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Protein

General alpha-glucoside permease

Gene

MAL11

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

High-affinity uptake of alpha-glucosides such as maltose, turanose, isomaltose, alpha-methylglucoside, maltotriose, palatinose, trehalose, melezitose and glucose. Acts with the concomitant transport of protons into the cell (symport system).3 Publications

GO - Molecular functioni

  • alpha-glucoside:proton symporter activity Source: SGD
  • glucose transmembrane transporter activity Source: GO_Central
  • maltose:proton symporter activity Source: SGD
  • trehalose transmembrane transporter activity Source: SGD

GO - Biological processi

  • alpha-glucoside transport Source: UniProtKB
  • disaccharide catabolic process Source: SGD
  • glucose import Source: GO_Central
  • hexose transmembrane transport Source: GO_Central
  • maltose metabolic process Source: UniProtKB-KW
  • maltose transport Source: SGD
  • trehalose transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Maltose metabolism, Sugar transport, Symport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-30949-MONOMER.

Protein family/group databases

TCDBi2.A.1.1.11. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
General alpha-glucoside permease
Alternative name(s):
Maltose permease MAL11
Maltose transport protein MAL11
Gene namesi
Name:MAL11
Synonyms:AGT1, MAL1T, MTP1
Ordered Locus Names:YGR289C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR289C.
SGDiS000003521. MAL11.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 115CytoplasmicSequence analysisAdd BLAST115
Transmembranei116 – 136Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini137 – 150ExtracellularSequence analysisAdd BLAST14
Transmembranei151 – 171Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini172 – 186CytoplasmicSequence analysisAdd BLAST15
Transmembranei187 – 207Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini208ExtracellularSequence analysis1
Transmembranei209 – 229Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini230 – 242CytoplasmicSequence analysisAdd BLAST13
Transmembranei243 – 263Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini264 – 278ExtracellularSequence analysisAdd BLAST15
Transmembranei279 – 299Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini300 – 370CytoplasmicSequence analysisAdd BLAST71
Transmembranei371 – 391Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini392 – 404ExtracellularSequence analysisAdd BLAST13
Transmembranei405 – 425Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini426 – 433CytoplasmicSequence analysis8
Transmembranei434 – 454Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini455 – 466ExtracellularSequence analysisAdd BLAST12
Transmembranei467 – 487Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini488 – 499CytoplasmicSequence analysisAdd BLAST12
Transmembranei500 – 520Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini521 – 532ExtracellularSequence analysisAdd BLAST12
Transmembranei533 – 553Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini554 – 616CytoplasmicSequence analysisAdd BLAST63

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000504251 – 616General alpha-glucoside permeaseAdd BLAST616

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi523N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP53048.

Expressioni

Inductioni

By maltose and maltotriose. Repressed by glucose.3 Publications

Interactioni

Protein-protein interaction databases

BioGridi33539. 70 interactors.
DIPiDIP-5567N.
IntActiP53048. 2 interactors.
MINTiMINT-552607.

Structurei

3D structure databases

ProteinModelPortaliP53048.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00850000132516.
HOGENOMiHOG000159003.
InParanoidiP53048.
KOiK08141.
OMAiEANDREH.
OrthoDBiEOG092C1DHG.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR003663. Sugar/inositol_transpt.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53048-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNIISLVSK KKAASKNEDK NISESSRDIV NQQEVFNTED FEEGKKDSAF
60 70 80 90 100
ELDHLEFTTN SAQLGDSDED NENVINEMNA TDDANEANSE EKSMTLKQAL
110 120 130 140 150
LKYPKAALWS ILVSTTLVME GYDTALLSAL YALPVFQRKF GTLNGEGSYE
160 170 180 190 200
ITSQWQIGLN MCVLCGEMIG LQITTYMVEF MGNRYTMITA LGLLTAYIFI
210 220 230 240 250
LYYCKSLAMI AVGQILSAIP WGCFQSLAVT YASEVCPLAL RYYMTSYSNI
260 270 280 290 300
CWLFGQIFAS GIMKNSQENL GNSDLGYKLP FALQWIWPAP LMIGIFFAPE
310 320 330 340 350
SPWWLVRKDR VAEARKSLSR ILSGKGAEKD IQVDLTLKQI ELTIEKERLL
360 370 380 390 400
ASKSGSFFNC FKGVNGRRTR LACLTWVAQN SSGAVLLGYS TYFFERAGMA
410 420 430 440 450
TDKAFTFSLI QYCLGLAGTL CSWVISGRVG RWTILTYGLA FQMVCLFIIG
460 470 480 490 500
GMGFGSGSSA SNGAGGLLLA LSFFYNAGIG AVVYCIVAEI PSAELRTKTI
510 520 530 540 550
VLARICYNLM AVINAILTPY MLNVSDWNWG AKTGLYWGGF TAVTLAWVII
560 570 580 590 600
DLPETTGRTF SEINELFNQG VPARKFASTV VDPFGKGKTQ HDSLADESIS
610
QSSSIKQREL NAADKC
Length:616
Mass (Da):67,980
Last modified:October 1, 1996 - v1
Checksum:iEE84AD9E15F7926D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti396 – 398RAG → KKQV in AAB07600 (PubMed:8594329).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L47346 Genomic DNA. Translation: AAB07600.1.
Z73074 Genomic DNA. Translation: CAA97322.1.
BK006941 Genomic DNA. Translation: DAA08377.1.
PIRiS64624.
RefSeqiNP_011805.3. NM_001181418.3.

Genome annotation databases

EnsemblFungiiYGR289C; YGR289C; YGR289C.
GeneIDi853207.
KEGGisce:YGR289C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L47346 Genomic DNA. Translation: AAB07600.1.
Z73074 Genomic DNA. Translation: CAA97322.1.
BK006941 Genomic DNA. Translation: DAA08377.1.
PIRiS64624.
RefSeqiNP_011805.3. NM_001181418.3.

3D structure databases

ProteinModelPortaliP53048.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33539. 70 interactors.
DIPiDIP-5567N.
IntActiP53048. 2 interactors.
MINTiMINT-552607.

Protein family/group databases

TCDBi2.A.1.1.11. the major facilitator superfamily (mfs).

Proteomic databases

PRIDEiP53048.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGR289C; YGR289C; YGR289C.
GeneIDi853207.
KEGGisce:YGR289C.

Organism-specific databases

EuPathDBiFungiDB:YGR289C.
SGDiS000003521. MAL11.

Phylogenomic databases

GeneTreeiENSGT00850000132516.
HOGENOMiHOG000159003.
InParanoidiP53048.
KOiK08141.
OMAiEANDREH.
OrthoDBiEOG092C1DHG.

Enzyme and pathway databases

BioCyciYEAST:G3O-30949-MONOMER.

Miscellaneous databases

PROiP53048.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR003663. Sugar/inositol_transpt.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMAL11_YEAST
AccessioniPrimary (citable) accession number: P53048
Secondary accession number(s): D6VV66
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 30, 2016
This is version 146 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.