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Protein

Oligomycin resistance ATP-dependent permease YOR1

Gene

YOR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for oligomycin resistance.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi621 – 628ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1247 – 1254ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • xenobiotic-transporting ATPase activity Source: SGD

GO - Biological processi

  • xenobiotic transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-30944-MONOMER.

Protein family/group databases

TCDBi3.A.1.208.3. the atp-binding cassette (abc) superfamily.

Chemistry databases

SwissLipidsiSLP:000000522.

Names & Taxonomyi

Protein namesi
Recommended name:
Oligomycin resistance ATP-dependent permease YOR1
Gene namesi
Name:YOR1
Ordered Locus Names:YGR281W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR281W.
SGDiS000003513. YOR1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 206CytoplasmicSequence analysisAdd BLAST206
Transmembranei207 – 227HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini228 – 249ExtracellularSequence analysisAdd BLAST22
Transmembranei250 – 270HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini271 – 328CytoplasmicSequence analysisAdd BLAST58
Transmembranei329 – 349HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini350 – 357ExtracellularSequence analysis8
Transmembranei358 – 370HelicalPROSITE-ProRule annotationAdd BLAST13
Topological domaini371 – 433CytoplasmicSequence analysisAdd BLAST63
Transmembranei434 – 454HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini455 – 478ExtracellularSequence analysisAdd BLAST24
Transmembranei479 – 499HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini500 – 615CytoplasmicSequence analysisAdd BLAST116
Transmembranei616 – 636HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini637 – 892ExtracellularSequence analysisAdd BLAST256
Transmembranei893 – 913HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini914 – 940CytoplasmicSequence analysisAdd BLAST27
Transmembranei941 – 961HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini962 – 1027ExtracellularSequence analysisAdd BLAST66
Transmembranei1028 – 1048HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini1049 – 1117CytoplasmicSequence analysisAdd BLAST69
Transmembranei1118 – 1138HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini1139 – 1141ExtracellularSequence analysis3
Transmembranei1142 – 1162HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini1163 – 1477CytoplasmicSequence analysisAdd BLAST315

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000934501 – 1477Oligomycin resistance ATP-dependent permease YOR1Add BLAST1477

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10PhosphoserineCombined sources1
Modified residuei24PhosphoserineCombined sources1
Modified residuei53PhosphothreonineCombined sources1
Glycosylationi661N-linked (GlcNAc...)Sequence analysis1
Glycosylationi759N-linked (GlcNAc...)Sequence analysis1
Glycosylationi799N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP53049.
PRIDEiP53049.

PTM databases

iPTMnetiP53049.

Expressioni

Inductioni

Transcriptionally regulated by PDR8.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi33531. 328 interactors.
DIPiDIP-6796N.
IntActiP53049. 36 interactors.
MINTiMINT-627617.

Structurei

3D structure databases

ProteinModelPortaliP53049.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini207 – 493ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST287
Domaini581 – 808ABC transporter 1PROSITE-ProRule annotationAdd BLAST228
Domaini897 – 1175ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST279
Domaini1213 – 1464ABC transporter 2PROSITE-ProRule annotationAdd BLAST252

