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P52957

- AFLR_EMENI

UniProt

P52957 - AFLR_EMENI

Protein

Sterigmatocystin biosynthesis regulatory protein

Gene

aflR

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed - Annotation score: 5 out of 5- Protein inferred from homologyi
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 2 (01 May 2007)
      Previous versions | rss
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    Functioni

    Involved in the regulation of sterigmatocystin biosynthesis.1 Publication

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi28 – 5528Zn(2)-C6 fungal-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: ASPGD
    2. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: InterPro
    3. sequence-specific DNA binding transcription factor activity Source: ASPGD
    4. zinc ion binding Source: InterPro

    GO - Biological processi

    1. aflatoxin biosynthetic process Source: InterPro
    2. asperthecin biosynthetic process Source: ASPGD
    3. monodictyphenone biosynthetic process Source: ASPGD
    4. positive regulation of asperthecin biosynthetic process Source: ASPGD
    5. positive regulation of secondary metabolite biosynthetic process Source: ASPGD
    6. positive regulation of sterigmatocystin biosynthetic process Source: ASPGD
    7. positive regulation of transcription, DNA-templated Source: ASPGD
    8. positive regulation of transcription from RNA polymerase II promoter Source: ASPGD
    9. regulation of secondary metabolic process Source: ASPGD
    10. sterigmatocystin biosynthetic process Source: ASPGD

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00377.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sterigmatocystin biosynthesis regulatory protein
    Gene namesi
    Name:aflR
    ORF Names:AN7820
    OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
    Taxonomic identifieri227321 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000000560: Chromosome IV

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: ASPGD

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 433433Sterigmatocystin biosynthesis regulatory proteinPRO_0000114934Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi162425.CADANIAP00000963.

    Structurei

    3D structure databases

    ProteinModelPortaliP52957.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi381 – 39010Poly-Ser

    Sequence similaritiesi

    Contains 1 Zn(2)-C6 fungal-type DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG289594.
    HOGENOMiHOG000033838.
    OMAiNTNEDEH.
    OrthoDBiEOG77M8Z1.

    Family and domain databases

    Gene3Di4.10.240.10. 1 hit.
    InterProiIPR002409. Aflatoxin_BRP.
    IPR013700. AflR.
    IPR001138. Zn2-C6_fun-type_DNA-bd.
    [Graphical view]
    PfamiPF08493. AflR. 1 hit.
    PF00172. Zn_clus. 1 hit.
    [Graphical view]
    PRINTSiPR00755. AFLATOXINBRP.
    SMARTiSM00066. GAL4. 1 hit.
    [Graphical view]
    SUPFAMiSSF57701. SSF57701. 1 hit.
    PROSITEiPS00463. ZN2_CY6_FUNGAL_1. 1 hit.
    PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P52957-1 [UniParc]FASTAAdd to Basket

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    MEPPAISQQS TPTAPGGTQG TRKLRESCIS CSRSKVKCNK EKPTCSRCVR    50
    RGLPCEYMVS RRTGRTRVIG VEQPKTAPSP TTPTNTTAAT TATKAGPPVT 100
    TDSAVHTPVI TTAPSPKPVQ IQSPPAEPDL WGAILSPNTS TSTDLSSLLS 150
    VNTNFSQLFA SLSPSLLEGM DGMDAEMHAP ELGALSVADP SSSMMQGLEA 200
    PNAAQPPSSN TTSHSYCLSI CLDTLMRLFP NAGANCERPG HESNPGKLFT 250
    IESVIEDNKQ ILDTAQTILA CRCAEDEYVV TLVSLIVFKV LGWYVAAARD 300
    RSSDPGREED FNWSTAQDSR RGSVSSFEEQ VLHLPTVVGS YCIDGHHQSR 350
    MAAQLVLSEL YRVQRLVTQV SRRLESIRRR SSSSSSSASS NTTDSDGGMS 400
    TPLSSTTLVH LEDDLRKRLR AVSSETISIL RHA 433
    Length:433
    Mass (Da):46,566
    Last modified:May 1, 2007 - v2
    Checksum:iC9B8A0F83799472D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti340 – 3401S → T in AAC49195. (PubMed:8643646)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U34740 Genomic DNA. Translation: AAC49195.1.
    AACD01000132 Genomic DNA. Translation: EAA61608.1.
    BN001304 Genomic DNA. Translation: CBF80174.1.
    PIRiS69999.
    RefSeqiXP_681089.1. XM_675997.1.

    Genome annotation databases

    EnsemblFungiiCADANIAT00000963; CADANIAP00000963; CADANIAG00000963.
    GeneIDi2869641.
    KEGGiani:AN7820.2.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U34740 Genomic DNA. Translation: AAC49195.1 .
    AACD01000132 Genomic DNA. Translation: EAA61608.1 .
    BN001304 Genomic DNA. Translation: CBF80174.1 .
    PIRi S69999.
    RefSeqi XP_681089.1. XM_675997.1.

    3D structure databases

    ProteinModelPortali P52957.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 162425.CADANIAP00000963.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADANIAT00000963 ; CADANIAP00000963 ; CADANIAG00000963 .
    GeneIDi 2869641.
    KEGGi ani:AN7820.2.

    Phylogenomic databases

    eggNOGi NOG289594.
    HOGENOMi HOG000033838.
    OMAi NTNEDEH.
    OrthoDBi EOG77M8Z1.

    Enzyme and pathway databases

    UniPathwayi UPA00377 .

    Family and domain databases

    Gene3Di 4.10.240.10. 1 hit.
    InterProi IPR002409. Aflatoxin_BRP.
    IPR013700. AflR.
    IPR001138. Zn2-C6_fun-type_DNA-bd.
    [Graphical view ]
    Pfami PF08493. AflR. 1 hit.
    PF00172. Zn_clus. 1 hit.
    [Graphical view ]
    PRINTSi PR00755. AFLATOXINBRP.
    SMARTi SM00066. GAL4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57701. SSF57701. 1 hit.
    PROSITEi PS00463. ZN2_CY6_FUNGAL_1. 1 hit.
    PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Twenty-five coregulated transcripts define a sterigmatocystin gene cluster in Aspergillus nidulans."
      Brown D.W., Yu J.-H., Kelkar H.S., Fernandes M., Nesbitt T.C., Keller N.P., Adams T.H., Leonard T.J.
      Proc. Natl. Acad. Sci. U.S.A. 93:1418-1422(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: FGSC 26.
    2. "Conservation of structure and function of the aflatoxin regulatory gene aflR from Aspergillus nidulans and A. flavus."
      Yu J.-H., Butchko R.A.E., Fernandes M., Keller N.P., Leonard T.J., Adams T.H.
      Curr. Genet. 29:549-555(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
    4. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
      Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
      , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
      Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

    Entry informationi

    Entry nameiAFLR_EMENI
    AccessioniPrimary (citable) accession number: P52957
    Secondary accession number(s): C8VDU4, Q5AV60
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: May 1, 2007
    Last modified: October 1, 2014
    This is version 86 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3