UniProtKB - P52954 (LBX1_HUMAN)
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Protein
Transcription factor LBX1
Gene
LBX1
Organism
Homo sapiens (Human)
Status
Functioni
Transcription factor required for the development of GABAergic interneurons in the dorsal horn of the spinal cord and migration and further development of hypaxial muscle precursor cells for limb muscles, diaphragm and hypoglossal cord.By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 125 – 184 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB
- sequence-specific DNA binding Source: InterPro
GO - Biological processi
- anatomical structure morphogenesis Source: ProtInc
- heart looping Source: Ensembl
- muscle organ development Source: UniProtKB-KW
- negative regulation of cell proliferation Source: Ensembl
- negative regulation of neuron differentiation Source: Ensembl
- neuron fate determination Source: Ensembl
- regulation of transcription from RNA polymerase II promoter involved in spinal cord association neuron specification Source: Ensembl
- spinal cord motor neuron differentiation Source: Ensembl
- transcription, DNA-templated Source: UniProtKB-KW
Keywordsi
Molecular function | Developmental protein, DNA-binding |
Biological process | Differentiation, Myogenesis, Neurogenesis, Transcription, Transcription regulation |
Enzyme and pathway databases
SIGNORi | P52954. |
Names & Taxonomyi
Protein namesi | Recommended name: Transcription factor LBX1Alternative name(s): Ladybird homeobox protein homolog 1 |
Gene namesi | Name:LBX1 Synonyms:LBX1H |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000138136.6. |
HGNCi | HGNC:16960. LBX1. |
MIMi | 604255. gene. |
neXtProti | NX_P52954. |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 10660. |
OpenTargetsi | ENSG00000138136. |
PharmGKBi | PA142671561. |
Polymorphism and mutation databases
BioMutai | LBX1. |
DMDMi | 117949813. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000049166 | 1 – 281 | Transcription factor LBX1Add BLAST | 281 |
Proteomic databases
PaxDbi | P52954. |
PeptideAtlasi | P52954. |
PRIDEi | P52954. |
PTM databases
iPTMneti | P52954. |
PhosphoSitePlusi | P52954. |
Expressioni
Gene expression databases
Bgeei | ENSG00000138136. |
CleanExi | HS_LBX1. |
Genevisiblei | P52954. HS. |
Organism-specific databases
HPAi | HPA002016. HPA002086. |
Interactioni
Subunit structurei
Interacts with SKOR1 which acts as a transcriptional corepressor.By similarity
Protein-protein interaction databases
BioGridi | 115903. 1 interactor. |
STRINGi | 9606.ENSP00000359212. |
Structurei
3D structure databases
ProteinModelPortali | P52954. |
SMRi | P52954. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 220 – 226 | Poly-Gly | 7 | |
Compositional biasi | 270 – 281 | Asp/Glu-rich (highly acidic)Add BLAST | 12 |
Keywords - Domaini
HomeoboxPhylogenomic databases
eggNOGi | KOG0488. Eukaryota. ENOG411188D. LUCA. |
GeneTreei | ENSGT00910000143996. |
HOGENOMi | HOG000007247. |
HOVERGENi | HBG006244. |
InParanoidi | P52954. |
KOi | K09353. |
OMAi | HTTSKEC. |
OrthoDBi | EOG091G09CY. |
PhylomeDBi | P52954. |
TreeFami | TF325047. |
Family and domain databases
CDDi | cd00086. homeodomain. 1 hit. |
InterProi | View protein in InterPro IPR009057. Homeobox-like_sf. IPR017970. Homeobox_CS. IPR001356. Homeobox_dom. IPR000047. HTH_motif. |
Pfami | View protein in Pfam PF00046. Homeobox. 1 hit. |
PRINTSi | PR00031. HTHREPRESSR. |
SMARTi | View protein in SMART SM00389. HOX. 1 hit. |
SUPFAMi | SSF46689. SSF46689. 1 hit. |
PROSITEi | View protein in PROSITE PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. |
i Sequence
Sequence statusi: Complete.
P52954-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTSKEDGKAA PGEERRRSPL DHLPPPANSN KPLTPFSIED ILNKPSVRRS
60 70 80 90 100
YSLCGAAHLL AAADKHAQGG LPLAGRALLS QTSPLCALEE LASKTFKGLE
110 120 130 140 150
VSVLQAAEGR DGMTIFGQRQ TPKKRRKSRT AFTNHQIYEL EKRFLYQKYL
160 170 180 190 200
SPADRDQIAQ QLGLTNAQVI TWFQNRRAKL KRDLEEMKAD VESAKKLGPS
210 220 230 240 250
GQMDIVALAE LEQNSEATAG GGGGCGRAKS RPGSPVLPPG APKAPGAGAL
260 270 280
QLSPASPLTD QPASSQDCSE DEEDEEIDVD D
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 33 – 72 | LTPFS…QGGLP → YAVQHRGHPQQAVRAEKLLA AWGGAPAGRRGQARAGRLA in CAA62342 (PubMed:8645601).CuratedAdd BLAST | 40 | |
Sequence conflicti | 81 | Q → K in CAA62342 (PubMed:8645601).Curated | 1 | |
Sequence conflicti | 183 | D → E in CAA62342 (PubMed:8645601).Curated | 1 | |
Sequence conflicti | 194 | A → P in CAA62342 (PubMed:8645601).Curated | 1 | |
Sequence conflicti | 247 – 248 | AG → RC in CAA62342 (PubMed:8645601).Curated | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X90828 mRNA. Translation: CAA62342.1. AL135794 Genomic DNA. No translation available. CH471066 Genomic DNA. Translation: EAW49777.1. BC069156 mRNA. Translation: AAH69156.1. BC136321 mRNA. Translation: AAI36322.1. |
CCDSi | CCDS31270.1. |
RefSeqi | NP_006553.2. NM_006562.4. |
UniGenei | Hs.37128. |
Genome annotation databases
Ensembli | ENST00000370193; ENSP00000359212; ENSG00000138136. |
GeneIDi | 10660. |
KEGGi | hsa:10660. |
UCSCi | uc001ksx.4. human. |
Similar proteinsi
Entry informationi
Entry namei | LBX1_HUMAN | |
Accessioni | P52954Primary (citable) accession number: P52954 Secondary accession number(s): B9EGA2, Q05BB2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | November 14, 2006 | |
Last modified: | March 28, 2018 | |
This is version 141 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |