Nuclear pore complex protein Nup98-Nup96 precursor

Preferred order of sections

Names and origin

Protein names

Recommended name:
Nuclear pore complex protein Nup98-Nup96

Cleaved into the following 2 chains:

Nuclear pore complex protein Nup98
Alternative name(s):
98 kDa nucleoporin
Nucleoporin Nup98
Nuclear pore complex protein Nup96
Alternative name(s):
96 kDa nucleoporin
Nucleoporin Nup96

Gene names

Name:	NUP98
Synonyms:	ADAR2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1817 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Nup98 and Nup96 play a role in the bidirectional transport across the nucleoporin complex (NPC). The repeat domain in Nup98 has a direct role in the transport.
Subunit structure	Nup98 interacts directly with Nup96. Nup96 is part of the Nup160 subcomplex in the nuclear pore which is composed of Nup160, Nup133, Nup107 and Nup96. This complex plays a role in RNA export and in tethering Nup98 and Nup153 to the nucleus. May interact with RAE1. Interacts with vesicular stomatitis virus protein M. Ref.11 Ref.12 Ref.14 Ref.32
Subcellular location	Nucleus › nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Note: Nup96 is localized to the nucleoplasmic side of the nuclear pore complex, at or near the nucleoplasmic basket.
Domain	Contains G-L-F-G repeats.
Post-translational modification	Isoform 1 to isoform 4 are autoproteolytically cleaved to yield Nup98 and Nup96 or Nup98 only, respectively. Cleaved Nup98 is necessary for the targeting of Nup98 to the nuclear pore and the interaction with Nup96.
Involvement in disease	Note=A chromosomal aberration involving NUP98 is found in a form of acute myeloid leukemia. Translocation t(7;11)(p15;p15) with HOXA9. Translocation t(11;17)(p15;p13) with PHF23. Note=A chromosomal aberration involving NUP98 is found in childhood acute myeloid leukemia. Translocation t(5;11)(q35;p15.5) with NSD1. Translocation t(8;11)(p11.2;p15) with WHSC1L1. Note=A chromosomal aberration involving NUP98 is found in a form of therapy-related myelodysplastic syndrome. Translocation t(11;20)(p15;q11) with TOP1. Note=A chromosomal aberration involving NUP98 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(3;11)(q12.2;p15.4) with LNP1. Note=A chromosomal aberration involving NUP98 is associated with pediatric acute myeloid leukemia (AML) with intermediate characteristics between M2-M3 French-American-British (FAB) subtypes. Translocation t(9;11)(p22;p15) with PSIP1/LEDGF. The chimeric transcript is an in-frame fusion of NUP98 exon 8 to PSIP1/LEDGF exon 4.
Sequence similarities	Belongs to the nucleoporin GLFG family. Contains 1 peptidase S59 domain.
Sequence caution	The sequence AAD22395.1 differs from that shown. Reason: Contaminating sequence. Sequence of unknown origin in the C-terminal part. The sequence AAD22396.1 differs from that shown. Reason: Contaminating sequence. Sequence of unknown origin in the C-terminal part. The sequence AAF19342.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence AAF19342.1 differs from that shown. Reason: Frameshift at position 1551.

