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P52961

- NAR1_HUMAN

UniProt

P52961 - NAR1_HUMAN

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Protein

GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1

Gene

ART1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Has ADP-ribosyltransferase activity toward GLP1R.1 Publication

Catalytic activityi

NAD+ + protein-L-arginine = nicotinamide + N(omega)-(ADP-D-ribosyl)-protein-L-arginine.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei121 – 1211NADBy similarity
Binding sitei179 – 1791NADBy similarity
Binding sitei233 – 2331NADBy similarity
Active sitei247 – 2471By similarity

GO - Molecular functioni

  1. NAD(P)+-protein-arginine ADP-ribosyltransferase activity Source: UniProtKB-EC
  2. NAD+ ADP-ribosyltransferase activity Source: ProtInc

GO - Biological processi

  1. innate immune response Source: Reactome
  2. protein ADP-ribosylation Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Ligandi

NAD, NADP

Enzyme and pathway databases

ReactomeiREACT_115574. Alpha-defensins.

Names & Taxonomyi

Protein namesi
Recommended name:
GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 (EC:2.4.2.31)
Alternative name(s):
ADP-ribosyltransferase C2 and C3 toxin-like 1
Short name:
ARTC1
Mono(ADP-ribosyl)transferase 1
CD_antigen: CD296
Gene namesi
Name:ART1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:723. ART1.

Subcellular locationi

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
  2. cell surface Source: Ensembl
  3. integral component of plasma membrane Source: ProtInc
  4. plasma membrane Source: Reactome
  5. sarcoplasmic reticulum Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Sarcoplasmic reticulum

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25014.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 295273GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1PRO_0000019311Add
BLAST
Propeptidei296 – 32732Removed in mature formSequence AnalysisPRO_0000019312Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi53 ↔ 277By similarity
Glycosylationi65 – 651N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi174 ↔ 224By similarity
Glycosylationi253 – 2531N-linked (GlcNAc...)Sequence Analysis
Lipidationi295 – 2951GPI-anchor amidated serineSequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiP52961.
PRIDEiP52961.

PTM databases

PhosphoSiteiP52961.

Expressioni

Gene expression databases

BgeeiP52961.
CleanExiHS_ART1.
GenevestigatoriP52961.

Organism-specific databases

HPAiHPA051148.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000250693.

Structurei

3D structure databases

ProteinModelPortaliP52961.
SMRiP52961. Positions 37-279.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG40339.
GeneTreeiENSGT00530000062975.
HOGENOMiHOG000273888.
HOVERGENiHBG004464.
InParanoidiP52961.
KOiK06716.
OMAiCLGAPIK.
OrthoDBiEOG7D85WV.
PhylomeDBiP52961.
TreeFamiTF335356.

Family and domain databases

InterProiIPR000768. ART.
[Graphical view]
PANTHERiPTHR10339. PTHR10339. 1 hit.
PfamiPF01129. ART. 1 hit.
[Graphical view]
PRINTSiPR00970. RIBTRNSFRASE.
PROSITEiPS01291. ART. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P52961 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQMPAMMSLL LVSVGLMEAL QAQSHPITRR DLFSQEIQLD MALASFDDQY
60 70 80 90 100
AGCAAAMTAA LPDLNHTEFQ ANQVYADSWT LASSQWQERQ ARWPEWSLSP
110 120 130 140 150
TRPSPPPLGF RDEHGVALLA YTANSPLHKE FNAAVREAGR SRAHYLHHFS
160 170 180 190 200
FKTLHFLLTE ALQLLGSGQR PPRCHQVFRG VHGLRFRPAG PRATVRLGGF
210 220 230 240 250
ASASLKHVAA QQFGEDTFFG IWTCLGAPIK GYSFFPGEEE VLIPPFETFQ
260 270 280 290 300
VINASRLAQG PARIYLRALG KHSTYNCEYI KDKKCKSGPC HLDNSAMGQS
310 320
PLSAVWSLLL LLWFLVVRAF PDGPGLL
Length:327
Mass (Da):36,335
Last modified:September 23, 2008 - v2
Checksum:i8FDC568197031EA5
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti105 – 1051P → L.
Corresponds to variant rs35123761 [ dbSNP | Ensembl ].
VAR_034125
Natural varianti126 – 1261P → R.
Corresponds to variant rs35619488 [ dbSNP | Ensembl ].
VAR_034126
Natural varianti257 – 2571L → P.1 Publication
Corresponds to variant rs2280134 [ dbSNP | Ensembl ].
VAR_053526

