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Protein

Sterigmatocystin biosynthesis regulatory protein

Gene

aflR

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the regulation of sterigmatocystin biosynthesis.1 Publication

Pathwayi: sterigmatocystin biosynthesis

This protein regulates the pathway sterigmatocystin biosynthesis, which is part of Mycotoxin biosynthesis.
View all proteins of this organism that are known to be involved in the pathway sterigmatocystin biosynthesis and in Mycotoxin biosynthesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi28 – 55Zn(2)-C6 fungal-typePROSITE-ProRule annotationAdd BLAST28

GO - Molecular functioni

GO - Biological processi

  • aflatoxin biosynthetic process Source: InterPro
  • asperthecin biosynthetic process Source: AspGD
  • positive regulation of asperthecin biosynthetic process Source: AspGD
  • positive regulation of secondary metabolite biosynthetic process Source: AspGD
  • positive regulation of sterigmatocystin biosynthetic process Source: AspGD
  • positive regulation of transcription, DNA-templated Source: AspGD
  • positive regulation of transcription by RNA polymerase II Source: AspGD
  • sterigmatocystin biosynthetic process Source: AspGD
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00377

Names & Taxonomyi

Protein namesi
Recommended name:
Sterigmatocystin biosynthesis regulatory protein
Gene namesi
Name:aflR
ORF Names:AN7820
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000000560 Componenti: Chromosome IV
  • UP000005890 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001149341 – 433Sterigmatocystin biosynthesis regulatory proteinAdd BLAST433

Interactioni

Protein-protein interaction databases

STRINGi162425.CADANIAP00000963

Structurei

3D structure databases

ProteinModelPortaliP52957
SMRiP52957
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi381 – 390Poly-Ser10

Phylogenomic databases

HOGENOMiHOG000033838
InParanoidiP52957
OMAiACARCIE
OrthoDBiEOG092C2XOY

Family and domain databases

CDDicd00067 GAL4, 1 hit
Gene3Di4.10.240.10, 1 hit
InterProiView protein in InterPro
IPR013700 AflR
IPR001138 Zn2-C6_fun-type_DNA-bd
IPR036864 Zn2-C6_fun-type_DNA-bd_sf
PfamiView protein in Pfam
PF08493 AflR, 1 hit
PF00172 Zn_clus, 1 hit
SMARTiView protein in SMART
SM00066 GAL4, 1 hit
SUPFAMiSSF57701 SSF57701, 1 hit
PROSITEiView protein in PROSITE
PS00463 ZN2_CY6_FUNGAL_1, 1 hit
PS50048 ZN2_CY6_FUNGAL_2, 1 hit

Sequencei

Sequence statusi: Complete.

P52957-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPPAISQQS TPTAPGGTQG TRKLRESCIS CSRSKVKCNK EKPTCSRCVR
60 70 80 90 100
RGLPCEYMVS RRTGRTRVIG VEQPKTAPSP TTPTNTTAAT TATKAGPPVT
110 120 130 140 150
TDSAVHTPVI TTAPSPKPVQ IQSPPAEPDL WGAILSPNTS TSTDLSSLLS
160 170 180 190 200
VNTNFSQLFA SLSPSLLEGM DGMDAEMHAP ELGALSVADP SSSMMQGLEA
210 220 230 240 250
PNAAQPPSSN TTSHSYCLSI CLDTLMRLFP NAGANCERPG HESNPGKLFT
260 270 280 290 300
IESVIEDNKQ ILDTAQTILA CRCAEDEYVV TLVSLIVFKV LGWYVAAARD
310 320 330 340 350
RSSDPGREED FNWSTAQDSR RGSVSSFEEQ VLHLPTVVGS YCIDGHHQSR
360 370 380 390 400
MAAQLVLSEL YRVQRLVTQV SRRLESIRRR SSSSSSSASS NTTDSDGGMS
410 420 430
TPLSSTTLVH LEDDLRKRLR AVSSETISIL RHA
Length:433
Mass (Da):46,566
Last modified:May 1, 2007 - v2
Checksum:iC9B8A0F83799472D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti340S → T in AAC49195 (PubMed:8643646).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34740 Genomic DNA Translation: AAC49195.1
AACD01000132 Genomic DNA Translation: EAA61608.1
BN001304 Genomic DNA Translation: CBF80174.1
PIRiS69999
RefSeqiXP_681089.1, XM_675997.1

Genome annotation databases

EnsemblFungiiCADANIAT00000963; CADANIAP00000963; CADANIAG00000963
EAA61608; EAA61608; AN7820.2
GeneIDi2869641
KEGGiani:AN7820.2

Similar proteinsi

Entry informationi

Entry nameiAFLR_EMENI
AccessioniPrimary (citable) accession number: P52957
Secondary accession number(s): C8VDU4, Q5AV60
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 1, 2007
Last modified: March 28, 2018
This is version 106 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health