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Protein

Homeobox protein GBX-2

Gene

GBX2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May act as a transcription factor for cell pluripotency and differentiation in the embryo.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi247 – 306HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein GBX-2
Alternative name(s):
Gastrulation and brain-specific homeobox protein 2
Gene namesi
Name:GBX2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000168505.6
HGNCiHGNC:4186 GBX2
MIMi601135 gene
neXtProtiNX_P52951

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi2637
OpenTargetsiENSG00000168505
PharmGKBiPA28600

Polymorphism and mutation databases

BioMutaiGBX2
DMDMi12644308

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000488801 – 348Homeobox protein GBX-2Add BLAST348

Proteomic databases

EPDiP52951
MaxQBiP52951
PaxDbiP52951
PeptideAtlasiP52951
PRIDEiP52951

PTM databases

iPTMnetiP52951
PhosphoSitePlusiP52951

Expressioni

Gene expression databases

BgeeiENSG00000168505
CleanExiHS_GBX2
ExpressionAtlasiP52951 baseline and differential
GenevisibleiP52951 HS

Organism-specific databases

HPAiHPA067809

Interactioni

Protein-protein interaction databases

BioGridi108907, 3 interactors
STRINGi9606.ENSP00000302251

Structurei

3D structure databases

ProteinModelPortaliP52951
SMRiP52951
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi56 – 63Poly-Pro8
Compositional biasi121 – 124Poly-Ala4
Compositional biasi248 – 251Poly-Arg4

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000144024
HOGENOMiHOG000060099
HOVERGENiHBG003967
InParanoidiP52951
KOiK09321
OMAiFMPYRSV
OrthoDBiEOG091G0SCQ
PhylomeDBiP52951
TreeFamiTF351530

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR031250 GBX-2
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PANTHERiPTHR24334:SF3 PTHR24334:SF3, 1 hit
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P52951-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAAFPPSLM MMQRPLGSST AFSIDSLIGS PPQPSPGHFV YTGYPMFMPY
60 70 80 90 100
RPVVLPPPPP PPPALPQAAL QPALPPAHPH HQIPSLPTGF CSSLAQGMAL
110 120 130 140 150
TSTLMATLPG GFSASPQHQE AAAARKFAPQ PLPGGGNFDK AEALQADAED
160 170 180 190 200
GKGFLAKEGS LLAFSAAETV QASLVGAVRG QGKDESKVED DPKGKEESFS
210 220 230 240 250
LESDVDYSSD DNLTGQAAHK EEDPGHALEE TPPSSGAAGS TTSTGKNRRR
260 270 280 290 300
RTAFTSEQLL ELEKEFHCKK YLSLTERSQI AHALKLSEVQ VKIWFQNRRA
310 320 330 340
KWKRVKAGNA NSKTGEPSRN PKIVVPIPVH VSRFAIRSQH QQLEQARP
Length:348
Mass (Da):37,348
Last modified:January 11, 2001 - v3
Checksum:i5D31EA57B0CB07C0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti74 – 194LPPAH…DDPKG → CRPHTLTTRSPACPQASAPA WRRAWRSPLRSWPRSPAASP RRPSTRRRQRPASSRRSRCP AAVTSTRRRRCRLTRRTAKA SWPKRARCSPSPRPRRCRLR SSGLSEGKGKTSQRWKTTRS in AAC03241 (PubMed:8838315).CuratedAdd BLAST121
Sequence conflicti216 – 237QAAHK…PSSGA → PGSSQGGRPGPRGGGDPAEQ RR (PubMed:7903253).CuratedAdd BLAST22

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31468 Genomic DNA Translation: AAC03241.1
AF118452 mRNA Translation: AAD39907.1
AC079135 Genomic DNA Translation: AAX93240.1
CH471063 Genomic DNA Translation: EAW71084.1
BC137448 mRNA Translation: AAI37449.1
BC137449 mRNA Translation: AAI37450.1
U02080 Genomic DNA Translation: AAA17406.1
CCDSiCCDS2515.1
PIRiS39540
RefSeqiNP_001476.2, NM_001485.3
UniGeneiHs.184945
Hs.735751

Genome annotation databases

EnsembliENST00000306318; ENSP00000302251; ENSG00000168505
GeneIDi2637
KEGGihsa:2637
UCSCiuc002vvw.2 human

Similar proteinsi

Entry informationi

Entry nameiGBX2_HUMAN
AccessioniPrimary (citable) accession number: P52951
Secondary accession number(s): B2RPH7
, O43833, Q53RX5, Q9Y5Y1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 11, 2001
Last modified: May 23, 2018
This is version 147 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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