P52948 (NUP98_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nuclear pore complex protein Nup98-Nup96

Cleaved into the following 2 chains:

1. Nuclear pore complex protein Nup98
   Alternative name(s):
   98 kDa nucleoporin
   Nucleoporin Nup98
   Short name=Nup98
2. Nuclear pore complex protein Nup96
   Alternative name(s):
   96 kDa nucleoporin
   Nucleoporin Nup96
   Short name=Nup96

Gene names

Name:	NUP98
Synonyms:	ADAR2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1817 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. Nup98 and Nup96 are involved in the bidirectional transport across the NPC. May anchor NUP153 and TPR to the NPC. Ref.18
Subunit structure	Part of the nuclear pore complex (NPC). Nup98 interacts directly with Nup96. Nup98 interacts directly with NUP88 and NUP214, subunits of the cytoplasmic filaments of the NPC By similarity. Nup96 is part of the Nup160 subcomplex in the nuclear pore which is composed of NUP160, NUP133, NUP107 and Nup96. This complex plays a role in RNA export and in tethering Nup98 and NUP153 to the nucleus. Interacts with RAE1. Does not interact with TPR. Interacts with vesicular stomatitis virus protein M. Ref.11 Ref.12 Ref.14 Ref.17 Ref.18 Ref.37 Ref.38
Subcellular location	Nucleus. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Nucleus › nuclear pore complex. Note: Nup96 is localized to the nucleoplasmic side of the nuclear pore complex (NPC), at or near the nucleoplasmic basket. Dissociates from the dissasembled NPC structure early during prophase of mitosis. Colocalized with NUP153 and TPR to the nuclear basket of NPC. Detected in diffuse and discrete intranuclear foci. Remained localized to the nuclear membrane after poliovirus (PV) infection. Ref.16 Ref.17 Ref.18 Ref.32
Domain	Contains G-L-F-G repeats. The FG repeat domains in Nup98 have a direct role in the transport.
Post-translational modification	Isoform 1 to isoform 4 are autoproteolytically cleaved to yield Nup98 and Nup96 or Nup98 only, respectively. Cleaved Nup98 is necessary for the targeting of Nup98 to the nuclear pore and the interaction with Nup96. Ref.32 Ref.38 Proteolytically degraded after poliovirus (PV) infection; degradation is partial and NCP- and TPR-binding domains withstand degradation.
Involvement in disease	A chromosomal aberration involving NUP98 is found in a form of acute myeloid leukemia. Translocation t(7;11)(p15;p15) with HOXA9. Translocation t(11;17)(p15;p13) with PHF23. Ref.19 A chromosomal aberration involving NUP98 is found in childhood acute myeloid leukemia. Translocation t(5;11)(q35;p15.5) with NSD1. Translocation t(8;11)(p11.2;p15) with WHSC1L1. A chromosomal aberration involving NUP98 is found in a form of therapy-related myelodysplastic syndrome. Translocation t(11;20)(p15;q11) with TOP1. A chromosomal aberration involving NUP98 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(3;11)(q12.2;p15.4) with LNP1. A chromosomal aberration involving NUP98 is associated with pediatric acute myeloid leukemia (AML) with intermediate characteristics between M2-M3 French-American-British (FAB) subtypes. Translocation t(9;11)(p22;p15) with PSIP1/LEDGF. The chimeric transcript is an in-frame fusion of NUP98 exon 8 to PSIP1/LEDGF exon 4. A chromosomal aberration involving NUP98 has been identified in acute leukemias. Translocation t(6;11)(q24.1;p15.5) with CCDC28A. The chimeric transcript is an in-frame fusion of NUP98 exon 13 to CCDC28A exon 2. Ectopic expression of NUP98-CCDC28A in mouse promotes the proliferative capacity and self-renewal potential of hematopoietic progenitors and rapidly induced fatal myeloproliferative neoplasms and defects in the differentiation of the erythro-megakaryocytic lineage. Ref.19
Sequence similarities	Belongs to the nucleoporin GLFG family. Contains 1 peptidase S59 domain.
Sequence caution	The sequence AAD22395.1 differs from that shown. Reason: Contaminating sequence. Sequence of unknown origin in the C-terminal part. The sequence AAD22396.1 differs from that shown. Reason: Contaminating sequence. Sequence of unknown origin in the C-terminal part. The sequence AAF19342.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence AAF19342.1 differs from that shown. Reason: Frameshift at position 1551.

Ontologies

Keywords
Biological process	Host-virus interaction mRNA transport Protein transport Translocation Transport
Cellular component	Membrane Nuclear pore complex Nucleus
Coding sequence diversity	Alternative splicing Chromosomal rearrangement Polymorphism
Domain	Repeat
PTM	Acetylation Autocatalytic cleavage Phosphoprotein
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	DNA replication Inferred from mutant phenotype PubMed 9348540. Source: UniProtKB carbohydrate metabolic process Traceable author statement. Source: Reactome cytokine-mediated signaling pathway Traceable author statement. Source: Reactome glucose transport Traceable author statement. Source: Reactome hexose transport Traceable author statement. Source: Reactome mRNA transport Inferred from electronic annotation. Source: UniProtKB-KW mitotic cell cycle Traceable author statement. Source: Reactome mitotic nuclear envelope disassembly Traceable author statement. Source: Reactome nuclear pore complex assembly Inferred from mutant phenotype Ref.18. Source: UniProtKB nuclear pore organization Non-traceable author statement PubMed 9348540. Source: UniProtKB nucleocytoplasmic transport Traceable author statement PubMed 9348540. Source: UniProtKB protein import into nucleus, docking Non-traceable author statement Ref.18. Source: UniProtKB regulation of glucose transport Traceable author statement. Source: Reactome small molecule metabolic process Traceable author statement. Source: Reactome transmembrane transport Traceable author statement. Source: Reactome viral process Traceable author statement. Source: Reactome
Cellular_component	cytosol Traceable author statement. Source: Reactome nuclear envelope Inferred from direct assay PubMed 15146057. Source: UniProtKB nuclear inclusion body Inferred from direct assay Ref.16. Source: UniProtKB nuclear membrane Inferred from direct assay Ref.16Ref.17Ref.18Ref.32. Source: UniProtKB nuclear periphery Inferred from direct assay Ref.16Ref.18. Source: UniProtKB nuclear pore Inferred from direct assay Ref.17Ref.18PubMed 9348540. Source: UniProtKB nuclear pore nuclear basket Inferred from direct assay Ref.16. Source: UniProtKB nuclear pore outer ring Inferred from direct assay PubMed 17360435. Source: UniProtKB nucleoplasm Traceable author statement. Source: Reactome
Molecular_function	peptide binding Inferred from electronic annotation. Source: Ensembl structural constituent of nuclear pore Inferred from mutant phenotype Ref.18. Source: UniProtKB transporter activity Traceable author statement PubMed 7736573. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P52948-1)

Also known as: Nup98-Nup96 precursor;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P52948-2)

Also known as: Nup98-Nup96 precursor splice variant 1;

The sequence of this isoform differs from the canonical sequence as follows:
     393-409: Missing.
     1502-1576: RHYDLNQLLE...FVLLHIDNSG → S

Isoform 3 (identifier: P52948-3)

Also known as: Nup98-specific 1;

The sequence of this isoform differs from the canonical sequence as follows:
     932-937: SQSPEV → VEKKGQ
     938-1817: Missing.

