P52949 (HXA5_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homeobox protein Hox-A5

Alternative name(s):
Homeobox protein Hox-1.3

Gene names

Name:	Hoxa5
Synonyms:	Hox-1.3, Hoxa-5

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	233 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5'-CYYNATTA[TG]Y-3' By similarity.
Subcellular location	Nucleus.
Sequence similarities	Belongs to the Antp homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›233	›233	Homeobox protein Hox-A5		PRO_0000200059
Regions
	DNA binding	174 – 233	60	Homeobox
	Motif	155 – 160	6	Antp-type hexapeptide
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	233	1

Sequences

	Sequence		Length	Mass (Da)
	P52949 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 0937608EEDAF368C	FASTA	233	25,391
	10 20 30 40 50 60 HNYGDHSSVS EQFRDSASMH SGRYGYGYNG MDLSVGRSGS GHFGSGEXXR SYXAGASAAP 70 80 90 100 110 120 AEPRYSQPAT STHSPPPDPL PCSAVAPLPG SDTHHGGKNS LGNSSGCSAN CGSTHISSRE 130 140 150 160 170 180 GVGTASAAEE DAPASSEQAG AQSEPSPAPP AQPQIYPWMR KLHISHDNIG GPEGKRARTC 190 200 210 220 230 YTRYQTLELE KEFHFNRYLT RRRRIEIAHA LCLSERQIKI WFQNRRMKWK KDK

References

[1]	"Cloning and sequence analysis of homeobox transcription factor cDNAs with an inosine-containing probe." Gorski D.H., LePage D.F., Walsh K. BioTechniques 16:856-858(1994) [PubMed: 7915120] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Aorta.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L03556 mRNA. Translation: AAA67844.1.
IPI	IPI00211208.
PIR	I65197.
UniGene	Rn.8465.
3D structure databases
ProteinModelPortal	P52949.
SMR	P52949. Positions 153-232.
ModBase	Search...
Protein-protein interaction databases
STRING	P52949.
Proteomic databases
PRIDE	P52949.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
RGD	620609. Hoxa5.
Phylogenomic databases
eggNOG	maNOG08919.
GeneTree	ENSGT00600000084133.
HOVERGEN	HBG016849.
InParanoid	P52949.
OrthoDB	EOG49S677.
Gene expression databases
ArrayExpress	P52949.
Genevestigator	P52949.
GermOnline	ENSRNOG00000006466. Rattus norvegicus.
Family and domain databases
InterPro	IPR001356. Homeobox. IPR017995. Homeobox_antennapedia. IPR001827. Homeobox_Antennapedia_CS. IPR017970. Homeobox_CS. IPR020479. Homeobox_eu. IPR009057. Homeodomain-like. IPR012287. Homeodomain-rel. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00025. ANTENNAPEDIA. PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00032. ANTENNAPEDIA. 1 hit. PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HXA5_RAT

Accession

Primary (citable) accession number: P52949

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	December 14, 2011
This is version 84 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program