P52983 (G6PI_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glucose-6-phosphate isomerase
Short name=GPI
EC=5.3.1.9

Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI

Gene names

Name:	pgi
Ordered Locus Names:	slr1349

Organism

Synechocystis sp. (strain PCC 6803 / Kazusa)

Taxonomic identifier

1111708 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechocystis

Protein attributes

Sequence length	531 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP MF_00473
Pathway	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP MF_00473
Subcellular location	Cytoplasm HAMAP MF_00473.
Sequence similarities	Belongs to the GPI family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-KW glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 531	531	Glucose-6-phosphate isomerase HAMAP MF_00473		PRO_0000180755
Sites
	Active site	324	1	Proton donor By similarity
	Active site	353	1	By similarity
	Active site	457	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P52983 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: ABD5AA851C0BEF48	FASTA	531	58,356
	10 20 30 40 50 60 MNNQQLWQRY QDWLYYHGGL DFYLDVSRMG FSDALVEDLQ PKFAKAFQDM VALEKGAIAN 70 80 90 100 110 120 PDEQRMVGHY WLRNPALAPN DGIRAEITEP LRQIKAFVAD VHQGNIKPPT APKFTDLLAI 130 140 150 160 170 180 GIGGSALGPQ FVAQALAPNF PPLAIHFIDN SDPDGIDRVL NCLKAQDKLK STLVVTTSKS 190 200 210 220 230 240 GGTPEPRNGL AETKAVFEAQ GLHFADYAVA VTMPGSKLSQ QAQTEQWLQA FPMQDWVGGR 250 260 270 280 290 300 TSELSAVGLL PAALQGIDIQ AMLDGAKTMD EATRVRELRQ NPAALLALAW YYAGDGQGKK 310 320 330 340 350 360 DMVILPYKDR LLLFSRYLQQ LVMESLGKER DLDGNVVHQG IAVYGNKGST DQHAYVQQLR 370 380 390 400 410 420 DGVPNFFATF IEVLHDRQGP SLELEPGVTS GDYLSGFLQG TRQALFENQR DSITVTIPEV 430 440 450 460 470 480 DATSVGALIA LYERAVSFYG SLVNVNAYHQ PGVEAGKKAA ASILELQKAI LSTLQNESGP 490 500 510 520 530 IALEALATKV QAPEQVETVY KIVRHLAAND RGVTLQGDRQ FPQRLQIQWR S

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence analysis of a DNA fragment from Synechocystis PCC6803 containing genes homologous to cysE (serine acetyltransferase) and pgi (glucose-6-phosphate isomerase)." Sakamoto T., Wada H., Nishida I., Ohta H., Murata N. Plant Mol. Biol. 29:187-187(1995) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions." Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S. DNA Res. 3:109-136(1996) [PubMed: 8905231] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 27184 / PCC 6803 / N-1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D13777 Genomic DNA. Translation: BAA02920.1. BA000022 Genomic DNA. Translation: BAA18168.1.
PIR	S75607.
RefSeq	NP_441488.1. NC_000911.1.
3D structure databases
ProteinModelPortal	P52983.
ModBase	Search...
Protein-protein interaction databases
IntAct	P52983. 2 interactions.
STRING	P52983.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	954868.
GenomeReviews	Gene locus slr1349 in contig BA000022_GR.
KEGG	syn:slr1349.
NMPDR	fig|1148.1.peg.1589.
PATRIC	23840391. VBISynSp132158_1753.
Phylogenomic databases
eggNOG	COG0166.
HOGENOM	HBG285902.
OMA	RTSITSA.
PhylomeDB	P52983.
ProtClustDB	PRK14096.
Enzyme and pathway databases
BioCyc	SSP1148:SLR1349-MONOMER.
Family and domain databases
HAMAP	MF_00473. G6P_isomerase. [Tree]
InterPro	IPR001672. G6P_Isomerase. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
KO	K01810.
PANTHER	PTHR11469. G6P_Isomerase. 1 hit.
Pfam	PF00342. PGI. 2 hits. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. False negative. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PI_SYNY3

Accession

Primary (citable) accession number: P52983

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	January 25, 2012
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program