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P53048

- MAL11_YEAST

UniProt

P53048 - MAL11_YEAST

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Protein
General alpha-glucoside permease
Gene
MAL11, AGT1, MAL1T, MTP1, YGR289C
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

High-affinity uptake of alpha-glucosides such as maltose, turanose, isomaltose, alpha-methylglucoside, maltotriose, palatinose, trehalose, melezitose and glucose. Acts with the concomitant transport of protons into the cell (symport system).3 Publications

GO - Molecular functioni

  1. alpha-glucoside:proton symporter activity Source: SGD
  2. maltose:proton symporter activity Source: SGD
  3. trehalose transmembrane transporter activity Source: SGD

GO - Biological processi

  1. alpha-glucoside transport Source: UniProtKB
  2. disaccharide catabolic process Source: SGD
  3. maltose metabolic process Source: UniProtKB-KW
  4. maltose transport Source: SGD
  5. trehalose transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Maltose metabolism, Sugar transport, Symport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-30949-MONOMER.

Protein family/group databases

TCDBi2.A.1.1.11. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
General alpha-glucoside permease
Alternative name(s):
Maltose permease MAL11
Maltose transport protein MAL11
Gene namesi
Name:MAL11
Synonyms:AGT1, MAL1T, MTP1
Ordered Locus Names:YGR289C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VII

Organism-specific databases

CYGDiYGR289c.
SGDiS000003521. MAL11.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 115115Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei116 – 13621Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini137 – 15014Extracellular Reviewed prediction
Add
BLAST
Transmembranei151 – 17121Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini172 – 18615Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei187 – 20721Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini208 – 2081Extracellular Reviewed prediction
Transmembranei209 – 22921Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini230 – 24213Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei243 – 26321Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini264 – 27815Extracellular Reviewed prediction
Add
BLAST
Transmembranei279 – 29921Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini300 – 37071Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei371 – 39121Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini392 – 40413Extracellular Reviewed prediction
Add
BLAST
Transmembranei405 – 42521Helical; Name=8; Reviewed prediction
Add
BLAST
Topological domaini426 – 4338Cytoplasmic Reviewed prediction
Transmembranei434 – 45421Helical; Name=9; Reviewed prediction
Add
BLAST
Topological domaini455 – 46612Extracellular Reviewed prediction
Add
BLAST
Transmembranei467 – 48721Helical; Name=10; Reviewed prediction
Add
BLAST
Topological domaini488 – 49912Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei500 – 52021Helical; Name=11; Reviewed prediction
Add
BLAST
Topological domaini521 – 53212Extracellular Reviewed prediction
Add
BLAST
Transmembranei533 – 55321Helical; Name=12; Reviewed prediction
Add
BLAST
Topological domaini554 – 61663Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 616616General alpha-glucoside permease
PRO_0000050425Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi523 – 5231N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP53048.
PeptideAtlasiP53048.

Expressioni

Inductioni

By maltose and maltotriose. Repressed by glucose.3 Publications

Gene expression databases

GenevestigatoriP53048.

Interactioni

Protein-protein interaction databases

BioGridi33539. 65 interactions.
DIPiDIP-5567N.
IntActiP53048. 2 interactions.
MINTiMINT-552607.

Structurei

3D structure databases

ProteinModelPortaliP53048.
SMRiP53048. Positions 163-567.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00720000109429.
HOGENOMiHOG000159003.
KOiK08141.
OMAiWPVPIFI.
OrthoDBiEOG7MKWG3.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
IPR003663. Sugar/inositol_transpt.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53048-1 [UniParc]FASTAAdd to Basket