Ontologies

Keywords
Biological process	Host-virus interaction Protein transport Translocation Transport mRNA transport
Cellular component	Membrane Nuclear pore complex Nucleus
Coding sequence diversity	Alternative splicing Chromosomal rearrangement Polymorphism
Domain	Repeat
PTM	Acetylation Autocatalytic cleavage Phosphoprotein
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	DNA replication Inferred from mutant phenotype. Source: UniProtKB carbohydrate metabolic process Traceable author statement. Source: Reactome glucose transport Traceable author statement. Source: Reactome interspecies interaction between organisms Inferred from electronic annotation. Source: UniProtKB-KW mRNA transport Inferred from electronic annotation. Source: UniProtKB-KW mitotic prometaphase Traceable author statement. Source: Reactome nuclear pore organization Non-traceable author statement. Source: UniProtKB protein import into nucleus, docking Non-traceable author statement. Source: UniProtKB regulation of glucose transport Traceable author statement. Source: Reactome transmembrane transport Traceable author statement. Source: Reactome viral reproduction Traceable author statement. Source: Reactome
Cellular component	Nup107-160 complex Inferred from direct assay. Source: UniProtKB cytosol Traceable author statement. Source: Reactome nuclear membrane Inferred from electronic annotation. Source: UniProtKB-SubCell nucleoplasm Traceable author statement. Source: ProtInc
Molecular function	protein binding Inferred from physical interaction. Source: UniProtKB structural constituent of nuclear pore Non-traceable author statement. Source: UniProtKB transporter activity Traceable author statement. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P52948-1) Also known as: Nup98-Nup96 precursor; This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P52948-2) Also known as: Nup98-Nup96 precursor splice variant 1; The sequence of this isoform differs from the canonical sequence as follows: 393-409: Missing. 1502-1576: RHYDLNQLLE...FVLLHIDNSG → S

Isoform 3 (identifier: P52948-3) Also known as: Nup98-specific 1; The sequence of this isoform differs from the canonical sequence as follows: 932-937: SQSPEV → VEKKGQ 938-1817: Missing.

Isoform 4 (identifier: P52948-4) The sequence of this isoform differs from the canonical sequence as follows: 393-409: Missing. 932-937: SQSPEV → VEKKGQ 938-1817: Missing.

Isoform 5 (identifier: P52948-5) Also known as: Nup196; ADIR2; The sequence of this isoform differs from the canonical sequence as follows: 393-409: Missing.

Isoform 6 (identifier: P52948-6) The sequence of this isoform differs from the canonical sequence as follows: 1085-1188: WSVPPPLTSV...FLPNPVAVKP → C

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 880

880

Nuclear pore complex protein Nup98

PRO_0000019929

Chain

881 – 1817

937

Nuclear pore complex protein Nup96

PRO_0000019930

Regions

Domain

738 – 880

143

Peptidase S59

Compositional bias

7 – 480

474

Gly/Thr-rich

Compositional bias

890 – 894

5

Poly-Glu

Sites

Site

531 – 532

2

Breakpoint for translocation to form NUP98-PHF23 oncogene

Amino acid modifications

Modified residue

603

1

N6-acetyllysine Ref.31

Modified residue

608

1

Phosphoserine Ref.18 Ref.20 Ref.25 Ref.27 Ref.29 Ref.30

Modified residue

612

1

Phosphoserine Ref.18 Ref.20 Ref.25 Ref.27 Ref.29 Ref.30

Modified residue

618

1

Phosphoserine Ref.30

Modified residue

623

1

Phosphoserine Ref.16 Ref.18 Ref.20 Ref.23 Ref.24 Ref.27 Ref.29 Ref.30

Modified residue

625

1

Phosphoserine Ref.30

Modified residue

670

1

Phosphothreonine Ref.29

Modified residue

673

1

Phosphoserine Ref.29

Modified residue

839

1

Phosphoserine Ref.18 Ref.27

Modified residue

888

1

Phosphoserine Ref.18 Ref.21 Ref.23 Ref.26 Ref.27 Ref.28 Ref.29 Ref.30

Modified residue

916

1

Phosphothreonine Ref.29

Modified residue

934

1

Phosphoserine Ref.23 Ref.26 Ref.27

Modified residue

1000

1

Phosphothreonine Ref.27

Modified residue

1023

1

Phosphoserine Ref.23 Ref.27 Ref.29

Modified residue

1028

1

Phosphoserine Ref.20 Ref.23 Ref.27 Ref.29

Modified residue

1043

1

Phosphoserine Ref.27

Modified residue

1060

1

Phosphoserine Ref.20 Ref.25 Ref.27 Ref.29

Modified residue

1064

1

Phosphoserine Ref.25

Modified residue

1070

1

Phosphothreonine Ref.27

Natural variations

Alternative sequence

393 – 409

17

Missing in isoform 2, isoform 4 and isoform 5.