Isoform 4 (identifier: P52948-4)

The sequence of this isoform differs from the canonical sequence as follows:
     393-409: Missing.
     932-937: SQSPEV → VEKKGQ
     938-1817: Missing.

Isoform 5 (identifier: P52948-5)

Also known as: Nup196; ADIR2;

The sequence of this isoform differs from the canonical sequence as follows:
     393-409: Missing.

Isoform 6 (identifier: P52948-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1085-1188: WSVPPPLTSV...FLPNPVAVKP → C

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 880

880

Nuclear pore complex protein Nup98

PRO_0000019929

Chain

881 – 1817

937

Nuclear pore complex protein Nup96

PRO_0000019930

Regions

Domain

738 – 880

143

Peptidase S59

Region

1 – 156

156

FG repeats 1

Region

157 – 213

57

GLEBS; interaction with RAE1

Region

214 – 480

267

FG repeats 2

Compositional bias

7 – 480

474

Gly/Thr-rich

Compositional bias

890 – 894

5

Poly-Glu

Sites

Site

531 – 532

2

Breakpoint for translocation to form NUP98-CCDC28A

Site

531 – 532

2

Breakpoint for translocation to form NUP98-PHF23 oncogene

Amino acid modifications

Modified residue

524

1

Phosphoserine Ref.33

Modified residue

603

1

N6-acetyllysine Ref.31

Modified residue

608

1

Phosphoserine Ref.21 Ref.23 Ref.25 Ref.30 Ref.33

Modified residue

612

1

Phosphoserine Ref.21 Ref.23 Ref.25 Ref.30 Ref.33 Ref.35

Modified residue

618

1

Phosphoserine Ref.30

Modified residue

623

1

Phosphoserine Ref.23 Ref.27 Ref.30 Ref.33 Ref.35

Modified residue

625

1

Phosphoserine Ref.30

Modified residue

653

1

Phosphoserine By similarity

Modified residue

670

1

Phosphothreonine Ref.33

Modified residue

673

1

Phosphoserine Ref.33

Modified residue

681

1

Phosphoserine Ref.33

Modified residue

683

1

Phosphoserine Ref.35

Modified residue

839

1

Phosphoserine Ref.21 Ref.27 Ref.33 Ref.35

Modified residue

888

1

Phosphoserine Ref.21 Ref.26 Ref.27 Ref.28 Ref.33 Ref.35

Modified residue

934

1

Phosphoserine Ref.27 Ref.33

Modified residue

1000

1

Phosphothreonine Ref.27

Modified residue

1023

1

Phosphoserine Ref.27

Modified residue

1028

1

Phosphoserine Ref.23 Ref.27

Modified residue

1043

1

Phosphoserine Ref.27

Modified residue

1060

1

Phosphoserine Ref.23 Ref.27

Modified residue

1070

1

Phosphothreonine Ref.27

Natural variations

Alternative sequence

393 – 409

17

Missing in isoform 2, isoform 4 and isoform 5.

VSP_003619

Alternative sequence

932 – 937

6

SQSPEV → VEKKGQ in isoform 3 and isoform 4.

VSP_007942

Alternative sequence

938 – 1817

880

Missing in isoform 3 and isoform 4.

VSP_007943

Alternative sequence

1085 – 1188

104

WSVPP…VAVKP → C in isoform 6.

VSP_038328

Alternative sequence

1502 – 1576

75

RHYDL…IDNSG → S in isoform 2.

VSP_007944

Natural variant

1669

1

G → V in a breast cancer sample; somatic mutation. Ref.40

VAR_035859

Experimental info

Sequence conflict

318

1

L → S in AAH41136. Ref.6

Sequence conflict

376

1

S → G in AAH41136. Ref.6

Sequence conflict

756 – 757

2

EK → VF in AAD22395. Ref.3

Sequence conflict

756 – 757

2

EK → VF in AAD22396. Ref.3

Sequence conflict

1281

1

G → A in AAD22395. Ref.3

Sequence conflict

1281

1

G → A in AAD22396. Ref.3

Sequence conflict

1281

1

G → A in AAL56659. Ref.4

Sequence conflict

1534 – 1536

3

ALN → DLK in AAD22395. Ref.3

Sequence conflict

1594

1

E → D in AAF19342. Ref.7

Sequence conflict

1598

1

S → T in AAL56659. Ref.4

Sequence conflict

1639

1

K → N in AAF19342. Ref.7

Sequence conflict

1680

1

S → T in AAF19342. Ref.7

Secondary structure

1

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1817

Helix Strand Turn

Details...

