LBX1

Functionⁱ

Transcription factor required for the development of GABAergic interneurons in the dorsal horn of the spinal cord and migration and further development of hypaxial muscle precursor cells for limb muscles, diaphragm and hypoglossal cord.By similarity

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	125 – 184	HomeoboxPROSITE-ProRule annotationAdd BLAST		60

GO - Molecular functionⁱ

RNA polymerase II transcription factor activity, sequence-specific DNA binding
Source: NTNU_SB
Inferred from sequence modelⁱ
- 19274049
sequence-specific DNA binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

anatomical structure morphogenesis
Source: ProtInc
Traceable author statementⁱ
- 8645601
heart looping Source: Ensembl
muscle organ development Source: UniProtKB-KW
negative regulation of cell proliferation Source: Ensembl
negative regulation of neuron differentiation Source: Ensembl
neuron fate determination Source: Ensembl
regulation of transcription from RNA polymerase II promoter involved in spinal cord association neuron specification Source: Ensembl
spinal cord motor neuron differentiation Source: Ensembl
transcription, DNA-templated Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, DNA-binding
Biological process	Differentiation, Myogenesis, Neurogenesis, Transcription, Transcription regulation

Enzyme and pathway databases

SIGNORⁱ	P52954.

SIGNORⁱ

P52954.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transcription factor LBX1 Alternative name(s): Ladybird homeobox protein homolog 1
Gene namesⁱ	Name:LBX1 Synonyms:LBX1H
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 10

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000138136.6.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:16960. LBX1.
MIMⁱ	604255. gene.
neXtProtⁱ	NX_P52954.

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	10660.
Open Targets More...OpenTargetsⁱ	ENSG00000138136.
PharmGKBⁱ	PA142671561.

Polymorphism and mutation databases

BioMutaⁱ	LBX1.
DMDMⁱ	117949813.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000049166	1 – 281	Transcription factor LBX1Add BLAST		281

Proteomic databases

PaxDbⁱ	P52954.
PeptideAtlas More...PeptideAtlasⁱ	P52954.
PRIDEⁱ	P52954.

PTM databases

iPTMnetⁱ	P52954.
PhosphoSitePlusⁱ	P52954.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000138136.
CleanExⁱ	HS_LBX1.
Genevisibleⁱ	P52954. HS.

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA002016. HPA002086.

HPAⁱ

HPA002016.
HPA002086.

Interactionⁱ

Subunit structureⁱ

Interacts with SKOR1 which acts as a transcriptional corepressor.By similarity

Protein-protein interaction databases

BioGridⁱ	115903. 1 interactor.
STRINGⁱ	9606.ENSP00000359212.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P52954.
SMRⁱ	P52954.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	220 – 226	Poly-Gly		7
Compositional biasⁱ	270 – 281	Asp/Glu-rich (highly acidic)Add BLAST		12

Keywords - Domainⁱ

Homeobox

Phylogenomic databases

eggNOGⁱ	KOG0488. Eukaryota. ENOG411188D. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000143996.
HOGENOMⁱ	HOG000007247.
HOVERGENⁱ	HBG006244.
InParanoidⁱ	P52954.
KEGG Orthology (KO) More...KOⁱ	K09353.
OMAⁱ	HTTSKEC.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G09CY.
PhylomeDBⁱ	P52954.
TreeFamⁱ	TF325047.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00086. homeodomain. 1 hit.
InterProⁱ	View protein in InterPro IPR009057. Homeobox-like_sf. IPR017970. Homeobox_CS. IPR001356. Homeobox_dom. IPR000047. HTH_motif.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00046. Homeobox. 1 hit.
PRINTSⁱ	PR00031. HTHREPRESSR.
SMARTⁱ	View protein in SMART SM00389. HOX. 1 hit.
SUPFAMⁱ	SSF46689. SSF46689. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

P52954-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTSKEDGKAA PGEERRRSPL DHLPPPANSN KPLTPFSIED ILNKPSVRRS 
        60         70         80         90        100
YSLCGAAHLL AAADKHAQGG LPLAGRALLS QTSPLCALEE LASKTFKGLE 
       110        120        130        140        150
VSVLQAAEGR DGMTIFGQRQ TPKKRRKSRT AFTNHQIYEL EKRFLYQKYL 
       160        170        180        190        200
SPADRDQIAQ QLGLTNAQVI TWFQNRRAKL KRDLEEMKAD VESAKKLGPS 
       210        220        230        240        250
GQMDIVALAE LEQNSEATAG GGGGCGRAKS RPGSPVLPPG APKAPGAGAL 
       260        270        280 
QLSPASPLTD QPASSQDCSE DEEDEEIDVD D

Length:281

Mass (Da):30,221

Last modified:November 14, 2006 - v2

Checksum:ⁱ8467F2B515681CCA

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	33 – 72	LTPFS…QGGLP → YAVQHRGHPQQAVRAEKLLA AWGGAPAGRRGQARAGRLA in CAA62342 (PubMed:8645601).CuratedAdd BLAST	40
Sequence conflictⁱ	81	Q → K in CAA62342 (PubMed:8645601).Curated	1
Sequence conflictⁱ	183	D → E in CAA62342 (PubMed:8645601).Curated	1
Sequence conflictⁱ	194	A → P in CAA62342 (PubMed:8645601).Curated	1
Sequence conflictⁱ	247 – 248	AG → RC in CAA62342 (PubMed:8645601).Curated	2

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X90828 mRNA. Translation: CAA62342.1. AL135794 Genomic DNA. No translation available. CH471066 Genomic DNA. Translation: EAW49777.1. BC069156 mRNA. Translation: AAH69156.1. BC136321 mRNA. Translation: AAI36322.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31270.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_006553.2. NM_006562.4.
UniGeneⁱ	Hs.37128.

