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P52955

- LBX1_MOUSE

UniProt

P52955 - LBX1_MOUSE

Protein

Transcription factor LBX1

Gene

Lbx1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 2 (14 Nov 2006)
      Previous versions | rss
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    Functioni

    Transcription factor required for the development of GABAergic interneurons in the dorsal horn of the spinal cord and migration and further development of hypaxial muscle precursor cells for limb muscles, diaphragm and hypoglossal cord.3 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi125 – 18460HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. sequence-specific DNA binding transcription factor activity Source: MGI
    3. transcription regulatory region sequence-specific DNA binding Source: InterPro

    GO - Biological processi

    1. heart looping Source: MGI
    2. muscle organ development Source: UniProtKB-KW
    3. negative regulation of cell proliferation Source: MGI
    4. negative regulation of neuron differentiation Source: MGI
    5. neuron fate commitment Source: MGI
    6. neuron fate determination Source: MGI
    7. regulation of transcription, DNA-templated Source: MGI
    8. regulation of transcription from RNA polymerase II promoter involved in spinal cord association neuron specification Source: MGI
    9. spinal cord motor neuron differentiation Source: MGI
    10. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Myogenesis, Neurogenesis, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription factor LBX1
    Alternative name(s):
    Ladybird homeobox protein homolog 1
    Gene namesi
    Name:Lbx1
    Synonyms:Lbx1h
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 19

    Organism-specific databases

    MGIiMGI:104867. Lbx1.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell
    2. transcription factor complex Source: MGI

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Disruption phenotypei

    Death at birth. Mice fail to expand their lungs and do not move their abnormally thin limbs.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 282282Transcription factor LBX1PRO_0000049167Add
    BLAST

    Proteomic databases

    PRIDEiP52955.

    Expressioni

    Tissue specificityi

    Expressed in the dorsal part of the spinal cord and hindbrain and in presumptive myogenic cells in lateral regions of differentiating somites.1 Publication

    Developmental stagei

    Expressed in the developing central nervous system from 10.5 dpc to 16.5 dpc. Expressed in presumptive myogenic cells from 9.5 dpc until 16.5 dpc with highest levels at 10.5-11.5 dpc.1 Publication

    Gene expression databases

    BgeeiP52955.
    CleanExiMM_LBX1.
    GenevestigatoriP52955.

    Interactioni

    Subunit structurei

    Interacts with SKOR1 which acts as a transcriptional corepressor.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Skor1Q8BX462EBI-604594,EBI-604451

    Protein-protein interaction databases

    BioGridi201117. 1 interaction.
    IntActiP52955. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliP52955.
    SMRiP52955. Positions 124-182.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi219 – 2279Poly-Gly
    Compositional biasi271 – 28212Asp/Glu-rich (highly acidic)Add
    BLAST

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG240187.
    GeneTreeiENSGT00740000114906.
    HOGENOMiHOG000007247.
    HOVERGENiHBG006244.
    InParanoidiP52955.
    KOiK09353.
    OMAiNSEATAG.
    OrthoDBiEOG7X3QRB.
    PhylomeDBiP52955.
    TreeFamiTF325047.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR000047. HTH_motif.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00031. HTHREPRESSR.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P52955-1 [UniParc]FASTAAdd to Basket

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    MTSKEDGKAA PGEERRRSPL DHLPPPANSN KPLTPFSIED ILNKPSVRRS    50
    YSLCGAAHLL AAADKHAPGG LPLAGRALLS QTSPLCALEE LASKTFKGLE 100
    VSVLQAAEGR DGMTIFGQRQ TPKKRRKSRT AFTNHQIYEL EKRFLYQKYL 150
    SPADRDQIAQ QLGLTNAQVI TWFQNRRAKL KRDLEEMKAD VESAKKLGPS 200
    GQMDIVALAE LEQNSEASGG GGGGGCGRAK SRPGSPALPP GAPQAPGGGP 250
    LQLSPASPLT DQRASSQDCS EDEEDEEIDV DD 282
    Length:282
    Mass (Da):30,262
    Last modified:November 14, 2006 - v2
    Checksum:i3A4A80CD47B0228C
    GO

    Sequence cautioni

    The sequence BAE25939.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti33 – 7240LTPFS…PGGLP → YAVQHRGHPQQAVRAEKLLA VWGGAPAGGRGQARAGRLA in CAA62343. (PubMed:8645601)CuratedAdd
    BLAST
    Sequence conflicti225 – 2251Missing in CAA62343. (PubMed:8645601)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X90829 mRNA. Translation: CAA62343.1.
    AB108497 mRNA. Translation: BAC75634.1.
    BC119177 mRNA. Translation: AAI19178.1.
    BC120586 mRNA. Translation: AAI20587.1.
    AK144562 mRNA. Translation: BAE25939.1. Different initiation.
    CCDSiCCDS29859.1.
    RefSeqiNP_034821.2. NM_010691.5.
    XP_006526785.1. XM_006526722.1.
    UniGeneiMm.116815.