Beta strand

168 – 172

5

Beta strand

181 – 186

6

Helix

189 – 191

3

Turn

193 – 197

5

Helix

200 – 209

10

Beta strand

741 – 745

5

Helix

747 – 753

7

Beta strand

761 – 769

9

Turn

770 – 772

3

Beta strand

773 – 782

10

Helix

788 – 791

4

Beta strand

792 – 795

4

Beta strand

798 – 801

4

Helix

805 – 807

3

Beta strand

819 – 823

5

Turn

831 – 833

3

Helix

840 – 845

6

Helix

848 – 858

11

Beta strand

862 – 867

6

Turn

868 – 871

4

Beta strand

872 – 879

8

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (Nup98-Nup96 precursor) [UniParc]. Last modified October 5, 2010. Version 4. Checksum: BC60E5456B936C79	FASTA	1,817	197,579
	10 20 30 40 50 60 MFNKSFGTPF GGGTGGFGTT STFGQNTGFG TTSGGAFGTS AFGSSNNTGG LFGNSQTKPG 70 80 90 100 110 120 GLFGTSSFSQ PATSTSTGFG FGTSTGTANT LFGTASTGTS LFSSQNNAFA QNKPTGFGNF 130 140 150 160 170 180 GTSTSSGGLF GTTNTTSNPF GSTSGSLFGP SSFTAAPTGT TIKFNPPTGT DTMVKAGVST 190 200 210 220 230 240 NISTKHQCIT AMKEYESKSL EELRLEDYQA NRKGPQNQVG AGTTTGLFGS SPATSSATGL 250 260 270 280 290 300 FSSSTTNSGF AYGQNKTAFG TSTTGFGTNP GGLFGQQNQQ TTSLFSKPFG QATTTQNTGF 310 320 330 340 350 360 SFGNTSTIGQ PSTNTMGLFG VTQASQPGGL FGTATNTSTG TAFGTGTGLF GQTNTGFGAV 370 380 390 400 410 420 GSTLFGNNKL TTFGSSTTSA PSFGTTSGGL FGNKPTLTLG TNTNTSNFGF GTNTSGNSIF 430 440 450 460 470 480 GSKPAPGTLG TGLGAGFGTA LGAGQASLFG NNQPKIGGPL GTGAFGAPGF NTTTATLGFG 490 500 510 520 530 540 APQAPVALTD PNASAAQQAV LQQHINSLTY SPFGDSPLFR NPMSDPKKKE ERLKPTNPAA 550 560 570 580 590 600 QKALTTPTHY KLTPRPATRV RPKALQTTGT AKSHLFDGLD DDEPSLANGA FMPKKSIKKL 610 620 630 640 650 660 VLKNLNNSNL FSPVNRDSEN LASPSEYPEN GERFSFLSKP VDENHQQDGD EDSLVSHFYT 670 680 690 700 710 720 NPIAKPIPQT PESAGNKHSN SNSVDDTIVA LNMRAALRNG LEGSSEETSF HDESLQDDRE 730 740 750 760 770 780 EIENNSYHMH PAGIILTKVG YYTIPSMDDL AKITNEKGEC IVSDFTIGRK GYGSIYFEGD 790 800 810 820 830 840 VNLTNLNLDD IVHIRRKEVV VYLDDNQKPP VGEGLNRKAE VTLDGVWPTD KTSRCLIKSP 850 860 870 880 890 900 DRLADINYEG RLEAVSRKQG AQFKEYRPET GSWVFKVSHF SKYGLQDSDE EEEEHPSKTS 910 920 930 940 950 960 TKKLKTAPLP PASQTTPLQM ALNGKPAPPP QSQSPEVEQL GRVVELDSDM VDITQEPVLD 970 980 990 1000 1010 1020 TMLEESMPED QEPVSASTHI ASSLGINPHV LQIMKASLLT DEEDVDMALD QRFSRLPSKA 1030 1040 1050 1060 1070 1080 DTSQEICSPR LPISASHSSK TRSLVGGLLQ SKFTSGAFLS PSVSVQECRT PRAASLMNIP 1090 1100 1110 1120 1130 1140 STSSWSVPPP LTSVFTMPSP APEVPLKTVG TRRQLGLVPR EKSVTYGKGK LLMDMALFMG 1150 1160 1170 1180 1190 1200 RSFRVGWGPN WTLANSGEQL NGSHELENHQ IADSMEFGFL PNPVAVKPLT ESPFKVHLEK 1210 1220 1230 1240 1250 1260 LSLRQRKPDE DMKLYQTPLE LKLKHSTVHV DELCPLIVPN LGVAVIHDYA DWVKEASGDL 1270 1280 1290 1300 1310 1320 PEAQIVKHWS LTWTLCEALW GHLKELDSQL NEPREYIQIL ERRRAFSRWL SCTATPQIEE 1330 1340 1350 1360 1370 1380 EVSLTQKNSP VEAVFSYLTG KRISEACSLA QQSGDHRLAL LLSQFVGSQS VRELLTMQLV 1390 1400 1410 1420 1430 1440 DWHQLQADSF IQDERLRIFA LLAGKPVWQL SEKKQINVCS QLDWKRSLAI HLWYLLPPTA 1450 1460 1470 1480 1490 1500 SISRALSMYE EAFQNTSDSD RYACSPLPSY LEGSGCVIAE EQNSQTPLRD VCFHLLKLYS 1510 1520 1530 1540 1550 1560 DRHYDLNQLL EPRSITADPL DYRLSWHLWE VLRALNYTHL SAQCEGVLQA SYAGQLESEG 1570 1580 1590 1600 1610 1620 LWEWAIFVLL HIDNSGIREK AVRELLTRHC QLLETPESWA KETFLTQKLR VPAKWIHEAK 1630 1640 1650 1660 1670 1680 AVRAHMESDK HLEALCLFKA EHWNRCHKLI IRHLASDAII NENYDYLKGF LEDLAPPERS 1690 1700 1710 1720 1730 1740 SLIQDWETSG LVYLDYIRVI EMLRHIQQVD CSGNDLEQLH IKVTSLCSRI EQIQCYSAKD 1750 1760 1770 1780 1790 1800 RLAQSDMAKR VANLLRVVLS LHHPPDRTSD STPDPQRVPL RLLAPHIGRL PMPEDYAMDE 1810 LRSLTQSYLR ELAVGSL
	Isoform 2 (Nup98-Nup96 precursor splice variant 1) [UniParc]. Checksum: 0F92C34F9FD7DC92	FASTA	1,726	187,199
	10 20 30 40 50 60 MFNKSFGTPF GGGTGGFGTT STFGQNTGFG TTSGGAFGTS AFGSSNNTGG LFGNSQTKPG 70 80 90 100 110 120 GLFGTSSFSQ PATSTSTGFG FGTSTGTANT LFGTASTGTS LFSSQNNAFA QNKPTGFGNF 130 140 150 160 170 180 GTSTSSGGLF GTTNTTSNPF GSTSGSLFGP SSFTAAPTGT TIKFNPPTGT DTMVKAGVST 190 200 210 220 230 240 NISTKHQCIT AMKEYESKSL EELRLEDYQA NRKGPQNQVG AGTTTGLFGS SPATSSATGL 250 260 270 280 290 300 FSSSTTNSGF AYGQNKTAFG TSTTGFGTNP GGLFGQQNQQ TTSLFSKPFG QATTTQNTGF 310 320 330 340 350 360 SFGNTSTIGQ PSTNTMGLFG VTQASQPGGL FGTATNTSTG TAFGTGTGLF GQTNTGFGAV 370 380 390 400 410 420 GSTLFGNNKL TTFGSSTTSA PSFGTTSGGL FGFGTNTSGN SIFGSKPAPG TLGTGLGAGF 430 440 450 460 470 480 GTALGAGQAS LFGNNQPKIG GPLGTGAFGA PGFNTTTATL GFGAPQAPVA LTDPNASAAQ 490 500 510 520 530 540 QAVLQQHINS LTYSPFGDSP LFRNPMSDPK KKEERLKPTN PAAQKALTTP THYKLTPRPA 550 560 570 580 590 600 TRVRPKALQT TGTAKSHLFD GLDDDEPSLA NGAFMPKKSI KKLVLKNLNN SNLFSPVNRD 610 620 630 640 650 660 SENLASPSEY PENGERFSFL SKPVDENHQQ DGDEDSLVSH FYTNPIAKPI PQTPESAGNK 670 680 690 700 710 720 HSNSNSVDDT IVALNMRAAL RNGLEGSSEE TSFHDESLQD DREEIENNSY HMHPAGIILT 730 740 750 760 770 780 KVGYYTIPSM DDLAKITNEK GECIVSDFTI GRKGYGSIYF EGDVNLTNLN LDDIVHIRRK 790 800 810 820 830 840 EVVVYLDDNQ KPPVGEGLNR KAEVTLDGVW PTDKTSRCLI KSPDRLADIN