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Protein

Probable propionyl-CoA carboxylase beta chain 5

Gene

accD5

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA.

Pathwayi: propanoyl-CoA degradation

This protein is involved in step 1 of the subpathway that synthesizes succinyl-CoA from propanoyl-CoA.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Probable propionyl-CoA carboxylase beta chain 5 (accD5)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
This subpathway is part of the pathway propanoyl-CoA degradation, which is itself part of Metabolic intermediate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes succinyl-CoA from propanoyl-CoA, the pathway propanoyl-CoA degradation and in Metabolic intermediate metabolism.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00945; UER00908.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable propionyl-CoA carboxylase beta chain 5 (EC:6.4.1.3)
Short name:
PCCase
Alternative name(s):
Propanoyl-CoA:carbon dioxide ligase
Gene namesi
Name:accD5
Synonyms:pccB
Ordered Locus Names:ML0731
ORF Names:B1308_C1_125
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML0731.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001997981 – 549Probable propionyl-CoA carboxylase beta chain 5Add BLAST549

Interactioni

Subunit structurei

Probably a dodecamer composed of six biotin-containing alpha subunits and six beta subunits.By similarity

Protein-protein interaction databases

STRINGi272631.ML0731.

Structurei

3D structure databases

ProteinModelPortaliP53002.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 281CoA carboxyltransferase N-terminalPROSITE-ProRule annotationAdd BLAST257
Domaini295 – 542CoA carboxyltransferase C-terminalPROSITE-ProRule annotationAdd BLAST248

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni25 – 542CarboxyltransferasePROSITE-ProRule annotationAdd BLAST518

Sequence similaritiesi

Belongs to the AccD/PCCB family.Curated
Contains 1 CoA carboxyltransferase C-terminal domain.PROSITE-ProRule annotation
Contains 1 CoA carboxyltransferase N-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105D8K. Bacteria.
COG4799. LUCA.
HOGENOMiHOG000218693.
KOiK01966.
OMAiYLAMGSK.
OrthoDBiPOG091H00L6.

Family and domain databases

Gene3Di3.90.226.10. 2 hits.
InterProiIPR000022. Carboxyl_trans.
IPR029045. ClpP/crotonase-like_dom.
IPR011763. COA_CT_C.
IPR011762. COA_CT_N.
[Graphical view]
PfamiPF01039. Carboxyl_trans. 1 hit.
[Graphical view]
SUPFAMiSSF52096. SSF52096. 2 hits.
PROSITEiPS50989. COA_CT_CTER. 1 hit.
PS50980. COA_CT_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53002-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSVTDHSAH SMERAAEHTI NIHTTAGKLA ELHKRTEEAL HPVGAAAFEK
60 70 80 90 100
VHAKGKFTAR ERIYALLDDD SFVELDALAR HRSTNFGLGE NRPVGDGVVT
110 120 130 140 150
GYGTIDGRDV CIFSQDVTVF GGSLGEVYGE KIVKVQELAI KTGRPLIGIN
160 170 180 190 200
DGAGARIQEG VVSLGLYSRI FRNNILASGV IPQISLIMGA AAGGHVYSPA
210 220 230 240 250
LTDFVVMVDQ TSQMFITGPD VIKTVTGEDV TMEELGGAHT HMAKSGTAHY
260 270 280 290 300
VASGEQDAFD WVRDVLSYLP SNNFTDAPRY SKPVPHGSIE DNLTAKDLEL
310 320 330 340 350
DTLIPDSPNQ PYDMHEVVTR LLDEEEFLEV QAGYATNIVV GLGRIDDRPV
360 370 380 390 400
GIVANQPIQF AGCLDINASE KAARFVRVCD CFNIPIVMLV DVPGFLPGTE
410 420 430 440 450
QEYDGIIRRG AKLLFAYGEA TVPKITVITR KAYGGAYCVM GSKNMGCDVN
460 470 480 490 500
LAWPTAQIAV MGASGAVGFV YRKELAQAAK NGANVDELRL QLQQEYEDTL
510 520 530 540
VNPYIAAERG YVDAVIPPSH TRGYIATALH LLERKIAHLP PKKHGNIPL
Length:549
Mass (Da):59,396
Last modified:October 1, 1996 - v1
Checksum:i949FAA54101E76CB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00012 Genomic DNA. Translation: AAA85917.1.
AL583919 Genomic DNA. Translation: CAC30240.1.
PIRiD87000.
RefSeqiNP_301571.1. NC_002677.1.
WP_010907895.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC30240; CAC30240; CAC30240.
GeneIDi909674.
KEGGimle:ML0731.
PATRICi18052764. VBIMycLep78757_1328.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00012 Genomic DNA. Translation: AAA85917.1.
AL583919 Genomic DNA. Translation: CAC30240.1.
PIRiD87000.
RefSeqiNP_301571.1. NC_002677.1.
WP_010907895.1. NC_002677.1.

3D structure databases

ProteinModelPortaliP53002.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML0731.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC30240; CAC30240; CAC30240.
GeneIDi909674.
KEGGimle:ML0731.
PATRICi18052764. VBIMycLep78757_1328.

Organism-specific databases

LepromaiML0731.

Phylogenomic databases

eggNOGiENOG4105D8K. Bacteria.
COG4799. LUCA.
HOGENOMiHOG000218693.
KOiK01966.
OMAiYLAMGSK.
OrthoDBiPOG091H00L6.

Enzyme and pathway databases

UniPathwayiUPA00945; UER00908.

Family and domain databases

Gene3Di3.90.226.10. 2 hits.
InterProiIPR000022. Carboxyl_trans.
IPR029045. ClpP/crotonase-like_dom.
IPR011763. COA_CT_C.
IPR011762. COA_CT_N.
[Graphical view]
PfamiPF01039. Carboxyl_trans. 1 hit.
[Graphical view]
SUPFAMiSSF52096. SSF52096. 2 hits.
PROSITEiPS50989. COA_CT_CTER. 1 hit.
PS50980. COA_CT_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPCCB_MYCLE
AccessioniPrimary (citable) accession number: P53002
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.