« Hide

MKNIISLVSK KKAASKNEDK NISESSRDIV NQQEVFNTED FEEGKKDSAF    50
ELDHLEFTTN SAQLGDSDED NENVINEMNA TDDANEANSE EKSMTLKQAL 100
LKYPKAALWS ILVSTTLVME GYDTALLSAL YALPVFQRKF GTLNGEGSYE 150
ITSQWQIGLN MCVLCGEMIG LQITTYMVEF MGNRYTMITA LGLLTAYIFI 200
LYYCKSLAMI AVGQILSAIP WGCFQSLAVT YASEVCPLAL RYYMTSYSNI 250
CWLFGQIFAS GIMKNSQENL GNSDLGYKLP FALQWIWPAP LMIGIFFAPE 300
SPWWLVRKDR VAEARKSLSR ILSGKGAEKD IQVDLTLKQI ELTIEKERLL 350
ASKSGSFFNC FKGVNGRRTR LACLTWVAQN SSGAVLLGYS TYFFERAGMA 400
TDKAFTFSLI QYCLGLAGTL CSWVISGRVG RWTILTYGLA FQMVCLFIIG 450
GMGFGSGSSA SNGAGGLLLA LSFFYNAGIG AVVYCIVAEI PSAELRTKTI 500
VLARICYNLM AVINAILTPY MLNVSDWNWG AKTGLYWGGF TAVTLAWVII 550
DLPETTGRTF SEINELFNQG VPARKFASTV VDPFGKGKTQ HDSLADESIS 600
QSSSIKQREL NAADKC 616
Length:616
Mass (Da):67,980
Last modified:October 1, 1996 - v1
Checksum:iEE84AD9E15F7926D
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti396 – 3983RAG → KKQV in AAB07600. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L47346 Genomic DNA. Translation: AAB07600.1.
Z73074 Genomic DNA. Translation: CAA97322.1.
BK006941 Genomic DNA. Translation: DAA08377.1.
PIRiS64624.
RefSeqiNP_011805.3. NM_001181418.3.

Genome annotation databases

EnsemblFungiiYGR289C; YGR289C; YGR289C.
GeneIDi853207.
KEGGisce:YGR289C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L47346 Genomic DNA. Translation: AAB07600.1 .
Z73074 Genomic DNA. Translation: CAA97322.1 .
BK006941 Genomic DNA. Translation: DAA08377.1 .
PIRi S64624.
RefSeqi NP_011805.3. NM_001181418.3.

3D structure databases

ProteinModelPortali P53048.
SMRi P53048. Positions 163-567.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 33539. 65 interactions.
DIPi DIP-5567N.
IntActi P53048. 2 interactions.
MINTi MINT-552607.

Protein family/group databases

TCDBi 2.A.1.1.11. the major facilitator superfamily (mfs).

Proteomic databases

PaxDbi P53048.
PeptideAtlasi P53048.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YGR289C ; YGR289C ; YGR289C .
GeneIDi 853207.
KEGGi sce:YGR289C.

Organism-specific databases

CYGDi YGR289c.
SGDi S000003521. MAL11.

Phylogenomic databases

eggNOGi COG0477.
GeneTreei ENSGT00720000109429.
HOGENOMi HOG000159003.
KOi K08141.
OMAi WPVPIFI.
OrthoDBi EOG7MKWG3.

Enzyme and pathway databases

BioCyci YEAST:G3O-30949-MONOMER.

Miscellaneous databases

NextBioi 973389.

Gene expression databases

Genevestigatori P53048.

Family and domain databases

InterProi IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
IPR003663. Sugar/inositol_transpt.
[Graphical view ]
Pfami PF00083. Sugar_tr. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 1 hit.
TIGRFAMsi TIGR00879. SP. 1 hit.
PROSITEi PS50850. MFS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of AGT1 encoding a general alpha-glucoside transporter from Saccharomyces."
    Han E.-K., Cotty F., Sottas C., Jiang H., Michels C.A.
    Mol. Microbiol. 17:1093-1107(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, INDUCTION.
  2. "Sequence analysis of a near-subtelomeric 35.4 kb DNA segment on the right arm of chromosome VII from Saccharomyces cerevisiae carrying the MAL1 locus reveals 15 complete open reading frames, including ZUO1, BGL2 and BIO2 genes and an ABC transporter gene."
    Volckaert G., Voet M., Robben J.
    Yeast 13:251-259(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 96604 / S288c / FY1679.
  3. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
    Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
    , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
    Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. "Concurrent knock-out of at least 20 transporter genes is required to block uptake of hexoses in Saccharomyces cerevisiae."
    Wieczorke R., Krampe S., Weierstall T., Freidel K., Hollenberg C.P., Boles E.
    FEBS Lett. 464:123-128(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION.
  6. "Characterization of the putative maltose transporters encoded by YDL247w and YJR160c."
    Day R.E., Higgins V.J., Rogers P.J., Dawes I.W.
    Yeast 19:1015-1027(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION.
  7. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.

Entry informationi

Entry nameiMAL11_YEAST
AccessioniPrimary (citable) accession number: P53048
Secondary accession number(s): D6VV66
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 9, 2014
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

External Data

Dasty 3

Similar proteinsi