YEGRLEAVSR 850 860 870 880 890 900 KQGAQFKEYR PETGSWVFKV SHFSKYGLQD SDEEEEEHPS KTSTKKLKTA PLPPASQTTP 910 920 930 940 950 960 LQMALNGKPA PPPQSQSPEV EQLGRVVELD SDMVDITQEP VLDTMLEESM PEDQEPVSAS 970 980 990 1000 1010 1020 THIASSLGIN PHVLQIMKAS LLTDEEDVDM ALDQRFSRLP SKADTSQEIC SPRLPISASH 1030 1040 1050 1060 1070 1080 SSKTRSLVGG LLQSKFTSGA FLSPSVSVQE CRTPRAASLM NIPSTSSWSV PPPLTSVFTM 1090 1100 1110 1120 1130 1140 PSPAPEVPLK TVGTRRQLGL VPREKSVTYG KGKLLMDMAL FMGRSFRVGW GPNWTLANSG 1150 1160 1170 1180 1190 1200 EQLNGSHELE NHQIADSMEF GFLPNPVAVK PLTESPFKVH LEKLSLRQRK PDEDMKLYQT 1210 1220 1230 1240 1250 1260 PLELKLKHST VHVDELCPLI VPNLGVAVIH DYADWVKEAS GDLPEAQIVK HWSLTWTLCE 1270 1280 1290 1300 1310 1320 ALWGHLKELD SQLNEPREYI QILERRRAFS RWLSCTATPQ IEEEVSLTQK NSPVEAVFSY 1330 1340 1350 1360 1370 1380 LTGKRISEAC SLAQQSGDHR LALLLSQFVG SQSVRELLTM QLVDWHQLQA DSFIQDERLR 1390 1400 1410 1420 1430 1440 IFALLAGKPV WQLSEKKQIN VCSQLDWKRS LAIHLWYLLP PTASISRALS MYEEAFQNTS 1450 1460 1470 1480 1490 1500 DSDRYACSPL PSYLEGSGCV IAEEQNSQTP LRDVCFHLLK LYSDSIREKA VRELLTRHCQ 1510 1520 1530 1540 1550 1560 LLETPESWAK ETFLTQKLRV PAKWIHEAKA VRAHMESDKH LEALCLFKAE HWNRCHKLII 1570 1580 1590 1600 1610 1620 RHLASDAIIN ENYDYLKGFL EDLAPPERSS LIQDWETSGL VYLDYIRVIE MLRHIQQVDC 1630 1640 1650 1660 1670 1680 SGNDLEQLHI KVTSLCSRIE QIQCYSAKDR LAQSDMAKRV ANLLRVVLSL HHPPDRTSDS 1690 1700 1710 1720 TPDPQRVPLR LLAPHIGRLP MPEDYAMDEL RSLTQSYLRE LAVGSL
	Isoform 3 (Nup98-specific 1) [UniParc]. Checksum: 2CB6CE36734F0B82	FASTA	937	97,836
	10 20 30 40 50 60 MFNKSFGTPF GGGTGGFGTT STFGQNTGFG TTSGGAFGTS AFGSSNNTGG LFGNSQTKPG 70 80 90 100 110 120 GLFGTSSFSQ PATSTSTGFG FGTSTGTANT LFGTASTGTS LFSSQNNAFA QNKPTGFGNF 130 140 150 160 170 180 GTSTSSGGLF GTTNTTSNPF GSTSGSLFGP SSFTAAPTGT TIKFNPPTGT DTMVKAGVST 190 200 210 220 230 240 NISTKHQCIT AMKEYESKSL EELRLEDYQA NRKGPQNQVG AGTTTGLFGS SPATSSATGL 250 260 270 280 290 300 FSSSTTNSGF AYGQNKTAFG TSTTGFGTNP GGLFGQQNQQ TTSLFSKPFG QATTTQNTGF 310 320 330 340 350 360 SFGNTSTIGQ PSTNTMGLFG VTQASQPGGL FGTATNTSTG TAFGTGTGLF GQTNTGFGAV 370 380 390 400 410 420 GSTLFGNNKL TTFGSSTTSA PSFGTTSGGL FGNKPTLTLG TNTNTSNFGF GTNTSGNSIF 430 440 450 460 470 480 GSKPAPGTLG TGLGAGFGTA LGAGQASLFG NNQPKIGGPL GTGAFGAPGF NTTTATLGFG 490 500 510 520 530 540 APQAPVALTD PNASAAQQAV LQQHINSLTY SPFGDSPLFR NPMSDPKKKE ERLKPTNPAA 550 560 570 580 590 600 QKALTTPTHY KLTPRPATRV RPKALQTTGT AKSHLFDGLD DDEPSLANGA FMPKKSIKKL 610 620 630 640 650 660 VLKNLNNSNL FSPVNRDSEN LASPSEYPEN GERFSFLSKP VDENHQQDGD EDSLVSHFYT 670 680 690 700 710 720 NPIAKPIPQT PESAGNKHSN SNSVDDTIVA LNMRAALRNG LEGSSEETSF HDESLQDDRE 730 740 750 760 770 780 EIENNSYHMH PAGIILTKVG YYTIPSMDDL AKITNEKGEC IVSDFTIGRK GYGSIYFEGD 790 800 810 820 830 840 VNLTNLNLDD IVHIRRKEVV VYLDDNQKPP VGEGLNRKAE VTLDGVWPTD KTSRCLIKSP 850 860 870 880 890 900 DRLADINYEG RLEAVSRKQG AQFKEYRPET GSWVFKVSHF SKYGLQDSDE EEEEHPSKTS 910 920 930 TKKLKTAPLP PASQTTPLQM ALNGKPAPPP QVEKKGQ
	Isoform 4 [UniParc]. Checksum: 129DABAFB69253AD	FASTA	920	96,075
	10 20 30 40 50 60 MFNKSFGTPF GGGTGGFGTT STFGQNTGFG TTSGGAFGTS AFGSSNNTGG LFGNSQTKPG 70 80 90 100 110 120 GLFGTSSFSQ PATSTSTGFG FGTSTGTANT LFGTASTGTS LFSSQNNAFA QNKPTGFGNF 130 140 150 160 170 180 GTSTSSGGLF GTTNTTSNPF GSTSGSLFGP SSFTAAPTGT TIKFNPPTGT DTMVKAGVST 190 200 210 220 230 240 NISTKHQCIT AMKEYESKSL EELRLEDYQA NRKGPQNQVG AGTTTGLFGS SPATSSATGL 250 260 270 280 290 300 FSSSTTNSGF AYGQNKTAFG TSTTGFGTNP GGLFGQQNQQ TTSLFSKPFG QATTTQNTGF 310 320 330 340 350 360 SFGNTSTIGQ PSTNTMGLFG VTQASQPGGL FGTATNTSTG TAFGTGTGLF GQTNTGFGAV 370 380 390 400 410 420 GSTLFGNNKL TTFGSSTTSA PSFGTTSGGL FGFGTNTSGN SIFGSKPAPG TLGTGLGAGF 430 440 450 460 470 480 GTALGAGQAS LFGNNQPKIG GPLGTGAFGA PGFNTTTATL GFGAPQAPVA LTDPNASAAQ 490 500 510 520 530 540 QAVLQQHINS LTYSPFGDSP LFRNPMSDPK KKEERLKPTN PAAQKALTTP THYKLTPRPA 550 560 570 580 590 600 TRVRPKALQT TGTAKSHLFD GLDDDEPSLA NGAFMPKKSI KKLVLKNLNN SNLFSPVNRD 610 620 630 640 650 660 SENLASPSEY PENGERFSFL SKPVDENHQQ DGDEDSLVSH FYTNPIAKPI PQTPESAGNK 670 680 690 700 710 720 HSNSNSVDDT IVALNMRAAL RNGLEGSSEE TSFHDESLQD DREEIENNSY HMHPAGIILT 730 740 750 760 770 780 KVGYYTIPSM DDLAKITNEK GECIVSDFTI GRKGYGSIYF EGDVNLTNLN LDDIVHIRRK 790 800 810 820 830 840 EVVVYLDDNQ KPPVGEGLNR KAEVTLDGVW PTDKTSRCLI KSPDRLADIN YEGRLEAVSR 850 860 870 880 890 900 KQGAQFKEYR PETGSWVFKV SHFSKYGLQD SDEEEEEHPS KTSTKKLKTA PLPPASQTTP 910 920 LQMALNGKPA PPPQVEKKGQ
	Isoform 5 (Nup196) (ADIR2) [UniParc]. Checksum: 4BCA483C2E9E1A8E	FASTA	1,800	195,817
