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Reviewed, UniProtKB/Swiss-Prot P52961 (NAR1_HUMAN)

Last modified November 25, 2008. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1
    EC=2.4.2.31
Alternative name(s):
    Mono(ADP-ribosyl)transferase
    CD_antigen=CD296
Gene names
Name: ART1
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length327 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Catalytic activity

NAD(+) + protein-L-arginine = nicotinamide + N(omega)-(ADP-D-ribosyl)-protein-L-arginine.

NADP(+) + protein-L-arginine = nicotinamide + N(omega)-((2'-phospho-ADP)-D-ribosyl)-protein-L-arginine.

Subcellular location

Sarcoplasmic reticulum membrane; Lipid-anchorGPI-anchor.

Sequence similarities

Belongs to the Arg-specific ADP-ribosyltransferase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 295273GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1
PRO_0000019311
Propeptide296 – 32732Removed in mature form Potential
PRO_0000019312

Sites

Active site2471 By similarity

Amino acid modifications

Lipidation2951GPI-anchor amidated serine Potential
Glycosylation651N-linked (GlcNAc...) Potential
Glycosylation2531N-linked (GlcNAc...) Potential

Natural variations

Natural variant1051P → L: dbSNP rs35123761.
VAR_034125
Natural variant1261P → R: dbSNP rs35619488.
VAR_034126

Experimental info

Sequence conflict2571L → P in AAB32387. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P52961-1 [UniParc].

Last modified September 23, 2008. Version 2.
Checksum: 8FDC568197031EA5

FASTA32736,335
        10         20         30         40         50         60 
MQMPAMMSLL LVSVGLMEAL QAQSHPITRR DLFSQEIQLD MALASFDDQY AGCAAAMTAA 

        70         80         90        100        110        120 
LPDLNHTEFQ ANQVYADSWT LASSQWQERQ ARWPEWSLSP TRPSPPPLGF RDEHGVALLA 

       130        140        150        160        170        180 
YTANSPLHKE FNAAVREAGR SRAHYLHHFS FKTLHFLLTE ALQLLGSGQR PPRCHQVFRG 

       190        200        210        220        230        240 
VHGLRFRPAG PRATVRLGGF ASASLKHVAA QQFGEDTFFG IWTCLGAPIK GYSFFPGEEE 

       250        260        270        280        290        300 
VLIPPFETFQ VINASRLAQG PARIYLRALG KHSTYNCEYI KDKKCKSGPC HLDNSAMGQS 

       310        320 
PLSAVWSLLL LLWFLVVRAF PDGPGLL 

« Hide

References

« Hide 'large scale' references
[1]"Immunological and structural conservation of mammalian skeletal muscle glycosylphosphatidylinositol-linked ADP-ribosyltransferases."
Okazaki I.J., Zolkiewska A., Nightingale M.S., Moss J.
Biochemistry 33:12828-12836(1994) [PubMed: 7947688] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Skeletal muscle.
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"Conservation of the ART gene family across mammalian species."
Kuehl M., Glowacki G., Haag F., Koch-Nolte F.
Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 122-223.
+Additional computationally mapped references.

Cross-references

Sequence databases

S74683 mRNA. Translation: AAB32387.1.
CH471158 Genomic DNA. Translation: EAX02559.1.
BC069102 mRNA. Translation: AAH69102.1.
BC111729 mRNA. Translation: AAI11730.1.
AJ291430 mRNA. Translation: CAC69964.1.
PIRA55966.
RefSeqNP_004305.2.
UniGeneHs.382188

3D structure databases

HSSPHSSP built from PDB template 1GXY based on UniProtKB P20974.
ModBaseSearch...

Genome annotation databases

EnsemblENSG00000129744. Homo sapiens. [Contig view]
GeneID417.

Organism-specific databases

H-InvDBHIX0035913.
HGNCHGNC:723. ART1.
MIM601625. gene.
PharmGKBPA25014.
GenAtlasSearch...
GeneCardsSearch...

Phylogenomic databases

HOGENOMP52961.
HOVERGENP52961.

Gene expression databases

ArrayExpressP52961.
CleanExHS_ART1.
GermOnlineENSG00000129744. Homo sapiens.

Family and domain databases

InterProIPR000768. ART.
[Graphical view]
PANTHERPTHR10339. ART. 1 hit.
PfamPF01129. ART. 1 hit.
[Graphical view]
PRINTSPR00970. RIBTRNSFRASE.
PROSITEPS01291. ART. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

DrugBankDB00102. Becaplermin.
LinkHubP52961.
SOURCESearch...

Entry information

Entry nameNAR1_HUMAN
AccessionPrimary (citable) accession number: P52961
Secondary accession number(s): Q6NTD2, Q96KT9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: September 23, 2008
Last modified: November 25, 2008
This is version 68 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents