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Protein

60S ribosomal protein L10a

Gene

Rpl10a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L10a
Alternative name(s):
CSA-19
Neural precursor cell expressed developmentally down-regulated protein 6
Short name:
NEDD-6
Gene namesi
Name:Rpl10a
Synonyms:Nedd-6, Nedd6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1343877. Rpl10a.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 21721660S ribosomal protein L10aPRO_0000125820Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei11 – 111PhosphotyrosineCombined sources
Modified residuei91 – 911N6-acetyllysineCombined sources
Modified residuei106 – 1061N6-acetyllysineCombined sources
Modified residuei118 – 1181N6-acetyllysine; alternateBy similarity
Cross-linki118 – 118Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki118 – 118Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP53026.
MaxQBiP53026.
PaxDbiP53026.
PeptideAtlasiP53026.
PRIDEiP53026.
TopDownProteomicsiP53026.

PTM databases

iPTMnetiP53026.
PhosphoSiteiP53026.
SwissPalmiP53026.

Expressioni

Gene expression databases

CleanExiMM_RPL10A.

Interactioni

Protein-protein interaction databases

IntActiP53026. 6 interactions.
MINTiMINT-4132577.
STRINGi10090.ENSMUSP00000048469.

Structurei

3D structure databases

ProteinModelPortaliP53026.
SMRiP53026. Positions 5-216.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L1P family.Curated

Phylogenomic databases

eggNOGiKOG1570. Eukaryota.
COG0081. LUCA.
HOGENOMiHOG000207014.
HOVERGENiHBG055239.
InParanoidiP53026.
PhylomeDBiP53026.

Family and domain databases

Gene3Di3.30.190.20. 2 hits.
3.40.50.790. 1 hit.
InterProiIPR002143. Ribosomal_L1.
IPR023674. Ribosomal_L1-like.
IPR028364. Ribosomal_L1/biogenesis.
IPR016094. Ribosomal_L1_2-a/b-sand.
IPR016095. Ribosomal_L1_3-a/b-sand.
IPR023673. Ribosomal_L1_CS.
[Graphical view]
PfamiPF00687. Ribosomal_L1. 1 hit.
[Graphical view]
PIRSFiPIRSF002155. Ribosomal_L1. 1 hit.
SUPFAMiSSF56808. SSF56808. 1 hit.
PROSITEiPS01199. RIBOSOMAL_L1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P53026-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSKVSRDTL YEAVREVLHG NQRKRRKFLE TVELQISLKN YDPQKDKRFS
60 70 80 90 100
GTVRLKSTPR PKFSVCVLGD QQHCDERKAV DIPHMDIEAL KKLNKNKKLV
110 120 130 140 150
KKLAKKYDAF LASESLIKQI PRILGPGLNK AGKFPSLLTH NENMVAKVDE
160 170 180 190 200
VKSTIKFQMK KVLCLAVAVG HVKMTDDELV YNIHLAVNFL VSLLKKNWQN
210
VRALYIKSTM GKPQRLY
Length:217
Mass (Da):24,916
Last modified:January 23, 2007 - v3
Checksum:i38F1BCCB81E2D64C
GO

Sequence cautioni

The sequence D10916 differs from that shown. Reason: Frameshift at positions 128 and 211. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12403 mRNA. Translation: AAA86464.1.
D10916 mRNA. No translation available.
UniGeneiMm.336955.
Mm.467207.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12403 mRNA. Translation: AAA86464.1.
D10916 mRNA. No translation available.
UniGeneiMm.336955.
Mm.467207.

3D structure databases

ProteinModelPortaliP53026.
SMRiP53026. Positions 5-216.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP53026. 6 interactions.
MINTiMINT-4132577.
STRINGi10090.ENSMUSP00000048469.

PTM databases

iPTMnetiP53026.
PhosphoSiteiP53026.
SwissPalmiP53026.

Proteomic databases

EPDiP53026.
MaxQBiP53026.
PaxDbiP53026.
PeptideAtlasiP53026.
PRIDEiP53026.
TopDownProteomicsiP53026.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1343877. Rpl10a.

Phylogenomic databases

eggNOGiKOG1570. Eukaryota.
COG0081. LUCA.
HOGENOMiHOG000207014.
HOVERGENiHBG055239.
InParanoidiP53026.
PhylomeDBiP53026.

Miscellaneous databases

PROiP53026.
SOURCEiSearch...

Gene expression databases

CleanExiMM_RPL10A.

Family and domain databases

Gene3Di3.30.190.20. 2 hits.
3.40.50.790. 1 hit.
InterProiIPR002143. Ribosomal_L1.
IPR023674. Ribosomal_L1-like.
IPR028364. Ribosomal_L1/biogenesis.
IPR016094. Ribosomal_L1_2-a/b-sand.
IPR016095. Ribosomal_L1_3-a/b-sand.
IPR023673. Ribosomal_L1_CS.
[Graphical view]
PfamiPF00687. Ribosomal_L1. 1 hit.
[Graphical view]
PIRSFiPIRSF002155. Ribosomal_L1. 1 hit.
SUPFAMiSSF56808. SSF56808. 1 hit.
PROSITEiPS01199. RIBOSOMAL_L1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of genes downregulated in the thymus by cyclosporin-A: preliminary characterization of clone CSA-19."
    Fisicaro N., Katerelos M., Williams J., Power D., D'Apice A., Pearse M.
    Mol. Immunol. 32:565-572(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Identification of a set of genes with developmentally down-regulated expression in the mouse brain."
    Kumar S., Tomooka Y., Noda M.
    Biochem. Biophys. Res. Commun. 185:1155-1161(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 92-217.
  3. "Quantitative time-resolved phosphoproteomic analysis of mast cell signaling."
    Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y., Kawakami T., Salomon A.R.
    J. Immunol. 179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-11, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Mast cell.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.
  5. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-106, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.
  6. "Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways."
    Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B., Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.
    Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-91 AND LYS-106, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiRL10A_MOUSE
AccessioniPrimary (citable) accession number: P53026
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: July 6, 2016
This is version 118 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.