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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.

Pathway: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi)
  3. ATP-dependent 6-phosphofructokinase 2 (pfkA2), ATP-dependent 6-phosphofructokinase 1 (pfkA1)
  4. Fructose-bisphosphate aldolase class 1 (fda), Fructose-bisphosphate aldolase class 2 (fbaA)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei324 – 3241Proton donorBy similarity
Active sitei353 – 3531By similarity
Active sitei457 – 4571By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase (EC:5.3.1.9)
Short name:
GPI
Alternative name(s):
Phosphoglucose isomerase
Short name:
PGI
Phosphohexose isomerase
Short name:
PHI
Gene namesi
Name:pgi
Ordered Locus Names:slr1349
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
ProteomesiUP000001425 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 531531Glucose-6-phosphate isomerasePRO_0000180755Add
BLAST

Proteomic databases

PaxDbiP52983.

Interactioni

Protein-protein interaction databases

IntActiP52983. 2 interactions.
STRINGi1148.SYNGTS_1593.

Structurei

3D structure databases

ProteinModelPortaliP52983.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.Curated

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000131425.
InParanoidiP52983.
KOiK01810.
OMAiRQVGHYW.
OrthoDBiEOG64R61J.
PhylomeDBiP52983.

Family and domain databases

HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 2 hits.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P52983-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNQQLWQRY QDWLYYHGGL DFYLDVSRMG FSDALVEDLQ PKFAKAFQDM
60 70 80 90 100
VALEKGAIAN PDEQRMVGHY WLRNPALAPN DGIRAEITEP LRQIKAFVAD
110 120 130 140 150
VHQGNIKPPT APKFTDLLAI GIGGSALGPQ FVAQALAPNF PPLAIHFIDN
160 170 180 190 200
SDPDGIDRVL NCLKAQDKLK STLVVTTSKS GGTPEPRNGL AETKAVFEAQ
210 220 230 240 250
GLHFADYAVA VTMPGSKLSQ QAQTEQWLQA FPMQDWVGGR TSELSAVGLL
260 270 280 290 300
PAALQGIDIQ AMLDGAKTMD EATRVRELRQ NPAALLALAW YYAGDGQGKK
310 320 330 340 350
DMVILPYKDR LLLFSRYLQQ LVMESLGKER DLDGNVVHQG IAVYGNKGST
360 370 380 390 400
DQHAYVQQLR DGVPNFFATF IEVLHDRQGP SLELEPGVTS GDYLSGFLQG
410 420 430 440 450
TRQALFENQR DSITVTIPEV DATSVGALIA LYERAVSFYG SLVNVNAYHQ
460 470 480 490 500
PGVEAGKKAA ASILELQKAI LSTLQNESGP IALEALATKV QAPEQVETVY
510 520 530
KIVRHLAAND RGVTLQGDRQ FPQRLQIQWR S
Length:531
Mass (Da):58,356
Last modified:October 1, 1996 - v1
Checksum:iABD5AA851C0BEF48
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13777 Genomic DNA. Translation: BAA02920.1.
BA000022 Genomic DNA. Translation: BAA18168.1.
PIRiS75607.
RefSeqiYP_005651546.1. NC_017277.1.
YP_007451370.1. NC_020286.1.

Genome annotation databases

EnsemblBacteriaiBAA18168; BAA18168; BAA18168.
KEGGisyn:slr1349.
PATRICi23840391. VBISynSp132158_1753.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13777 Genomic DNA. Translation: BAA02920.1.
BA000022 Genomic DNA. Translation: BAA18168.1.
PIRiS75607.
RefSeqiYP_005651546.1. NC_017277.1.
YP_007451370.1. NC_020286.1.

3D structure databases

ProteinModelPortaliP52983.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP52983. 2 interactions.
STRINGi1148.SYNGTS_1593.

Proteomic databases

PaxDbiP52983.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA18168; BAA18168; BAA18168.
KEGGisyn:slr1349.
PATRICi23840391. VBISynSp132158_1753.

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000131425.
InParanoidiP52983.
KOiK01810.
OMAiRQVGHYW.
OrthoDBiEOG64R61J.
PhylomeDBiP52983.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.

Family and domain databases

HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 2 hits.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence analysis of a DNA fragment from Synechocystis PCC6803 containing genes homologous to cysE (serine acetyltransferase) and pgi (glucose-6-phosphate isomerase)."
    Sakamoto T., Wada H., Nishida I., Ohta H., Murata N.
    Plant Mol. Biol. 29:187-187(1995)
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / Kazusa.

Entry informationi

Entry nameiG6PI_SYNY3
AccessioniPrimary (citable) accession number: P52983
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 24, 2015
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.