Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P52957

- AFLR_EMENI

UniProt

P52957 - AFLR_EMENI

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Sterigmatocystin biosynthesis regulatory protein

Gene

aflR

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed - Annotation score: 5 out of 5- Protein inferred from homologyi

Functioni

Involved in the regulation of sterigmatocystin biosynthesis.1 Publication

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi28 – 5528Zn(2)-C6 fungal-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: ASPGD
  2. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: InterPro
  3. sequence-specific DNA binding transcription factor activity Source: ASPGD
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. aflatoxin biosynthetic process Source: InterPro
  2. asperthecin biosynthetic process Source: ASPGD
  3. monodictyphenone biosynthetic process Source: ASPGD
  4. positive regulation of asperthecin biosynthetic process Source: ASPGD
  5. positive regulation of secondary metabolite biosynthetic process Source: ASPGD
  6. positive regulation of sterigmatocystin biosynthetic process Source: ASPGD
  7. positive regulation of transcription, DNA-templated Source: ASPGD
  8. positive regulation of transcription from RNA polymerase II promoter Source: ASPGD
  9. regulation of secondary metabolic process Source: ASPGD
  10. sterigmatocystin biosynthetic process Source: ASPGD
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00377.

Names & Taxonomyi

Protein namesi
Recommended name:
Sterigmatocystin biosynthesis regulatory protein
Gene namesi
Name:aflR
ORF Names:AN7820
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000000560: Chromosome IV

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: ASPGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 433433Sterigmatocystin biosynthesis regulatory proteinPRO_0000114934Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi162425.CADANIAP00000963.

Structurei

3D structure databases

ProteinModelPortaliP52957.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi381 – 39010Poly-Ser

Sequence similaritiesi

Contains 1 Zn(2)-C6 fungal-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG289594.
HOGENOMiHOG000033838.
InParanoidiP52957.
OMAiNTNEDEH.
OrthoDBiEOG77M8Z1.

Family and domain databases

Gene3Di4.10.240.10. 1 hit.
InterProiIPR002409. Aflatoxin_BRP.
IPR013700. AflR.
IPR001138. Zn2-C6_fun-type_DNA-bd.
[Graphical view]
PfamiPF08493. AflR. 1 hit.
PF00172. Zn_clus. 1 hit.
[Graphical view]
PRINTSiPR00755. AFLATOXINBRP.
SMARTiSM00066. GAL4. 1 hit.
[Graphical view]
SUPFAMiSSF57701. SSF57701. 1 hit.
PROSITEiPS00463. ZN2_CY6_FUNGAL_1. 1 hit.
PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P52957-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEPPAISQQS TPTAPGGTQG TRKLRESCIS CSRSKVKCNK EKPTCSRCVR
60 70 80 90 100
RGLPCEYMVS RRTGRTRVIG VEQPKTAPSP TTPTNTTAAT TATKAGPPVT
110 120 130 140 150
TDSAVHTPVI TTAPSPKPVQ IQSPPAEPDL WGAILSPNTS TSTDLSSLLS
160 170 180 190 200
VNTNFSQLFA SLSPSLLEGM DGMDAEMHAP ELGALSVADP SSSMMQGLEA
210 220 230 240 250
PNAAQPPSSN TTSHSYCLSI CLDTLMRLFP NAGANCERPG HESNPGKLFT
260 270 280 290 300
IESVIEDNKQ ILDTAQTILA CRCAEDEYVV TLVSLIVFKV LGWYVAAARD
310 320 330 340 350
RSSDPGREED FNWSTAQDSR RGSVSSFEEQ VLHLPTVVGS YCIDGHHQSR
360 370 380 390 400
MAAQLVLSEL YRVQRLVTQV SRRLESIRRR SSSSSSSASS NTTDSDGGMS
410 420 430
TPLSSTTLVH LEDDLRKRLR AVSSETISIL RHA
Length:433
Mass (Da):46,566
Last modified:May 1, 2007 - v2
Checksum:iC9B8A0F83799472D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti340 – 3401S → T in AAC49195. (PubMed:8643646)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U34740 Genomic DNA. Translation: AAC49195.1.
AACD01000132 Genomic DNA. Translation: EAA61608.1.
BN001304 Genomic DNA. Translation: CBF80174.1.
PIRiS69999.
RefSeqiXP_681089.1. XM_675997.1.

Genome annotation databases

EnsemblFungiiCADANIAT00000963; CADANIAP00000963; CADANIAG00000963.
GeneIDi2869641.
KEGGiani:AN7820.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U34740 Genomic DNA. Translation: AAC49195.1 .
AACD01000132 Genomic DNA. Translation: EAA61608.1 .
BN001304 Genomic DNA. Translation: CBF80174.1 .
PIRi S69999.
RefSeqi XP_681089.1. XM_675997.1.

3D structure databases

ProteinModelPortali P52957.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 162425.CADANIAP00000963.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADANIAT00000963 ; CADANIAP00000963 ; CADANIAG00000963 .
GeneIDi 2869641.
KEGGi ani:AN7820.2.

Phylogenomic databases

eggNOGi NOG289594.
HOGENOMi HOG000033838.
InParanoidi P52957.
OMAi NTNEDEH.
OrthoDBi EOG77M8Z1.

Enzyme and pathway databases

UniPathwayi UPA00377 .

Family and domain databases

Gene3Di 4.10.240.10. 1 hit.
InterProi IPR002409. Aflatoxin_BRP.
IPR013700. AflR.
IPR001138. Zn2-C6_fun-type_DNA-bd.
[Graphical view ]
Pfami PF08493. AflR. 1 hit.
PF00172. Zn_clus. 1 hit.
[Graphical view ]
PRINTSi PR00755. AFLATOXINBRP.
SMARTi SM00066. GAL4. 1 hit.
[Graphical view ]
SUPFAMi SSF57701. SSF57701. 1 hit.
PROSITEi PS00463. ZN2_CY6_FUNGAL_1. 1 hit.
PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Twenty-five coregulated transcripts define a sterigmatocystin gene cluster in Aspergillus nidulans."
    Brown D.W., Yu J.-H., Kelkar H.S., Fernandes M., Nesbitt T.C., Keller N.P., Adams T.H., Leonard T.J.
    Proc. Natl. Acad. Sci. U.S.A. 93:1418-1422(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: FGSC 26.
  2. "Conservation of structure and function of the aflatoxin regulatory gene aflR from Aspergillus nidulans and A. flavus."
    Yu J.-H., Butchko R.A.E., Fernandes M., Keller N.P., Leonard T.J., Adams T.H.
    Curr. Genet. 29:549-555(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
  4. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
    Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
    , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
    Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

Entry informationi

Entry nameiAFLR_EMENI
AccessioniPrimary (citable) accession number: P52957
Secondary accession number(s): C8VDU4, Q5AV60
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 1, 2007
Last modified: October 29, 2014
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3