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Protein

Homeobox protein GBX-2

Gene

GBX2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May act as a transcription factor for cell pluripotency and differentiation in the embryo.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi247 – 306HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000168505-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein GBX-2
Alternative name(s):
Gastrulation and brain-specific homeobox protein 2
Gene namesi
Name:GBX2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:4186. GBX2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi2637.
OpenTargetsiENSG00000168505.
PharmGKBiPA28600.

Polymorphism and mutation databases

BioMutaiGBX2.
DMDMi12644308.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000488801 – 348Homeobox protein GBX-2Add BLAST348

Proteomic databases

EPDiP52951.
MaxQBiP52951.
PaxDbiP52951.
PeptideAtlasiP52951.
PRIDEiP52951.

PTM databases

iPTMnetiP52951.
PhosphoSitePlusiP52951.

Expressioni

Gene expression databases

BgeeiENSG00000168505.
CleanExiHS_GBX2.
ExpressionAtlasiP52951. baseline and differential.
GenevisibleiP52951. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000302251.

Structurei

3D structure databases

ProteinModelPortaliP52951.
SMRiP52951.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi56 – 63Poly-Pro8
Compositional biasi121 – 124Poly-Ala4
Compositional biasi248 – 251Poly-Arg4

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489. Eukaryota.
ENOG410ZTBY. LUCA.
GeneTreeiENSGT00850000132268.
HOGENOMiHOG000060099.
HOVERGENiHBG003967.
InParanoidiP52951.
KOiK09321.
OMAiLIGGPPQ.
OrthoDBiEOG091G0SCQ.
PhylomeDBiP52951.
TreeFamiTF351530.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR031250. GBX-2.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PANTHERiPTHR24334:SF3. PTHR24334:SF3. 1 hit.
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P52951-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAAFPPSLM MMQRPLGSST AFSIDSLIGS PPQPSPGHFV YTGYPMFMPY
60 70 80 90 100
RPVVLPPPPP PPPALPQAAL QPALPPAHPH HQIPSLPTGF CSSLAQGMAL
110 120 130 140 150
TSTLMATLPG GFSASPQHQE AAAARKFAPQ PLPGGGNFDK AEALQADAED
160 170 180 190 200
GKGFLAKEGS LLAFSAAETV QASLVGAVRG QGKDESKVED DPKGKEESFS
210 220 230 240 250
LESDVDYSSD DNLTGQAAHK EEDPGHALEE TPPSSGAAGS TTSTGKNRRR
260 270 280 290 300
RTAFTSEQLL ELEKEFHCKK YLSLTERSQI AHALKLSEVQ VKIWFQNRRA
310 320 330 340
KWKRVKAGNA NSKTGEPSRN PKIVVPIPVH VSRFAIRSQH QQLEQARP
Length:348
Mass (Da):37,348
Last modified:January 11, 2001 - v3
Checksum:i5D31EA57B0CB07C0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti74 – 194LPPAH…DDPKG → CRPHTLTTRSPACPQASAPA WRRAWRSPLRSWPRSPAASP RRPSTRRRQRPASSRRSRCP AAVTSTRRRRCRLTRRTAKA SWPKRARCSPSPRPRRCRLR SSGLSEGKGKTSQRWKTTRS in AAC03241 (PubMed:8838315).CuratedAdd BLAST121
Sequence conflicti216 – 237QAAHK…PSSGA → PGSSQGGRPGPRGGGDPAEQ RR (PubMed:7903253).CuratedAdd BLAST22

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31468 Genomic DNA. Translation: AAC03241.1.
AF118452 mRNA. Translation: AAD39907.1.
AC079135 Genomic DNA. Translation: AAX93240.1.
CH471063 Genomic DNA. Translation: EAW71084.1.
BC137448 mRNA. Translation: AAI37449.1.
BC137449 mRNA. Translation: AAI37450.1.
U02080 Genomic DNA. Translation: AAA17406.1.
CCDSiCCDS2515.1.
PIRiS39540.
RefSeqiNP_001476.2. NM_001485.3.
UniGeneiHs.184945.
Hs.735751.

Genome annotation databases

EnsembliENST00000306318; ENSP00000302251; ENSG00000168505.
GeneIDi2637.
KEGGihsa:2637.
UCSCiuc002vvw.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31468 Genomic DNA. Translation: AAC03241.1.
AF118452 mRNA. Translation: AAD39907.1.
AC079135 Genomic DNA. Translation: AAX93240.1.
CH471063 Genomic DNA. Translation: EAW71084.1.
BC137448 mRNA. Translation: AAI37449.1.
BC137449 mRNA. Translation: AAI37450.1.
U02080 Genomic DNA. Translation: AAA17406.1.
CCDSiCCDS2515.1.
PIRiS39540.
RefSeqiNP_001476.2. NM_001485.3.
UniGeneiHs.184945.
Hs.735751.

3D structure databases

ProteinModelPortaliP52951.
SMRiP52951.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000302251.

PTM databases

iPTMnetiP52951.
PhosphoSitePlusiP52951.

Polymorphism and mutation databases

BioMutaiGBX2.
DMDMi12644308.

Proteomic databases

EPDiP52951.
MaxQBiP52951.
PaxDbiP52951.
PeptideAtlasiP52951.
PRIDEiP52951.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306318; ENSP00000302251; ENSG00000168505.
GeneIDi2637.
KEGGihsa:2637.
UCSCiuc002vvw.2. human.

Organism-specific databases

CTDi2637.
DisGeNETi2637.
GeneCardsiGBX2.
HGNCiHGNC:4186. GBX2.
MIMi601135. gene.
neXtProtiNX_P52951.
OpenTargetsiENSG00000168505.
PharmGKBiPA28600.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0489. Eukaryota.
ENOG410ZTBY. LUCA.
GeneTreeiENSGT00850000132268.
HOGENOMiHOG000060099.
HOVERGENiHBG003967.
InParanoidiP52951.
KOiK09321.
OMAiLIGGPPQ.
OrthoDBiEOG091G0SCQ.
PhylomeDBiP52951.
TreeFamiTF351530.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000168505-MONOMER.

Miscellaneous databases

GeneWikiiGBX2.
GenomeRNAii2637.
PROiP52951.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000168505.
CleanExiHS_GBX2.
ExpressionAtlasiP52951. baseline and differential.
GenevisibleiP52951. HS.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR031250. GBX-2.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PANTHERiPTHR24334:SF3. PTHR24334:SF3. 1 hit.
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGBX2_HUMAN
AccessioniPrimary (citable) accession number: P52951
Secondary accession number(s): B2RPH7
, O43833, Q53RX5, Q9Y5Y1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 11, 2001
Last modified: November 2, 2016
This is version 135 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.