Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Oligomycin resistance ATP-dependent permease YOR1

Gene

YOR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for oligomycin resistance.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi621 – 6288ATP 1PROSITE-ProRule annotation
Nucleotide bindingi1247 – 12548ATP 2PROSITE-ProRule annotation

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • xenobiotic-transporting ATPase activity Source: SGD

GO - Biological processi

  • drug transmembrane transport Source: GOC
  • xenobiotic transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-30944-MONOMER.

Protein family/group databases

TCDBi3.A.1.208.3. the atp-binding cassette (abc) superfamily.

Chemistry

SwissLipidsiSLP:000000522.

Names & Taxonomyi

Protein namesi
Recommended name:
Oligomycin resistance ATP-dependent permease YOR1
Gene namesi
Name:YOR1
Ordered Locus Names:YGR281W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR281W.
SGDiS000003513. YOR1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 206206CytoplasmicSequence analysisAdd
BLAST
Transmembranei207 – 22721HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini228 – 24922ExtracellularSequence analysisAdd
BLAST
Transmembranei250 – 27021HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini271 – 32858CytoplasmicSequence analysisAdd
BLAST
Transmembranei329 – 34921HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini350 – 3578ExtracellularSequence analysis
Transmembranei358 – 37013HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini371 – 43363CytoplasmicSequence analysisAdd
BLAST
Transmembranei434 – 45421HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini455 – 47824ExtracellularSequence analysisAdd
BLAST
Transmembranei479 – 49921HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini500 – 615116CytoplasmicSequence analysisAdd
BLAST
Transmembranei616 – 63621HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini637 – 892256ExtracellularSequence analysisAdd
BLAST
Transmembranei893 – 91321HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini914 – 94027CytoplasmicSequence analysisAdd
BLAST
Transmembranei941 – 96121HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini962 – 102766ExtracellularSequence analysisAdd
BLAST
Transmembranei1028 – 104821HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini1049 – 111769CytoplasmicSequence analysisAdd
BLAST
Transmembranei1118 – 113821HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini1139 – 11413ExtracellularSequence analysis
Transmembranei1142 – 116221HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini1163 – 1477315CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14771477Oligomycin resistance ATP-dependent permease YOR1PRO_0000093450Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei10 – 101PhosphoserineCombined sources
Modified residuei24 – 241PhosphoserineCombined sources
Modified residuei53 – 531PhosphothreonineCombined sources
Glycosylationi661 – 6611N-linked (GlcNAc...)Sequence analysis
Glycosylationi759 – 7591N-linked (GlcNAc...)Sequence analysis
Glycosylationi799 – 7991N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP53049.

PTM databases

iPTMnetiP53049.

Expressioni

Inductioni

Transcriptionally regulated by PDR8.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi33531. 328 interactions.
DIPiDIP-6796N.
IntActiP53049. 36 interactions.
MINTiMINT-627617.

Structurei

3D structure databases

ProteinModelPortaliP53049.
SMRiP53049. Positions 561-816, 905-1469.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini207 – 493287ABC transmembrane type-1 1PROSITE-ProRule annotationAdd
BLAST
Domaini581 – 808228ABC transporter 1PROSITE-ProRule annotationAdd
BLAST
Domaini897 – 1175279ABC transmembrane type-1 2PROSITE-ProRule annotationAdd
BLAST
Domaini1213 – 1464252ABC transporter 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 ABC transmembrane type-1 domains.PROSITE-ProRule annotation
Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00840000129721.
InParanoidiP53049.
OMAiFRIAANI.
OrthoDBiEOG75XGV5.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
IPR030244. Yor1.
[Graphical view]
PANTHERiPTHR24223:SF218. PTHR24223:SF218. 4 hits.
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53049-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTITVGDAVS ETELENKSQN VVLSPKASAS SDISTDVDKD TSSSWDDKSL
60 70 80 90 100
LPTGEYIVDR NKPQTYLNSD DIEKVTESDI FPQKRLFSFL HSKKIPEVPQ
110 120 130 140 150
TDDERKIYPL FHTNIISNMF FWWVLPILRV GYKRTIQPND LFKMDPRMSI
160 170 180 190 200
ETLYDDFEKN MIYYFEKTRK KYRKRHPEAT EEEVMENAKL PKHTVLRALL
210 220 230 240 250
FTFKKQYFMS IVFAILANCT SGFNPMITKR LIEFVEEKAI FHSMHVNKGI
260 270 280 290 300
GYAIGACLMM FVNGLTFNHF FHTSQLTGVQ AKSILTKAAM KKMFNASNYA
310 320 330 340 350
RHCFPNGKVT SFVTTDLARI EFALSFQPFL AGFPAILAIC IVLLIVNLGP
360 370 380 390 400
IALVGIGIFF GGFFISLFAF KLILGFRIAA NIFTDARVTM MREVLNNIKM
410 420 430 440 450
IKYYTWEDAY EKNIQDIRTK EISKVRKMQL SRNFLIAMAM SLPSIASLVT
460 470 480 490 500
FLAMYKVNKG GRQPGNIFAS LSLFQVLSLQ MFFLPIAIGT GIDMIIGLGR
510 520 530 540 550
LQSLLEAPED DPNQMIEMKP SPGFDPKLAL KMTHCSFEWE DYELNDAIEE
560 570 580 590 600
AKGEAKDEGK KNKKKRKDTW GKPSASTNKA KRLDNMLKDR DGPEDLEKTS
610 620 630 640 650
FRGFKDLNFD IKKGEFIMIT GPIGTGKSSL LNAMAGSMRK TDGKVEVNGD
660 670 680 690 700
LLMCGYPWIQ NASVRDNIIF GSPFNKEKYD EVVRVCSLKA DLDILPAGDM
710 720 730 740 750
TEIGERGITL SGGQKARINL ARSVYKKKDI YLFDDVLSAV DSRVGKHIMD
760 770 780 790 800
ECLTGMLANK TRILATHQLS LIERASRVIV LGTDGQVDIG TVDELKARNQ
810 820 830 840 850
TLINLLQFSS QNSEKEDEEQ EAVVAGELGQ LKYESEVKEL TELKKKATEM
860 870 880 890 900
SQTANSGKIV ADGHTSSKEE RAVNSISLKI YREYIKAAVG KWGFIALPLY
910 920 930 940 950
AILVVGTTFC SLFSSVWLSY WTENKFKNRP PSFYMGLYSF FVFAAFIFMN
960 970 980 990 1000
GQFTILCAMG IMASKWLNLR AVKRILHTPM SYIDTTPLGR ILNRFTKDTD
1010 1020 1030 1040 1050
SLDNELTESL RLMTSQFANI VGVCVMCIVY LPWFAIAIPF LLVIFVLIAD
1060 1070 1080 1090 1100
HYQSSGREIK RLEAVQRSFV YNNLNEVLGG MDTIKAYRSQ ERFLAKSDFL
1110 1120 1130 1140 1150
INKMNEAGYL VVVLQRWVGI FLDMVAIAFA LIITLLCVTR AFPISAASVG
1160 1170 1180 1190 1200
VLLTYVLQLP GLLNTILRAM TQTENDMNSA ERLVTYATEL PLEASYRKPE
1210 1220 1230 1240 1250
MTPPESWPSM GEIIFENVDF AYRPGLPIVL KNLNLNIKSG EKIGICGRTG
1260 1270 1280 1290 1300
AGKSTIMSAL YRLNELTAGK ILIDNVDISQ LGLFDLRRKL AIIPQDPVLF
1310 1320 1330 1340 1350
RGTIRKNLDP FNERTDDELW DALVRGGAIA KDDLPEVKLQ KPDENGTHGK
1360 1370 1380 1390 1400
MHKFHLDQAV EEEGSNFSLG ERQLLALTRA LVRQSKILIL DEATSSVDYE
1410 1420 1430 1440 1450
TDGKIQTRIV EEFGDCTILC IAHRLKTIVN YDRILVLEKG EVAEFDTPWT
1460 1470
LFSQEDSIFR SMCSRSGIVE NDFENRS
Length:1,477
Mass (Da):166,728
Last modified:October 1, 1996 - v1
Checksum:i40C5D36CA9B6A8C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73066 Genomic DNA. Translation: CAA97312.1.
BK006941 Genomic DNA. Translation: DAA08369.1.
PIRiS64616.
RefSeqiNP_011797.3. NM_001181410.3.