Sequence similaritiesi

Contains 2 ABC transmembrane type-1 domains.PROSITE-ProRule annotation
Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00840000131000.
InParanoidiP53049.
OMAiWALHETY.
OrthoDBiEOG092C0QQU.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
IPR030244. Yor1.
[Graphical view]
PANTHERiPTHR24223:SF218. PTHR24223:SF218. 4 hits.
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53049-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTITVGDAVS ETELENKSQN VVLSPKASAS SDISTDVDKD TSSSWDDKSL
60 70 80 90 100
LPTGEYIVDR NKPQTYLNSD DIEKVTESDI FPQKRLFSFL HSKKIPEVPQ
110 120 130 140 150
TDDERKIYPL FHTNIISNMF FWWVLPILRV GYKRTIQPND LFKMDPRMSI
160 170 180 190 200
ETLYDDFEKN MIYYFEKTRK KYRKRHPEAT EEEVMENAKL PKHTVLRALL
210 220 230 240 250
FTFKKQYFMS IVFAILANCT SGFNPMITKR LIEFVEEKAI FHSMHVNKGI
260 270 280 290 300
GYAIGACLMM FVNGLTFNHF FHTSQLTGVQ AKSILTKAAM KKMFNASNYA
310 320 330 340 350
RHCFPNGKVT SFVTTDLARI EFALSFQPFL AGFPAILAIC IVLLIVNLGP
360 370 380 390 400
IALVGIGIFF GGFFISLFAF KLILGFRIAA NIFTDARVTM MREVLNNIKM
410 420 430 440 450
IKYYTWEDAY EKNIQDIRTK EISKVRKMQL SRNFLIAMAM SLPSIASLVT
460 470 480 490 500
FLAMYKVNKG GRQPGNIFAS LSLFQVLSLQ MFFLPIAIGT GIDMIIGLGR
510 520 530 540 550
LQSLLEAPED DPNQMIEMKP SPGFDPKLAL KMTHCSFEWE DYELNDAIEE
560 570 580 590 600
AKGEAKDEGK KNKKKRKDTW GKPSASTNKA KRLDNMLKDR DGPEDLEKTS
610 620 630 640 650
FRGFKDLNFD IKKGEFIMIT GPIGTGKSSL LNAMAGSMRK TDGKVEVNGD
660 670 680 690 700
LLMCGYPWIQ NASVRDNIIF GSPFNKEKYD EVVRVCSLKA DLDILPAGDM
710 720 730 740 750
TEIGERGITL SGGQKARINL ARSVYKKKDI YLFDDVLSAV DSRVGKHIMD
760 770 780 790 800
ECLTGMLANK TRILATHQLS LIERASRVIV LGTDGQVDIG TVDELKARNQ
810 820 830 840 850
TLINLLQFSS QNSEKEDEEQ EAVVAGELGQ LKYESEVKEL TELKKKATEM
860 870 880 890 900
SQTANSGKIV ADGHTSSKEE RAVNSISLKI YREYIKAAVG KWGFIALPLY
910 920 930 940 950
AILVVGTTFC SLFSSVWLSY WTENKFKNRP PSFYMGLYSF FVFAAFIFMN
960 970 980 990 1000
GQFTILCAMG IMASKWLNLR AVKRILHTPM SYIDTTPLGR ILNRFTKDTD
1010 1020 1030 1040 1050
SLDNELTESL RLMTSQFANI VGVCVMCIVY LPWFAIAIPF LLVIFVLIAD
1060 1070 1080 1090 1100
HYQSSGREIK RLEAVQRSFV YNNLNEVLGG MDTIKAYRSQ ERFLAKSDFL
1110 1120 1130 1140 1150
INKMNEAGYL VVVLQRWVGI FLDMVAIAFA LIITLLCVTR AFPISAASVG
1160 1170 1180 1190 1200
VLLTYVLQLP GLLNTILRAM TQTENDMNSA ERLVTYATEL PLEASYRKPE
1210 1220 1230 1240 1250
MTPPESWPSM GEIIFENVDF AYRPGLPIVL KNLNLNIKSG EKIGICGRTG
1260 1270 1280 1290 1300
AGKSTIMSAL YRLNELTAGK ILIDNVDISQ LGLFDLRRKL AIIPQDPVLF
1310 1320 1330 1340 1350
RGTIRKNLDP FNERTDDELW DALVRGGAIA KDDLPEVKLQ KPDENGTHGK
1360 1370 1380 1390 1400
MHKFHLDQAV EEEGSNFSLG ERQLLALTRA LVRQSKILIL DEATSSVDYE
1410 1420 1430 1440 1450
TDGKIQTRIV EEFGDCTILC IAHRLKTIVN YDRILVLEKG EVAEFDTPWT
1460 1470
LFSQEDSIFR SMCSRSGIVE NDFENRS
Length:1,477
Mass (Da):166,728
Last modified:October 1, 1996 - v1
Checksum:i40C5D36CA9B6A8C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73066 Genomic DNA. Translation: CAA97312.1.
BK006941 Genomic DNA. Translation: DAA08369.1.
PIRiS64616.
RefSeqiNP_011797.3. NM_001181410.3.

Genome annotation databases

EnsemblFungiiYGR281W; YGR281W; YGR281W.
GeneIDi853198.
KEGGisce:YGR281W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73066 Genomic DNA. Translation: CAA97312.1.
BK006941 Genomic DNA. Translation: DAA08369.1.
PIRiS64616.
RefSeqiNP_011797.3. NM_001181410.3.

3D structure databases

ProteinModelPortaliP53049.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33531. 328 interactors.
DIPiDIP-6796N.
IntActiP53049. 36 interactors.
MINTiMINT-627617.

Chemistry databases

SwissLipidsiSLP:000000522.

Protein family/group databases

TCDBi3.A.1.208.3. the atp-binding cassette (abc) superfamily.

PTM databases

iPTMnetiP53049.

Proteomic databases

MaxQBiP53049.
PRIDEiP53049.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGR281W; YGR281W; YGR281W.
GeneIDi853198.
KEGGisce:YGR281W.

Organism-specific databases

EuPathDBiFungiDB:YGR281W.
SGDiS000003513. YOR1.

Phylogenomic databases

GeneTreeiENSGT00840000131000.
InParanoidiP53049.
OMAiWALHETY.
OrthoDBiEOG092C0QQU.

Enzyme and pathway databases

BioCyciYEAST:G3O-30944-MONOMER.

Miscellaneous databases

PROiP53049.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
IPR030244. Yor1.
[Graphical view]
PANTHERiPTHR24223:SF218. PTHR24223:SF218. 4 hits.
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYOR1_YEAST
AccessioniPrimary (citable) accession number: P53049
Secondary accession number(s): D6VV58
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 30, 2016
This is version 161 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 3610 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.