VSP_003619

Alternative sequence

932 – 937

6

SQSPEV → VEKKGQ in isoform 3 and isoform 4.

VSP_007942

Alternative sequence

938 – 1817

880

Missing in isoform 3 and isoform 4.

VSP_007943

Alternative sequence

1085 – 1188

104

WSVPP…VAVKP → C in isoform 6.

VSP_038328

Alternative sequence

1502 – 1576

75

RHYDL…IDNSG → S in isoform 2.

VSP_007944

Natural variant

1669

1

G → V in a breast cancer sample; somatic mutation. Ref.33

VAR_035859

Experimental info

Sequence conflict

318

1

L → S in AAH41136. Ref.6

Sequence conflict

376

1

S → G in AAH41136. Ref.6

Sequence conflict

756 – 757

2

EK → VF in AAD22395. Ref.3

Sequence conflict

756 – 757

2

EK → VF in AAD22396. Ref.3

Sequence conflict

1281

1

G → A in AAD22395. Ref.3

Sequence conflict

1281

1

G → A in AAD22396. Ref.3

Sequence conflict

1281

1

G → A in AAL56659. Ref.4

Sequence conflict

1534 – 1536

3

ALN → DLK in AAD22395. Ref.3

Sequence conflict

1594

1

E → D in AAF19342. Ref.7

Sequence conflict

1598

1

S → T in AAL56659. Ref.4

Sequence conflict

1639

1

K → N in AAF19342. Ref.7

Sequence conflict

1680

1

S → T in AAF19342. Ref.7

Secondary structure

1

.

1817

Helix Strand Turn

Details...