Genome annotation databases

EnsemblFungiiYGR281W; YGR281W; YGR281W.
GeneIDi853198.
KEGGisce:YGR281W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73066 Genomic DNA. Translation: CAA97312.1.
BK006941 Genomic DNA. Translation: DAA08369.1.
PIRiS64616.
RefSeqiNP_011797.3. NM_001181410.3.

3D structure databases

ProteinModelPortaliP53049.
SMRiP53049. Positions 561-816, 905-1469.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33531. 328 interactions.
DIPiDIP-6796N.
IntActiP53049. 36 interactions.
MINTiMINT-627617.

Chemistry

SwissLipidsiSLP:000000522.

Protein family/group databases

TCDBi3.A.1.208.3. the atp-binding cassette (abc) superfamily.

PTM databases

iPTMnetiP53049.

Proteomic databases

MaxQBiP53049.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGR281W; YGR281W; YGR281W.
GeneIDi853198.
KEGGisce:YGR281W.

Organism-specific databases

EuPathDBiFungiDB:YGR281W.
SGDiS000003513. YOR1.

Phylogenomic databases

GeneTreeiENSGT00840000129721.
InParanoidiP53049.
OMAiFRIAANI.
OrthoDBiEOG75XGV5.

Enzyme and pathway databases

BioCyciYEAST:G3O-30944-MONOMER.

Miscellaneous databases

PROiP53049.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
IPR030244. Yor1.
[Graphical view]
PANTHERiPTHR24223:SF218. PTHR24223:SF218. 4 hits.
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Expression of an ATP-binding cassette transporter-encoding gene (YOR1) is required for oligomycin resistance in Saccharomyces cerevisiae."
    Katzmann D.J., Hallstrom T.C., Voet M., Wysock W., Golin J., Volckaert G., Moye-Rowley W.S.
    Mol. Cell. Biol. 15:6875-6883(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Sequence analysis of a near-subtelomeric 35.4 kb DNA segment on the right arm of chromosome VII from Saccharomyces cerevisiae carrying the MAL1 locus reveals 15 complete open reading frames, including ZUO1, BGL2 and BIO2 genes and an ABC transporter gene."
    Volckaert G., Voet M., Robben J.
    Yeast 13:251-259(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 96604 / S288c / FY1679.
  3. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
    Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
    , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
    Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. "A general strategy to uncover transcription factor properties identifies a new regulator of drug resistance in yeast."
    Hikkel I., Lucau-Danila A., Delaveau T., Marc P., Devaux F., Jacq C.
    J. Biol. Chem. 278:11427-11432(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  7. "Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway."
    Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J., Mann M., Jensen O.N.
    Mol. Cell. Proteomics 4:310-327(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: YAL6B.
  8. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.
  9. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-24, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  10. "Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry."
    Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.
    Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-53, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiYOR1_YEAST
AccessioniPrimary (citable) accession number: P53049
Secondary accession number(s): D6VV58
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 8, 2016
This is version 156 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 3610 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.