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Protein

Homeobox protein Hox-A5

Gene

Hoxa5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5'-CYYNATTA[TG]Y-3' (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi174 – 233HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-A5
Alternative name(s):
Homeobox protein Hox-1.3
Gene namesi
Name:Hoxa5
Synonyms:Hox-1.3, Hoxa-5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620609 Hoxa5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000200059‹1 – ›233Homeobox protein Hox-A5Add BLAST›233

Proteomic databases

PaxDbiP52949
PRIDEiP52949

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000067154

Structurei

3D structure databases

ProteinModelPortaliP52949
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi155 – 160Antp-type hexapeptide6

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
HOGENOMiHOG000231178
HOVERGENiHBG016849
InParanoidiP52949
PhylomeDBiP52949

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017995 Homeobox_antennapedia
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00025 ANTENNAPEDIA
PR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00032 ANTENNAPEDIA, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Fragment.

P52949-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
HNYGDHSSVS EQFRDSASMH SGRYGYGYNG MDLSVGRSGS GHFGSGEXXR
60 70 80 90 100
SYXAGASAAP AEPRYSQPAT STHSPPPDPL PCSAVAPLPG SDTHHGGKNS
110 120 130 140 150
LGNSSGCSAN CGSTHISSRE GVGTASAAEE DAPASSEQAG AQSEPSPAPP
160 170 180 190 200
AQPQIYPWMR KLHISHDNIG GPEGKRARTC YTRYQTLELE KEFHFNRYLT
210 220 230
RRRRIEIAHA LCLSERQIKI WFQNRRMKWK KDK
Length:233
Mass (Da):25,391
Last modified:October 1, 1996 - v1
Checksum:i0937608EEDAF368C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei2331

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L03556 mRNA Translation: AAA67844.1
PIRiI65197
UniGeneiRn.8465

Similar proteinsi

Entry informationi

Entry nameiHXA5_RAT
AccessioniPrimary (citable) accession number: P52949
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: March 28, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health