	10 20 30 40 50 60 MFNKSFGTPF GGGTGGFGTT STFGQNTGFG TTSGGAFGTS AFGSSNNTGG LFGNSQTKPG 70 80 90 100 110 120 GLFGTSSFSQ PATSTSTGFG FGTSTGTANT LFGTASTGTS LFSSQNNAFA QNKPTGFGNF 130 140 150 160 170 180 GTSTSSGGLF GTTNTTSNPF GSTSGSLFGP SSFTAAPTGT TIKFNPPTGT DTMVKAGVST 190 200 210 220 230 240 NISTKHQCIT AMKEYESKSL EELRLEDYQA NRKGPQNQVG AGTTTGLFGS SPATSSATGL 250 260 270 280 290 300 FSSSTTNSGF AYGQNKTAFG TSTTGFGTNP GGLFGQQNQQ TTSLFSKPFG QATTTQNTGF 310 320 330 340 350 360 SFGNTSTIGQ PSTNTMGLFG VTQASQPGGL FGTATNTSTG TAFGTGTGLF GQTNTGFGAV 370 380 390 400 410 420 GSTLFGNNKL TTFGSSTTSA PSFGTTSGGL FGFGTNTSGN SIFGSKPAPG TLGTGLGAGF 430 440 450 460 470 480 GTALGAGQAS LFGNNQPKIG GPLGTGAFGA PGFNTTTATL GFGAPQAPVA LTDPNASAAQ 490 500 510 520 530 540 QAVLQQHINS LTYSPFGDSP LFRNPMSDPK KKEERLKPTN PAAQKALTTP THYKLTPRPA 550 560 570 580 590 600 TRVRPKALQT TGTAKSHLFD GLDDDEPSLA NGAFMPKKSI KKLVLKNLNN SNLFSPVNRD 610 620 630 640 650 660 SENLASPSEY PENGERFSFL SKPVDENHQQ DGDEDSLVSH FYTNPIAKPI PQTPESAGNK 670 680 690 700 710 720 HSNSNSVDDT IVALNMRAAL RNGLEGSSEE TSFHDESLQD DREEIENNSY HMHPAGIILT 730 740 750 760 770 780 KVGYYTIPSM DDLAKITNEK GECIVSDFTI GRKGYGSIYF EGDVNLTNLN LDDIVHIRRK 790 800 810 820 830 840 EVVVYLDDNQ KPPVGEGLNR KAEVTLDGVW PTDKTSRCLI KSPDRLADIN YEGRLEAVSR 850 860 870 880 890 900 KQGAQFKEYR PETGSWVFKV SHFSKYGLQD SDEEEEEHPS KTSTKKLKTA PLPPASQTTP 910 920 930 940 950 960 LQMALNGKPA PPPQSQSPEV EQLGRVVELD SDMVDITQEP VLDTMLEESM PEDQEPVSAS 970 980 990 1000 1010 1020 THIASSLGIN PHVLQIMKAS LLTDEEDVDM ALDQRFSRLP SKADTSQEIC SPRLPISASH 1030 1040 1050 1060 1070 1080 SSKTRSLVGG LLQSKFTSGA FLSPSVSVQE CRTPRAASLM NIPSTSSWSV PPPLTSVFTM 1090 1100 1110 1120 1130 1140 PSPAPEVPLK TVGTRRQLGL VPREKSVTYG KGKLLMDMAL FMGRSFRVGW GPNWTLANSG 1150 1160 1170 1180 1190 1200 EQLNGSHELE NHQIADSMEF GFLPNPVAVK PLTESPFKVH LEKLSLRQRK PDEDMKLYQT 1210 1220 1230 1240 1250 1260 PLELKLKHST VHVDELCPLI VPNLGVAVIH DYADWVKEAS GDLPEAQIVK HWSLTWTLCE 1270 1280 1290 1300 1310 1320 ALWGHLKELD SQLNEPREYI QILERRRAFS RWLSCTATPQ IEEEVSLTQK NSPVEAVFSY 1330 1340 1350 1360 1370 1380 LTGKRISEAC SLAQQSGDHR LALLLSQFVG SQSVRELLTM QLVDWHQLQA DSFIQDERLR 1390 1400 1410 1420 1430 1440 IFALLAGKPV WQLSEKKQIN VCSQLDWKRS LAIHLWYLLP PTASISRALS MYEEAFQNTS 1450 1460 1470 1480 1490 1500 DSDRYACSPL PSYLEGSGCV IAEEQNSQTP LRDVCFHLLK LYSDRHYDLN QLLEPRSITA 1510 1520 1530 1540 1550 1560 DPLDYRLSWH LWEVLRALNY THLSAQCEGV LQASYAGQLE SEGLWEWAIF VLLHIDNSGI 1570 1580 1590 1600 1610 1620 REKAVRELLT RHCQLLETPE SWAKETFLTQ KLRVPAKWIH EAKAVRAHME SDKHLEALCL 1630 1640 1650 1660 1670 1680 FKAEHWNRCH KLIIRHLASD AIINENYDYL KGFLEDLAPP ERSSLIQDWE TSGLVYLDYI 1690 1700 1710 1720 1730 1740 RVIEMLRHIQ QVDCSGNDLE QLHIKVTSLC SRIEQIQCYS AKDRLAQSDM AKRVANLLRV 1750 1760 1770 1780 1790 1800 VLSLHHPPDR TSDSTPDPQR VPLRLLAPHI GRLPMPEDYA MDELRSLTQS YLRELAVGSL
	Isoform 6 [UniParc]. Checksum: 158300FBC47A0C0C	FASTA	1,714	186,268
	10 20 30 40 50 60 MFNKSFGTPF GGGTGGFGTT STFGQNTGFG TTSGGAFGTS AFGSSNNTGG LFGNSQTKPG 70 80 90 100 110 120 GLFGTSSFSQ PATSTSTGFG FGTSTGTANT LFGTASTGTS LFSSQNNAFA QNKPTGFGNF 130 140 150 160 170 180 GTSTSSGGLF GTTNTTSNPF GSTSGSLFGP SSFTAAPTGT TIKFNPPTGT DTMVKAGVST 190 200 210 220 230 240 NISTKHQCIT AMKEYESKSL EELRLEDYQA NRKGPQNQVG AGTTTGLFGS SPATSSATGL 250 260 270 280 290 300 FSSSTTNSGF AYGQNKTAFG TSTTGFGTNP GGLFGQQNQQ TTSLFSKPFG QATTTQNTGF 310 320 330 340 350 360 SFGNTSTIGQ PSTNTMGLFG VTQASQPGGL FGTATNTSTG TAFGTGTGLF GQTNTGFGAV 370 380 390 400 410 420 GSTLFGNNKL TTFGSSTTSA PSFGTTSGGL FGNKPTLTLG TNTNTSNFGF GTNTSGNSIF 430 440 450 460 470 480 GSKPAPGTLG TGLGAGFGTA LGAGQASLFG NNQPKIGGPL GTGAFGAPGF NTTTATLGFG 490 500 510 520 530 540 APQAPVALTD PNASAAQQAV LQQHINSLTY SPFGDSPLFR NPMSDPKKKE ERLKPTNPAA 550 560 570 580 590 600 QKALTTPTHY KLTPRPATRV RPKALQTTGT AKSHLFDGLD DDEPSLANGA FMPKKSIKKL 610 620 630 640 650 660 VLKNLNNSNL FSPVNRDSEN LASPSEYPEN GERFSFLSKP VDENHQQDGD EDSLVSHFYT 670 680 690 700 710 720 NPIAKPIPQT PESAGNKHSN SNSVDDTIVA LNMRAALRNG LEGSSEETSF HDESLQDDRE 730 740 750 760 770 780 EIENNSYHMH PAGIILTKVG YYTIPSMDDL AKITNEKGEC IVSDFTIGRK GYGSIYFEGD 790 800 810 820 830 840 VNLTNLNLDD IVHIRRKEVV VYLDDNQKPP VGEGLNRKAE VTLDGVWPTD KTSRCLIKSP 850 860 870 880 890 900 DRLADINYEG RLEAVSRKQG AQFKEYRPET GSWVFKVSHF SKYGLQDSDE EEEEHPSKTS 910 920 930 940 950 960 TKKLKTAPLP PASQTTPLQM ALNGKPAPPP QSQSPEVEQL GRVVELDSDM VDITQEPVLD 970 980 990 1000 1010 1020 TMLEESMPED QEPVSASTHI ASSLGINPHV LQIMKASLLT DEEDVDMALD QRFSRLPSKA 1030 1040 1050 1060 1070 1080 DTSQEICSPR LPISASHSSK TRSLVGGLLQ SKFTSGAFLS PSVSVQECRT PRAASLMNIP 1090 1100 1110 1120 1130 1140 STSSCLTESP FKVHLEKLSL RQRKPDEDMK LYQTPLELKL KHSTVHVDEL CPLIVPNLGV 1150 1160 1170 1180 1190 1200 AVIHDYADWV KEASGDLPEA QIVKHWSLTW TLCEALWGHL KELDSQLNEP REYIQILERR 1210 1220 1230 1240 1250 1260 RAFSRWLSCT ATPQIEEEVS LTQKNSPVEA VFSYLTGKRI SEACSLAQQS GDHRLALLLS 1270 1280 1290 1300 1310 1320 QFVGSQSVRE LLTMQLVDWH QLQADSFIQD ERLRIFALLA GKPVWQLSEK KQINVCSQLD 1330 1340 1350 1360 1370 1380 WKRSLAIHLW YLLPPTASIS RALSMYEEAF QNTSDSDRYA CSPLPSYLEG SGCVIAEEQN 1390 1400 1410 1420 1430 1440 SQTPLRDVCF HLLKLYSDRH YDLNQLLEPR SITADPLDYR LSWHLWEVLR ALNYTHLSAQ 1450 1460 1470 1480 1490 1500 CEGVLQASYA GQLESEGLWE WAIFVLLHID NSGIREKAVR ELLTRHCQLL ETPESWAKET 1510 1520 1530 1540 1550 1560 FLTQKLRVPA KWIHEAKAVR AHMESDKHLE ALCLFKAEHW NRCHKLIIRH LASDAIINEN 1570 1580 1590 1600 1610 1620 YDYLKGFLED LAPPERSSLI QDWETSGLVY LDYIRVIEML RHIQQVDCSG NDLEQLHIKV 1630 1640 1650 1660 1670 1680 TSLCSRIEQI QCYSAKDRLA QSDMAKRVAN LLRVVLSLHH PPDRTSDSTP DPQRVPLRLL 1690 1700 1710 APHIGRLPMP EDYAMDELRS LTQSYLRELA VGSL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9." Borrow J., Shearman A.M., Stanton V.P., Becher R., Collins T., Williams A.J., Dube I., Katz F., Kwong Y.L., Morris C., Ohyashiki K., Toyama K., Rowley J., Housman D.E. Nat. Genet. 12:159-167(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), CHROMOSOMAL TRANSLOCATION WITH HOXA9.
