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P52951

- GBX2_HUMAN

UniProt

P52951 - GBX2_HUMAN

Protein

Homeobox protein GBX-2

Gene

GBX2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 3 (11 Jan 2001)
      Previous versions | rss
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    Functioni

    May act as a transcription factor for cell pluripotency and differentiation in the embryo.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi247 – 30660HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: ProtInc

    GO - Biological processi

    1. autonomic nervous system development Source: Ensembl
    2. axon guidance Source: Ensembl
    3. cerebellar granule cell precursor proliferation Source: Ensembl
    4. cerebellum development Source: Ensembl
    5. forebrain neuron development Source: Ensembl
    6. inner ear morphogenesis Source: Ensembl
    7. midbrain-hindbrain boundary morphogenesis Source: Ensembl
    8. nervous system development Source: ProtInc
    9. neural crest cell migration Source: Ensembl
    10. patterning of blood vessels Source: Ensembl
    11. rhombomere 2 development Source: Ensembl
    12. thalamus development Source: Ensembl
    13. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein GBX-2
    Alternative name(s):
    Gastrulation and brain-specific homeobox protein 2
    Gene namesi
    Name:GBX2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:4186. GBX2.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28600.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 348348Homeobox protein GBX-2PRO_0000048880Add
    BLAST

    Proteomic databases

    MaxQBiP52951.
    PaxDbiP52951.
    PRIDEiP52951.

    PTM databases

    PhosphoSiteiP52951.

    Expressioni

    Gene expression databases

    ArrayExpressiP52951.
    BgeeiP52951.
    CleanExiHS_GBX2.
    GenevestigatoriP52951.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000302251.

    Structurei

    3D structure databases

    ProteinModelPortaliP52951.
    SMRiP52951. Positions 245-311.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi56 – 638Poly-Pro
    Compositional biasi121 – 1244Poly-Ala
    Compositional biasi248 – 2514Poly-Arg

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG315879.
    HOGENOMiHOG000060099.
    HOVERGENiHBG003967.
    InParanoidiP52951.
    KOiK09321.
    OMAiGQTAHKE.
    OrthoDBiEOG7D2FDK.
    PhylomeDBiP52951.
    TreeFamiTF351530.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P52951-1 [UniParc]FASTAAdd to Basket

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    MSAAFPPSLM MMQRPLGSST AFSIDSLIGS PPQPSPGHFV YTGYPMFMPY    50
    RPVVLPPPPP PPPALPQAAL QPALPPAHPH HQIPSLPTGF CSSLAQGMAL 100
    TSTLMATLPG GFSASPQHQE AAAARKFAPQ PLPGGGNFDK AEALQADAED 150
    GKGFLAKEGS LLAFSAAETV QASLVGAVRG QGKDESKVED DPKGKEESFS 200
    LESDVDYSSD DNLTGQAAHK EEDPGHALEE TPPSSGAAGS TTSTGKNRRR 250
    RTAFTSEQLL ELEKEFHCKK YLSLTERSQI AHALKLSEVQ VKIWFQNRRA 300
    KWKRVKAGNA NSKTGEPSRN PKIVVPIPVH VSRFAIRSQH QQLEQARP 348
    Length:348
    Mass (Da):37,348
    Last modified:January 11, 2001 - v3
    Checksum:i5D31EA57B0CB07C0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti74 – 194121LPPAH…DDPKG → CRPHTLTTRSPACPQASAPA WRRAWRSPLRSWPRSPAASP RRPSTRRRQRPASSRRSRCP AAVTSTRRRRCRLTRRTAKA SWPKRARCSPSPRPRRCRLR SSGLSEGKGKTSQRWKTTRS in AAC03241. (PubMed:8838315)CuratedAdd
    BLAST
    Sequence conflicti216 – 23722QAAHK…PSSGA → PGSSQGGRPGPRGGGDPAEQ RR(PubMed:7903253)CuratedAdd
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U31468 Genomic DNA. Translation: AAC03241.1.
    AF118452 mRNA. Translation: AAD39907.1.
    AC079135 Genomic DNA. Translation: AAX93240.1.
    CH471063 Genomic DNA. Translation: EAW71084.1.
    BC137448 mRNA. Translation: AAI37449.1.
    BC137449 mRNA. Translation: AAI37450.1.
    U02080 Genomic DNA. Translation: AAA17406.1.
    CCDSiCCDS2515.1.
    PIRiS39540.
    RefSeqiNP_001476.2. NM_001485.2.
    UniGeneiHs.184945.

