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Protein

Aspartate aminotransferase

Gene

aspB

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei38Aspartate; via amide nitrogenBy similarity1
Binding sitei124AspartateBy similarity1
Binding sitei174AspartateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciBSUB:BSU22370-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate aminotransferase (EC:2.6.1.1)
Short name:
AspAT
Alternative name(s):
Transaminase A
Gene namesi
Name:aspB
Ordered Locus Names:BSU22370
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001238361 – 393Aspartate aminotransferaseAdd BLAST393

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei237N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

PaxDbiP53001.
PRIDEiP53001.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

IntActiP53001. 1 interactor.
MINTiMINT-8366329.
STRINGi224308.Bsubs1_010100012301.

Structurei

3D structure databases

ProteinModelPortaliP53001.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CHM. Bacteria.
COG0436. LUCA.
HOGENOMiHOG000223062.
InParanoidiP53001.
KOiK00812.
OMAiRSMNEGH.
PhylomeDBiP53001.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR004839. Aminotransferase_I/II.
IPR004838. NHTrfase_class1_PyrdxlP-BS.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00105. AA_TRANSFER_CLASS_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53001-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLAKRVSAL TPSTTLAITA KAKELKAAGH DVIGLGAGEP DFNTPQHIID
60 70 80 90 100
AAVRSMNEGH TKYTPSGGLA ELKNSIAEKF KRDQNIEYKP SQIIVCTGAK
110 120 130 140 150
HALYTLFQVI LDEEDEVIIP TPYWVSYPEQ VKLAGGKPVY VEGLEENHFK
160 170 180 190 200
ISPEQLKNAI TEKTKAIVIN SPSNPTGVMY TEEELSALGE VCLEHDILIV
210 220 230 240 250
SDEIYEKLTY GGKKHVSIAQ LSDRLKEQTV IINGVSKSHS MTGWRIGYAA
260 270 280 290 300
GSEDIIKAMT NLASHSTSNP TSIAQYGAIA AYNGPSEPLE EMREAFEHRL
310 320 330 340 350
NTIYAKLIEI PGFSCVKPEG AFYLFPNAKE AAQSCGFKDV DEFVKALLEE
360 370 380 390
EKVAIVPGSG FGSPENVRLS YATSLDLLEE AIERIKRFVE KHS
Length:393
Mass (Da):43,088
Last modified:October 1, 1996 - v1
Checksum:i97CDA1F389B8E13B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L47709 Genomic DNA. Translation: AAB38454.1.
AL009126 Genomic DNA. Translation: CAB14153.1.
PIRiC69591.
RefSeqiNP_390118.1. NC_000964.3.
WP_004398489.1. NZ_JNCM01000036.1.

Genome annotation databases

EnsemblBacteriaiCAB14153; CAB14153; BSU22370.
GeneIDi939037.
KEGGibsu:BSU22370.
PATRICi18976283. VBIBacSub10457_2332.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L47709 Genomic DNA. Translation: AAB38454.1.
AL009126 Genomic DNA. Translation: CAB14153.1.
PIRiC69591.
RefSeqiNP_390118.1. NC_000964.3.
WP_004398489.1. NZ_JNCM01000036.1.

3D structure databases

ProteinModelPortaliP53001.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP53001. 1 interactor.
MINTiMINT-8366329.
STRINGi224308.Bsubs1_010100012301.

Proteomic databases

PaxDbiP53001.
PRIDEiP53001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB14153; CAB14153; BSU22370.
GeneIDi939037.
KEGGibsu:BSU22370.
PATRICi18976283. VBIBacSub10457_2332.

Phylogenomic databases

eggNOGiENOG4105CHM. Bacteria.
COG0436. LUCA.
HOGENOMiHOG000223062.
InParanoidiP53001.
KOiK00812.
OMAiRSMNEGH.
PhylomeDBiP53001.

Enzyme and pathway databases

BioCyciBSUB:BSU22370-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR004839. Aminotransferase_I/II.
IPR004838. NHTrfase_class1_PyrdxlP-BS.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00105. AA_TRANSFER_CLASS_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAAT1_BACSU
AccessioniPrimary (citable) accession number: P53001
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 5, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.