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P52950 (DBX1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein DBX1
Alternative name(s):
Developing brain homeobox protein 1
Gene names
Name:Dbx1
Synonyms:Dbx
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length335 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Could have a role in patterning the central nervous system during embryogenesis. Has a key role in regulating the distinct phenotypic features that distinguish two major classes of ventral interneurons, V0 and V1 neurons. Regulates the transcription factor profile, neurotransmitter phenotype, intraspinal migratory path and axonal trajectory of V0 neurons, features that differentiate them from an adjacent set of V1 neurons. Ref.4

Subcellular location

Nucleus.

Developmental stage

During early and mid-gestation, dbx expression is restricted to the telencephalon, diencephalon, dorsal mesencephalon and spinal cord. At later gestational stages, dbx expression continues in the dorsal mesencephalon and diencephalon, in which expression is more restricted than at the earlier stages.

Sequence similarities

Belongs to the H2.0 homeobox family.

Contains 1 homeobox DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 335335Homeobox protein DBX1
PRO_0000048864

Regions

DNA binding181 – 24060Homeobox
Compositional bias319 – 33113Asp/Glu-rich (highly acidic)

Sequences

Sequence LengthMass (Da)Tools
P52950 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 06312CD41F03F369

FASTA33536,334
        10         20         30         40         50         60 
MMFPGLLAPP AGYPSLLRPT PTLTLPQSLQ SAFSGHSSFL VEDLIRISRP PTYLSRSIPA 

        70         80         90        100        110        120 
ASLSPPSQEA PAALADSGTS DLGSPGSGSR RGSSPQTALS PASEPTFLKF GVNAILSSAP 

       130        140        150        160        170        180 
RRETSPALLQ SPPPKTFAFP YFEGSFQPFI RSSYFPASSS VVPIPGTFSW PLAARGKPRR 

       190        200        210        220        230        240 
GMLRRAVFSD VQRKALEKTF QKQKYISKPD RKKLASKLGL KDSQVKIWFQ NRRMKWRNSK 

       250        260        270        280        290        300 
ERELLSSGGC REQTLPTKLN PHPDLSDVGQ KGPGDEEEDN PGARLAYHAP ADPRHLLEGP 

       310        320        330 
LPASPAHSSS PGKPSDFSDS DEDEEGEEDE EITVS 

« Hide

References

« Hide 'large scale' references
[1]"Mouse homeobox gene Dbx: sequence, gene structure and expression pattern during mid-gestation."
Lu S., Wise T.L., Ruddle F.H.
Mech. Dev. 47:187-195(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 180-335.
Strain: C57BL/6J.
Tissue: Head.
[4]"Control of interneuron fate in the developing spinal cord by the progenitor homeodomain protein Dbx1."
Pierani A., Moran-Rivard L., Sunshine M.J., Littman D.R., Goulding M., Jessell T.M.
Neuron 29:367-384(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S75837 mRNA. Translation: AAB33013.1.
BC082541 mRNA. Translation: AAH82541.1.
AK134473 mRNA. Translation: BAE22155.1.
CCDSCCDS21306.1.
PIRE41606.
RefSeqNP_001005232.1. NM_001005232.1.
UniGeneMm.307176.

3D structure databases

ProteinModelPortalP52950.
SMRP52950. Positions 188-239.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000032717.

PTM databases

PhosphoSiteP52950.

Proteomic databases

PRIDEP52950.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000032717; ENSMUSP00000032717; ENSMUSG00000030507.
GeneID13172.
KEGGmmu:13172.
UCSCuc009hbn.1. mouse.

Organism-specific databases

CTD120237.
MGIMGI:94867. Dbx1.

Phylogenomic databases

eggNOGNOG257690.
GeneTreeENSGT00730000110534.
HOGENOMHOG000112172.
HOVERGENHBG005454.
InParanoidP52950.
OMAMMFPSLI.
OrthoDBEOG7SXW4H.
PhylomeDBP52950.
TreeFamTF350735.

Gene expression databases

BgeeP52950.
CleanExMM_DBX1.
GenevestigatorP52950.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio283272.
PROP52950.
SOURCESearch...

Entry information

Entry nameDBX1_MOUSE
AccessionPrimary (citable) accession number: P52950
Secondary accession number(s): Q3UYQ7
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 9, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot