Reviewed,
UniProtKB/Swiss-Prot P52955 (LBX1_MOUSE)
Last modified
June 16, 2009.
Version 71.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Transcription factor LBX1 Alternative name(s): Ladybird homeobox protein homolog 1 | ||||
| Gene names |
| ||||
| Organism | Mus musculus (Mouse) | ||||
| Taxonomic identifier | 10090 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 282 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Transcription factor required for the development of GABAergic interneurons in the dorsal horn of the spinal cord and migration and further development of hypaxial muscle precursor cells for limb muscles, diaphragm and hypoglossal cord. Ref.6 Ref.7 Ref.9 |
| Subunit structure | Interacts with LBXCOR1 which acts as a transcriptional corepressor. Ref.8 |
| Subcellular location | Nucleus Probable. |
| Tissue specificity | Expressed in the dorsal part of the spinal cord and hindbrain and in presumptive myogenic cells in lateral regions of differentiating somites. Ref.1 |
| Developmental stage | Expressed in the developing central nervous system from 10.5 dpc to 16.5 dpc. Expressed in presumptive myogenic cells from 9.5 dpc until 16.5 dpc with highest levels at 10.5-11.5 dpc. Ref.1 |
| Disruption phenotype | Death at birth. Mice fail to expand their lungs and do not move their abnormally thin limbs. Ref.6 |
| Sequence similarities | Contains 1 homeobox DNA-binding domain. |
Ontologies
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| Lbxcor1 | Q8BX46 | 1 | EBI-604594,EBI-604451 | |
| Tle1 | Q62440 | 1 | EBI-604594,EBI-604471 |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 282 | 282 | Transcription factor LBX1 | PRO_0000049167 | |||||
Regions | |||||||||
| DNA binding | 125 – 184 | 60 | Homeobox | ||||||
| Compositional bias | 219 – 227 | 9 | Poly-Gly | ||||||
| Compositional bias | 271 – 282 | 12 | Asp/Glu-rich (highly acidic) | ||||||
Experimental info | |||||||||
| Sequence conflict | 33 – 72 | 40 | LTPFS…PGGLP → YAVQHRGHPQQAVRAEKLLA VWGGAPAGGRGQARAGRLA in CAA62343. Ref.1 | ||||||
| Sequence conflict | 225 | 1 | Missing in CAA62343. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Mouse Lbx1 and human LBX1 define a novel mammalian homeobox gene family related to the Drosophila lady bird genes." Jagla K., Dolle P., Mattei M.-G., Jagla T., Schuhbaur B., Dretzen G., Bellard F., Bellard M. Mech. Dev. 53:345-356(1995) [PubMed: 8645601] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE. Strain: BALB/c. |
| [2] | Jagla K. Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION. |
| [3] | "Mouse homeobox gene Lbx1 in myogenesis." Kurose T., Endo T. Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: ICR. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain. |
| [5] | "The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y.Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 50-282. Strain: C57BL/6J. Tissue: Medulla oblongata. |
| [6] | "The role of Lbx1 in migration of muscle precursor cells." Brohmann H., Jagla K., Birchmeier C. Development 127:437-445(2000) [PubMed: 10603359] [Abstract] Cited for: FUNCTION, DISRUPTION PHENOTYPE. |
| [7] | "The homeodomain factor lbx1 distinguishes two major programs of neuronal differentiation in the dorsal spinal cord." Muller T., Brohmann H., Pierani A., Heppenstall P.A., Lewin G.R., Jessell T.M., Birchmeier C. Neuron 34:551-562(2002) [PubMed: 12062039] [Abstract] Cited for: FUNCTION. |
| [8] | "Corl1, a novel neuronal lineage-specific transcriptional corepressor for the homeodomain transcription factor Lbx1." Mizuhara E., Nakatani T., Minaki Y., Sakamoto Y., Ono Y. J. Biol. Chem. 280:3645-3655(2005) [PubMed: 15528197] [Abstract] Cited for: INTERACTION WITH LBXCOR1. |
| [9] | "Lbx1 and Tlx3 are opposing switches in determining GABAergic versus glutamatergic transmitter phenotypes." Cheng L., Samad O.A., Xu Y., Mizuguchi R., Luo P., Shirasawa S., Goulding M., Ma Q. Nat. Neurosci. 8:1510-1515(2005) [PubMed: 16234809] [Abstract] Cited for: FUNCTION. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| X90829 mRNA. Translation: CAA62343.1. AB108497 mRNA. Translation: BAC75634.1. BC119177 mRNA. Translation: AAI19178.1. BC120586 mRNA. Translation: AAI20587.1. AK144562 mRNA. Translation: BAE25939.1. Different initiation. | |
| IPI | IPI00132589. |
| RefSeq | NP_034821.2. |
| UniGene | Mm.116815 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1IG7 based on UniProtKB P13297. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | P52955. 2 interactions. |
Genome annotation databases | |
| Ensembl | ENSMUSG00000025216. Mus musculus. [Contig view] |
| GeneID | 16814. |
| KEGG | mmu:16814. |
Organism-specific databases | |
| MGI | MGI:104867. Lbx1. |
Phylogenomic databases | |
| HOVERGEN | P52955. |
| OMA | P52955. NSEATAG. |
Gene expression databases | |
| ArrayExpress | P52955. |
| Bgee | P52955. |
| CleanEx | MM_LBX1. |
| GermOnline | ENSMUSG00000025216. Mus musculus. |
Family and domain databases | |
| InterPro | IPR001356. Homeobox. IPR017970. Homeobox_CS. IPR012287. Homeodomain-rel. IPR000047. HTH_lambrepressr. IPR015704. Lbx_related. [Graphical view] |
| Gene3D | G3DSA:1.10.10.60. Homeodomain-rel. 1 hit. |
| PANTHER | PTHR19418:SF144. Lbx_related. 1 hit. |
| Pfam | PF00046. Homeobox. 1 hit. [Graphical view] |
| PRINTS | PR00031. HTHREPRESSR. |
| ProDom | PD000010. Homeobox. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| SMART | SM00389. HOX. 1 hit. [Graphical view] |
| PROSITE | PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 290692. |
| SOURCE | Search... |
Entry information
| Entry name | LBX1_MOUSE | ||||||||
| Accession | Primary (citable) accession number: P52955 Secondary accession number(s): Q3UN09, Q80XA3 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