Sequences

Sequence		Length	Mass (Da)
Isoform 1 (Nup98-Nup96 precursor) [UniParc]. Last modified October 5, 2010. Version 4. Checksum: BC60E5456B936C79 Show »	FASTA	1,817	197,579
10 20 30 40 50 60 MFNKSFGTPF GGGTGGFGTT STFGQNTGFG TTSGGAFGTS AFGSSNNTGG LFGNSQTKPG 70 80 90 100 110 120 GLFGTSSFSQ PATSTSTGFG FGTSTGTANT LFGTASTGTS LFSSQNNAFA QNKPTGFGNF 130 140 150 160 170 180 GTSTSSGGLF GTTNTTSNPF GSTSGSLFGP SSFTAAPTGT TIKFNPPTGT DTMVKAGVST 190 200 210 220 230 240 NISTKHQCIT AMKEYESKSL EELRLEDYQA NRKGPQNQVG AGTTTGLFGS SPATSSATGL 250 260 270 280 290 300 FSSSTTNSGF AYGQNKTAFG TSTTGFGTNP GGLFGQQNQQ TTSLFSKPFG QATTTQNTGF 310 320 330 340 350 360 SFGNTSTIGQ PSTNTMGLFG VTQASQPGGL FGTATNTSTG TAFGTGTGLF GQTNTGFGAV 370 380 390 400 410 420 GSTLFGNNKL TTFGSSTTSA PSFGTTSGGL FGNKPTLTLG TNTNTSNFGF GTNTSGNSIF 430 440 450 460 470 480 GSKPAPGTLG TGLGAGFGTA LGAGQASLFG NNQPKIGGPL GTGAFGAPGF NTTTATLGFG 490 500 510 520 530 540 APQAPVALTD PNASAAQQAV LQQHINSLTY SPFGDSPLFR NPMSDPKKKE ERLKPTNPAA 550 560 570 580 590 600 QKALTTPTHY KLTPRPATRV RPKALQTTGT AKSHLFDGLD DDEPSLANGA FMPKKSIKKL 610 620 630 640 650 660 VLKNLNNSNL FSPVNRDSEN LASPSEYPEN GERFSFLSKP VDENHQQDGD EDSLVSHFYT 670 680 690 700 710 720 NPIAKPIPQT PESAGNKHSN SNSVDDTIVA LNMRAALRNG LEGSSEETSF HDESLQDDRE 730 740 750 760 770 780 EIENNSYHMH PAGIILTKVG YYTIPSMDDL AKITNEKGEC IVSDFTIGRK GYGSIYFEGD 790 800 810 820 830 840 VNLTNLNLDD IVHIRRKEVV VYLDDNQKPP VGEGLNRKAE VTLDGVWPTD KTSRCLIKSP 850 860 870 880 890 900 DRLADINYEG RLEAVSRKQG AQFKEYRPET GSWVFKVSHF SKYGLQDSDE EEEEHPSKTS 910 920 930 940 950 960 TKKLKTAPLP PASQTTPLQM ALNGKPAPPP QSQSPEVEQL GRVVELDSDM VDITQEPVLD 970 980 990 1000 1010 1020 TMLEESMPED QEPVSASTHI ASSLGINPHV LQIMKASLLT DEEDVDMALD QRFSRLPSKA 1030 1040 1050 1060 1070 1080 DTSQEICSPR LPISASHSSK TRSLVGGLLQ SKFTSGAFLS PSVSVQECRT PRAASLMNIP 1090 1100 1110 1120 1130 1140 STSSWSVPPP LTSVFTMPSP APEVPLKTVG TRRQLGLVPR EKSVTYGKGK LLMDMALFMG 1150 1160 1170 1180 1190 1200 RSFRVGWGPN WTLANSGEQL NGSHELENHQ IADSMEFGFL PNPVAVKPLT ESPFKVHLEK 1210 1220 1230 1240 1250 1260 LSLRQRKPDE DMKLYQTPLE LKLKHSTVHV DELCPLIVPN LGVAVIHDYA DWVKEASGDL 1270 1280 1290 1300 1310 1320 PEAQIVKHWS LTWTLCEALW GHLKELDSQL NEPREYIQIL ERRRAFSRWL SCTATPQIEE 1330 1340 1350 1360 1370 1380 EVSLTQKNSP VEAVFSYLTG KRISEACSLA QQSGDHRLAL LLSQFVGSQS VRELLTMQLV 1390 1400 1410 1420 1430 1440 DWHQLQADSF IQDERLRIFA LLAGKPVWQL SEKKQINVCS QLDWKRSLAI