[2]	"Molecular analysis of the chromosomal breakpoints and identification of the repetitive sequences near the breakpoints of NUP98 in therapy-related leukemia with inv(11)(p15q22)." Arai Y., Kaneko Y., Kubo T., Arai K., Hosoda F., Ohki M. Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
[3]	"A conserved biogenesis pathway for nucleoporins: proteolytic processing of a 186-kilodalton precursor generates Nup98 and the novel nucleoporin, Nup96." Fontoura B.M.A., Blobel G., Matunis M.J. J. Cell Biol. 144:1097-1112(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), PROTEIN SEQUENCE OF 1648-1664.
[4]	"An alternative splice form of NUP98 encodes a 196kDa NUP196 isoform." Borrow J., Housman D.E. Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5).
[5]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 963-1817 (ISOFORM 6). Tissue: Lung carcinoma.
[7]	Xu Y.H., Guo B.C., Yu Y.L. Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1176-1817 (ISOFORM 5). Tissue: Liver.
[8]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1212-1817 (ISOFORM 5).
[9]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1227-1817 (ISOFORM 5). Tissue: Testis.
[10]	"The t(11;20)(p15;q11) chromosomal translocation associated with therapy-related myelodysplastic syndrome results in an NUP98-TOP1 fusion." Ahuja H.G., Felix C.A., Aplan P.D. Blood 94:3258-3261(1999) [PubMed] [Europe PMC] [Abstract] Cited for: CHROMOSOMAL TRANSLOCATION WITH TOP1.
[11]	"RAE1 is a shuttling mRNA export factor that binds to a GLEBS-like NUP98 motif at the nuclear pore complex through multiple domains." Pritchard C.E., Fornerod M., Kasper L.H., van Deursen J.M. J. Cell Biol. 145:237-254(1999) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH RAE1.
[12]	"Vesicular stomatitis virus matrix protein inhibits host cell gene expression by targeting the nucleoporin Nup98." von Kobbe C., van Deursen J.M., Rodrigues J.P., Sitterlin D., Bachi A., Wu X., Wilm M., Carmo-Fonseca M., Izaurralde E. Mol. Cell 6:1243-1252(2000) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH VESICULAR STOMATITIS VIRUS PROTEIN M.
[13]	"A novel gene, NSD1, is fused to NUP98 in the t(5;11)(q35;p15.5) in de novo childhood acute myeloid leukemia." Jaju R.J., Fidler C., Haas O.A., Strickson A.J., Watkins F., Clark K., Cross N.C., Cheng J.F., Aplan P.D., Kearney L., Boultwood J., Wainscoat J.S. Blood 98:1264-1267(2001) [PubMed] [Europe PMC] [Abstract] Cited for: CHROMOSOMAL TRANSLOCATION WITH NSD1.
[14]	"Novel vertebrate nucleoporins Nup133 and Nup160 play a role in mRNA export." Vasu S., Shah S., Orjalo A., Park M., Fischer W.H., Forbes D.J. J. Cell Biol. 155:339-354(2001) [PubMed] [Europe PMC] [Abstract] Cited for: SUBUNIT.
[15]	"NUP98 is fused to the NSD3 gene in acute myeloid leukemia associated with t(8;11)(p11.2;p15)." Rosati R., La Starza R., Veronese A., Aventin A., Schwienbacher C., Vallespi T., Negrini M., Martelli M.F., Mecucci C. Blood 99:3857-3860(2002) [PubMed] [Europe PMC] [Abstract] Cited for: CHROMOSOMAL TRANSLOCATION WITH WHSC1L1.
[16]	"Tpr is localized within the nuclear basket of the pore complex and has a role in nuclear protein export." Frosst P., Guan T., Subauste C., Hahn K., Gerace L. J. Cell Biol. 156:617-630(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION.
[17]	"Direct interaction with nup153 mediates binding of Tpr to the periphery of the nuclear pore complex." Hase M.E., Cordes V.C. Mol. Biol. Cell 14:1923-1940(2003) [PubMed] [Europe PMC] [Abstract] Cited for: ABSENCE OF INTERACTION WITH TPR, SUBCELLULAR LOCATION.
[18]	"Nucleoporins as components of the nuclear pore complex core structure and Tpr as the architectural element of the nuclear basket." Krull S., Thyberg J., Bjorkroth B., Rackwitz H.R., Cordes V.C. Mol. Biol. Cell 15:4261-4277(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, IDENTIFICATION IN THE NUCLEAR PORE COMPLEX, SUBCELLULAR LOCATION.
[19]	"Characterization of 6q abnormalities in childhood acute myeloid leukemia and identification of a novel t(6;11)(q24.1;p15.5) resulting in a NUP98-C6orf80 fusion in a case of acute megakaryoblastic leukemia." Tosi S., Ballabio E., Teigler-Schlegel A., Boultwood J., Bruch J., Harbott J. Genes Chromosomes Cancer 44:225-232(2005) [PubMed] [Europe PMC] [Abstract] Cited for: CHROMOSOMAL TRANSLOCATION WITH NUP98, DISEASE.