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S74683 mRNA. Translation: AAB32387.1.
CH471158 Genomic DNA. Translation: EAX02559.1.
BC069102 mRNA. Translation: AAH69102.1.
BC111729 mRNA. Translation: AAI11730.1.
AJ291430 mRNA. Translation: CAC69964.1.
CCDSiCCDS7744.1.
PIRiA55966.
RefSeqiNP_004305.2. NM_004314.2.
XP_005252990.1. XM_005252933.2.
UniGeneiHs.382188.

Genome annotation databases

EnsembliENST00000250693; ENSP00000250693; ENSG00000129744.
GeneIDi417.
KEGGihsa:417.
UCSCiuc001lye.1. human.

Polymorphism databases

DMDMi206729882.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S74683 mRNA. Translation: AAB32387.1 .
CH471158 Genomic DNA. Translation: EAX02559.1 .
BC069102 mRNA. Translation: AAH69102.1 .
BC111729 mRNA. Translation: AAI11730.1 .
AJ291430 mRNA. Translation: CAC69964.1 .
CCDSi CCDS7744.1.
PIRi A55966.
RefSeqi NP_004305.2. NM_004314.2.
XP_005252990.1. XM_005252933.2.
UniGenei Hs.382188.

3D structure databases

ProteinModelPortali P52961.
SMRi P52961. Positions 37-279.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000250693.

Chemistry

ChEMBLi CHEMBL2158.

PTM databases

PhosphoSitei P52961.

Polymorphism databases

DMDMi 206729882.

Proteomic databases

PaxDbi P52961.
PRIDEi P52961.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000250693 ; ENSP00000250693 ; ENSG00000129744 .
GeneIDi 417.
KEGGi hsa:417.
UCSCi uc001lye.1. human.

Organism-specific databases

CTDi 417.
GeneCardsi GC11P003666.
H-InvDB HIX0035913.
HGNCi HGNC:723. ART1.
HPAi HPA051148.
MIMi 601625. gene.
neXtProti NX_P52961.
PharmGKBi PA25014.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG40339.
GeneTreei ENSGT00530000062975.
HOGENOMi HOG000273888.
HOVERGENi HBG004464.
InParanoidi P52961.
KOi K06716.
OMAi CLGAPIK.
OrthoDBi EOG7D85WV.
PhylomeDBi P52961.
TreeFami TF335356.

Enzyme and pathway databases

Reactomei REACT_115574. Alpha-defensins.

Miscellaneous databases

GenomeRNAii 417.
NextBioi 1763.
PROi P52961.
SOURCEi Search...

Gene expression databases

Bgeei P52961.
CleanExi HS_ART1.
Genevestigatori P52961.

Family and domain databases

InterProi IPR000768. ART.
[Graphical view ]
PANTHERi PTHR10339. PTHR10339. 1 hit.
Pfami PF01129. ART. 1 hit.
[Graphical view ]
PRINTSi PR00970. RIBTRNSFRASE.
PROSITEi PS01291. ART. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Immunological and structural conservation of mammalian skeletal muscle glycosylphosphatidylinositol-linked ADP-ribosyltransferases."
    Okazaki I.J., Zolkiewska A., Nightingale M.S., Moss J.
    Biochemistry 33:12828-12836(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT PRO-257.
    Tissue: Skeletal muscle.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Conservation of the ART gene family across mammalian species."
    Kuehl M., Glowacki G., Haag F., Koch-Nolte F.
    Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 122-223.
  5. "Toward a unified nomenclature for mammalian ADP-ribosyltransferases."
    Hottiger M.O., Hassa P.O., Luscher B., Schuler H., Koch-Nolte F.
    Trends Biochem. Sci. 35:208-219(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NOMENCLATURE.
  6. "Glucagon like-peptide-1 receptor is covalently modified by endogenous mono-ADP-ribosyltransferase."
    Dezelak M., Bavec A.
    Mol. Biol. Rep. 39:4375-4381(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiNAR1_HUMAN
AccessioniPrimary (citable) accession number: P52961
Secondary accession number(s): Q6NTD2, Q96KT9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: September 23, 2008
Last modified: October 29, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3