HLWYLLPPTA 1450 1460 1470 1480 1490 1500 SISRALSMYE EAFQNTSDSD RYACSPLPSY LEGSGCVIAE EQNSQTPLRD VCFHLLKLYS 1510 1520 1530 1540 1550 1560 DRHYDLNQLL EPRSITADPL DYRLSWHLWE VLRALNYTHL SAQCEGVLQA SYAGQLESEG 1570 1580 1590 1600 1610 1620 LWEWAIFVLL HIDNSGIREK AVRELLTRHC QLLETPESWA KETFLTQKLR VPAKWIHEAK 1630 1640 1650 1660 1670 1680 AVRAHMESDK HLEALCLFKA EHWNRCHKLI IRHLASDAII NENYDYLKGF LEDLAPPERS 1690 1700 1710 1720 1730 1740 SLIQDWETSG LVYLDYIRVI EMLRHIQQVD CSGNDLEQLH IKVTSLCSRI EQIQCYSAKD 1750 1760 1770 1780 1790 1800 RLAQSDMAKR VANLLRVVLS LHHPPDRTSD STPDPQRVPL RLLAPHIGRL PMPEDYAMDE 1810 LRSLTQSYLR ELAVGSL « Hide
Isoform 2 (Nup98-Nup96 precursor splice variant 1) [UniParc]. Checksum: 0F92C34F9FD7DC92 Show »	FASTA	1,726	187,199
10 20 30 40 50 60 MFNKSFGTPF GGGTGGFGTT STFGQNTGFG TTSGGAFGTS AFGSSNNTGG LFGNSQTKPG 70 80 90 100 110 120 GLFGTSSFSQ PATSTSTGFG FGTSTGTANT LFGTASTGTS LFSSQNNAFA QNKPTGFGNF 130 140 150 160 170 180 GTSTSSGGLF GTTNTTSNPF GSTSGSLFGP SSFTAAPTGT TIKFNPPTGT DTMVKAGVST 190 200 210 220 230 240 NISTKHQCIT AMKEYESKSL EELRLEDYQA NRKGPQNQVG AGTTTGLFGS SPATSSATGL 250 260 270 280 290 300 FSSSTTNSGF AYGQNKTAFG TSTTGFGTNP GGLFGQQNQQ TTSLFSKPFG QATTTQNTGF 310 320 330 340 350 360 SFGNTSTIGQ PSTNTMGLFG VTQASQPGGL FGTATNTSTG TAFGTGTGLF GQTNTGFGAV 370 380 390 400 410 420 GSTLFGNNKL TTFGSSTTSA PSFGTTSGGL FGFGTNTSGN SIFGSKPAPG TLGTGLGAGF 430 440 450 460 470 480 GTALGAGQAS LFGNNQPKIG GPLGTGAFGA PGFNTTTATL GFGAPQAPVA LTDPNASAAQ 490 500 510 520 530 540 QAVLQQHINS LTYSPFGDSP LFRNPMSDPK KKEERLKPTN PAAQKALTTP THYKLTPRPA 550 560 570 580 590 600 TRVRPKALQT TGTAKSHLFD GLDDDEPSLA NGAFMPKKSI KKLVLKNLNN SNLFSPVNRD 610 620 630 640 650 660 SENLASPSEY PENGERFSFL SKPVDENHQQ DGDEDSLVSH FYTNPIAKPI PQTPESAGNK 670 680 690 700 710 720 HSNSNSVDDT IVALNMRAAL RNGLEGSSEE TSFHDESLQD DREEIENNSY HMHPAGIILT 730 740 750 760 770 780 KVGYYTIPSM DDLAKITNEK GECIVSDFTI GRKGYGSIYF EGDVNLTNLN LDDIVHIRRK 790 800 810 820 830 840 EVVVYLDDNQ KPPVGEGLNR KAEVTLDGVW PTDKTSRCLI KSPDRLADIN YEGRLEAVSR 850 860 870 880 890 900 KQGAQFKEYR PETGSWVFKV SHFSKYGLQD SDEEEEEHPS KTSTKKLKTA PLPPASQTTP 910 920 930 940 950 960 LQMALNGKPA PPPQSQSPEV EQLGRVVELD SDMVDITQEP VLDTMLEESM PEDQEPVSAS 970 980 990 1000 1010 1020 THIASSLGIN PHVLQIMKAS LLTDEEDVDM ALDQRFSRLP SKADTSQEIC SPRLPISASH 1030 1040 1050 1060 1070 1080 SSKTRSLVGG LLQSKFTSGA FLSPSVSVQE CRTPRAASLM NIPSTSSWSV PPPLTSVFTM 1090 1100 