    Genome annotation databases

    EnsembliENST00000306318; ENSP00000302251; ENSG00000168505.
    GeneIDi2637.
    KEGGihsa:2637.
    UCSCiuc002vvw.1. human.

    Polymorphism databases

    DMDMi12644308.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U31468 Genomic DNA. Translation: AAC03241.1 .
    AF118452 mRNA. Translation: AAD39907.1 .
    AC079135 Genomic DNA. Translation: AAX93240.1 .
    CH471063 Genomic DNA. Translation: EAW71084.1 .
    BC137448 mRNA. Translation: AAI37449.1 .
    BC137449 mRNA. Translation: AAI37450.1 .
    U02080 Genomic DNA. Translation: AAA17406.1 .
    CCDSi CCDS2515.1.
    PIRi S39540.
    RefSeqi NP_001476.2. NM_001485.2.
    UniGenei Hs.184945.

    3D structure databases

    ProteinModelPortali P52951.
    SMRi P52951. Positions 245-311.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000302251.

    PTM databases

    PhosphoSitei P52951.

    Polymorphism databases

    DMDMi 12644308.

    Proteomic databases

    MaxQBi P52951.
    PaxDbi P52951.
    PRIDEi P52951.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000306318 ; ENSP00000302251 ; ENSG00000168505 .
    GeneIDi 2637.
    KEGGi hsa:2637.
    UCSCi uc002vvw.1. human.

    Organism-specific databases

    CTDi 2637.
    GeneCardsi GC02M237090.
    HGNCi HGNC:4186. GBX2.
    MIMi 601135. gene.
    neXtProti NX_P52951.
    PharmGKBi PA28600.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG315879.
    HOGENOMi HOG000060099.
    HOVERGENi HBG003967.
    InParanoidi P52951.
    KOi K09321.
    OMAi GQTAHKE.
    OrthoDBi EOG7D2FDK.
    PhylomeDBi P52951.
    TreeFami TF351530.

    Miscellaneous databases

    GeneWikii GBX2.
    GenomeRNAii 2637.
    NextBioi 10396.
    PROi P52951.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P52951.
    Bgeei P52951.
    CleanExi HS_GBX2.
    Genevestigatori P52951.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization and sequence analysis of the human homeobox-containing gene GBX2."
      Lin X., Swaroop A., Vaccarino F.M., Murtha M.T., Haas M., Ji X., Ruddle F.H., Leckman J.F.
      Genomics 31:335-342(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Brain.
    2. "Enhanced GBX2 expression induces the growth of human prostate cancer cells via transcriptional stimulation of the interleukin-6 gene."
      Gao A.C., Lou W., Isaacs J.T.
      Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    6. "The HOX complex neighbored by the EVX gene, as well as two other homeobox-containing genes, the GBX-class and the EN-class, are located on the same chromosomes 2 and 7 in humans."
      Matsui T., Hirai M., Hirano M., Kurosawa Y.
      FEBS Lett. 336:107-110(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 216-348.

    Entry informationi

    Entry nameiGBX2_HUMAN
    AccessioniPrimary (citable) accession number: P52951
    Secondary accession number(s): B2RPH7
    , O43833, Q53RX5, Q9Y5Y1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: January 11, 2001
    Last modified: October 1, 2014
    This is version 118 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3