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P52951 (GBX2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 117. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein GBX-2
Alternative name(s):
Gastrulation and brain-specific homeobox protein 2
Gene names
Name:GBX2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length348 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May act as a transcription factor for cell pluripotency and differentiation in the embryo.

Subcellular location

Nucleus Probable.

Sequence similarities

Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processautonomic nervous system development

Inferred from electronic annotation. Source: Ensembl

axon guidance

Inferred from electronic annotation. Source: Ensembl

cerebellar granule cell precursor proliferation

Inferred from electronic annotation. Source: Ensembl

cerebellum development

Inferred from electronic annotation. Source: Ensembl

forebrain neuron development

Inferred from electronic annotation. Source: Ensembl

inner ear morphogenesis

Inferred from electronic annotation. Source: Ensembl

midbrain-hindbrain boundary morphogenesis

Inferred from electronic annotation. Source: Ensembl

nervous system development

Traceable author statement Ref.1. Source: ProtInc

neural crest cell migration

Inferred from electronic annotation. Source: Ensembl

patterning of blood vessels

Inferred from electronic annotation. Source: Ensembl

rhombomere 2 development

Inferred from electronic annotation. Source: Ensembl

thalamus development

Inferred from electronic annotation. Source: Ensembl

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Traceable author statement PubMed 9346236. Source: ProtInc

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 348348Homeobox protein GBX-2
PRO_0000048880

Regions

DNA binding247 – 30660Homeobox
Compositional bias56 – 638Poly-Pro
Compositional bias121 – 1244Poly-Ala
Compositional bias248 – 2514Poly-Arg

Experimental info

Sequence conflict74 – 194121LPPAH…DDPKG → CRPHTLTTRSPACPQASAPA WRRAWRSPLRSWPRSPAASP RRPSTRRRQRPASSRRSRCP AAVTSTRRRRCRLTRRTAKA SWPKRARCSPSPRPRRCRLR SSGLSEGKGKTSQRWKTTRS in AAC03241. Ref.1
Sequence conflict216 – 23722QAAHK…PSSGA → PGSSQGGRPGPRGGGDPAEQ RR Ref.6

Sequences

Sequence LengthMass (Da)Tools
P52951 [UniParc].

Last modified January 11, 2001. Version 3.
Checksum: 5D31EA57B0CB07C0

FASTA34837,348
        10         20         30         40         50         60 
MSAAFPPSLM MMQRPLGSST AFSIDSLIGS PPQPSPGHFV YTGYPMFMPY RPVVLPPPPP 

        70         80         90        100        110        120 
PPPALPQAAL QPALPPAHPH HQIPSLPTGF CSSLAQGMAL TSTLMATLPG GFSASPQHQE 

       130        140        150        160        170        180 
AAAARKFAPQ PLPGGGNFDK AEALQADAED GKGFLAKEGS LLAFSAAETV QASLVGAVRG 

       190        200        210        220        230        240 
QGKDESKVED DPKGKEESFS LESDVDYSSD DNLTGQAAHK EEDPGHALEE TPPSSGAAGS 

       250        260        270        280        290        300 
TTSTGKNRRR RTAFTSEQLL ELEKEFHCKK YLSLTERSQI AHALKLSEVQ VKIWFQNRRA 

       310        320        330        340 
KWKRVKAGNA NSKTGEPSRN PKIVVPIPVH VSRFAIRSQH QQLEQARP 

« Hide

References

« Hide 'large scale' references
[1]"Characterization and sequence analysis of the human homeobox-containing gene GBX2."
Lin X., Swaroop A., Vaccarino F.M., Murtha M.T., Haas M., Ji X., Ruddle F.H., Leckman J.F.
Genomics 31:335-342(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Brain.
[2]"Enhanced GBX2 expression induces the growth of human prostate cancer cells via transcriptional stimulation of the interleukin-6 gene."
Gao A.C., Lou W., Isaacs J.T.
Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[6]"The HOX complex neighbored by the EVX gene, as well as two other homeobox-containing genes, the GBX-class and the EN-class, are located on the same chromosomes 2 and 7 in humans."
Matsui T., Hirai M., Hirano M., Kurosawa Y.
FEBS Lett. 336:107-110(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 216-348.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U31468 Genomic DNA. Translation: AAC03241.1.
AF118452 mRNA. Translation: AAD39907.1.
AC079135 Genomic DNA. Translation: AAX93240.1.
CH471063 Genomic DNA. Translation: EAW71084.1.
BC137448 mRNA. Translation: AAI37449.1.
BC137449 mRNA. Translation: AAI37450.1.
U02080 Genomic DNA. Translation: AAA17406.1.
CCDSCCDS2515.1.
PIRS39540.
RefSeqNP_001476.2. NM_001485.2.
UniGeneHs.184945.

3D structure databases

ProteinModelPortalP52951.
SMRP52951. Positions 245-311.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000302251.

PTM databases

PhosphoSiteP52951.

Polymorphism databases

DMDM12644308.

Proteomic databases

MaxQBP52951.
PaxDbP52951.
PRIDEP52951.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000306318; ENSP00000302251; ENSG00000168505.
GeneID2637.
KEGGhsa:2637.
UCSCuc002vvw.1. human.

Organism-specific databases

CTD2637.
GeneCardsGC02M237090.
HGNCHGNC:4186. GBX2.
MIM601135. gene.
neXtProtNX_P52951.
PharmGKBPA28600.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG315879.
HOGENOMHOG000060099.
HOVERGENHBG003967.
InParanoidP52951.
KOK09321.
OMAGQTAHKE.
OrthoDBEOG7D2FDK.
PhylomeDBP52951.
TreeFamTF351530.

Gene expression databases

ArrayExpressP52951.
BgeeP52951.
CleanExHS_GBX2.
GenevestigatorP52951.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiGBX2.
GenomeRNAi2637.
NextBio10396.
PROP52951.
SOURCESearch...

Entry information

Entry nameGBX2_HUMAN
AccessionPrimary (citable) accession number: P52951
Secondary accession number(s): B2RPH7 expand/collapse secondary AC list , O43833, Q53RX5, Q9Y5Y1
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 11, 2001
Last modified: July 9, 2014
This is version 117 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM