P52948 (NUP98_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 133.
History...
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Nuclear pore complex protein Nup98-Nup96 Cleaved into the following 2 chains:
| ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 1817 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Nup98 and Nup96 play a role in the bidirectional transport across the nucleoporin complex (NPC). The repeat domain in Nup98 has a direct role in the transport. |
| Subunit structure | Nup98 interacts directly with Nup96. Nup96 is part of the Nup160 subcomplex in the nuclear pore which is composed of Nup160, Nup133, Nup107 and Nup96. This complex plays a role in RNA export and in tethering Nup98 and Nup153 to the nucleus. May interact with RAE1. Interacts with vesicular stomatitis virus protein M. Ref.11 Ref.12 Ref.14 Ref.32 |
| Subcellular location | Nucleus › nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Note: Nup96 is localized to the nucleoplasmic side of the nuclear pore complex, at or near the nucleoplasmic basket. |
| Domain | Contains G-L-F-G repeats. |
| Post-translational modification | Isoform 1 to isoform 4 are autoproteolytically cleaved to yield Nup98 and Nup96 or Nup98 only, respectively. Cleaved Nup98 is necessary for the targeting of Nup98 to the nuclear pore and the interaction with Nup96. |
| Involvement in disease | Note=A chromosomal aberration involving NUP98 is found in a form of acute myeloid leukemia. Translocation t(7;11)(p15;p15) with HOXA9. Translocation t(11;17)(p15;p13) with PHF23. Note=A chromosomal aberration involving NUP98 is found in childhood acute myeloid leukemia. Translocation t(5;11)(q35;p15.5) with NSD1. Translocation t(8;11)(p11.2;p15) with WHSC1L1. Note=A chromosomal aberration involving NUP98 is found in a form of therapy-related myelodysplastic syndrome. Translocation t(11;20)(p15;q11) with TOP1. Note=A chromosomal aberration involving NUP98 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(3;11)(q12.2;p15.4) with LNP1. Note=A chromosomal aberration involving NUP98 is associated with pediatric acute myeloid leukemia (AML) with intermediate characteristics between M2-M3 French-American-British (FAB) subtypes. Translocation t(9;11)(p22;p15) with PSIP1/LEDGF. The chimeric transcript is an in-frame fusion of NUP98 exon 8 to PSIP1/LEDGF exon 4. |
| Sequence similarities | Belongs to the nucleoporin GLFG family. Contains 1 peptidase S59 domain. |
| Sequence caution | The sequence AAD22395.1 differs from that shown. Reason: Contaminating sequence. Sequence of unknown origin in the C-terminal part. The sequence AAD22396.1 differs from that shown. Reason: Contaminating sequence. Sequence of unknown origin in the C-terminal part. The sequence AAF19342.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence AAF19342.1 differs from that shown. Reason: Frameshift at position 1551. |
Ontologies
Alternative products
| This entry describes 6 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: P52948-1) Also known as: Nup98-Nup96 precursor; This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: P52948-2) Also known as: Nup98-Nup96 precursor splice variant 1; The sequence of this isoform differs from the canonical sequence as follows: 393-409: Missing. 1502-1576: RHYDLNQLLE...FVLLHIDNSG → S | ||||||