Genome annotation databases

Ensemblⁱ	ENST00000370193; ENSP00000359212; ENSG00000138136.
GeneIDⁱ	10660.
KEGGⁱ	hsa:10660.
UCSC genome browser More...UCSCⁱ	uc001ksx.4. human.

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
P52954	P52955 UPI00038EC4CB Q1XID0 A0A1S3AEP6 UPI0002C45C01 UPI0002BD1329 UPI000CEAC8DB UPI0003333332 UPI000952F2AD E1BC20 +68	Mus musculus (Mouse) Chinchilla lanigera (Long-tailed chinchilla) (Chinchilla villidera) Rattus norvegicus (Rat) Erinaceus europaeus (Western European hedgehog) Trichechus manatus latirostris (Florida manatee) Orcinus orca (Killer whale) Physeter catodon (Sperm whale) (Physeter macrocephalus) Jaculus jaculus (Lesser Egyptian jerboa) Bos indicus (Zebu) Bos taurus (Bovine) And more	282	UniRef90_P52955	Cluster: Transcription factor LBX1	79

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
P52954	P52955 UPI00038EC4CB Q1XID0 A0A1S3AEP6 UPI0002C45C01 UPI0002BD1329 UPI000CEAC8DB G1PIX2 UPI000333F59C UPI0003290DC5 +73	Mus musculus (Mouse) Chinchilla lanigera (Long-tailed chinchilla) (Chinchilla villidera) Rattus norvegicus (Rat) Erinaceus europaeus (Western European hedgehog) Trichechus manatus latirostris (Florida manatee) Orcinus orca (Killer whale) Physeter catodon (Sperm whale) (Physeter macrocephalus) Myotis lucifugus (Little brown bat) Octodon degus (Degu) (Sciurus degus) Dasypus novemcinctus (Nine-banded armadillo) And more	282	UniRef50_P52955	Cluster: Transcription factor LBX1	84

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X90828 mRNA. Translation: CAA62342.1. AL135794 Genomic DNA. No translation available. CH471066 Genomic DNA. Translation: EAW49777.1. BC069156 mRNA. Translation: AAH69156.1. BC136321 mRNA. Translation: AAI36322.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31270.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_006553.2. NM_006562.4.
UniGeneⁱ	Hs.37128.

3D structure databases

ProteinModelPortalⁱ	P52954.
SMRⁱ	P52954.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	115903. 1 interactor.
STRINGⁱ	9606.ENSP00000359212.

PTM databases

iPTMnetⁱ	P52954.
PhosphoSitePlusⁱ	P52954.

Polymorphism and mutation databases

BioMutaⁱ	LBX1.
DMDMⁱ	117949813.

Proteomic databases

PaxDbⁱ	P52954.
PeptideAtlas More...PeptideAtlasⁱ	P52954.
PRIDEⁱ	P52954.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000370193; ENSP00000359212; ENSG00000138136.
GeneIDⁱ	10660.
KEGGⁱ	hsa:10660.
UCSC genome browser More...UCSCⁱ	uc001ksx.4. human.

Organism-specific databases

CTDⁱ	10660.
DisGeNET More...DisGeNETⁱ	10660.
EuPathDBⁱ	HostDB:ENSG00000138136.6.
GeneCardsⁱ	LBX1.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:16960. LBX1.
Human Protein Atlas More...HPAⁱ	HPA002016. HPA002086.
MIMⁱ	604255. gene.
neXtProtⁱ	NX_P52954.
Open Targets More...OpenTargetsⁱ	ENSG00000138136.
PharmGKBⁱ	PA142671561.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0488. Eukaryota. ENOG411188D. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000143996.
HOGENOMⁱ	HOG000007247.
HOVERGENⁱ	HBG006244.
InParanoidⁱ	P52954.
KEGG Orthology (KO) More...KOⁱ	K09353.
OMAⁱ	HTTSKEC.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G09CY.
PhylomeDBⁱ	P52954.
TreeFamⁱ	TF325047.

Enzyme and pathway databases

SIGNORⁱ	P52954.

SIGNORⁱ

P52954.

Miscellaneous databases

GeneWikiⁱ	LBX1.
GenomeRNAiⁱ	10660.
Protein Ontology More...PROⁱ	PR:P52954.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000138136.
CleanExⁱ	HS_LBX1.
Genevisibleⁱ	P52954. HS.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00086. homeodomain. 1 hit.
InterProⁱ	View protein in InterPro IPR009057. Homeobox-like_sf. IPR017970. Homeobox_CS. IPR001356. Homeobox_dom. IPR000047. HTH_motif.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00046. Homeobox. 1 hit.
PRINTSⁱ	PR00031. HTHREPRESSR.
SMARTⁱ	View protein in SMART SM00389. HOX. 1 hit.
SUPFAMⁱ	SSF46689. SSF46689. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	LBX1_HUMAN
Accessionⁱ	P52954Primary (citable) accession number: P52954 Secondary accession number(s): B9EGA2, Q05BB2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	November 14, 2006
	Last modified:	March 28, 2018
	This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P52954 (LBX1_HUMAN)

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Transcription factor LBX1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