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P53048

- MAL11_YEAST

UniProt

P53048 - MAL11_YEAST

Protein

General alpha-glucoside permease

Gene

MAL11

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 126 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    High-affinity uptake of alpha-glucosides such as maltose, turanose, isomaltose, alpha-methylglucoside, maltotriose, palatinose, trehalose, melezitose and glucose. Acts with the concomitant transport of protons into the cell (symport system).3 Publications

    GO - Molecular functioni

    1. alpha-glucoside:proton symporter activity Source: SGD
    2. maltose:proton symporter activity Source: SGD
    3. trehalose transmembrane transporter activity Source: SGD

    GO - Biological processi

    1. alpha-glucoside transport Source: UniProtKB
    2. disaccharide catabolic process Source: SGD
    3. maltose metabolic process Source: UniProtKB-KW
    4. maltose transport Source: SGD
    5. trehalose transport Source: SGD

    Keywords - Biological processi

    Maltose metabolism, Sugar transport, Symport, Transport

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30949-MONOMER.

    Protein family/group databases

    TCDBi2.A.1.1.11. the major facilitator superfamily (mfs).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    General alpha-glucoside permease
    Alternative name(s):
    Maltose permease MAL11
    Maltose transport protein MAL11
    Gene namesi
    Name:MAL11
    Synonyms:AGT1, MAL1T, MTP1
    Ordered Locus Names:YGR289C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VII

    Organism-specific databases

    CYGDiYGR289c.
    SGDiS000003521. MAL11.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: SGD

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 616616General alpha-glucoside permeasePRO_0000050425Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi523 – 5231N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiP53048.
    PeptideAtlasiP53048.

    Expressioni

    Inductioni

    By maltose and maltotriose. Repressed by glucose.3 Publications

    Gene expression databases

    GenevestigatoriP53048.

    Interactioni

    Protein-protein interaction databases

    BioGridi33539. 65 interactions.
    DIPiDIP-5567N.
    IntActiP53048. 2 interactions.
    MINTiMINT-552607.

    Structurei

    3D structure databases

    ProteinModelPortaliP53048.
    SMRiP53048. Positions 163-567.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 115115CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini137 – 15014ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini172 – 18615CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini208 – 2081ExtracellularSequence Analysis
    Topological domaini230 – 24213CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini264 – 27815ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini300 – 37071CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini392 – 40413ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini426 – 4338CytoplasmicSequence Analysis
    Topological domaini455 – 46612ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini488 – 49912CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini521 – 53212ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini554 – 61663CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei116 – 13621Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei151 – 17121Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei187 – 20721Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei209 – 22921Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei243 – 26321Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei279 – 29921Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei371 – 39121Helical; Name=7Sequence AnalysisAdd
    BLAST
    Transmembranei405 – 42521Helical; Name=8Sequence AnalysisAdd
    BLAST
    Transmembranei434 – 45421Helical; Name=9Sequence AnalysisAdd
    BLAST
    Transmembranei467 – 48721Helical; Name=10Sequence AnalysisAdd
    BLAST
    Transmembranei500 – 52021Helical; Name=11Sequence AnalysisAdd
    BLAST
    Transmembranei533 – 55321Helical; Name=12Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0477.
    GeneTreeiENSGT00720000109429.
    HOGENOMiHOG000159003.
    KOiK08141.
    OMAiWPVPIFI.
    OrthoDBiEOG7MKWG3.