[20]	"t(9;11)(p22;p15) with NUP98-LEDGF fusion gene in pediatric acute myeloid leukemia." Morerio C., Acquila M., Rosanda C., Rapella A., Tassano E., Micalizzi C., Panarello C. Leuk. Res. 29:467-470(2005) [PubMed] [Europe PMC] [Abstract] Cited for: CHROMOSOMAL TRANSLOCATION WITH PSIP1/LEDGF.
[21]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-608; SER-612; SER-839 AND SER-888, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[22]	"NUP98 rearrangements in hematopoietic malignancies: a study of the Groupe Francophone de Cytogenetique Hematologique." Romana S.P., Radford-Weiss I., Ben Abdelali R., Schluth C., Petit A., Dastugue N., Talmant P., Bilhou-Nabera C., Mugneret F., Lafage-Pochitaloff M., Mozziconacci M.-J., Andrieu J., Lai J.-L., Terre C., Rack K., Cornillet-Lefebvre P., Luquet I., Nadal N. , Nguyen-Khac F., Perot C., Van den Akker J., Fert-Ferrer S., Cabrol C., Charrin C., Tigaud I., Poirel H., Vekemans M., Bernard O.A., Berger R. Leukemia 20:696-706(2006) [PubMed] [Europe PMC] [Abstract] Cited for: CHROMOSOMAL TRANSLOCATION WITH LNP1.
[23]	"A probability-based approach for high-throughput protein phosphorylation analysis and site localization." Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P. Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-608; SER-612; SER-623; SER-1028 AND SER-1060, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[24]	"A novel NUP98-PHF23 fusion resulting from a cryptic translocation t(11;17)(p15;p13) in acute myeloid leukemia." Reader J.C., Meekins J.S., Gojo I., Ning Y. Leukemia 21:842-844(2007) [PubMed] [Europe PMC] [Abstract] Cited for: CHROMOSOMAL TRANSLOCATION WITH PHF23. Tissue: Peripheral blood.
[25]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-608 AND SER-612, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[26]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-888, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[27]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-623; SER-839; SER-888; SER-934; THR-1000; SER-1023; SER-1028; SER-1043; SER-1060 AND THR-1070, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[28]	"Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography." Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J. Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-888, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Liver.
[29]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[30]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-608; SER-612; SER-618; SER-623 AND SER-625, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Leukemic T-cell.
[31]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-603, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[32]	"Protein Tpr is required for establishing nuclear pore-associated zones of heterochromatin exclusion." Krull S., Dorries J., Boysen B., Reidenbach S., Magnius L., Norder H., Thyberg J., Cordes V.C. EMBO J. 29:1659-1673(2010) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, PROTEOLYTIC PROCESSING.
[33]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-524; SER-608; SER-612; SER-623; THR-670; SER-673; SER-681; SER-839; SER-888 AND SER-934, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[34]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[35]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-612; SER-623; SER-683; SER-839 AND SER-888, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[36]	"Functional analysis of the NUP98-CCDC28A fusion protein." Petit A., Ragu C., Soler G., Ottolenghi C., Schluth C., Radford-Weiss I., Schneider-Maunoury S., Callebaut I., Dastugue N., Drabkin H.A., Bernard O.A., Romana S., Penard-Lacronique V. Haematologica 97:379-387(2012) [PubMed] [Europe PMC] [Abstract] Cited for: CHROMOSOMAL TRANSLOCATION WITH NUP98.
[37]	"The three-dimensional structure of the autoproteolytic, nuclear pore-targeting domain of the human nucleoporin Nup98." Hodel A.E., Hodel M.R., Griffis E.R., Hennig K.A., Ratner G.A., Xu S., Powers M.A. Mol. Cell 10:347-358(2002) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 710-870 OF NUP98, INTERACTION WITH NUP96.
[38]	"Structural constraints on autoprocessing of the human nucleoporin Nup98." Sun Y., Guo H.C. Protein Sci. 17:494-505(2008) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 733-887, SUBUNIT, AUTOPROTEOLYTIC PROCESSING.
[39]	"Structural and functional analysis of the interaction between the nucleoporin Nup98 and the mRNA export factor Rae1." Ren Y., Seo H.S., Blobel G., Hoelz A. Proc. Natl. Acad. Sci. U.S.A. 107:10406-10411(2010) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS) OF 158-213 IN COMPLEX WITH RAE1.
[40]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] VAL-1669.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

