVYKAMN TLDYAVGNIG NHEFNYGLDY LKKSLAGAKF PYVNANVIDV
160 170 180 190 200
KTGKPLFQPY LIVDTPVKDR DGKNHNLRIG YIGFGPPQVM IWDKANLTGK
210 220 230 240 250
VTVDDITETA KKWVPEMRKQ GANLVVAIPH SGLSSDPYKT MAENSVYYLS
260 270 280 290 300
QVPGIDAIMF GHAHAVFPSK DFATIKGADI AQGTLNGIPA VMPGQWGDHL
310 320 330 340 350
GVVDFVLNND QGQWQVTQAK AEARPIFDKA TQKSLAAENA NLMKVLAADH
360 370 380 390 400
QGTRDFVSQP IGTASDNMYS YLSLIQDDPT VQIVNNAQRA YTEHFIQGDP
410 420 430 440 450
DLADLPVLSA AAPFKAGGRK NDPASFVEVE KGELTFRNAA DLYLYPNTLV
460 470 480 490 500
VVKASGADVK QWLECSAAQF NQIDVNSSKP QSLINWDSFR TYNFDVIDGV
510 520 530 540 550
NYEIDVSQPA RYDGECALIN DKAERIKNLT FNGKPIDPQA TFLIGTNNYR
560 570 580 590 600
AYSGKFAGTG DSHIAFASPD ENRAVLSAYI SAETKKHGQV TPQADNNWRL
610 620 630 640 650
ATLNSQQPLD IRFETSPSTK AAEFIKQKAQ YPMKAMGTDE IGFAVFKIDL

QK
Length:652
Mass (Da):71,492
Last modified:October 1, 1996 - v1
Checksum:i8781369575794E17
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X85742 Genomic DNA Translation: CAA59745.1
PIRiS52695

Similar proteinsi

Entry informationi

Entry nameiCPDB_YEREN
AccessioniPrimary (citable) accession number: P53052
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: March 28, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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