| Isoform 3 (identifier: P52948-3) Also known as: Nup98-specific 1; The sequence of this isoform differs from the canonical sequence as follows: 932-937: SQSPEV → VEKKGQ 938-1817: Missing. | ||||||
| Isoform 4 (identifier: P52948-4) The sequence of this isoform differs from the canonical sequence as follows: 393-409: Missing. 932-937: SQSPEV → VEKKGQ 938-1817: Missing. | ||||||
| Isoform 5 (identifier: P52948-5) Also known as: Nup196; ADIR2; The sequence of this isoform differs from the canonical sequence as follows: 393-409: Missing. | ||||||
| Isoform 6 (identifier: P52948-6) The sequence of this isoform differs from the canonical sequence as follows: 1085-1188: WSVPPPLTSV...FLPNPVAVKP → C |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||||||||||||||||||||||||||
Molecule processing | |||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 880 | 880 | Nuclear pore complex protein Nup98 | PRO_0000019929 | |||||||||||||||||||||||||||||||
| Chain | 881 – 1817 | 937 | Nuclear pore complex protein Nup96 | PRO_0000019930 | |||||||||||||||||||||||||||||||
Regions | |||||||||||||||||||||||||||||||||||
| Domain | 738 – 880 | 143 | Peptidase S59 | ||||||||||||||||||||||||||||||||
| Compositional bias | 7 – 480 | 474 | Gly/Thr-rich | ||||||||||||||||||||||||||||||||
| Compositional bias | 890 – 894 | 5 | Poly-Glu | ||||||||||||||||||||||||||||||||
Sites | |||||||||||||||||||||||||||||||||||
| Site | 531 – 532 | 2 | Breakpoint for translocation to form NUP98-PHF23 oncogene | ||||||||||||||||||||||||||||||||
Amino acid modifications | |||||||||||||||||||||||||||||||||||
| Modified residue | 603 | 1 | N6-acetyllysine Ref.31 | ||||||||||||||||||||||||||||||||
| Modified residue | 608 | 1 | Phosphoserine Ref.18 Ref.20 Ref.25 Ref.27 Ref.29 Ref.30 | ||||||||||||||||||||||||||||||||
| Modified residue | 612 | 1 | Phosphoserine Ref.18 Ref.20 Ref.25 Ref.27 Ref.29 Ref.30 | ||||||||||||||||||||||||||||||||
| Modified residue | 618 | 1 | Phosphoserine Ref.30 | ||||||||||||||||||||||||||||||||
| Modified residue | 623 | 1 | Phosphoserine Ref.16 Ref.18 Ref.20 Ref.23 Ref.24 Ref.27 Ref.29 Ref.30 | ||||||||||||||||||||||||||||||||
| Modified residue | 625 | 1 | Phosphoserine Ref.30 | ||||||||||||||||||||||||||||||||
| Modified residue | 670 | 1 | Phosphothreonine Ref.29 | ||||||||||||||||||||||||||||||||
| Modified residue | 673 | 1 | Phosphoserine Ref.29 | ||||||||||||||||||||||||||||||||
| Modified residue | 839 | 1 | Phosphoserine Ref.18 Ref.27 | ||||||||||||||||||||||||||||||||
| Modified residue | 888 | 1 | Phosphoserine Ref.18 Ref.21 Ref.23 Ref.26 Ref.27 Ref.28 Ref.29 Ref.30 | ||||||||||||||||||||||||||||||||
| Modified residue | 916 | 1 | Phosphothreonine Ref.29 | ||||||||||||||||||||||||||||||||
| Modified residue | 934 | 1 | Phosphoserine Ref.23 Ref.26 Ref.27 | ||||||||||||||||||||||||||||||||
| Modified residue | 1000 | 1 | Phosphothreonine Ref.27 | ||||||||||||||||||||||||||||||||
| Modified residue | 1023 | 1 | Phosphoserine Ref.23 Ref.27 Ref.29 | ||||||||||||||||||||||||||||||||
| Modified residue | 1028 | 1 | Phosphoserine Ref.20 Ref.23 Ref.27 Ref.29 | ||||||||||||||||||||||||||||||||
| Modified residue | 1043 | 1 | Phosphoserine Ref.27 | ||||||||||||||||||||||||||||||||
| Modified residue | 1060 | 1 | Phosphoserine Ref.20 Ref.25 Ref.27 Ref.29 | ||||||||||||||||||||||||||||||||
| Modified residue | 1064 | 1 | Phosphoserine Ref.25 | ||||||||||||||||||||||||||||||||
| Modified residue | 1070 | 1 | Phosphothreonine Ref.27 | ||||||||||||||||||||||||||||||||
