Reviewed, UniProtKB/Swiss-Prot P52954 (LBX1_HUMAN)

Names and origin

Protein names

Recommended name:
    Transcription factor LBX1
Alternative name(s):
    Ladybird homeobox protein homolog 1

Gene names

Name:	LBX1
Synonyms:	LBX1H

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	281 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Transcription factor required for the development of GABAergic interneurons in the dorsal horn of the spinal cord and migration and further development of hypaxial muscle precursor cells for limb muscles, diaphragm and hypoglossal cord By similarity.
Subunit structure	Interacts with LBXCOR1 which acts as a transcriptional corepressor By similarity.
Subcellular location	Nucleus Probable.
Sequence similarities	Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Differentiation Myogenesis Neurogenesis Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	muscle organ development Inferred from electronic annotation. Source: UniProtKB-KW transcription Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 281	281	Transcription factor LBX1		PRO_0000049166
Regions
	DNA binding	125 – 184	60	Homeobox
	Compositional bias	220 – 226	7	Poly-Gly
	Compositional bias	270 – 281	12	Asp/Glu-rich (highly acidic)
Experimental info
	Sequence conflict	33 – 72	40	LTPFS…QGGLP → YAVQHRGHPQQAVRAEKLLA AWGGAPAGRRGQARAGRLA in CAA62342. Ref.1
	Sequence conflict	81	1	Q → K in CAA62342. Ref.1
	Sequence conflict	183	1	D → E in CAA62342. Ref.1
	Sequence conflict	194	1	A → P in CAA62342. Ref.1
	Sequence conflict	247 – 248	2	AG → RC in CAA62342. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P52954-1 [UniParc]. Last modified November 14, 2006. Version 2. Checksum: 8467F2B515681CCA	FASTA	281	30,221
	10 20 30 40 50 60 MTSKEDGKAA PGEERRRSPL DHLPPPANSN KPLTPFSIED ILNKPSVRRS YSLCGAAHLL 70 80 90 100 110 120 AAADKHAQGG LPLAGRALLS QTSPLCALEE LASKTFKGLE VSVLQAAEGR DGMTIFGQRQ 130 140 150 160 170 180 TPKKRRKSRT AFTNHQIYEL EKRFLYQKYL SPADRDQIAQ QLGLTNAQVI TWFQNRRAKL 190 200 210 220 230 240 KRDLEEMKAD VESAKKLGPS GQMDIVALAE LEQNSEATAG GGGGCGRAKS RPGSPVLPPG 250 260 270 280 APKAPGAGAL QLSPASPLTD QPASSQDCSE DEEDEEIDVD D

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Mouse Lbx1 and human LBX1 define a novel mammalian homeobox gene family related to the Drosophila lady bird genes." Jagla K., Dolle P., Mattei M.-G., Jagla T., Schuhbaur B., Dretzen G., Bellard F., Bellard M. Mech. Dev. 53:345-356(1995) [PubMed: 8645601] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed: 15164054] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X90828 mRNA. Translation: CAA62342.1. AL135794 Genomic DNA. Translation: CAH72508.2. CH471066 Genomic DNA. Translation: EAW49777.1. BC069156 mRNA. Translation: AAH69156.1. BC136321 mRNA. Translation: AAI36322.1.
IPI	IPI00006058.
RefSeq	NP_006553.2.
UniGene	Hs.37128
3D structure databases
SMR	P52954. Positions 78-182, 120-184.
ModBase	Search...
Protein-protein interaction databases
STRING	P52954.
Proteomic databases
PRIDE	P52954.
Genome annotation databases
Ensembl	ENST00000370193; ENSP00000359212; ENSG00000138136; Homo sapiens. [Genome view]
GeneID	10660.
KEGG	hsa:10660.
UCSC	uc001ksx.1. human.
Organism-specific databases
CTD	10660.
GeneCards	GC10M102976.
HGNC	HGNC:16960. LBX1.
HPA	HPA002086.
MIM	604255. gene.
PharmGKB	PA142671561.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HBG714837.
HOVERGEN	P52954.
InParanoid	P52954.
OMA	NSEATAG.
OrthoDB	EOG9RFPBQ.
Gene expression databases
ArrayExpress	P52954.
Bgee	P52954.
CleanEx	HS_LBX1.
Genevestigator	P52954.
GermOnline	ENSG00000138136. Homo sapiens.
Family and domain databases
InterPro	IPR001356. Homeobox. IPR017970. Homeobox_CS. IPR009057. Homeodomain-like. IPR012287. Homeodomain-rel. IPR000047. HTH_lambrepressr. IPR015704. Lbx_related. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
PANTHER	PTHR19418:SF144. Lbx_related. 1 hit.
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00031. HTHREPRESSR.
SMART	SM00389. HOX. 1 hit. [Graphical view]
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	40539.
SOURCE	Search...

Entry information

Entry name

LBX1_HUMAN

Accession

Primary (citable) accession number: P52954
Secondary accession number(s): B9EGA2, Q05BB2

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	November 14, 2006
Last modified:	January 19, 2010
This is version 75 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.