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Protein

Sterigmatocystin biosynthesis regulatory protein

Gene

aflR

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Involved in the regulation of sterigmatocystin biosynthesis.1 Publication

Pathway:isterigmatocystin biosynthesis

This protein regulates the pathway sterigmatocystin biosynthesis, which is part of Mycotoxin biosynthesis.
View all proteins of this organism that are known to be involved in the pathway sterigmatocystin biosynthesis and in Mycotoxin biosynthesis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi28 – 5528Zn(2)-C6 fungal-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • aflatoxin biosynthetic process Source: InterPro
  • asperthecin biosynthetic process Source: ASPGD
  • positive regulation of asperthecin biosynthetic process Source: ASPGD
  • positive regulation of secondary metabolite biosynthetic process Source: ASPGD
  • positive regulation of sterigmatocystin biosynthetic process Source: ASPGD
  • positive regulation of transcription, DNA-templated Source: ASPGD
  • positive regulation of transcription from RNA polymerase II promoter Source: ASPGD
  • sterigmatocystin biosynthetic process Source: ASPGD
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00377.

Names & Taxonomyi

Protein namesi
Recommended name:
Sterigmatocystin biosynthesis regulatory protein
Gene namesi
Name:aflR
ORF Names:AN7820
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000000560 Componenti: Chromosome IV

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  • nucleus Source: ASPGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 433433Sterigmatocystin biosynthesis regulatory proteinPRO_0000114934Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP52957.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi381 – 39010Poly-Ser

Sequence similaritiesi

Contains 1 Zn(2)-C6 fungal-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG289594.
HOGENOMiHOG000033838.
InParanoidiP52957.
OMAiACARCIE.
OrthoDBiEOG77M8Z1.

Family and domain databases

Gene3Di4.10.240.10. 1 hit.
InterProiIPR002409. Aflatoxin_BRP.
IPR013700. AflR.
IPR001138. Zn2-C6_fun-type_DNA-bd.
[Graphical view]
PfamiPF08493. AflR. 1 hit.
PF00172. Zn_clus. 1 hit.
[Graphical view]
PRINTSiPR00755. AFLATOXINBRP.
SMARTiSM00066. GAL4. 1 hit.
[Graphical view]
SUPFAMiSSF57701. SSF57701. 1 hit.
PROSITEiPS00463. ZN2_CY6_FUNGAL_1. 1 hit.
PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P52957-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPPAISQQS TPTAPGGTQG TRKLRESCIS CSRSKVKCNK EKPTCSRCVR
60 70 80 90 100
RGLPCEYMVS RRTGRTRVIG VEQPKTAPSP TTPTNTTAAT TATKAGPPVT
110 120 130 140 150
TDSAVHTPVI TTAPSPKPVQ IQSPPAEPDL WGAILSPNTS TSTDLSSLLS
160 170 180 190 200
VNTNFSQLFA SLSPSLLEGM DGMDAEMHAP ELGALSVADP SSSMMQGLEA
210 220 230 240 250
PNAAQPPSSN TTSHSYCLSI CLDTLMRLFP NAGANCERPG HESNPGKLFT
260 270 280 290 300
IESVIEDNKQ ILDTAQTILA CRCAEDEYVV TLVSLIVFKV LGWYVAAARD
310 320 330 340 350
RSSDPGREED FNWSTAQDSR RGSVSSFEEQ VLHLPTVVGS YCIDGHHQSR
360 370 380 390 400
MAAQLVLSEL YRVQRLVTQV SRRLESIRRR SSSSSSSASS NTTDSDGGMS
410 420 430
TPLSSTTLVH LEDDLRKRLR AVSSETISIL RHA
Length:433
Mass (Da):46,566
Last modified:May 1, 2007 - v2
Checksum:iC9B8A0F83799472D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti340 – 3401S → T in AAC49195 (PubMed:8643646).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34740 Genomic DNA. Translation: AAC49195.1.
AACD01000132 Genomic DNA. Translation: EAA61608.1.
BN001304 Genomic DNA. Translation: CBF80174.1.
PIRiS69999.
RefSeqiXP_681089.1. XM_675997.1.

Genome annotation databases

EnsemblFungiiCADANIAT00000963; CADANIAP00000963; CADANIAG00000963.
GeneIDi2869641.
KEGGiani:AN7820.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34740 Genomic DNA. Translation: AAC49195.1.
AACD01000132 Genomic DNA. Translation: EAA61608.1.
BN001304 Genomic DNA. Translation: CBF80174.1.
PIRiS69999.
RefSeqiXP_681089.1. XM_675997.1.

3D structure databases

ProteinModelPortaliP52957.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADANIAT00000963; CADANIAP00000963; CADANIAG00000963.
GeneIDi2869641.
KEGGiani:AN7820.2.

Phylogenomic databases

eggNOGiNOG289594.
HOGENOMiHOG000033838.
InParanoidiP52957.
OMAiACARCIE.
OrthoDBiEOG77M8Z1.

Enzyme and pathway databases

UniPathwayiUPA00377.

Family and domain databases

Gene3Di4.10.240.10. 1 hit.
InterProiIPR002409. Aflatoxin_BRP.
IPR013700. AflR.
IPR001138. Zn2-C6_fun-type_DNA-bd.
[Graphical view]
PfamiPF08493. AflR. 1 hit.
PF00172. Zn_clus. 1 hit.
[Graphical view]
PRINTSiPR00755. AFLATOXINBRP.
SMARTiSM00066. GAL4. 1 hit.
[Graphical view]
SUPFAMiSSF57701. SSF57701. 1 hit.
PROSITEiPS00463. ZN2_CY6_FUNGAL_1. 1 hit.
PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Twenty-five coregulated transcripts define a sterigmatocystin gene cluster in Aspergillus nidulans."
    Brown D.W., Yu J.-H., Kelkar H.S., Fernandes M., Nesbitt T.C., Keller N.P., Adams T.H., Leonard T.J.
    Proc. Natl. Acad. Sci. U.S.A. 93:1418-1422(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: FGSC 26.
  2. "Conservation of structure and function of the aflatoxin regulatory gene aflR from Aspergillus nidulans and A. flavus."
    Yu J.-H., Butchko R.A.E., Fernandes M., Keller N.P., Leonard T.J., Adams T.H.
    Curr. Genet. 29:549-555(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
  4. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
    Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
    , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
    Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

Entry informationi

Entry nameiAFLR_EMENI
AccessioniPrimary (citable) accession number: P52957
Secondary accession number(s): C8VDU4, Q5AV60
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 1, 2007
Last modified: July 22, 2015
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.