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P53047 (RTA1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein RTA1
Gene names
Name:RTA1
Ordered Locus Names:YGR213C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length317 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in 7-aminocholesterol resistance.

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the lipid-translocating exporter (LTE) (TC 9.A.26.1) family. [View classification]

Ontologies

Keywords
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processresponse to stress

Inferred from electronic annotation. Source: InterPro

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from direct assay PubMed 22129104. Source: SGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 317317Protein RTA1
PRO_0000097510

Regions

Topological domain1 – 1616Extracellular Potential
Transmembrane17 – 3721Helical; Potential
Topological domain38 – 6427Cytoplasmic Potential
Transmembrane65 – 8521Helical; Potential
Topological domain86 – 9914Extracellular Potential
Transmembrane100 – 12021Helical; Potential
Topological domain121 – 14222Cytoplasmic Potential
Transmembrane143 – 16321Helical; Potential
Topological domain164 – 17815Extracellular Potential
Transmembrane179 – 19921Helical; Potential
Topological domain200 – 21415Cytoplasmic Potential
Transmembrane215 – 23521Helical; Potential
Topological domain236 – 25924Extracellular Potential
Transmembrane260 – 28021Helical; Potential
Topological domain281 – 31737Cytoplasmic Potential

Experimental info

Sequence conflict2341I → V in AAT93162. Ref.5

Sequences

Sequence LengthMass (Da)Tools
P53047 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: D4CF78080D129B4A

FASTA31735,486
        10         20         30         40         50         60 
MAKDGFELYR YTPELGASIL FTVLFAVSGV AFVILLFHYS VKSKRRVGSL MKSQPVLRYY 

        70         80         90        100        110        120 
GTVNLAGAYI PFIFGCFVEC VGFAFRCKSS KDTTLLNPYI IQTVFLLVSP TLYAASIYMI 

       130        140        150        160        170        180 
FGRMATLLFA ENLMIMPARF NTTIFVIGDV GSLLLQAIGG AMMSKVTSAS SGSHLVTAGL 

       190        200        210        220        230        240 
FIQIAFFGLF IINEVLFIFK MSKKPTNVSV RYGSWKYLNI ALLVNSFLIL IRSIVRAVEF 

       250        260        270        280        290        300 
IQGYDGEIAS HEWYLYIFDG LPMFLLVLIF IVAFPLINIF RIHEESIQAQ QSARFDGTDY 

       310 
PDVEVTSIEE DLASKSE 

« Hide

References

« Hide 'large scale' references
[1]"Characterization of the Saccharomyces cerevisiae RTA1 gene involved in 7-aminocholesterol resistance."
Soustre I., Letourneux Y., Karst F.
Curr. Genet. 30:121-125(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 28383 / FL100 / VTT C-80102.
[2]"Sequence analysis of 203 kilobases from Saccharomyces cerevisiae chromosome VII."
Rieger M., Brueckner M., Schaefer M., Mueller-Auer S.
Yeast 13:1077-1090(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]"The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E. expand/collapse author list , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[5]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[6]"A global topology map of the Saccharomyces cerevisiae membrane proteome."
Kim H., Melen K., Oesterberg M., von Heijne G.
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
Strain: ATCC 208353 / W303-1A.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X84736 Genomic DNA. Translation: CAA59227.1.
Z72998 Genomic DNA. Translation: CAA97240.1.
AY693143 Genomic DNA. Translation: AAT93162.1.
BK006941 Genomic DNA. Translation: DAA08307.1.
PIRS64536.
RefSeqNP_011729.1. NM_001181342.1.

3D structure databases

ProteinModelPortalP53047.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid33466. 9 interactions.
DIPDIP-1599N.
IntActP53047. 1 interaction.
MINTMINT-411524.
STRING4932.YGR213C.

Protein family/group databases

TCDB9.A.26.1.1. the lipid-translocating exporter (lte) family.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYGR213C; YGR213C; YGR213C.
GeneID853127.
KEGGsce:YGR213C.

Organism-specific databases

CYGDYGR213c.
SGDS000003445. RTA1.

Phylogenomic databases

eggNOGNOG71659.
GeneTreeENSGT00390000008587.
HOGENOMHOG000179260.
OMAGELMAKE.
OrthoDBEOG7X0VV6.

Enzyme and pathway databases

BioCycYEAST:G3O-30895-MONOMER.

Gene expression databases

GenevestigatorP53047.

Family and domain databases

InterProIPR007568. RTA1.
[Graphical view]
PfamPF04479. RTA1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio973175.

Entry information

Entry nameRTA1_YEAST
AccessionPrimary (citable) accession number: P53047
Secondary accession number(s): D6VUZ6, E9P922
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: February 19, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome VII

Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families