Natural variations | |||||||||||||||||||||||||||||||||||
| Alternative sequence | 393 – 409 | 17 | Missing in isoform 2, isoform 4 and isoform 5. | VSP_003619 | |||||||||||||||||||||||||||||||
| Alternative sequence | 932 – 937 | 6 | SQSPEV → VEKKGQ in isoform 3 and isoform 4. | VSP_007942 | |||||||||||||||||||||||||||||||
| Alternative sequence | 938 – 1817 | 880 | Missing in isoform 3 and isoform 4. | VSP_007943 | |||||||||||||||||||||||||||||||
| Alternative sequence | 1085 – 1188 | 104 | WSVPP…VAVKP → C in isoform 6. | VSP_038328 | |||||||||||||||||||||||||||||||
| Alternative sequence | 1502 – 1576 | 75 | RHYDL…IDNSG → S in isoform 2. | VSP_007944 | |||||||||||||||||||||||||||||||
| Natural variant | 1669 | 1 | G → V in a breast cancer sample; somatic mutation. Ref.33 | VAR_035859 | |||||||||||||||||||||||||||||||
Experimental info | |||||||||||||||||||||||||||||||||||
| Sequence conflict | 318 | 1 | L → S in AAH41136. Ref.6 | ||||||||||||||||||||||||||||||||
| Sequence conflict | 376 | 1 | S → G in AAH41136. Ref.6 | ||||||||||||||||||||||||||||||||
| Sequence conflict | 756 – 757 | 2 | EK → VF in AAD22395. Ref.3 | ||||||||||||||||||||||||||||||||
| Sequence conflict | 756 – 757 | 2 | EK → VF in AAD22396. Ref.3 | ||||||||||||||||||||||||||||||||
| Sequence conflict | 1281 | 1 | G → A in AAD22395. Ref.3 | ||||||||||||||||||||||||||||||||
| Sequence conflict | 1281 | 1 | G → A in AAD22396. Ref.3 | ||||||||||||||||||||||||||||||||
| Sequence conflict | 1281 | 1 | G → A in AAL56659. Ref.4 | ||||||||||||||||||||||||||||||||
| Sequence conflict | 1534 – 1536 | 3 | ALN → DLK in AAD22395. Ref.3 | ||||||||||||||||||||||||||||||||
| Sequence conflict | 1594 | 1 | E → D in AAF19342. Ref.7 | ||||||||||||||||||||||||||||||||
| Sequence conflict | 1598 | 1 | S → T in AAL56659. Ref.4 | ||||||||||||||||||||||||||||||||
| Sequence conflict | 1639 | 1 | K → N in AAF19342. Ref.7 | ||||||||||||||||||||||||||||||||
| Sequence conflict | 1680 | 1 | S → T in AAF19342. Ref.7 | ||||||||||||||||||||||||||||||||
Secondary structure | |||||||||||||||||||||||||||||||||||
Helix Strand Turn | |||||||||||||||||||||||||||||||||||
| Beta strand | 741 – 745 | 5 | |||||||||||||||||||||||||||||||||
| Helix | 747 – 753 | 7 | |||||||||||||||||||||||||||||||||
| Beta strand | 761 – 769 | 9 | |||||||||||||||||||||||||||||||||
| Turn | 770 – 772 | 3 | |||||||||||||||||||||||||||||||||
| Beta strand | 773 – 777 | 5 | |||||||||||||||||||||||||||||||||
| Helix | 788 – 791 | 4 | |||||||||||||||||||||||||||||||||
| Beta strand | 792 – 795 | 4 | |||||||||||||||||||||||||||||||||
| Beta strand | 798 – 804 | 7 | |||||||||||||||||||||||||||||||||
| Beta strand | 819 – 823 | 5 | |||||||||||||||||||||||||||||||||
| Turn | 831 – 833 | 3 | |||||||||||||||||||||||||||||||||
| Helix | 840 – 846 | 7 | |||||||||||||||||||||||||||||||||
| Helix | 848 – 858 | 11 | |||||||||||||||||||||||||||||||||
| Beta strand | 862 – 867 | 6 | |||||||||||||||||||||||||||||||||
| Helix | 868 – 870 | 3 | |||||||||||||||||||||||||||||||||
| Beta strand | 872 – 878 | 7 | |||||||||||||||||||||||||||||||||
Sequences
| ||||||||||||||||||||||||||||||||||||||||||||||||
References
| « Hide 'large scale' references | |
| [1] | "The t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9." Borrow J., Shearman A.M., Stanton V.P., Becher R., Collins T., Williams A.J., Dube I., Katz F., Kwong Y.L., Morris C., Ohyashiki K., Toyama K., Rowley J., Housman D.E. Nat. Genet. 12:159-167(1996) [PubMed: 8563754] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), CHROMOSOMAL TRANSLOCATION WITH HOXA9. |
