Serine/threonine-protein phosphatase 5 - Rattus norvegicus (Rat)

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P53042 (PPP5_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 110. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Serine/threonine-protein phosphatase 5
Short name=PP5
EC=3.1.3.16

Alternative name(s):
Protein phosphatase T
Short name=PPT

Gene names

Name:

Ppp5c

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	499 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May play a role in the regulation of RNA biogenesis and/or mitosis.
Catalytic activity	A phosphoprotein + H₂O = a protein + phosphate.
Cofactor	Binds 1 iron ion per subunit By similarity. Binds 1 manganese ion per subunit By similarity.
Subunit structure	Interacts with CDC16 and CDC27 By similarity.
Subcellular location	Nucleus.
Tissue specificity	Predominantly found in brain and, in lower levels, in testis, but was nearly undetectable in spleen, lung, skeletal muscle, kidney and liver.
Sequence similarities	Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily. Contains 3 TPR repeats.

Ontologies

Keywords
Cellular component	Nucleus
Domain	Repeat TPR repeat
Ligand	Iron Manganese Metal-binding
Molecular function	Hydrolase Protein phosphatase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	positive regulation of I-kappaB kinase/NF-kappaB cascade Inferred from electronic annotation. Source: Compara protein dephosphorylation Inferred from electronic annotation. Source: InterPro protein heterooligomerization Inferred from physical interaction PubMed 12786973. Source: RGD response to morphine Inferred from electronic annotation. Source: Compara
Cellular_component	Golgi apparatus Inferred from electronic annotation. Source: Compara cytoplasm Inferred from direct assay PubMed 12786973. Source: RGD cytosol Inferred from electronic annotation. Source: Compara neuron projection Inferred from direct assay PubMed 12786973. Source: RGD neuronal cell body Inferred from direct assay PubMed 12786973. Source: RGD nucleus Inferred from direct assay PubMed 12786973. Source: RGD
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoprotein phosphatase activity Inferred from direct assay PubMed 9383998. Source: UniProtKB signal transducer activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 499

499

Serine/threonine-protein phosphatase 5

PRO_0000058897

Regions

Repeat

28 – 61

TPR 1

Repeat

62 – 95

TPR 2

Repeat

96 – 129

TPR 3

Region

200 – 499

300

Catalytic

Sites

Active site

304

Proton donor By similarity

Metal binding

242

Iron By similarity

Metal binding

244

Iron By similarity

Metal binding

271

Iron By similarity

Metal binding

271

Manganese By similarity

Metal binding

303

Manganese By similarity

Metal binding

352

Manganese By similarity

Metal binding

427

Manganese By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

P53042 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 720A7FB7AFC701D2
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FASTA

499

56,917

        10         20         30         40         50         60 
MAMAEGERTE CAEPPRDEPP AEGTLKRAEE LKTQANDYFK AKDYENAIKF YSQAIELNPS 

        70         80         90        100        110        120 
NAIYYGNRSL AYLRTECYGY ALGDATRAIE LDKKYIKGYY RRAASNMALG KFRAALRDYE 

       130        140        150        160        170        180 
TVVKVKPNDK DAKMKYQECS KIVKQKAFER AIAGDEHRRS VVDSLDIESM TIEDEYSGPK 

       190        200        210        220        230        240 
LEDGKVTITF MKDLMQWYKD QKKLHRKCAY QILVQVKEVL CKLSTLVETT LKETEKITVC 

       250        260        270        280        290        300 
GDTHGQFYDL LNIFELNGLP SETNPYIFNG DFVDRGSFSV EVILTLFGFK LLYPDHFHLL 

       310        320        330        340        350        360 
RGNHETDNMN QIYGFEGEVK AKYTAQMYEL FSEVFEWLPL AQCINGKVLI MHGGLFSEDG 

       370        380        390        400        410        420 
VTLDDIRKIE RNRQPPDSGP MCDLLWSDPQ PQNGRSVSKR GVSCQFGPDV TKAFLEENQL 

       430        440        450        460        470        480 
DYIIRSHEVK AEGYEVAHGG RCVTVFSAPN YCDQMGNKAS YIHLQGSDLR PQFHQFTAVP 

       490 
HPNVKPMAYA NTLLQLGMM

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References

[1]	"Molecular cloning of a protein serine/threonine phosphatase containing a putative regulatory tetratricopeptide repeat domain." Becker W., Kentrup H., Klumpp S., Schultz J.E., Joost H.G. J. Biol. Chem. 269:22586-22592(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Sprague-Dawley. Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X77237 mRNA. Translation: CAA54454.1.
IPI	IPI00205990.
PIR	A55346.
RefSeq	NP_113917.1. NM_031729.1.
UniGene	Rn.6107.
3D structure databases
ProteinModelPortal	P53042.
SMR	P53042. Positions 23-499.
ModBase	Search...
Proteomic databases
PRIDE	P53042.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000023078; ENSRNOP00000023078; ENSRNOG00000016907.
GeneID	65179.
KEGG	rno:65179.
UCSC	RGD:68415. rat.
Organism-specific databases
CTD	5536.
RGD	68415. Ppp5c.
Phylogenomic databases
eggNOG	COG0639.
GeneTree	ENSGT00530000063173.
HOGENOM	HOG000172698.
HOVERGEN	HBG000216.
InParanoid	P53042.
KO	K04460.
OMA	GERTECA.
OrthoDB	EOG4PVNZ1.
Enzyme and pathway databases
BRENDA	3.1.3.16. 5301.
Gene expression databases
ArrayExpress	P53042.
Genevestigator	P53042.
GermOnline	ENSRNOG00000016907. Rattus norvegicus.
Family and domain databases
Gene3D	1.25.40.10. 1 hit.
InterPro	IPR004843. Metallo_PEstase_dom. IPR013235. PPP_dom. IPR006186. Ser/Thr-sp_prot-phosphatase. IPR011236. Ser/Thr_PPase_5. IPR001440. TPR-1. IPR013026. TPR-contain_dom. IPR011990. TPR-like_helical. IPR019734. TPR_repeat. [Graphical view]
PANTHER	PTHR11668:SF12. PTHR11668:SF12. 1 hit.
Pfam	PF00149. Metallophos. 1 hit. PF08321. PPP5. 1 hit. PF00515. TPR_1. 2 hits. [Graphical view]
PIRSF	PIRSF033096. PPPtase_5. 1 hit.
PRINTS	PR00114. STPHPHTASE.
SMART	SM00156. PP2Ac. 1 hit. SM00028. TPR. 3 hits. [Graphical view]
PROSITE	PS00125. SER_THR_PHOSPHATASE. 1 hit. PS50005. TPR. 3 hits. PS50293. TPR_REGION. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	614076.

Entry information

Entry name

PPP5_RAT

Accession

Primary (citable) accession number: P53042

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	April 3, 2013
This is version 110 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Sequences

References

Cross-references

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents