ID   DBX1_MOUSE              Reviewed;         335 AA.
AC   P52950; Q3UYQ7;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   27-MAR-2024, entry version 160.
DE   RecName: Full=Homeobox protein DBX1;
DE   AltName: Full=Developing brain homeobox protein 1;
GN   Name=Dbx1; Synonyms=Dbx;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=7811640; DOI=10.1016/0925-4773(94)90089-2;
RA   Lu S., Wise T.L., Ruddle F.H.;
RT   "Mouse homeobox gene Dbx: sequence, gene structure and expression pattern
RT   during mid-gestation.";
RL   Mech. Dev. 47:187-195(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 180-335.
RC   STRAIN=C57BL/6J; TISSUE=Head;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [4]
RP   FUNCTION.
RX   PubMed=11239429; DOI=10.1016/s0896-6273(01)00212-4;
RA   Pierani A., Moran-Rivard L., Sunshine M.J., Littman D.R., Goulding M.,
RA   Jessell T.M.;
RT   "Control of interneuron fate in the developing spinal cord by the
RT   progenitor homeodomain protein Dbx1.";
RL   Neuron 29:367-384(2001).
CC   -!- FUNCTION: Could have a role in patterning the central nervous system
CC       during embryogenesis. Has a key role in regulating the distinct
CC       phenotypic features that distinguish two major classes of ventral
CC       interneurons, V0 and V1 neurons. Regulates the transcription factor
CC       profile, neurotransmitter phenotype, intraspinal migratory path and
CC       axonal trajectory of V0 neurons, features that differentiate them from
CC       an adjacent set of V1 neurons. {ECO:0000269|PubMed:11239429}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- DEVELOPMENTAL STAGE: During early and mid-gestation, dbx expression is
CC       restricted to the telencephalon, diencephalon, dorsal mesencephalon and
CC       spinal cord. At later gestational stages, dbx expression continues in
CC       the dorsal mesencephalon and diencephalon, in which expression is more
CC       restricted than at the earlier stages.
CC   -!- SIMILARITY: Belongs to the H2.0 homeobox family. {ECO:0000305}.
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DR   EMBL; S75837; AAB33013.1; -; mRNA.
DR   EMBL; BC082541; AAH82541.1; -; mRNA.
DR   EMBL; AK134473; BAE22155.1; -; mRNA.
DR   CCDS; CCDS21306.1; -.
DR   PIR; E41606; E41606.
DR   RefSeq; NP_001005232.1; NM_001005232.1.
DR   AlphaFoldDB; P52950; -.
DR   SMR; P52950; -.
DR   BioGRID; 199062; 2.
DR   STRING; 10090.ENSMUSP00000032717; -.
DR   iPTMnet; P52950; -.
DR   PhosphoSitePlus; P52950; -.
DR   PaxDb; 10090-ENSMUSP00000032717; -.
DR   Antibodypedia; 42553; 121 antibodies from 23 providers.
DR   DNASU; 13172; -.
DR   Ensembl; ENSMUST00000032717.7; ENSMUSP00000032717.7; ENSMUSG00000030507.7.
DR   GeneID; 13172; -.
DR   KEGG; mmu:13172; -.
DR   UCSC; uc009hbn.1; mouse.
DR   AGR; MGI:94867; -.
DR   CTD; 120237; -.
DR   MGI; MGI:94867; Dbx1.
DR   VEuPathDB; HostDB:ENSMUSG00000030507; -.
DR   eggNOG; KOG0488; Eukaryota.
DR   GeneTree; ENSGT00950000183093; -.
DR   HOGENOM; CLU_053401_0_0_1; -.
DR   InParanoid; P52950; -.
DR   OMA; PSHRLAY; -.
DR   OrthoDB; 5387838at2759; -.
DR   PhylomeDB; P52950; -.
DR   TreeFam; TF350735; -.
DR   BioGRID-ORCS; 13172; 2 hits in 77 CRISPR screens.
DR   PRO; PR:P52950; -.
DR   Proteomes; UP000000589; Chromosome 7.
DR   RNAct; P52950; Protein.
DR   Bgee; ENSMUSG00000030507; Expressed in neural tube ventricular layer and 51 other cell types or tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0021515; P:cell differentiation in spinal cord; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IMP:MGI.
DR   GO; GO:0021521; P:ventral spinal cord interneuron specification; IMP:MGI.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR000047; HTH_motif.
DR   PANTHER; PTHR24331; DBX; 1.
DR   PANTHER; PTHR24331:SF6; HOMEOBOX PROTEIN DBX1; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   Genevisible; P52950; MM.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           1..335
FT                   /note="Homeobox protein DBX1"
FT                   /id="PRO_0000048864"
FT   DNA_BIND        181..240
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          58..102
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          240..335
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        80..102
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        269..283
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        318..335
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   335 AA;  36334 MW;  06312CD41F03F369 CRC64;
     MMFPGLLAPP AGYPSLLRPT PTLTLPQSLQ SAFSGHSSFL VEDLIRISRP PTYLSRSIPA
     ASLSPPSQEA PAALADSGTS DLGSPGSGSR RGSSPQTALS PASEPTFLKF GVNAILSSAP
     RRETSPALLQ SPPPKTFAFP YFEGSFQPFI RSSYFPASSS VVPIPGTFSW PLAARGKPRR
     GMLRRAVFSD VQRKALEKTF QKQKYISKPD RKKLASKLGL KDSQVKIWFQ NRRMKWRNSK
     ERELLSSGGC REQTLPTKLN PHPDLSDVGQ KGPGDEEEDN PGARLAYHAP ADPRHLLEGP
     LPASPAHSSS PGKPSDFSDS DEDEEGEEDE EITVS
//