| [2] | "Molecular analysis of the chromosomal breakpoints and identification of the repetitive sequences near the breakpoints of NUP98 in therapy-related leukemia with inv(11)(p15q22)." Arai Y., Kaneko Y., Kubo T., Arai K., Hosoda F., Ohki M. Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3). |
| [3] | "A conserved biogenesis pathway for nucleoporins: proteolytic processing of a 186-kilodalton precursor generates Nup98 and the novel nucleoporin, Nup96." Fontoura B.M.A., Blobel G., Matunis M.J. J. Cell Biol. 144:1097-1112(1999) [PubMed: 10087256] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), PROTEIN SEQUENCE OF 1648-1664. |
| [4] | "An alternative splice form of NUP98 encodes a 196kDa NUP196 isoform." Borrow J., Housman D.E. Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5). |
| [5] | "Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. Sakaki Y.Nature 440:497-500(2006) [PubMed: 16554811] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [6] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 963-1817 (ISOFORM 6). Tissue: Lung carcinoma. |
| [7] | Xu Y.H., Guo B.C., Yu Y.L. Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1176-1817 (ISOFORM 5). Tissue: Liver. |
| [8] | "Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1212-1817 (ISOFORM 5). |
| [9] | "The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1227-1817 (ISOFORM 5). Tissue: Testis. |
| [10] | "The t(11;20)(p15;q11) chromosomal translocation associated with therapy-related myelodysplastic syndrome results in an NUP98-TOP1 fusion." Ahuja H.G., Felix C.A., Aplan P.D. Blood 94:3258-3261(1999) [PubMed: 10556215] [Abstract] Cited for: CHROMOSOMAL TRANSLOCATION WITH TOP1. |
| [11] | "RAE1 is a shuttling mRNA export factor that binds to a GLEBS-like NUP98 motif at the nuclear pore complex through multiple domains." Pritchard C.E., Fornerod M., Kasper L.H., van Deursen J.M. J. Cell Biol. 145:237-254(1999) [PubMed: 10209021] [Abstract] Cited for: INTERACTION WITH RAE1. |
| [12] | "Vesicular stomatitis virus matrix protein inhibits host cell gene expression by targeting the nucleoporin Nup98." von Kobbe C., van Deursen J.M., Rodrigues J.P., Sitterlin D., Bachi A., Wu X., Wilm M., Carmo-Fonseca M., Izaurralde E. Mol. Cell 6:1243-1252(2000) [PubMed: 11106761] [Abstract] Cited for: INTERACTION WITH VESICULAR STOMATITIS VIRUS PROTEIN M. |
| [13] | "A novel gene, NSD1, is fused to NUP98 in the t(5;11)(q35;p15.5) in de novo childhood acute myeloid leukemia." Jaju R.J., Fidler C., Haas O.A., Strickson A.J., Watkins F., Clark K., Cross N.C., Cheng J.F., Aplan P.D., Kearney L., Boultwood J., Wainscoat J.S. Blood 98:1264-1267(2001) [PubMed: 11493482] [Abstract] Cited for: CHROMOSOMAL TRANSLOCATION WITH NSD1. |
| [14] | "Novel vertebrate nucleoporins Nup133 and Nup160 play a role in mRNA export." Vasu S., Shah S., Orjalo A., Park M., Fischer W.H., Forbes D.J. J. Cell Biol. 155:339-354(2001) [PubMed: 11684705] [Abstract] Cited for: SUBUNIT. |
| [15] | "NUP98 is fused to the NSD3 gene in acute myeloid leukemia associated with t(8;11)(p11.2;p15)." Rosati R., La Starza R., Veronese A., Aventin A., Schwienbacher C., Vallespi T., Negrini M., Martelli M.F., Mecucci C. Blood 99:3857-3860(2002) [PubMed: 11986249] [Abstract] Cited for: CHROMOSOMAL TRANSLOCATION WITH WHSC1L1. |
