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Protein

Transcription factor LBX1

Gene

Lbx1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor required for the development of GABAergic interneurons in the dorsal horn of the spinal cord and migration and further development of hypaxial muscle precursor cells for limb muscles, diaphragm and hypoglossal cord.3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi125 – 184HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • heart looping Source: MGI
  • muscle organ development Source: UniProtKB-KW
  • negative regulation of cell proliferation Source: MGI
  • negative regulation of neuron differentiation Source: MGI
  • neuron fate commitment Source: MGI
  • neuron fate determination Source: MGI
  • regulation of transcription, DNA-templated Source: MGI
  • regulation of transcription from RNA polymerase II promoter involved in spinal cord association neuron specification Source: MGI
  • spinal cord motor neuron differentiation Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, Myogenesis, Neurogenesis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor LBX1
Alternative name(s):
Ladybird homeobox protein homolog 1
Gene namesi
Name:Lbx1
Synonyms:Lbx1h
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:104867. Lbx1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Death at birth. Mice fail to expand their lungs and do not move their abnormally thin limbs.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000491671 – 282Transcription factor LBX1Add BLAST282

Proteomic databases

PaxDbiP52955.
PRIDEiP52955.

PTM databases

iPTMnetiP52955.
PhosphoSitePlusiP52955.

Expressioni

Tissue specificityi

Expressed in the dorsal part of the spinal cord and hindbrain and in presumptive myogenic cells in lateral regions of differentiating somites.1 Publication

Developmental stagei

Expressed in the developing central nervous system from 10.5 dpc to 16.5 dpc. Expressed in presumptive myogenic cells from 9.5 dpc until 16.5 dpc with highest levels at 10.5-11.5 dpc.1 Publication

Gene expression databases

BgeeiENSMUSG00000025216.
CleanExiMM_LBX1.
GenevisibleiP52955. MM.

Interactioni

Subunit structurei

Interacts with SKOR1 which acts as a transcriptional corepressor.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Skor1Q8BX462EBI-604594,EBI-604451

Protein-protein interaction databases

BioGridi201117. 1 interactor.
IntActiP52955. 2 interactors.
STRINGi10090.ENSMUSP00000096997.

Structurei

3D structure databases

ProteinModelPortaliP52955.
SMRiP52955.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi219 – 227Poly-Gly9
Compositional biasi271 – 282Asp/Glu-rich (highly acidic)Add BLAST12

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0488. Eukaryota.
ENOG411188D. LUCA.
GeneTreeiENSGT00890000139333.
HOGENOMiHOG000007247.
HOVERGENiHBG006244.
InParanoidiP52955.
KOiK09353.
OMAiHTTSKEC.
OrthoDBiEOG091G09CY.
PhylomeDBiP52955.
TreeFamiTF325047.

Family and domain databases

CDDicd00086. homeodomain. 1 hit.
InterProiView protein in InterPro
IPR009057. Homeobox-like_sf.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR000047. HTH_motif.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PRINTSiPR00031. HTHREPRESSR.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P52955-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSKEDGKAA PGEERRRSPL DHLPPPANSN KPLTPFSIED ILNKPSVRRS
60 70 80 90 100
YSLCGAAHLL AAADKHAPGG LPLAGRALLS QTSPLCALEE LASKTFKGLE
110 120 130 140 150
VSVLQAAEGR DGMTIFGQRQ TPKKRRKSRT AFTNHQIYEL EKRFLYQKYL
160 170 180 190 200
SPADRDQIAQ QLGLTNAQVI TWFQNRRAKL KRDLEEMKAD VESAKKLGPS
210 220 230 240 250
GQMDIVALAE LEQNSEASGG GGGGGCGRAK SRPGSPALPP GAPQAPGGGP
260 270 280
LQLSPASPLT DQRASSQDCS EDEEDEEIDV DD
Length:282
Mass (Da):30,262
Last modified:November 14, 2006 - v2
Checksum:i3A4A80CD47B0228C
GO

Sequence cautioni

The sequence BAE25939 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti33 – 72LTPFS…PGGLP → YAVQHRGHPQQAVRAEKLLA VWGGAPAGGRGQARAGRLA in CAA62343 (PubMed:8645601).CuratedAdd BLAST40
Sequence conflicti225Missing in CAA62343 (PubMed:8645601).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X90829 mRNA. Translation: CAA62343.1.
AB108497 mRNA. Translation: BAC75634.1.
BC119177 mRNA. Translation: AAI19178.1.
BC120586 mRNA. Translation: AAI20587.1.
AK144562 mRNA. Translation: BAE25939.1. Different initiation.
CCDSiCCDS29859.1.
RefSeqiNP_034821.2. NM_010691.5.
XP_006526785.1. XM_006526722.3.
UniGeneiMm.116815.

Genome annotation databases

EnsembliENSMUST00000099401; ENSMUSP00000096997; ENSMUSG00000025216.
GeneIDi16814.
KEGGimmu:16814.
UCSCiuc008hqv.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiLBX1_MOUSE
AccessioniPrimary (citable) accession number: P52955
Secondary accession number(s): Q3UN09, Q80XA3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 14, 2006
Last modified: November 22, 2017
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot