Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transcription factor LBX1

Gene

Lbx1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor required for the development of GABAergic interneurons in the dorsal horn of the spinal cord and migration and further development of hypaxial muscle precursor cells for limb muscles, diaphragm and hypoglossal cord.3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi125 – 184HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

  • DNA binding transcription factor activity Source: MGI
  • sequence-specific DNA binding Source: InterPro

GO - Biological processi

  • heart looping Source: MGI
  • muscle organ development Source: UniProtKB-KW
  • negative regulation of cell proliferation Source: MGI
  • negative regulation of neuron differentiation Source: MGI
  • neuron fate commitment Source: MGI
  • neuron fate determination Source: MGI
  • regulation of transcription, DNA-templated Source: MGI
  • regulation of transcription from RNA polymerase II promoter involved in spinal cord association neuron specification Source: MGI
  • spinal cord motor neuron differentiation Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, Myogenesis, Neurogenesis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor LBX1
Alternative name(s):
Ladybird homeobox protein homolog 1
Gene namesi
Name:Lbx1
Synonyms:Lbx1h
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:104867 Lbx1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Death at birth. Mice fail to expand their lungs and do not move their abnormally thin limbs.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000491671 – 282Transcription factor LBX1Add BLAST282

Proteomic databases

PaxDbiP52955
PRIDEiP52955

PTM databases

iPTMnetiP52955
PhosphoSitePlusiP52955

Expressioni

Tissue specificityi

Expressed in the dorsal part of the spinal cord and hindbrain and in presumptive myogenic cells in lateral regions of differentiating somites.1 Publication

Developmental stagei

Expressed in the developing central nervous system from 10.5 dpc to 16.5 dpc. Expressed in presumptive myogenic cells from 9.5 dpc until 16.5 dpc with highest levels at 10.5-11.5 dpc.1 Publication

Gene expression databases

BgeeiENSMUSG00000025216
CleanExiMM_LBX1
GenevisibleiP52955 MM

Interactioni

Subunit structurei

Interacts with SKOR1 which acts as a transcriptional corepressor.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Skor1Q8BX462EBI-604594,EBI-604451

Protein-protein interaction databases

BioGridi201117, 1 interactor
IntActiP52955, 2 interactors
STRINGi10090.ENSMUSP00000096997

Structurei

3D structure databases

ProteinModelPortaliP52955
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi219 – 227Poly-Gly9
Compositional biasi271 – 282Asp/Glu-rich (highly acidic)Add BLAST12

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0488 Eukaryota
ENOG411188D LUCA
GeneTreeiENSGT00910000143996
HOGENOMiHOG000007247
HOVERGENiHBG006244
InParanoidiP52955
KOiK09353
OMAiHTTSKEC
OrthoDBiEOG091G09CY
PhylomeDBiP52955
TreeFamiTF325047

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR000047 HTH_motif
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00031 HTHREPRESSR
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P52955-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSKEDGKAA PGEERRRSPL DHLPPPANSN KPLTPFSIED ILNKPSVRRS
60 70 80 90 100
YSLCGAAHLL AAADKHAPGG LPLAGRALLS QTSPLCALEE LASKTFKGLE
110 120 130 140 150
VSVLQAAEGR DGMTIFGQRQ TPKKRRKSRT AFTNHQIYEL EKRFLYQKYL
160 170 180 190 200
SPADRDQIAQ QLGLTNAQVI TWFQNRRAKL KRDLEEMKAD VESAKKLGPS
210 220 230 240 250
GQMDIVALAE LEQNSEASGG GGGGGCGRAK SRPGSPALPP GAPQAPGGGP
260 270 280
LQLSPASPLT DQRASSQDCS EDEEDEEIDV DD
Length:282
Mass (Da):30,262
Last modified:November 14, 2006 - v2
Checksum:i3A4A80CD47B0228C
GO

Sequence cautioni

The sequence BAE25939 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti33 – 72LTPFS…PGGLP → YAVQHRGHPQQAVRAEKLLA VWGGAPAGGRGQARAGRLA in CAA62343 (PubMed:8645601).CuratedAdd BLAST40
Sequence conflicti225Missing in CAA62343 (PubMed:8645601).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X90829 mRNA Translation: CAA62343.1
AB108497 mRNA Translation: BAC75634.1
BC119177 mRNA Translation: AAI19178.1
BC120586 mRNA Translation: AAI20587.1
AK144562 mRNA Translation: BAE25939.1 Different initiation.
CCDSiCCDS29859.1
RefSeqiNP_034821.2, NM_010691.5
XP_006526785.1, XM_006526722.3
UniGeneiMm.116815

Genome annotation databases

EnsembliENSMUST00000099401; ENSMUSP00000096997; ENSMUSG00000025216
GeneIDi16814
KEGGimmu:16814
UCSCiuc008hqv.1 mouse

Similar proteinsi

Entry informationi

Entry nameiLBX1_MOUSE
AccessioniPrimary (citable) accession number: P52955
Secondary accession number(s): Q3UN09, Q80XA3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 14, 2006
Last modified: May 23, 2018
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health