| [16] | "Large-scale characterization of HeLa cell nuclear phosphoproteins." Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004) [PubMed: 15302935] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-623, MASS SPECTROMETRY. Tissue: Cervix carcinoma. |
| [17] | "t(9;11)(p22;p15) with NUP98-LEDGF fusion gene in pediatric acute myeloid leukemia." Morerio C., Acquila M., Rosanda C., Rapella A., Tassano E., Micalizzi C., Panarello C. Leuk. Res. 29:467-470(2005) [PubMed: 15725483] [Abstract] Cited for: CHROMOSOMAL TRANSLOCATION WITH PSIP1/LEDGF. |
| [18] | "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-608; SER-612; SER-623; SER-839 AND SER-888, MASS SPECTROMETRY. Tissue: Cervix carcinoma. |
| [19] | "NUP98 rearrangements in hematopoietic malignancies: a study of the Groupe Francophone de Cytogenetique Hematologique." Romana S.P., Radford-Weiss I., Ben Abdelali R., Schluth C., Petit A., Dastugue N., Talmant P., Bilhou-Nabera C., Mugneret F., Lafage-Pochitaloff M., Mozziconacci M.-J., Andrieu J., Lai J.-L., Terre C., Rack K., Cornillet-Lefebvre P., Luquet I., Nadal N. Berger R.Leukemia 20:696-706(2006) [PubMed: 16467868] [Abstract] Cited for: CHROMOSOMAL TRANSLOCATION WITH LNP1. |
| [20] | "A probability-based approach for high-throughput protein phosphorylation analysis and site localization." Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P. Nat. Biotechnol. 24:1285-1292(2006) [PubMed: 16964243] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-608; SER-612; SER-623; SER-1028 AND SER-1060, MASS SPECTROMETRY. Tissue: Cervix carcinoma. |
| [21] | "Phosphoproteome analysis of the human mitotic spindle." Nousiainen M., Sillje H.H.W., Sauer G., Nigg E.A., Koerner R. Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006) [PubMed: 16565220] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-888, MASS SPECTROMETRY. Tissue: Cervix adenocarcinoma. |
| [22] | "A novel NUP98-PHF23 fusion resulting from a cryptic translocation t(11;17)(p15;p13) in acute myeloid leukemia." Reader J.C., Meekins J.S., Gojo I., Ning Y. Leukemia 21:842-844(2007) [PubMed: 17287853] [Abstract] Cited for: CHROMOSOMAL TRANSLOCATION WITH PHF23. Tissue: Peripheral blood. |
| [23] | "Evaluation of the low-specificity protease elastase for large-scale phosphoproteome analysis." Wang B., Malik R., Nigg E.A., Korner R. Anal. Chem. 80:9526-9533(2008) [PubMed: 19007248] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-623; SER-888; SER-934; SER-1023 AND SER-1028, MASS SPECTROMETRY. Tissue: Cervix carcinoma. |
| [24] | "Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column." Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y. Anal. Sci. 24:161-166(2008) [PubMed: 18187866] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-623, MASS SPECTROMETRY. Tissue: Cervix carcinoma. |
| [25] | "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed: 18220336] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-608; SER-612; SER-1060 AND SER-1064, MASS SPECTROMETRY. Tissue: Cervix carcinoma. |
| [26] | "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-888 AND SER-934, MASS SPECTROMETRY. Tissue: Cervix carcinoma. |
| [27] | "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-608; SER-612; SER-623; SER-839; SER-888; SER-934; THR-1000; SER-1023; SER-1028; SER-1043; SER-1060 AND THR-1070, MASS SPECTROMETRY. Tissue: Cervix carcinoma. |
