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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi)
  3. ATP-dependent 6-phosphofructokinase 2 (pfkA2), ATP-dependent 6-phosphofructokinase 1 (pfkA1)
  4. Fructose-bisphosphate aldolase class 1 (fda), Fructose-bisphosphate aldolase class 2 (fbaA)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei324Proton donorBy similarity1
Active sitei353By similarity1
Active sitei457By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase (EC:5.3.1.9)
Short name:
GPI
Alternative name(s):
Phosphoglucose isomerase
Short name:
PGI
Phosphohexose isomerase
Short name:
PHI
Gene namesi
Name:pgi
Ordered Locus Names:slr1349
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesMerismopediaceaeSynechocystis
Proteomesi
  • UP000001425 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001807551 – 531Glucose-6-phosphate isomeraseAdd BLAST531

Proteomic databases

PaxDbiP52983

Interactioni

Protein-protein interaction databases

IntActiP52983 2 interactors.
STRINGi1148.SYNGTS_1593

Structurei

3D structure databases

ProteinModelPortaliP52983
SMRiP52983
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.Curated

Phylogenomic databases

HOGENOMiHOG000131425
InParanoidiP52983
KOiK01810
OMAiTNSQHAF
PhylomeDBiP52983

Family and domain databases

CDDicd05015 SIS_PGI_1, 1 hit
cd05016 SIS_PGI_2, 1 hit
HAMAPiMF_00473 G6P_isomerase, 1 hit
InterProiView protein in InterPro
IPR001672 G6P_Isomerase
IPR018189 Phosphoglucose_isomerase_CS
IPR035476 SIS_PGI_1
IPR035482 SIS_PGI_2
PANTHERiPTHR11469 PTHR11469, 1 hit
PfamiView protein in Pfam
PF00342 PGI, 2 hits
PRINTSiPR00662 G6PISOMERASE
PROSITEiView protein in PROSITE
PS00174 P_GLUCOSE_ISOMERASE_2, 1 hit
PS51463 P_GLUCOSE_ISOMERASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

P52983-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNQQLWQRY QDWLYYHGGL DFYLDVSRMG FSDALVEDLQ PKFAKAFQDM
60 70 80 90 100
VALEKGAIAN PDEQRMVGHY WLRNPALAPN DGIRAEITEP LRQIKAFVAD
110 120 130 140 150
VHQGNIKPPT APKFTDLLAI GIGGSALGPQ FVAQALAPNF PPLAIHFIDN
160 170 180 190 200
SDPDGIDRVL NCLKAQDKLK STLVVTTSKS GGTPEPRNGL AETKAVFEAQ
210 220 230 240 250
GLHFADYAVA VTMPGSKLSQ QAQTEQWLQA FPMQDWVGGR TSELSAVGLL
260 270 280 290 300
PAALQGIDIQ AMLDGAKTMD EATRVRELRQ NPAALLALAW YYAGDGQGKK
310 320 330 340 350
DMVILPYKDR LLLFSRYLQQ LVMESLGKER DLDGNVVHQG IAVYGNKGST
360 370 380 390 400
DQHAYVQQLR DGVPNFFATF IEVLHDRQGP SLELEPGVTS GDYLSGFLQG
410 420 430 440 450
TRQALFENQR DSITVTIPEV DATSVGALIA LYERAVSFYG SLVNVNAYHQ
460 470 480 490 500
PGVEAGKKAA ASILELQKAI LSTLQNESGP IALEALATKV QAPEQVETVY
510 520 530
KIVRHLAAND RGVTLQGDRQ FPQRLQIQWR S
Length:531
Mass (Da):58,356
Last modified:October 1, 1996 - v1
Checksum:iABD5AA851C0BEF48
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13777 Genomic DNA Translation: BAA02920.1
BA000022 Genomic DNA Translation: BAA18168.1
PIRiS75607

Genome annotation databases

EnsemblBacteriaiBAA18168; BAA18168; BAA18168
KEGGisyn:slr1349

Similar proteinsi

Entry informationi

Entry nameiG6PI_SYNY3
AccessioniPrimary (citable) accession number: P52983
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: January 31, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome