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Protein

Replication factor C subunit 4

Gene

rfc-4

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. This subunit may be involved in the elongation of the multiprimed DNA template (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi55 – 628ATPSequence analysis

GO - Molecular functioni

GO - Biological processi

  • DNA replication Source: WormBase
Complete GO annotation...

Keywords - Biological processi

DNA replication

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-110312. Translesion synthesis by REV1.
R-CEL-110320. Translesion Synthesis by POLH.
R-CEL-174411. Polymerase switching on the C-strand of the telomere.
R-CEL-176187. Activation of ATR in response to replication stress.
R-CEL-5655862. Translesion synthesis by POLK.
R-CEL-5696400. Dual Incision in GG-NER.
R-CEL-6782135. Dual incision in TC-NER.
R-CEL-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER.
R-CEL-69091. Polymerase switching.

Names & Taxonomyi

Protein namesi
Recommended name:
Replication factor C subunit 4
Alternative name(s):
Activator 1 subunit 4
Gene namesi
Name:rfc-4
ORF Names:F31E3.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiF31E3.3; CE01268; WBGene00004340; rfc-4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 334334Replication factor C subunit 4PRO_0000121758Add
BLAST

Proteomic databases

EPDiP53016.
PaxDbiP53016.
PRIDEiP53016.

Interactioni

Subunit structurei

Heteropentamer of various rfc subunits that forms a complex (RFC) with PCNA in the presence of ATP.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
rfc-3Q185473EBI-318155,EBI-314981

Protein-protein interaction databases

BioGridi41190. 7 interactions.
DIPiDIP-24293N.
IntActiP53016. 7 interactions.
MINTiMINT-226482.
STRINGi6239.F31E3.3.

Structurei

3D structure databases

ProteinModelPortaliP53016.
SMRiP53016. Positions 17-266.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the activator 1 small subunits family.Curated

Phylogenomic databases

eggNOGiKOG0989. Eukaryota.
COG0470. LUCA.
GeneTreeiENSGT00550000074917.
HOGENOMiHOG000224154.
InParanoidiP53016.
KOiK10755.
OMAiFPKNIFH.
OrthoDBiEOG7SR4MP.
PhylomeDBiP53016.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

P53016-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEPMEVDNK RPKVLTWTEK YRPKTLDDIA YQDEVVTMLK GALQGRDLPH
60 70 80 90 100
LLFYGPPGTG KTSAALAFCR QLFPKNIFHD RVLDLNASDE RGIAVVRQKI
110 120 130 140 150
QSFSKSSLGH SHREDVLKLK IIILDEVDAM TREAQAAMRR VIEDFSKTTR
160 170 180 190 200
FILICNYVSR LIPPVVSRCA KFRFKSLPAE IQVQRLRTIC DAEGTPMSDD
210 220 230 240 250
ELKQVMEYSE GDLRRAVCTL QSLAPILKSG DDNARNCYLR GSSDSLLISN
260 270 280 290 300
VCKSILTADV PQIIALTKDI TKSCTGVAFI RRCFQQLMDE DVINDENIGV
310 320 330
MGKLVATCEK RILDGCDLEN NLLDFLLTLR ETIQ
Length:334
Mass (Da):37,706
Last modified:October 1, 1996 - v1
Checksum:iFBADEFE1CEF8DAC8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080392 Genomic DNA. Translation: CCD63405.1.
PIRiT16219.
RefSeqiNP_498521.1. NM_066120.6.
UniGeneiCel.10145.

Genome annotation databases

EnsemblMetazoaiF31E3.3; F31E3.3; WBGene00004340.
GeneIDi175976.
KEGGicel:CELE_F31E3.3.
UCSCiF31E3.3. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080392 Genomic DNA. Translation: CCD63405.1.
PIRiT16219.
RefSeqiNP_498521.1. NM_066120.6.
UniGeneiCel.10145.

3D structure databases

ProteinModelPortaliP53016.
SMRiP53016. Positions 17-266.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi41190. 7 interactions.
DIPiDIP-24293N.
IntActiP53016. 7 interactions.
MINTiMINT-226482.
STRINGi6239.F31E3.3.

Proteomic databases

EPDiP53016.
PaxDbiP53016.
PRIDEiP53016.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF31E3.3; F31E3.3; WBGene00004340.
GeneIDi175976.
KEGGicel:CELE_F31E3.3.
UCSCiF31E3.3. c. elegans.

Organism-specific databases

CTDi175976.
WormBaseiF31E3.3; CE01268; WBGene00004340; rfc-4.

Phylogenomic databases

eggNOGiKOG0989. Eukaryota.
COG0470. LUCA.
GeneTreeiENSGT00550000074917.
HOGENOMiHOG000224154.
InParanoidiP53016.
KOiK10755.
OMAiFPKNIFH.
OrthoDBiEOG7SR4MP.
PhylomeDBiP53016.

Enzyme and pathway databases

ReactomeiR-CEL-110312. Translesion synthesis by REV1.
R-CEL-110320. Translesion Synthesis by POLH.
R-CEL-174411. Polymerase switching on the C-strand of the telomere.
R-CEL-176187. Activation of ATR in response to replication stress.
R-CEL-5655862. Translesion synthesis by POLK.
R-CEL-5696400. Dual Incision in GG-NER.
R-CEL-6782135. Dual incision in TC-NER.
R-CEL-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER.
R-CEL-69091. Polymerase switching.

Miscellaneous databases

NextBioi890574.
PROiP53016.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiRFC4_CAEEL
AccessioniPrimary (citable) accession number: P53016
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 11, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.