| [28] | "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography." Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J. Proteomics 8:1346-1361(2008) [PubMed: 18318008] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-888, MASS SPECTROMETRY. Tissue: Liver. |
| [29] | "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-608; SER-612; SER-623; THR-670; SER-673; SER-888; THR-916; SER-1023; SER-1028 AND SER-1060, MASS SPECTROMETRY. Tissue: Embryonic kidney. |
| [30] | "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-608; SER-612; SER-618; SER-623; SER-625 AND SER-888, MASS SPECTROMETRY. Tissue: Leukemic T-cell. |
| [31] | "Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed: 19608861] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-603, MASS SPECTROMETRY. |
| [32] | "The three-dimensional structure of the autoproteolytic, nuclear pore-targeting domain of the human nucleoporin Nup98." Hodel A.E., Hodel M.R., Griffis E.R., Hennig K.A., Ratner G.A., Xu S., Powers M.A. Mol. Cell 10:347-358(2002) [PubMed: 12191480] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 710-870 OF NUP98, INTERACTION WITH NUP96. |
| [33] | "The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. Velculescu V.E.Science 314:268-274(2006) [PubMed: 16959974] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] VAL-1669. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EMBL GenBank DDBJ | U41815 mRNA. Translation: AAC50366.1. AB040538 mRNA. Translation: BAB18537.1. AF071076 mRNA. Translation: AAD22395.1. Sequence problems. AF071077 mRNA. Translation: AAD22396.1. Sequence problems. AF231130 mRNA. Translation: AAL56659.1. AC060812 Genomic DNA. No translation available. AC090587 Genomic DNA. No translation available. BC041136 mRNA. Translation: AAH41136.1. BC012906 mRNA. Translation: AAH12906.2. AF116074 mRNA. Translation: AAF19342.1. Sequence problems. BT007349 mRNA. Translation: AAP36013.1. AL133601 mRNA. Translation: CAB63736.1. AL137613 mRNA. Translation: CAB70842.1. | ||||||||||||||||||||||||||||||||||||
| IPI | IPI00006038. IPI00216688. IPI00337395. IPI00337397. IPI00936708. IPI00953181. | ||||||||||||||||||||||||||||||||||||
| PIR | T43443. | ||||||||||||||||||||||||||||||||||||
| RefSeq | NP_005378.4. NM_005387.5. NP_057404.2. NM_016320.4. NP_624357.1. NM_139131.3. NP_624358.2. NM_139132.3. | ||||||||||||||||||||||||||||||||||||
| UniGene | Hs.524750. | ||||||||||||||||||||||||||||||||||||
3D structure databases | |||||||||||||||||||||||||||||||||||||
| PDBe RCSB PDB PDBj |
| ||||||||||||||||||||||||||||||||||||
| ProteinModelPortal | P52948. | ||||||||||||||||||||||||||||||||||||
| SMR | P52948. Positions 158-213, 729-880. | ||||||||||||||||||||||||||||||||||||
| ModBase | Search... | ||||||||||||||||||||||||||||||||||||
Protein-protein interaction databases | |||||||||||||||||||||||||||||||||||||
| DIP | DIP-32484N. | ||||||||||||||||||||||||||||||||||||
| IntAct | P52948. 11 interactions. | ||||||||||||||||||||||||||||||||||||
| MINT | MINT-121544. | ||||||||||||||||||||||||||||||||||||
| STRING | P52948. | ||||||||||||||||||||||||||||||||||||
Protein family/group databases | |||||||||||||||||||||||||||||||||||||
| MEROPS | S59.001. | ||||||||||||||||||||||||||||||||||||
PTM databases | |||||||||||||||||||||||||||||||||||||
| PhosphoSite | P52948. | ||||||||||||||||||||||||||||||||||||
