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P53047

- RTA1_YEAST

UniProt

P53047 - RTA1_YEAST

Protein

Protein RTA1

Gene

RTA1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Involved in 7-aminocholesterol resistance.

    GO - Biological processi

    1. response to stress Source: InterPro

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30895-MONOMER.

    Protein family/group databases

    TCDBi9.A.26.1.1. the lipid-translocating exporter (lte) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein RTA1
    Gene namesi
    Name:RTA1
    Ordered Locus Names:YGR213C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VII

    Organism-specific databases

    CYGDiYGR213c.
    SGDiS000003445. RTA1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: SGD

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 317317Protein RTA1PRO_0000097510Add
    BLAST

    Expressioni

    Gene expression databases

    GenevestigatoriP53047.

    Interactioni

    Protein-protein interaction databases

    BioGridi33466. 9 interactions.
    DIPiDIP-1599N.
    IntActiP53047. 1 interaction.
    MINTiMINT-411524.
    STRINGi4932.YGR213C.

    Structurei

    3D structure databases

    ProteinModelPortaliP53047.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1616ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini38 – 6427CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini86 – 9914ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini121 – 14222CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini164 – 17815ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini200 – 21415CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini236 – 25924ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini281 – 31737CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei17 – 3721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei65 – 8521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei100 – 12021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei143 – 16321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei179 – 19921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei215 – 23521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei260 – 28021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG71659.
    GeneTreeiENSGT00390000008587.
    HOGENOMiHOG000179260.
    OMAiLRSWYFI.
    OrthoDBiEOG7X0VV6.

    Family and domain databases

    InterProiIPR007568. RTA1.
    [Graphical view]
    PfamiPF04479. RTA1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P53047-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKDGFELYR YTPELGASIL FTVLFAVSGV AFVILLFHYS VKSKRRVGSL    50
    MKSQPVLRYY GTVNLAGAYI PFIFGCFVEC VGFAFRCKSS KDTTLLNPYI 100
    IQTVFLLVSP TLYAASIYMI FGRMATLLFA ENLMIMPARF NTTIFVIGDV 150
    GSLLLQAIGG AMMSKVTSAS SGSHLVTAGL FIQIAFFGLF IINEVLFIFK 200
    MSKKPTNVSV RYGSWKYLNI ALLVNSFLIL IRSIVRAVEF IQGYDGEIAS 250
    HEWYLYIFDG LPMFLLVLIF IVAFPLINIF RIHEESIQAQ QSARFDGTDY 300
    PDVEVTSIEE DLASKSE 317
    Length:317
    Mass (Da):35,486
    Last modified:October 1, 1996 - v1
    Checksum:iD4CF78080D129B4A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti234 – 2341I → V in AAT93162. (PubMed:17322287)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X84736 Genomic DNA. Translation: CAA59227.1.
    Z72998 Genomic DNA. Translation: CAA97240.1.
    AY693143 Genomic DNA. Translation: AAT93162.1.
    BK006941 Genomic DNA. Translation: DAA08307.1.
    PIRiS64536.
    RefSeqiNP_011729.1. NM_001181342.1.

    Genome annotation databases

    EnsemblFungiiYGR213C; YGR213C; YGR213C.
    GeneIDi853127.
    KEGGisce:YGR213C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X84736 Genomic DNA. Translation: CAA59227.1 .
    Z72998 Genomic DNA. Translation: CAA97240.1 .
    AY693143 Genomic DNA. Translation: AAT93162.1 .
    BK006941 Genomic DNA. Translation: DAA08307.1 .
    PIRi S64536.
    RefSeqi NP_011729.1. NM_001181342.1.

    3D structure databases

    ProteinModelPortali P53047.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33466. 9 interactions.
    DIPi DIP-1599N.
    IntActi P53047. 1 interaction.
    MINTi MINT-411524.
    STRINGi 4932.YGR213C.

    Protein family/group databases

    TCDBi 9.A.26.1.1. the lipid-translocating exporter (lte) family.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YGR213C ; YGR213C ; YGR213C .
    GeneIDi 853127.
    KEGGi sce:YGR213C.

    Organism-specific databases

    CYGDi YGR213c.
    SGDi S000003445. RTA1.

    Phylogenomic databases

    eggNOGi NOG71659.
    GeneTreei ENSGT00390000008587.
    HOGENOMi HOG000179260.
    OMAi LRSWYFI.
    OrthoDBi EOG7X0VV6.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30895-MONOMER.

    Miscellaneous databases

    NextBioi 973175.

    Gene expression databases

    Genevestigatori P53047.

    Family and domain databases

    InterProi IPR007568. RTA1.
    [Graphical view ]
    Pfami PF04479. RTA1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of the Saccharomyces cerevisiae RTA1 gene involved in 7-aminocholesterol resistance."
      Soustre I., Letourneux Y., Karst F.
      Curr. Genet. 30:121-125(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 28383 / FL100 / VTT C-80102.
    2. "Sequence analysis of 203 kilobases from Saccharomyces cerevisiae chromosome VII."
      Rieger M., Brueckner M., Schaefer M., Mueller-Auer S.
      Yeast 13:1077-1090(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
      Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
      , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
      Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    6. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
      Kim H., Melen K., Oesterberg M., von Heijne G.
      Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
      Strain: ATCC 208353 / W303-1A.

    Entry informationi

    Entry nameiRTA1_YEAST
    AccessioniPrimary (citable) accession number: P53047
    Secondary accession number(s): D6VUZ6, E9P922
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome VII
      Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

    External Data

    Dasty 3