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Protein

Replication factor C subunit 4

Gene

rfc-4

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. This subunit may be involved in the elongation of the multiprimed DNA template (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi55 – 62ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

  • DNA-dependent DNA replication Source: GO_Central
  • DNA repair Source: GO_Central
  • DNA replication Source: WormBase

Keywordsi

Biological processDNA replication
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-110320. Translesion Synthesis by POLH.
R-CEL-174411. Polymerase switching on the C-strand of the telomere.
R-CEL-176187. Activation of ATR in response to replication stress.
R-CEL-5696400. Dual Incision in GG-NER.
R-CEL-6782135. Dual incision in TC-NER.
R-CEL-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER.
R-CEL-69091. Polymerase switching.

Names & Taxonomyi

Protein namesi
Recommended name:
Replication factor C subunit 4
Alternative name(s):
Activator 1 subunit 4
Gene namesi
Name:rfc-4
ORF Names:F31E3.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiF31E3.3; CE01268; WBGene00004340; rfc-4.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001217581 – 334Replication factor C subunit 4Add BLAST334

Proteomic databases

EPDiP53016.
PaxDbiP53016.
PeptideAtlasiP53016.
PRIDEiP53016.

Expressioni

Gene expression databases

BgeeiWBGene00004340.

Interactioni

Subunit structurei

Heteropentamer of various rfc subunits that forms a complex (RFC) with PCNA in the presence of ATP.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
rfc-3Q185473EBI-318155,EBI-314981

Protein-protein interaction databases

BioGridi41190. 7 interactors.
DIPiDIP-24293N.
IntActiP53016. 7 interactors.
MINTiMINT-226482.
STRINGi6239.F31E3.3.

Structurei

3D structure databases

ProteinModelPortaliP53016.
SMRiP53016.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the activator 1 small subunits family.Curated

Phylogenomic databases

eggNOGiKOG0989. Eukaryota.
COG0470. LUCA.
GeneTreeiENSGT00550000074917.
HOGENOMiHOG000224154.
InParanoidiP53016.
KOiK10755.
OMAiTCEKRIL.
OrthoDBiEOG091G0CKT.
PhylomeDBiP53016.

Family and domain databases

InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00004. AAA. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

P53016-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEPMEVDNK RPKVLTWTEK YRPKTLDDIA YQDEVVTMLK GALQGRDLPH
60 70 80 90 100
LLFYGPPGTG KTSAALAFCR QLFPKNIFHD RVLDLNASDE RGIAVVRQKI
110 120 130 140 150
QSFSKSSLGH SHREDVLKLK IIILDEVDAM TREAQAAMRR VIEDFSKTTR
160 170 180 190 200
FILICNYVSR LIPPVVSRCA KFRFKSLPAE IQVQRLRTIC DAEGTPMSDD
210 220 230 240 250
ELKQVMEYSE GDLRRAVCTL QSLAPILKSG DDNARNCYLR GSSDSLLISN
260 270 280 290 300
VCKSILTADV PQIIALTKDI TKSCTGVAFI RRCFQQLMDE DVINDENIGV
310 320 330
MGKLVATCEK RILDGCDLEN NLLDFLLTLR ETIQ
Length:334
Mass (Da):37,706
Last modified:October 1, 1996 - v1
Checksum:iFBADEFE1CEF8DAC8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080392 Genomic DNA. Translation: CCD63405.1.
PIRiT16219.
RefSeqiNP_498521.1. NM_066120.6.
UniGeneiCel.10145.

Genome annotation databases

EnsemblMetazoaiF31E3.3; F31E3.3; WBGene00004340.
GeneIDi175976.
KEGGicel:CELE_F31E3.3.
UCSCiF31E3.3. c. elegans.

Similar proteinsi

Entry informationi

Entry nameiRFC4_CAEEL
AccessioniPrimary (citable) accession number: P53016
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 27, 2017
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families