    Family and domain databases

    InterProiIPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR005828. Sub_transporter.
    IPR003663. Sugar/inositol_transpt.
    [Graphical view]
    PfamiPF00083. Sugar_tr. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 1 hit.
    TIGRFAMsiTIGR00879. SP. 1 hit.
    PROSITEiPS50850. MFS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P53048-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKNIISLVSK KKAASKNEDK NISESSRDIV NQQEVFNTED FEEGKKDSAF    50
    ELDHLEFTTN SAQLGDSDED NENVINEMNA TDDANEANSE EKSMTLKQAL 100
    LKYPKAALWS ILVSTTLVME GYDTALLSAL YALPVFQRKF GTLNGEGSYE 150
    ITSQWQIGLN MCVLCGEMIG LQITTYMVEF MGNRYTMITA LGLLTAYIFI 200
    LYYCKSLAMI AVGQILSAIP WGCFQSLAVT YASEVCPLAL RYYMTSYSNI 250
    CWLFGQIFAS GIMKNSQENL GNSDLGYKLP FALQWIWPAP LMIGIFFAPE 300
    SPWWLVRKDR VAEARKSLSR ILSGKGAEKD IQVDLTLKQI ELTIEKERLL 350
    ASKSGSFFNC FKGVNGRRTR LACLTWVAQN SSGAVLLGYS TYFFERAGMA 400
    TDKAFTFSLI QYCLGLAGTL CSWVISGRVG RWTILTYGLA FQMVCLFIIG 450
    GMGFGSGSSA SNGAGGLLLA LSFFYNAGIG AVVYCIVAEI PSAELRTKTI 500
    VLARICYNLM AVINAILTPY MLNVSDWNWG AKTGLYWGGF TAVTLAWVII 550
    DLPETTGRTF SEINELFNQG VPARKFASTV VDPFGKGKTQ HDSLADESIS 600
    QSSSIKQREL NAADKC 616
    Length:616
    Mass (Da):67,980
    Last modified:October 1, 1996 - v1
    Checksum:iEE84AD9E15F7926D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti396 – 3983RAG → KKQV in AAB07600. (PubMed:8594329)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L47346 Genomic DNA. Translation: AAB07600.1.
    Z73074 Genomic DNA. Translation: CAA97322.1.
    BK006941 Genomic DNA. Translation: DAA08377.1.
    PIRiS64624.
    RefSeqiNP_011805.3. NM_001181418.3.

    Genome annotation databases

    EnsemblFungiiYGR289C; YGR289C; YGR289C.
    GeneIDi853207.
    KEGGisce:YGR289C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L47346 Genomic DNA. Translation: AAB07600.1 .
    Z73074 Genomic DNA. Translation: CAA97322.1 .
    BK006941 Genomic DNA. Translation: DAA08377.1 .
    PIRi S64624.
    RefSeqi NP_011805.3. NM_001181418.3.

    3D structure databases

    ProteinModelPortali P53048.
    SMRi P53048. Positions 163-567.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33539. 65 interactions.
    DIPi DIP-5567N.
    IntActi P53048. 2 interactions.
    MINTi MINT-552607.

    Protein family/group databases

    TCDBi 2.A.1.1.11. the major facilitator superfamily (mfs).

    Proteomic databases

    PaxDbi P53048.
    PeptideAtlasi P53048.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YGR289C ; YGR289C ; YGR289C .
    GeneIDi 853207.
    KEGGi sce:YGR289C.

    Organism-specific databases

    CYGDi YGR289c.
    SGDi S000003521. MAL11.

    Phylogenomic databases

    eggNOGi COG0477.
    GeneTreei ENSGT00720000109429.
    HOGENOMi HOG000159003.
    KOi K08141.
    OMAi WPVPIFI.
    OrthoDBi EOG7MKWG3.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30949-MONOMER.

    Miscellaneous databases

    NextBioi 973389.

    Gene expression databases

    Genevestigatori P53048.

    Family and domain databases

    InterProi IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR005828. Sub_transporter.
    IPR003663. Sugar/inositol_transpt.
    [Graphical view ]
    Pfami PF00083. Sugar_tr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 1 hit.
    TIGRFAMsi TIGR00879. SP. 1 hit.
    PROSITEi PS50850. MFS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of AGT1 encoding a general alpha-glucoside transporter from Saccharomyces."
      Han E.-K., Cotty F., Sottas C., Jiang H., Michels C.A.
      Mol. Microbiol. 17:1093-1107(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, INDUCTION.
    2. "Sequence analysis of a near-subtelomeric 35.4 kb DNA segment on the right arm of chromosome VII from Saccharomyces cerevisiae carrying the MAL1 locus reveals 15 complete open reading frames, including ZUO1, BGL2 and BIO2 genes and an ABC transporter gene."
      Volckaert G., Voet M., Robben J.
      Yeast 13:251-259(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 96604 / S288c / FY1679.
    3. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
      Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
      , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
      Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    5. "Concurrent knock-out of at least 20 transporter genes is required to block uptake of hexoses in Saccharomyces cerevisiae."
      Wieczorke R., Krampe S., Weierstall T., Freidel K., Hollenberg C.P., Boles E.
      FEBS Lett. 464:123-128(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INDUCTION.
    6. "Characterization of the putative maltose transporters encoded by YDL247w and YJR160c."
      Day R.E., Higgins V.J., Rogers P.J., Dawes I.W.
      Yeast 19:1015-1027(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INDUCTION.
    7. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
      Kim H., Melen K., Oesterberg M., von Heijne G.
      Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
      Strain: ATCC 208353 / W303-1A.

    Entry informationi

    Entry nameiMAL11_YEAST
    AccessioniPrimary (citable) accession number: P53048
    Secondary accession number(s): D6VV66
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 126 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome VII
      Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

    External Data

    Dasty 3