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Protein

Replication factor C subunit 2

Gene

RFC2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit binds ATP (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi81 – 888ATPSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA replication

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-GGA-110312. Translesion synthesis by REV1.
R-GGA-110314. Recognition of DNA damage by PCNA-containing replication complex.
R-GGA-110320. Translesion Synthesis by POLH.
R-GGA-174411. Polymerase switching on the C-strand of the telomere.
R-GGA-176187. Activation of ATR in response to replication stress.
R-GGA-351451. Homologous recombination repair of replication-dependent double-strand breaks.
R-GGA-5651801. PCNA-Dependent Long Patch Base Excision Repair.
R-GGA-5655862. Translesion synthesis by POLK.
R-GGA-5656121. Translesion synthesis by POLI.
R-GGA-5656169. Termination of translesion DNA synthesis.
R-GGA-5685938. HDR through Single Strand Annealing (SSA).
R-GGA-5685942. HDR through Homologous Recombination (HRR).
R-GGA-5693607. Processing of DNA double-strand break ends.
R-GGA-5693616. Presynaptic phase of homologous DNA pairing and strand exchange.
R-GGA-5696397. Gap-filling DNA repair synthesis and ligation in GG-NER.
R-GGA-5696400. Dual Incision in GG-NER.
R-GGA-6782135. Dual incision in TC-NER.
R-GGA-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER.
R-GGA-69091. Polymerase switching.

Names & Taxonomyi

Protein namesi
Recommended name:
Replication factor C subunit 2
Alternative name(s):
Activator 1 40 kDa subunit
Short name:
A1 40 kDa subunit
Activator 1 subunit 2
Replication factor C 40 kDa subunit
Short name:
RF-C 40 kDa subunit
Short name:
RFC40
Gene namesi
Name:RFC2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 359359Replication factor C subunit 2PRO_0000121768Add
BLAST

Proteomic databases

PaxDbiP53033.

Interactioni

Subunit structurei

Heterotetramer of subunits RFC2, RFC3, RFC4 and RFC5 that can form a complex either with RFC1 or with RAD17. The former interacts with PCNA in the presence of ATP, while the latter has ATPase activity but is not stimulated by PCNA (By similarity).By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000001978.

Structurei

3D structure databases

ProteinModelPortaliP53033.
SMRiP53033. Positions 40-349.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the activator 1 small subunits family.Curated

Phylogenomic databases

eggNOGiKOG0991. Eukaryota.
COG0470. LUCA.
GeneTreeiENSGT00550000075050.
HOGENOMiHOG000224155.
HOVERGENiHBG002053.
InParanoidiP53033.
KOiK10755.
OMAiTHSGFGY.
OrthoDBiEOG7SR4MP.
PhylomeDBiP53033.
TreeFamiTF300585.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR008921. DNA_pol3_clamp-load_cplx_C.
IPR027417. P-loop_NTPase.
IPR013748. Rep_factorC_C.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF08542. Rep_fac_C. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF48019. SSF48019. 1 hit.
SSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

P53033-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEEEVLEVV EDEKAGPAAA EKRGPTDTLG SAPAASGHYE LPWVEKYRPL
60 70 80 90 100
KLCEVVGNED TVSRLEVFAK EGNVPNIIIA GPPGTGKTTS ILCLARALLG
110 120 130 140 150
PALKDAVLEL NASNDRGIDV VRNKIKMFAQ QKVTLPKGRH KIIILDEADS
160 170 180 190 200
MTDGAQQALR RTMEIYSKTT RFALACNASD KIIEPIQSRC AVLRYTKLTD
210 220 230 240 250
SQILARLLKI VEKEDVPYTD DGLEAIIFTA QGDMRQALNN LQSTYSGFGF
260 270 280 290 300
INSENVFKVC DEPHPLLVKE MIQHCINANI DEAYKILAHL WRLGYSPEDV
310 320 330 340 350
IGNIFRVCKT FQMPEYLKLE FIKEIGYTHM KIAEGVNSLL QMAGLLARLC

QKTAAPAAS
Length:359
Mass (Da):39,707
Last modified:October 1, 1996 - v1
Checksum:iA2FD38F964CD11F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12438 mRNA. Translation: AAA20552.1.
PIRiI50704.
RefSeqiNP_990861.1. NM_205530.1.
UniGeneiGga.883.

Genome annotation databases

EnsembliENSGALT00000001980; ENSGALP00000001978; ENSGALG00000001298.
GeneIDi396542.
KEGGigga:396542.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12438 mRNA. Translation: AAA20552.1.
PIRiI50704.
RefSeqiNP_990861.1. NM_205530.1.
UniGeneiGga.883.

3D structure databases

ProteinModelPortaliP53033.
SMRiP53033. Positions 40-349.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000001978.

Proteomic databases

PaxDbiP53033.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000001980; ENSGALP00000001978; ENSGALG00000001298.
GeneIDi396542.
KEGGigga:396542.

Organism-specific databases

CTDi5982.

Phylogenomic databases

eggNOGiKOG0991. Eukaryota.
COG0470. LUCA.
GeneTreeiENSGT00550000075050.
HOGENOMiHOG000224155.
HOVERGENiHBG002053.
InParanoidiP53033.
KOiK10755.
OMAiTHSGFGY.
OrthoDBiEOG7SR4MP.
PhylomeDBiP53033.
TreeFamiTF300585.

Enzyme and pathway databases

ReactomeiR-GGA-110312. Translesion synthesis by REV1.
R-GGA-110314. Recognition of DNA damage by PCNA-containing replication complex.
R-GGA-110320. Translesion Synthesis by POLH.
R-GGA-174411. Polymerase switching on the C-strand of the telomere.
R-GGA-176187. Activation of ATR in response to replication stress.
R-GGA-351451. Homologous recombination repair of replication-dependent double-strand breaks.
R-GGA-5651801. PCNA-Dependent Long Patch Base Excision Repair.
R-GGA-5655862. Translesion synthesis by POLK.
R-GGA-5656121. Translesion synthesis by POLI.
R-GGA-5656169. Termination of translesion DNA synthesis.
R-GGA-5685938. HDR through Single Strand Annealing (SSA).
R-GGA-5685942. HDR through Homologous Recombination (HRR).
R-GGA-5693607. Processing of DNA double-strand break ends.
R-GGA-5693616. Presynaptic phase of homologous DNA pairing and strand exchange.
R-GGA-5696397. Gap-filling DNA repair synthesis and ligation in GG-NER.
R-GGA-5696400. Dual Incision in GG-NER.
R-GGA-6782135. Dual incision in TC-NER.
R-GGA-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER.
R-GGA-69091. Polymerase switching.

Miscellaneous databases

PROiP53033.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR008921. DNA_pol3_clamp-load_cplx_C.
IPR027417. P-loop_NTPase.
IPR013748. Rep_factorC_C.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF08542. Rep_fac_C. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF48019. SSF48019. 1 hit.
SSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning of a chick cochlea cDNA encoding a subunit of DNA replication factor C/activator 1."
    Oberholtzer J., Cohen E.L., Davis J.G.
    DNA Cell Biol. 13:857-863(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Leghorn.
    Tissue: Cochlea.

Entry informationi

Entry nameiRFC2_CHICK
AccessioniPrimary (citable) accession number: P53033
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 8, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.