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P52950

- DBX1_MOUSE

UniProt

P52950 - DBX1_MOUSE

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Protein

Homeobox protein DBX1

Gene

Dbx1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Could have a role in patterning the central nervous system during embryogenesis. Has a key role in regulating the distinct phenotypic features that distinguish two major classes of ventral interneurons, V0 and V1 neurons. Regulates the transcription factor profile, neurotransmitter phenotype, intraspinal migratory path and axonal trajectory of V0 neurons, features that differentiate them from an adjacent set of V1 neurons.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi181 – 24060HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro

GO - Biological processi

  1. regulation of transcription from RNA polymerase II promoter Source: MGI
  2. ventral spinal cord interneuron specification Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein DBX1
Alternative name(s):
Developing brain homeobox protein 1
Gene namesi
Name:Dbx1
Synonyms:Dbx
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:94867. Dbx1.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 335335Homeobox protein DBX1PRO_0000048864Add
BLAST

Proteomic databases

PRIDEiP52950.

PTM databases

PhosphoSiteiP52950.

Expressioni

Developmental stagei

During early and mid-gestation, dbx expression is restricted to the telencephalon, diencephalon, dorsal mesencephalon and spinal cord. At later gestational stages, dbx expression continues in the dorsal mesencephalon and diencephalon, in which expression is more restricted than at the earlier stages.

Gene expression databases

BgeeiP52950.
CleanExiMM_DBX1.
GenevestigatoriP52950.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032717.

Structurei

3D structure databases

ProteinModelPortaliP52950.
SMRiP52950. Positions 188-239.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi319 – 33113Asp/Glu-rich (highly acidic)Add
BLAST

Sequence similaritiesi

Belongs to the H2.0 homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG257690.
GeneTreeiENSGT00770000120470.
HOGENOMiHOG000112172.
HOVERGENiHBG005454.
InParanoidiP52950.
OMAiMMFPSLI.
OrthoDBiEOG7SXW4H.
PhylomeDBiP52950.
TreeFamiTF350735.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P52950-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMFPGLLAPP AGYPSLLRPT PTLTLPQSLQ SAFSGHSSFL VEDLIRISRP
60 70 80 90 100
PTYLSRSIPA ASLSPPSQEA PAALADSGTS DLGSPGSGSR RGSSPQTALS
110 120 130 140 150
PASEPTFLKF GVNAILSSAP RRETSPALLQ SPPPKTFAFP YFEGSFQPFI
160 170 180 190 200
RSSYFPASSS VVPIPGTFSW PLAARGKPRR GMLRRAVFSD VQRKALEKTF
210 220 230 240 250
QKQKYISKPD RKKLASKLGL KDSQVKIWFQ NRRMKWRNSK ERELLSSGGC
260 270 280 290 300
REQTLPTKLN PHPDLSDVGQ KGPGDEEEDN PGARLAYHAP ADPRHLLEGP
310 320 330
LPASPAHSSS PGKPSDFSDS DEDEEGEEDE EITVS
Length:335
Mass (Da):36,334
Last modified:October 1, 1996 - v1
Checksum:i06312CD41F03F369
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S75837 mRNA. Translation: AAB33013.1.
BC082541 mRNA. Translation: AAH82541.1.
AK134473 mRNA. Translation: BAE22155.1.
CCDSiCCDS21306.1.
PIRiE41606.
RefSeqiNP_001005232.1. NM_001005232.1.
UniGeneiMm.307176.

Genome annotation databases

EnsembliENSMUST00000032717; ENSMUSP00000032717; ENSMUSG00000030507.
GeneIDi13172.
KEGGimmu:13172.
UCSCiuc009hbn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S75837 mRNA. Translation: AAB33013.1 .
BC082541 mRNA. Translation: AAH82541.1 .
AK134473 mRNA. Translation: BAE22155.1 .
CCDSi CCDS21306.1.
PIRi E41606.
RefSeqi NP_001005232.1. NM_001005232.1.
UniGenei Mm.307176.

3D structure databases

ProteinModelPortali P52950.
SMRi P52950. Positions 188-239.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000032717.

PTM databases

PhosphoSitei P52950.

Proteomic databases

PRIDEi P52950.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000032717 ; ENSMUSP00000032717 ; ENSMUSG00000030507 .
GeneIDi 13172.
KEGGi mmu:13172.
UCSCi uc009hbn.1. mouse.

Organism-specific databases

CTDi 120237.
MGIi MGI:94867. Dbx1.

Phylogenomic databases

eggNOGi NOG257690.
GeneTreei ENSGT00770000120470.
HOGENOMi HOG000112172.
HOVERGENi HBG005454.
InParanoidi P52950.
OMAi MMFPSLI.
OrthoDBi EOG7SXW4H.
PhylomeDBi P52950.
TreeFami TF350735.

Miscellaneous databases

NextBioi 283272.
PROi P52950.
SOURCEi Search...

Gene expression databases

Bgeei P52950.
CleanExi MM_DBX1.
Genevestigatori P52950.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse homeobox gene Dbx: sequence, gene structure and expression pattern during mid-gestation."
    Lu S., Wise T.L., Ruddle F.H.
    Mech. Dev. 47:187-195(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 180-335.
    Strain: C57BL/6J.
    Tissue: Head.
  4. "Control of interneuron fate in the developing spinal cord by the progenitor homeodomain protein Dbx1."
    Pierani A., Moran-Rivard L., Sunshine M.J., Littman D.R., Goulding M., Jessell T.M.
    Neuron 29:367-384(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiDBX1_MOUSE
AccessioniPrimary (citable) accession number: P52950
Secondary accession number(s): Q3UYQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 26, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3