Polymorphism databases | |||||||||||||||||||||||||||||||||||||
| DMDM | 308153660. | ||||||||||||||||||||||||||||||||||||
Proteomic databases | |||||||||||||||||||||||||||||||||||||
| PRIDE | P52948. | ||||||||||||||||||||||||||||||||||||
Protocols and materials databases | |||||||||||||||||||||||||||||||||||||
| StructuralBiologyKnowledgebase | Search... | ||||||||||||||||||||||||||||||||||||
Genome annotation databases | |||||||||||||||||||||||||||||||||||||
| Ensembl | ENST00000359171; ENSP00000352091; ENSG00000110713. | ||||||||||||||||||||||||||||||||||||
| GeneID | 4928. | ||||||||||||||||||||||||||||||||||||
| KEGG | hsa:4928. | ||||||||||||||||||||||||||||||||||||
| UCSC | uc001lyh.1. human. uc001lyi.1. human. uc001lyk.1. human. | ||||||||||||||||||||||||||||||||||||
Organism-specific databases | |||||||||||||||||||||||||||||||||||||
| CTD | 4928. | ||||||||||||||||||||||||||||||||||||
| GeneCards | GC11M003696. | ||||||||||||||||||||||||||||||||||||
| HGNC | HGNC:8068. NUP98. | ||||||||||||||||||||||||||||||||||||
| MIM | 601021. gene. | ||||||||||||||||||||||||||||||||||||
| neXtProt | NX_P52948. | ||||||||||||||||||||||||||||||||||||
| PharmGKB | PA31856. | ||||||||||||||||||||||||||||||||||||
| GenAtlas | Search... | ||||||||||||||||||||||||||||||||||||
Phylogenomic databases | |||||||||||||||||||||||||||||||||||||
| eggNOG | prNOG07907. | ||||||||||||||||||||||||||||||||||||
| HOVERGEN | HBG052702. | ||||||||||||||||||||||||||||||||||||
| OMA | DWVKEAS. | ||||||||||||||||||||||||||||||||||||
| PhylomeDB | P52948. | ||||||||||||||||||||||||||||||||||||
Enzyme and pathway databases | |||||||||||||||||||||||||||||||||||||
| Reactome | REACT_152. Cell Cycle, Mitotic. REACT_15518. Transmembrane transport of small molecules. REACT_383. DNA Replication. REACT_474. Metabolism of carbohydrates. REACT_6185. HIV Infection. | ||||||||||||||||||||||||||||||||||||
Gene expression databases | |||||||||||||||||||||||||||||||||||||
| ArrayExpress | P52948. | ||||||||||||||||||||||||||||||||||||
| Bgee | P52948. | ||||||||||||||||||||||||||||||||||||
| Genevestigator | P52948. | ||||||||||||||||||||||||||||||||||||
| GermOnline | ENSG00000110713. Homo sapiens. | ||||||||||||||||||||||||||||||||||||
Family and domain databases | |||||||||||||||||||||||||||||||||||||
| InterPro | IPR021967. Nup96. IPR007230. Peptidase_S59. [Graphical view] | ||||||||||||||||||||||||||||||||||||
| KO | K14297. | ||||||||||||||||||||||||||||||||||||
| Pfam | PF04096. Nucleoporin2. 1 hit. PF12110. Nup96. 1 hit. [Graphical view] | ||||||||||||||||||||||||||||||||||||
| SUPFAM | SSF82215. Peptidase_S59. 1 hit. | ||||||||||||||||||||||||||||||||||||
| PROSITE | PS51434. NUP_C. 1 hit. [Graphical view] | ||||||||||||||||||||||||||||||||||||
| ProtoNet | Search... | ||||||||||||||||||||||||||||||||||||
Other | |||||||||||||||||||||||||||||||||||||
| NextBio | 18979. | ||||||||||||||||||||||||||||||||||||
| PMAP-CutDB | P52948. | ||||||||||||||||||||||||||||||||||||
| SOURCE | Search... | ||||||||||||||||||||||||||||||||||||
Entry information
| Entry name | NUP98_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P52948 Secondary accession number(s): Q8IUT2 Q9Y6J5 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Peptidase families Classification of peptidase families and list of entries |
| Human chromosome 11 Human chromosome 11: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with