U41815 mRNA. Translation: AAC50366.1.
AB040538 mRNA. Translation: BAB18537.1.
AF071076 mRNA. Translation: AAD22395.1. Sequence problems.
AF071077 mRNA. Translation: AAD22396.1. Sequence problems.
AF231130 mRNA. Translation: AAL56659.1.
AC060812 Genomic DNA. No translation available.
AC090587 Genomic DNA. No translation available.
BC041136 mRNA. Translation: AAH41136.1.
BC012906 mRNA. Translation: AAH12906.2.
AF116074 mRNA. Translation: AAF19342.1. Sequence problems.
BT007349 mRNA. Translation: AAP36013.1.
AL133601 mRNA. Translation: CAB63736.1.
AL137613 mRNA. Translation: CAB70842.1.

PIR

T43443.

RefSeq

NP_005378.4. NM_005387.5.
NP_057404.2. NM_016320.4.
NP_624357.1. NM_139131.3.
NP_624358.2. NM_139132.3.
XP_005253007.1. XM_005252950.1.

UniGene

Hs.524750.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1KO6	X-ray	3.00	A/C	695-880	[»]
			B/D	881-931	[»]
2Q5X	X-ray	1.90	A	733-887	[»]
2Q5Y	X-ray	2.30	A/C	729-880	[»]
3MMY	X-ray	1.65	B/D/F/H	158-213	[»]

ProteinModelPortal

P52948.

SMR

P52948. Positions 158-213, 729-880.

ModBase

Search...

MobiDB

Search...

Protein-protein interaction databases

BioGrid

110982. 47 interactions.

DIP

DIP-32484N.

IntAct

P52948. 21 interactions.

MINT

MINT-121544.

Protein family/group databases

MEROPS

S59.001.

PTM databases

PhosphoSite

P52948.

Polymorphism databases

DMDM

308153660.

Proteomic databases

PaxDb

P52948.

PRIDE

P52948.

Protocols and materials databases

DNASU

4928.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000324932; ENSP00000316032; ENSG00000110713. [P52948-5]
ENST00000355260; ENSP00000347404; ENSG00000110713. [P52948-2]
ENST00000397004; ENSP00000380199; ENSG00000110713. [P52948-4]
ENST00000397007; ENSP00000380202; ENSG00000110713. [P52948-3]

GeneID

4928.

KEGG

hsa:4928.

UCSC

uc001lyh.3. human. [P52948-5]
uc001lyi.3. human. [P52948-2]
uc001lyj.2. human. [P52948-4]
uc001lyk.2. human. [P52948-3]

Organism-specific databases

CTD

4928.

GeneCards

GC11M003697.

HGNC

HGNC:8068. NUP98.

MIM

601021. gene.

neXtProt

NX_P52948.

PharmGKB

PA31856.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG12793.

HOVERGEN

HBG052702.

KO

K14297.

OMA

TSFHEES.

OrthoDB

EOG77WWBT.

PhylomeDB

P52948.

TreeFam

TF343335.

Enzyme and pathway databases

Reactome

REACT_111217. Metabolism.
REACT_115566. Cell Cycle.
REACT_116125. Disease.
REACT_15518. Transmembrane transport of small molecules.
REACT_21300. Mitotic M-M/G1 phases.
REACT_6900. Immune System.

Gene expression databases

ArrayExpress

P52948.

Bgee

P52948.

Genevestigator

P52948.

Family and domain databases

Gene3D

3.30.1610.10. 1 hit.

InterPro

IPR021967. Nup96.
IPR007230. Peptidase_S59.
[Graphical view]

Pfam

PF04096. Nucleoporin2. 1 hit.
PF12110. Nup96. 1 hit.
[Graphical view]

SUPFAM

SSF82215. SSF82215. 1 hit.

PROSITE

PS51434. NUP_C. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

NUP98. human.

EvolutionaryTrace

P52948.

GeneWiki

NUP98.

GenomeRNAi

4928.

NextBio

18979.

PMAP-CutDB

P52948.

PRO

P52948.

SOURCE

Search...

Entry information

Entry name

NUP98_HUMAN

Accession

Primary (citable) accession number: P52948
Secondary accession number(s): Q8IUT2 , Q8WYB0, Q96E54, Q9H3Q4, Q9NT02, Q9UF57, Q9UHX0, Q9Y6J4, Q9Y6J5

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 5, 2010
Last modified:	April 16, 2014
This is version 155 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.