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Protein

Transcription factor LBX1

Gene

LBX1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcription factor required for the development of GABAergic interneurons in the dorsal horn of the spinal cord and migration and further development of hypaxial muscle precursor cells for limb muscles, diaphragm and hypoglossal cord.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi125 – 184HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, Myogenesis, Neurogenesis, Transcription, Transcription regulation

Enzyme and pathway databases

SIGNORiP52954

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor LBX1
Alternative name(s):
Ladybird homeobox protein homolog 1
Gene namesi
Name:LBX1
Synonyms:LBX1H
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000138136.6
HGNCiHGNC:16960 LBX1
MIMi604255 gene
neXtProtiNX_P52954

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi10660
OpenTargetsiENSG00000138136
PharmGKBiPA142671561

Polymorphism and mutation databases

BioMutaiLBX1
DMDMi117949813

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000491661 – 281Transcription factor LBX1Add BLAST281

Proteomic databases

PaxDbiP52954
PeptideAtlasiP52954
PRIDEiP52954
ProteomicsDBi56564

PTM databases

iPTMnetiP52954
PhosphoSitePlusiP52954

Expressioni

Gene expression databases

BgeeiENSG00000138136
CleanExiHS_LBX1
GenevisibleiP52954 HS

Organism-specific databases

HPAiHPA002016
HPA002086

Interactioni

Subunit structurei

Interacts with SKOR1 which acts as a transcriptional corepressor.By similarity

Protein-protein interaction databases

BioGridi115903, 1 interactor
STRINGi9606.ENSP00000359212

Structurei

3D structure databases

ProteinModelPortaliP52954
SMRiP52954
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi220 – 226Poly-Gly7
Compositional biasi270 – 281Asp/Glu-rich (highly acidic)Add BLAST12

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0488 Eukaryota
ENOG411188D LUCA
GeneTreeiENSGT00910000143996
HOGENOMiHOG000007247
HOVERGENiHBG006244
InParanoidiP52954
KOiK09353
OMAiHTTSKEC
OrthoDBiEOG091G09CY
PhylomeDBiP52954
TreeFamiTF325047

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR000047 HTH_motif
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00031 HTHREPRESSR
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P52954-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSKEDGKAA PGEERRRSPL DHLPPPANSN KPLTPFSIED ILNKPSVRRS
60 70 80 90 100
YSLCGAAHLL AAADKHAQGG LPLAGRALLS QTSPLCALEE LASKTFKGLE
110 120 130 140 150
VSVLQAAEGR DGMTIFGQRQ TPKKRRKSRT AFTNHQIYEL EKRFLYQKYL
160 170 180 190 200
SPADRDQIAQ QLGLTNAQVI TWFQNRRAKL KRDLEEMKAD VESAKKLGPS
210 220 230 240 250
GQMDIVALAE LEQNSEATAG GGGGCGRAKS RPGSPVLPPG APKAPGAGAL
260 270 280
QLSPASPLTD QPASSQDCSE DEEDEEIDVD D
Length:281
Mass (Da):30,221
Last modified:November 14, 2006 - v2
Checksum:i8467F2B515681CCA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti33 – 72LTPFS…QGGLP → YAVQHRGHPQQAVRAEKLLA AWGGAPAGRRGQARAGRLA in CAA62342 (PubMed:8645601).CuratedAdd BLAST40
Sequence conflicti81Q → K in CAA62342 (PubMed:8645601).Curated1
Sequence conflicti183D → E in CAA62342 (PubMed:8645601).Curated1
Sequence conflicti194A → P in CAA62342 (PubMed:8645601).Curated1
Sequence conflicti247 – 248AG → RC in CAA62342 (PubMed:8645601).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X90828 mRNA Translation: CAA62342.1
AL135794 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49777.1
BC069156 mRNA Translation: AAH69156.1
BC136321 mRNA Translation: AAI36322.1
CCDSiCCDS31270.1
RefSeqiNP_006553.2, NM_006562.4
UniGeneiHs.37128

Genome annotation databases

EnsembliENST00000370193; ENSP00000359212; ENSG00000138136
GeneIDi10660
KEGGihsa:10660
UCSCiuc001ksx.4 human

Similar proteinsi

Entry informationi

Entry nameiLBX1_HUMAN
AccessioniPrimary (citable) accession number: P52954
Secondary accession number(s): B9EGA2, Q05BB2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 14, 2006
Last modified: June 20, 2018
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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