    Genome annotation databases

    EnsembliENSMUST00000099401; ENSMUSP00000096997; ENSMUSG00000025216.
    GeneIDi16814.
    KEGGimmu:16814.
    UCSCiuc008hqv.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X90829 mRNA. Translation: CAA62343.1 .
    AB108497 mRNA. Translation: BAC75634.1 .
    BC119177 mRNA. Translation: AAI19178.1 .
    BC120586 mRNA. Translation: AAI20587.1 .
    AK144562 mRNA. Translation: BAE25939.1 . Different initiation.
    CCDSi CCDS29859.1.
    RefSeqi NP_034821.2. NM_010691.5.
    XP_006526785.1. XM_006526722.1.
    UniGenei Mm.116815.

    3D structure databases

    ProteinModelPortali P52955.
    SMRi P52955. Positions 124-182.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 201117. 1 interaction.
    IntActi P52955. 2 interactions.

    Proteomic databases

    PRIDEi P52955.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000099401 ; ENSMUSP00000096997 ; ENSMUSG00000025216 .
    GeneIDi 16814.
    KEGGi mmu:16814.
    UCSCi uc008hqv.1. mouse.

    Organism-specific databases

    CTDi 10660.
    MGIi MGI:104867. Lbx1.

    Phylogenomic databases

    eggNOGi NOG240187.
    GeneTreei ENSGT00740000114906.
    HOGENOMi HOG000007247.
    HOVERGENi HBG006244.
    InParanoidi P52955.
    KOi K09353.
    OMAi NSEATAG.
    OrthoDBi EOG7X3QRB.
    PhylomeDBi P52955.
    TreeFami TF325047.

    Miscellaneous databases

    NextBioi 290692.
    PROi P52955.
    SOURCEi Search...

    Gene expression databases

    Bgeei P52955.
    CleanExi MM_LBX1.
    Genevestigatori P52955.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR000047. HTH_motif.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00031. HTHREPRESSR.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mouse Lbx1 and human LBX1 define a novel mammalian homeobox gene family related to the Drosophila lady bird genes."
      Jagla K., Dolle P., Mattei M.-G., Jagla T., Schuhbaur B., Dretzen G., Bellard F., Bellard M.
      Mech. Dev. 53:345-356(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
      Strain: BALB/c.
    2. Jagla K.
      Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    3. "Mouse homeobox gene Lbx1 in myogenesis."
      Kurose T., Endo T.
      Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: ICR.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    5. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 50-282.
      Strain: C57BL/6J.
      Tissue: Medulla oblongata.
    6. "The role of Lbx1 in migration of muscle precursor cells."
      Brohmann H., Jagla K., Birchmeier C.
      Development 127:437-445(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE.
    7. "The homeodomain factor lbx1 distinguishes two major programs of neuronal differentiation in the dorsal spinal cord."
      Muller T., Brohmann H., Pierani A., Heppenstall P.A., Lewin G.R., Jessell T.M., Birchmeier C.
      Neuron 34:551-562(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    8. "Corl1, a novel neuronal lineage-specific transcriptional corepressor for the homeodomain transcription factor Lbx1."
      Mizuhara E., Nakatani T., Minaki Y., Sakamoto Y., Ono Y.
      J. Biol. Chem. 280:3645-3655(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SKOR1.
    9. "Lbx1 and Tlx3 are opposing switches in determining GABAergic versus glutamatergic transmitter phenotypes."
      Cheng L., Samad O.A., Xu Y., Mizuguchi R., Luo P., Shirasawa S., Goulding M., Ma Q.
      Nat. Neurosci. 8:1510-1515(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiLBX1_MOUSE
    AccessioniPrimary (citable) accession number: P52955
    Secondary accession number(s): Q3UN09, Q80XA3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: November 14, 2006
    Last modified: October 1, 2014
    This is version 117 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3