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P53047

- RTA1_YEAST

UniProt

P53047 - RTA1_YEAST

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Protein

Protein RTA1

Gene

RTA1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Involved in 7-aminocholesterol resistance.

GO - Biological processi

  1. response to stress Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-30895-MONOMER.

Protein family/group databases

TCDBi9.A.26.1.1. the lipid-translocating exporter (lte) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein RTA1
Gene namesi
Name:RTA1
Ordered Locus Names:YGR213C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VII

Organism-specific databases

CYGDiYGR213c.
SGDiS000003445. RTA1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1616ExtracellularSequence AnalysisAdd
BLAST
Transmembranei17 – 3721HelicalSequence AnalysisAdd
BLAST
Topological domaini38 – 6427CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei65 – 8521HelicalSequence AnalysisAdd
BLAST
Topological domaini86 – 9914ExtracellularSequence AnalysisAdd
BLAST
Transmembranei100 – 12021HelicalSequence AnalysisAdd
BLAST
Topological domaini121 – 14222CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei143 – 16321HelicalSequence AnalysisAdd
BLAST
Topological domaini164 – 17815ExtracellularSequence AnalysisAdd
BLAST
Transmembranei179 – 19921HelicalSequence AnalysisAdd
BLAST
Topological domaini200 – 21415CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei215 – 23521HelicalSequence AnalysisAdd
BLAST
Topological domaini236 – 25924ExtracellularSequence AnalysisAdd
BLAST
Transmembranei260 – 28021HelicalSequence AnalysisAdd
BLAST
Topological domaini281 – 31737CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 317317Protein RTA1PRO_0000097510Add
BLAST

Expressioni

Gene expression databases

GenevestigatoriP53047.

Interactioni

Protein-protein interaction databases

BioGridi33466. 9 interactions.
DIPiDIP-1599N.
IntActiP53047. 1 interaction.
MINTiMINT-411524.
STRINGi4932.YGR213C.

Structurei

3D structure databases

ProteinModelPortaliP53047.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG71659.
GeneTreeiENSGT00390000008587.
HOGENOMiHOG000179260.
InParanoidiP53047.
OMAiLRSWYFI.
OrthoDBiEOG7X0VV6.

Family and domain databases

InterProiIPR007568. RTA1.
[Graphical view]
PfamiPF04479. RTA1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53047-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKDGFELYR YTPELGASIL FTVLFAVSGV AFVILLFHYS VKSKRRVGSL
60 70 80 90 100
MKSQPVLRYY GTVNLAGAYI PFIFGCFVEC VGFAFRCKSS KDTTLLNPYI
110 120 130 140 150
IQTVFLLVSP TLYAASIYMI FGRMATLLFA ENLMIMPARF NTTIFVIGDV
160 170 180 190 200
GSLLLQAIGG AMMSKVTSAS SGSHLVTAGL FIQIAFFGLF IINEVLFIFK
210 220 230 240 250
MSKKPTNVSV RYGSWKYLNI ALLVNSFLIL IRSIVRAVEF IQGYDGEIAS
260 270 280 290 300
HEWYLYIFDG LPMFLLVLIF IVAFPLINIF RIHEESIQAQ QSARFDGTDY
310
PDVEVTSIEE DLASKSE
Length:317
Mass (Da):35,486
Last modified:October 1, 1996 - v1
Checksum:iD4CF78080D129B4A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti234 – 2341I → V in AAT93162. (PubMed:17322287)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X84736 Genomic DNA. Translation: CAA59227.1.
Z72998 Genomic DNA. Translation: CAA97240.1.
AY693143 Genomic DNA. Translation: AAT93162.1.
BK006941 Genomic DNA. Translation: DAA08307.1.
PIRiS64536.
RefSeqiNP_011729.1. NM_001181342.1.

Genome annotation databases

EnsemblFungiiYGR213C; YGR213C; YGR213C.
GeneIDi853127.
KEGGisce:YGR213C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X84736 Genomic DNA. Translation: CAA59227.1 .
Z72998 Genomic DNA. Translation: CAA97240.1 .
AY693143 Genomic DNA. Translation: AAT93162.1 .
BK006941 Genomic DNA. Translation: DAA08307.1 .
PIRi S64536.
RefSeqi NP_011729.1. NM_001181342.1.

3D structure databases

ProteinModelPortali P53047.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 33466. 9 interactions.
DIPi DIP-1599N.
IntActi P53047. 1 interaction.
MINTi MINT-411524.
STRINGi 4932.YGR213C.

Protein family/group databases

TCDBi 9.A.26.1.1. the lipid-translocating exporter (lte) family.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YGR213C ; YGR213C ; YGR213C .
GeneIDi 853127.
KEGGi sce:YGR213C.

Organism-specific databases

CYGDi YGR213c.
SGDi S000003445. RTA1.

Phylogenomic databases

eggNOGi NOG71659.
GeneTreei ENSGT00390000008587.
HOGENOMi HOG000179260.
InParanoidi P53047.
OMAi LRSWYFI.
OrthoDBi EOG7X0VV6.

Enzyme and pathway databases

BioCyci YEAST:G3O-30895-MONOMER.

Miscellaneous databases

NextBioi 973175.

Gene expression databases

Genevestigatori P53047.

Family and domain databases

InterProi IPR007568. RTA1.
[Graphical view ]
Pfami PF04479. RTA1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the Saccharomyces cerevisiae RTA1 gene involved in 7-aminocholesterol resistance."
    Soustre I., Letourneux Y., Karst F.
    Curr. Genet. 30:121-125(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 28383 / FL100 / VTT C-80102.
  2. "Sequence analysis of 203 kilobases from Saccharomyces cerevisiae chromosome VII."
    Rieger M., Brueckner M., Schaefer M., Mueller-Auer S.
    Yeast 13:1077-1090(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
    Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
    , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
    Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  6. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.

Entry informationi

Entry nameiRTA1_YEAST
AccessioniPrimary (citable) accession number: P53047
Secondary accession number(s): D6VUZ6, E9P922
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

External Data

Dasty 3