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Protein

Aspartate aminotransferase

Gene

aspB

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei38Aspartate; via amide nitrogenBy similarity1
Binding sitei124AspartateBy similarity1
Binding sitei174AspartateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciBSUB:BSU22370-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate aminotransferase (EC:2.6.1.1)
Short name:
AspAT
Alternative name(s):
Transaminase A
Gene namesi
Name:aspB
Ordered Locus Names:BSU22370
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001238361 – 393Aspartate aminotransferaseAdd BLAST393

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei237N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

PaxDbiP53001
PRIDEiP53001

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

IntActiP53001, 1 interactor
MINTiP53001
STRINGi224308.Bsubs1_010100012301

Structurei

3D structure databases

ProteinModelPortaliP53001
SMRiP53001
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CHM Bacteria
COG0436 LUCA
HOGENOMiHOG000223062
InParanoidiP53001
KOiK00812
OMAiYWTTYPE
PhylomeDBiP53001

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
InterProiView protein in InterPro
IPR004839 Aminotransferase_I/II
IPR004838 NHTrfase_class1_PyrdxlP-BS
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
PROSITEiView protein in PROSITE
PS00105 AA_TRANSFER_CLASS_1, 1 hit

Sequencei

Sequence statusi: Complete.

P53001-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLAKRVSAL TPSTTLAITA KAKELKAAGH DVIGLGAGEP DFNTPQHIID
60 70 80 90 100
AAVRSMNEGH TKYTPSGGLA ELKNSIAEKF KRDQNIEYKP SQIIVCTGAK
110 120 130 140 150
HALYTLFQVI LDEEDEVIIP TPYWVSYPEQ VKLAGGKPVY VEGLEENHFK
160 170 180 190 200
ISPEQLKNAI TEKTKAIVIN SPSNPTGVMY TEEELSALGE VCLEHDILIV
210 220 230 240 250
SDEIYEKLTY GGKKHVSIAQ LSDRLKEQTV IINGVSKSHS MTGWRIGYAA
260 270 280 290 300
GSEDIIKAMT NLASHSTSNP TSIAQYGAIA AYNGPSEPLE EMREAFEHRL
310 320 330 340 350
NTIYAKLIEI PGFSCVKPEG AFYLFPNAKE AAQSCGFKDV DEFVKALLEE
360 370 380 390
EKVAIVPGSG FGSPENVRLS YATSLDLLEE AIERIKRFVE KHS
Length:393
Mass (Da):43,088
Last modified:October 1, 1996 - v1
Checksum:i97CDA1F389B8E13B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L47709 Genomic DNA Translation: AAB38454.1
AL009126 Genomic DNA Translation: CAB14153.1
PIRiC69591
RefSeqiNP_390118.1, NC_000964.3
WP_004398489.1, NZ_JNCM01000036.1

Genome annotation databases

EnsemblBacteriaiCAB14153; CAB14153; BSU22370
GeneIDi939037
KEGGibsu:BSU22370
PATRICifig|224308.179.peg.2441

Similar proteinsi

Entry informationi

Entry nameiAAT1_BACSU
AccessioniPrimary (citable) accession number: P53001
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 25, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health