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P53048 (MAL11_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 123. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
General alpha-glucoside permease
Alternative name(s):
Maltose permease MAL11
Maltose transport protein MAL11
Gene names
Name:MAL11
Synonyms:AGT1, MAL1T, MTP1
Ordered Locus Names:YGR289C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length616 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

High-affinity uptake of alpha-glucosides such as maltose, turanose, isomaltose, alpha-methylglucoside, maltotriose, palatinose, trehalose, melezitose and glucose. Acts with the concomitant transport of protons into the cell (symport system). Ref.1 Ref.5 Ref.6

Subcellular location

Membrane; Multi-pass membrane protein.

Induction

By maltose and maltotriose. Repressed by glucose. Ref.1 Ref.5 Ref.6

Sequence similarities

Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 616616General alpha-glucoside permease
PRO_0000050425

Regions

Topological domain1 – 115115Cytoplasmic Potential
Transmembrane116 – 13621Helical; Name=1; Potential
Topological domain137 – 15014Extracellular Potential
Transmembrane151 – 17121Helical; Name=2; Potential
Topological domain172 – 18615Cytoplasmic Potential
Transmembrane187 – 20721Helical; Name=3; Potential
Topological domain2081Extracellular Potential
Transmembrane209 – 22921Helical; Name=4; Potential
Topological domain230 – 24213Cytoplasmic Potential
Transmembrane243 – 26321Helical; Name=5; Potential
Topological domain264 – 27815Extracellular Potential
Transmembrane279 – 29921Helical; Name=6; Potential
Topological domain300 – 37071Cytoplasmic Potential
Transmembrane371 – 39121Helical; Name=7; Potential
Topological domain392 – 40413Extracellular Potential
Transmembrane405 – 42521Helical; Name=8; Potential
Topological domain426 – 4338Cytoplasmic Potential
Transmembrane434 – 45421Helical; Name=9; Potential
Topological domain455 – 46612Extracellular Potential
Transmembrane467 – 48721Helical; Name=10; Potential
Topological domain488 – 49912Cytoplasmic Potential
Transmembrane500 – 52021Helical; Name=11; Potential
Topological domain521 – 53212Extracellular Potential
Transmembrane533 – 55321Helical; Name=12; Potential
Topological domain554 – 61663Cytoplasmic Potential

Amino acid modifications

Glycosylation5231N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict396 – 3983RAG → KKQV in AAB07600. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P53048 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: EE84AD9E15F7926D

FASTA61667,980
        10         20         30         40         50         60 
MKNIISLVSK KKAASKNEDK NISESSRDIV NQQEVFNTED FEEGKKDSAF ELDHLEFTTN 

        70         80         90        100        110        120 
SAQLGDSDED NENVINEMNA TDDANEANSE EKSMTLKQAL LKYPKAALWS ILVSTTLVME 

       130        140        150        160        170        180 
GYDTALLSAL YALPVFQRKF GTLNGEGSYE ITSQWQIGLN MCVLCGEMIG LQITTYMVEF 

       190        200        210        220        230        240 
MGNRYTMITA LGLLTAYIFI LYYCKSLAMI AVGQILSAIP WGCFQSLAVT YASEVCPLAL 

       250        260        270        280        290        300 
RYYMTSYSNI CWLFGQIFAS GIMKNSQENL GNSDLGYKLP FALQWIWPAP LMIGIFFAPE 

       310        320        330        340        350        360 
SPWWLVRKDR VAEARKSLSR ILSGKGAEKD IQVDLTLKQI ELTIEKERLL ASKSGSFFNC 

       370        380        390        400        410        420 
FKGVNGRRTR LACLTWVAQN SSGAVLLGYS TYFFERAGMA TDKAFTFSLI QYCLGLAGTL 

       430        440        450        460        470        480 
CSWVISGRVG RWTILTYGLA FQMVCLFIIG GMGFGSGSSA SNGAGGLLLA LSFFYNAGIG 

       490        500        510        520        530        540 
AVVYCIVAEI PSAELRTKTI VLARICYNLM AVINAILTPY MLNVSDWNWG AKTGLYWGGF 

       550        560        570        580        590        600 
TAVTLAWVII DLPETTGRTF SEINELFNQG VPARKFASTV VDPFGKGKTQ HDSLADESIS 

       610 
QSSSIKQREL NAADKC 

« Hide

References

« Hide 'large scale' references
[1]"Characterization of AGT1 encoding a general alpha-glucoside transporter from Saccharomyces."
Han E.-K., Cotty F., Sottas C., Jiang H., Michels C.A.
Mol. Microbiol. 17:1093-1107(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, INDUCTION.
[2]"Sequence analysis of a near-subtelomeric 35.4 kb DNA segment on the right arm of chromosome VII from Saccharomyces cerevisiae carrying the MAL1 locus reveals 15 complete open reading frames, including ZUO1, BGL2 and BIO2 genes and an ABC transporter gene."
Volckaert G., Voet M., Robben J.
Yeast 13:251-259(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 96604 / S288c / FY1679.
[3]"The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E. expand/collapse author list , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[5]"Concurrent knock-out of at least 20 transporter genes is required to block uptake of hexoses in Saccharomyces cerevisiae."
Wieczorke R., Krampe S., Weierstall T., Freidel K., Hollenberg C.P., Boles E.
FEBS Lett. 464:123-128(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INDUCTION.
[6]"Characterization of the putative maltose transporters encoded by YDL247w and YJR160c."
Day R.E., Higgins V.J., Rogers P.J., Dawes I.W.
Yeast 19:1015-1027(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INDUCTION.
[7]"A global topology map of the Saccharomyces cerevisiae membrane proteome."
Kim H., Melen K., Oesterberg M., von Heijne G.
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
Strain: ATCC 208353 / W303-1A.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L47346 Genomic DNA. Translation: AAB07600.1.
Z73074 Genomic DNA. Translation: CAA97322.1.
BK006941 Genomic DNA. Translation: DAA08377.1.
PIRS64624.
RefSeqNP_011805.3. NM_001181418.3.

3D structure databases

ProteinModelPortalP53048.
SMRP53048. Positions 163-567.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid33539. 65 interactions.
DIPDIP-5567N.
IntActP53048. 2 interactions.
MINTMINT-552607.

Protein family/group databases

TCDB2.A.1.1.11. the major facilitator superfamily (mfs).

Proteomic databases

PaxDbP53048.
PeptideAtlasP53048.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYGR289C; YGR289C; YGR289C.
GeneID853207.
KEGGsce:YGR289C.

Organism-specific databases

CYGDYGR289c.
SGDS000003521. MAL11.

Phylogenomic databases

eggNOGCOG0477.
GeneTreeENSGT00720000109429.
HOGENOMHOG000159003.
KOK08141.
OMAWPVPIFI.
OrthoDBEOG7MKWG3.

Enzyme and pathway databases

BioCycYEAST:G3O-30949-MONOMER.

Gene expression databases

GenevestigatorP53048.

Family and domain databases

InterProIPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
IPR003663. Sugar/inositol_transpt.
[Graphical view]
PfamPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMSSF103473. SSF103473. 1 hit.
TIGRFAMsTIGR00879. SP. 1 hit.
PROSITEPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio973389.

Entry information

Entry nameMAL11_YEAST
AccessionPrimary (citable) accession number: P53048
Secondary accession number(s): D6VV66
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome VII

Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families