P53009 (SCY1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein kinase-like protein SCY1

Gene names

Name:	SCY1
Ordered Locus Names:	YGL083W

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	804 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Domain	The protein kinase domain is predicted to be catalytically inactive.
Miscellaneous	Present with 1480 molecules/cell in log phase SD medium.
Sequence similarities	Contains 1 protein kinase domain.

Ontologies

Keywords
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	ATP binding Inferred from electronic annotation. Source: InterPro protein kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 804	804	Protein kinase-like protein SCY1		PRO_0000097636
Regions
	Domain	1 – 324	324	Protein kinase
	Compositional bias	36 – 43	8	Poly-Ser
Amino acid modifications
	Modified residue	704	1	Phosphoserine Ref.6 Ref.8
	Modified residue	791	1	Phosphoserine Ref.7 Ref.8

Sequences

	Sequence		Length	Mass (Da)
	P53009 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 457A81DDC7AB808E	FASTA	804	91,001
	10 20 30 40 50 60 MMFWSSKTGI TSKYSFSSSP TFTAEPWSIY TGRPKSSSSS SPSKVSIFMF DKKQFENYLL 70 80 90 100 110 120 HYGIIKSKSG SRDKVLIQEA YEILRNQANN LAKLKHPNIL TLIEPLEEHS KNFMFVTEFV 130 140 150 160 170 180 TSSLETVFRE TDDEEQNFLQ GHVKDNIVVQ RGILQLVNAL DFVHNRASFV HLNIQPRAIF 190 200 210 220 230 240 INENSDWKIS GLGYLVKIPP GTNTSEYFLP QYDPRVPPFM HLQLNYTAPE IVFENTLTFK 250 260 270 280 290 300 NDYFSLGLLI YFLYTGKDLF RSENSTSEYK LEYNKFESKI STMSWDNIFS KVPQKLRHCI 310 320 330 340 350 360 PKLINRDIYS RYDNITLILD SEFFQDPLVK TLNFLDDLPT KNNEEKYVFL EGLVNLLPEF 370 380 390 400 410 420 PPALLQKKFL PILLELLSQF CAEKVVSDKC VGKSLDLIIK IGSTLSQLSF QEKVYPVLLS 430 440 450 460 470 480 DANFPVLLKK ATICLIDNLD TLKQKVKRSD FLENILKPLF NYVLHDSESD ITVVCQEKLL 490 500 510 520 530 540 SQIPLALEVL DFPTVKQFLL PLLSNLFTKT TSLTVKNTCV TCFQIMIEHK SIDSYTCSET 550 560 570 580 590 600 VLPLFKSMKT RDPRILSKLL KLFETVPLII TDEIVLVDQV LPLMWNYSMA STLTKSQYSG 610 620 630 640 650 660 YTKAINKMSS DIQKHHIAKL DDKVNDIGED AFHKVIEPTI MKKEDPETVA AKNIEVAAMQ 670 680 690 700 710 720 PVKKKTGSSY GETLPQSKSI LNSKPLNPKN ALATRGFPTR ILNSPPQTPS SRTGSKVMTK 730 740 750 760 770 780 GGSNDASSTK VEEEFNEFQS FSSTGSIRQT SAPSDVWMNS TPSPTPTSAS STNLPPGFSI 790 800 SLQPNKRKDG SSDIPRSNVY GSLI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Pietsch M., Gallwitz D. Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Sequence analysis of 203 kilobases from Saccharomyces cerevisiae chromosome VII." Rieger M., Brueckner M., Schaefer M., Mueller-Auer S. Yeast 13:1077-1090(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[3]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome VII." Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E. , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K. Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[4]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[5]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[6]	"Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway." Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J., Mann M., Jensen O.N. Mol. Cell. Proteomics 4:310-327(2005) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-704, MASS SPECTROMETRY. Strain: YAL6B.
[7]	"Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases." Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H. Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-791, MASS SPECTROMETRY.
[8]	"A multidimensional chromatography technology for in-depth phosphoproteome analysis." Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H. Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-704 AND SER-791, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X97305 Genomic DNA. Translation: CAA65975.1. Z72605 Genomic DNA. Translation: CAA96788.1. BK006941 Genomic DNA. Translation: DAA08022.1.
PIR	S64090.
RefSeq	NP_011432.1. NM_001180948.1.
3D structure databases
ProteinModelPortal	P53009.
SMR	P53009. Positions 64-311.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-4400N.
MINT	MINT-531565.
STRING	4932.YGL083W.
Proteomic databases
PaxDb	P53009.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YGL083W; YGL083W; YGL083W.
GeneID	852797.
KEGG	sce:YGL083W.
Organism-specific databases
CYGD	YGL083w.
SGD	S000003051. SCY1.
Phylogenomic databases
eggNOG	COG0515.
GeneTree	ENSGT00500000044907.
HOGENOM	HOG000141821.
OMA	DFANDIW.
OrthoDB	EOG48KVKN.
Enzyme and pathway databases
BioCyc	YEAST:G3O-30584-MONOMER.
Gene expression databases
Genevestigator	P53009.
GermOnline	YGL083W. Saccharomyces cerevisiae.
Family and domain databases
Gene3D	1.25.10.10. 1 hit.
InterPro	IPR011989. ARM-like. IPR016024. ARM-type_fold. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SUPFAM	SSF48371. ARM-type_fold. 1 hit. SSF56112. Kinase_like. 1 hit.
PROSITE	PS50011. PROTEIN_KINASE_DOM. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	972306.

Entry information

Entry name

SCY1_YEAST

Accession

Primary (citable) accession number: P53009
Secondary accession number(s): D6VU61

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	May 29, 2013
This is version 105 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program