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Protein

Protein RTA1

Gene

RTA1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in 7-aminocholesterol resistance.

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-30895-MONOMER.

Protein family/group databases

TCDBi9.A.26.1.1. the lipid-translocating exporter (lte) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein RTA1
Gene namesi
Name:RTA1
Ordered Locus Names:YGR213C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR213C.
SGDiS000003445. RTA1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 16ExtracellularSequence analysisAdd BLAST16
Transmembranei17 – 37HelicalSequence analysisAdd BLAST21
Topological domaini38 – 64CytoplasmicSequence analysisAdd BLAST27
Transmembranei65 – 85HelicalSequence analysisAdd BLAST21
Topological domaini86 – 99ExtracellularSequence analysisAdd BLAST14
Transmembranei100 – 120HelicalSequence analysisAdd BLAST21
Topological domaini121 – 142CytoplasmicSequence analysisAdd BLAST22
Transmembranei143 – 163HelicalSequence analysisAdd BLAST21
Topological domaini164 – 178ExtracellularSequence analysisAdd BLAST15
Transmembranei179 – 199HelicalSequence analysisAdd BLAST21
Topological domaini200 – 214CytoplasmicSequence analysisAdd BLAST15
Transmembranei215 – 235HelicalSequence analysisAdd BLAST21
Topological domaini236 – 259ExtracellularSequence analysisAdd BLAST24
Transmembranei260 – 280HelicalSequence analysisAdd BLAST21
Topological domaini281 – 317CytoplasmicSequence analysisAdd BLAST37

GO - Cellular componenti

  • fungal-type vacuole Source: GO_Central
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000975101 – 317Protein RTA1Add BLAST317

Proteomic databases

PRIDEiP53047.

Interactioni

Protein-protein interaction databases

BioGridi33466. 10 interactors.
DIPiDIP-1599N.
IntActiP53047. 1 interactor.
MINTiMINT-411524.

Structurei

3D structure databases

ProteinModelPortaliP53047.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000008587.
HOGENOMiHOG000179260.
InParanoidiP53047.
OMAiNIFRIHE.
OrthoDBiEOG092C3EMZ.

Family and domain databases

InterProiIPR007568. RTA1.
[Graphical view]
PfamiPF04479. RTA1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53047-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKDGFELYR YTPELGASIL FTVLFAVSGV AFVILLFHYS VKSKRRVGSL
60 70 80 90 100
MKSQPVLRYY GTVNLAGAYI PFIFGCFVEC VGFAFRCKSS KDTTLLNPYI
110 120 130 140 150
IQTVFLLVSP TLYAASIYMI FGRMATLLFA ENLMIMPARF NTTIFVIGDV
160 170 180 190 200
GSLLLQAIGG AMMSKVTSAS SGSHLVTAGL FIQIAFFGLF IINEVLFIFK
210 220 230 240 250
MSKKPTNVSV RYGSWKYLNI ALLVNSFLIL IRSIVRAVEF IQGYDGEIAS
260 270 280 290 300
HEWYLYIFDG LPMFLLVLIF IVAFPLINIF RIHEESIQAQ QSARFDGTDY
310
PDVEVTSIEE DLASKSE
Length:317
Mass (Da):35,486
Last modified:October 1, 1996 - v1
Checksum:iD4CF78080D129B4A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti234I → V in AAT93162 (PubMed:17322287).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X84736 Genomic DNA. Translation: CAA59227.1.
Z72998 Genomic DNA. Translation: CAA97240.1.
AY693143 Genomic DNA. Translation: AAT93162.1.
BK006941 Genomic DNA. Translation: DAA08307.1.
PIRiS64536.
RefSeqiNP_011729.1. NM_001181342.1.

Genome annotation databases

EnsemblFungiiYGR213C; YGR213C; YGR213C.
GeneIDi853127.
KEGGisce:YGR213C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X84736 Genomic DNA. Translation: CAA59227.1.
Z72998 Genomic DNA. Translation: CAA97240.1.
AY693143 Genomic DNA. Translation: AAT93162.1.
BK006941 Genomic DNA. Translation: DAA08307.1.
PIRiS64536.
RefSeqiNP_011729.1. NM_001181342.1.

3D structure databases

ProteinModelPortaliP53047.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33466. 10 interactors.
DIPiDIP-1599N.
IntActiP53047. 1 interactor.
MINTiMINT-411524.

Protein family/group databases

TCDBi9.A.26.1.1. the lipid-translocating exporter (lte) family.

Proteomic databases

PRIDEiP53047.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGR213C; YGR213C; YGR213C.
GeneIDi853127.
KEGGisce:YGR213C.

Organism-specific databases

EuPathDBiFungiDB:YGR213C.
SGDiS000003445. RTA1.

Phylogenomic databases

GeneTreeiENSGT00390000008587.
HOGENOMiHOG000179260.
InParanoidiP53047.
OMAiNIFRIHE.
OrthoDBiEOG092C3EMZ.

Enzyme and pathway databases

BioCyciYEAST:G3O-30895-MONOMER.

Miscellaneous databases

PROiP53047.

Family and domain databases

InterProiIPR007568. RTA1.
[Graphical view]
PfamiPF04479. RTA1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRTA1_YEAST
AccessioniPrimary (citable) accession number: P53047
Secondary accession number(s): D6VUZ6, E9P922
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.