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Protein

Homeobox protein GBX-2

Gene

GBX2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May act as a transcription factor for cell pluripotency and differentiation in the embryo.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi247 – 30660HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • sequence-specific DNA binding Source: InterPro
  • sequence-specific DNA binding transcription factor activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein GBX-2
Alternative name(s):
Gastrulation and brain-specific homeobox protein 2
Gene namesi
Name:GBX2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:4186. GBX2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28600.

Polymorphism and mutation databases

BioMutaiGBX2.
DMDMi12644308.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 348348Homeobox protein GBX-2PRO_0000048880Add
BLAST

Proteomic databases

MaxQBiP52951.
PaxDbiP52951.
PRIDEiP52951.

PTM databases

PhosphoSiteiP52951.

Expressioni

Gene expression databases

BgeeiP52951.
CleanExiHS_GBX2.
ExpressionAtlasiP52951. baseline and differential.
GenevisibleiP52951. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000302251.

Structurei

3D structure databases

ProteinModelPortaliP52951.
SMRiP52951. Positions 245-311.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi56 – 638Poly-Pro
Compositional biasi121 – 1244Poly-Ala
Compositional biasi248 – 2514Poly-Arg

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG315879.
GeneTreeiENSGT00760000118940.
HOGENOMiHOG000060099.
HOVERGENiHBG003967.
InParanoidiP52951.
OMAiLIGGPPQ.
OrthoDBiEOG7D2FDK.
PhylomeDBiP52951.
TreeFamiTF351530.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR031250. GBX-2.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PANTHERiPTHR24334:SF3. PTHR24334:SF3. 1 hit.
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P52951-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAAFPPSLM MMQRPLGSST AFSIDSLIGS PPQPSPGHFV YTGYPMFMPY
60 70 80 90 100
RPVVLPPPPP PPPALPQAAL QPALPPAHPH HQIPSLPTGF CSSLAQGMAL
110 120 130 140 150
TSTLMATLPG GFSASPQHQE AAAARKFAPQ PLPGGGNFDK AEALQADAED
160 170 180 190 200
GKGFLAKEGS LLAFSAAETV QASLVGAVRG QGKDESKVED DPKGKEESFS
210 220 230 240 250
LESDVDYSSD DNLTGQAAHK EEDPGHALEE TPPSSGAAGS TTSTGKNRRR
260 270 280 290 300
RTAFTSEQLL ELEKEFHCKK YLSLTERSQI AHALKLSEVQ VKIWFQNRRA
310 320 330 340
KWKRVKAGNA NSKTGEPSRN PKIVVPIPVH VSRFAIRSQH QQLEQARP
Length:348
Mass (Da):37,348
Last modified:January 11, 2001 - v3
Checksum:i5D31EA57B0CB07C0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti74 – 194121LPPAH…DDPKG → CRPHTLTTRSPACPQASAPA WRRAWRSPLRSWPRSPAASP RRPSTRRRQRPASSRRSRCP AAVTSTRRRRCRLTRRTAKA SWPKRARCSPSPRPRRCRLR SSGLSEGKGKTSQRWKTTRS in AAC03241 (PubMed:8838315).CuratedAdd
BLAST
Sequence conflicti216 – 23722QAAHK…PSSGA → PGSSQGGRPGPRGGGDPAEQ RR (PubMed:7903253).CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31468 Genomic DNA. Translation: AAC03241.1.
AF118452 mRNA. Translation: AAD39907.1.
AC079135 Genomic DNA. Translation: AAX93240.1.
CH471063 Genomic DNA. Translation: EAW71084.1.
BC137448 mRNA. Translation: AAI37449.1.
BC137449 mRNA. Translation: AAI37450.1.
U02080 Genomic DNA. Translation: AAA17406.1.
CCDSiCCDS2515.1.
PIRiS39540.
RefSeqiNP_001476.2. NM_001485.3.
UniGeneiHs.184945.
Hs.735751.

Genome annotation databases

EnsembliENST00000306318; ENSP00000302251; ENSG00000168505.
GeneIDi2637.
UCSCiuc002vvw.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31468 Genomic DNA. Translation: AAC03241.1.
AF118452 mRNA. Translation: AAD39907.1.
AC079135 Genomic DNA. Translation: AAX93240.1.
CH471063 Genomic DNA. Translation: EAW71084.1.
BC137448 mRNA. Translation: AAI37449.1.
BC137449 mRNA. Translation: AAI37450.1.
U02080 Genomic DNA. Translation: AAA17406.1.
CCDSiCCDS2515.1.
PIRiS39540.
RefSeqiNP_001476.2. NM_001485.3.
UniGeneiHs.184945.
Hs.735751.

3D structure databases

ProteinModelPortaliP52951.
SMRiP52951. Positions 245-311.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000302251.

PTM databases

PhosphoSiteiP52951.

Polymorphism and mutation databases

BioMutaiGBX2.
DMDMi12644308.

Proteomic databases

MaxQBiP52951.
PaxDbiP52951.
PRIDEiP52951.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306318; ENSP00000302251; ENSG00000168505.
GeneIDi2637.
UCSCiuc002vvw.1. human.

Organism-specific databases

CTDi2637.
GeneCardsiGC02M237090.
HGNCiHGNC:4186. GBX2.
MIMi601135. gene.
neXtProtiNX_P52951.
PharmGKBiPA28600.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG315879.
GeneTreeiENSGT00760000118940.
HOGENOMiHOG000060099.
HOVERGENiHBG003967.
InParanoidiP52951.
OMAiLIGGPPQ.
OrthoDBiEOG7D2FDK.
PhylomeDBiP52951.
TreeFamiTF351530.

Miscellaneous databases

GeneWikiiGBX2.
GenomeRNAii2637.
NextBioi10396.
PROiP52951.
SOURCEiSearch...

Gene expression databases

BgeeiP52951.
CleanExiHS_GBX2.
ExpressionAtlasiP52951. baseline and differential.
GenevisibleiP52951. HS.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR031250. GBX-2.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PANTHERiPTHR24334:SF3. PTHR24334:SF3. 1 hit.
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization and sequence analysis of the human homeobox-containing gene GBX2."
    Lin X., Swaroop A., Vaccarino F.M., Murtha M.T., Haas M., Ji X., Ruddle F.H., Leckman J.F.
    Genomics 31:335-342(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Brain.
  2. "Enhanced GBX2 expression induces the growth of human prostate cancer cells via transcriptional stimulation of the interleukin-6 gene."
    Gao A.C., Lou W., Isaacs J.T.
    Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  6. "The HOX complex neighbored by the EVX gene, as well as two other homeobox-containing genes, the GBX-class and the EN-class, are located on the same chromosomes 2 and 7 in humans."
    Matsui T., Hirai M., Hirano M., Kurosawa Y.
    FEBS Lett. 336:107-110(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 216-348.

Entry informationi

Entry nameiGBX2_HUMAN
AccessioniPrimary (citable) accession number: P52951
Secondary accession number(s): B2RPH7
, O43833, Q53RX5, Q9Y5Y1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 11, 2001
Last modified: July 22, 2015
This is version 126 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.