1110 1120 1130 1140 PSPAPEVPLK TVGTRRQLGL VPREKSVTYG KGKLLMDMAL FMGRSFRVGW GPNWTLANSG 1150 1160 1170 1180 1190 1200 EQLNGSHELE NHQIADSMEF GFLPNPVAVK PLTESPFKVH LEKLSLRQRK PDEDMKLYQT 1210 1220 1230 1240 1250 1260 PLELKLKHST VHVDELCPLI VPNLGVAVIH DYADWVKEAS GDLPEAQIVK HWSLTWTLCE 1270 1280 1290 1300 1310 1320 ALWGHLKELD SQLNEPREYI QILERRRAFS RWLSCTATPQ IEEEVSLTQK NSPVEAVFSY 1330 1340 1350 1360 1370 1380 LTGKRISEAC SLAQQSGDHR LALLLSQFVG SQSVRELLTM QLVDWHQLQA DSFIQDERLR 1390 1400 1410 1420 1430 1440 IFALLAGKPV WQLSEKKQIN VCSQLDWKRS LAIHLWYLLP PTASISRALS MYEEAFQNTS 1450 1460 1470 1480 1490 1500 DSDRYACSPL PSYLEGSGCV IAEEQNSQTP LRDVCFHLLK LYSDSIREKA VRELLTRHCQ 1510 1520 1530 1540 1550 1560 LLETPESWAK ETFLTQKLRV PAKWIHEAKA VRAHMESDKH LEALCLFKAE HWNRCHKLII 1570 1580 1590 1600 1610 1620 RHLASDAIIN ENYDYLKGFL EDLAPPERSS LIQDWETSGL VYLDYIRVIE MLRHIQQVDC 1630 1640 1650 1660 1670 1680 SGNDLEQLHI KVTSLCSRIE QIQCYSAKDR LAQSDMAKRV ANLLRVVLSL HHPPDRTSDS 1690 1700 1710 1720 TPDPQRVPLR LLAPHIGRLP MPEDYAMDEL RSLTQSYLRE LAVGSL « Hide
Isoform 3 (Nup98-specific 1) [UniParc]. Checksum: 2CB6CE36734F0B82 Show »	FASTA	937	97,836
10 20 30 40 50 60 MFNKSFGTPF GGGTGGFGTT STFGQNTGFG TTSGGAFGTS AFGSSNNTGG LFGNSQTKPG 70 80 90 100 110 120 GLFGTSSFSQ PATSTSTGFG FGTSTGTANT LFGTASTGTS LFSSQNNAFA QNKPTGFGNF 130 140 150 160 170 180 GTSTSSGGLF GTTNTTSNPF GSTSGSLFGP SSFTAAPTGT TIKFNPPTGT DTMVKAGVST 190 200 210 220 230 240 NISTKHQCIT AMKEYESKSL EELRLEDYQA NRKGPQNQVG AGTTTGLFGS SPATSSATGL 250 260 270 280 290 300 FSSSTTNSGF AYGQNKTAFG TSTTGFGTNP GGLFGQQNQQ TTSLFSKPFG QATTTQNTGF 310 320 330 340 350 360 SFGNTSTIGQ PSTNTMGLFG VTQASQPGGL FGTATNTSTG TAFGTGTGLF GQTNTGFGAV 370 380 390 400 410 420 GSTLFGNNKL TTFGSSTTSA PSFGTTSGGL FGNKPTLTLG TNTNTSNFGF GTNTSGNSIF 430 440 450 460 470 480 GSKPAPGTLG TGLGAGFGTA LGAGQASLFG NNQPKIGGPL GTGAFGAPGF NTTTATLGFG 490 500 510 520 530 540 APQAPVALTD PNASAAQQAV LQQHINSLTY SPFGDSPLFR NPMSDPKKKE ERLKPTNPAA 550 560 570 580 590 600 QKALTTPTHY KLTPRPATRV RPKALQTTGT AKSHLFDGLD DDEPSLANGA FMPKKSIKKL 610 620 630 640 650 660 VLKNLNNSNL FSPVNRDSEN LASPSEYPEN GERFSFLSKP VDENHQQDGD EDSLVSHFYT 670 680 690 700 710 720 NPIAKPIPQT PESAGNKHSN SNSVDDTIVA LNMRAALRNG LEGSSEETSF HDESLQDDRE 730 740 750 760 770 780 EIENNSYHMH PAGIILTKVG YYTIPSMDDL AKITNEKGEC IVSDFTIGRK GYGSIYFEGD 790 800 810 820 830 840 VNLTNLNLDD IVHIRRKEVV VYLDDNQKPP VGEGLNRKAE VTLDGVWPTD KTSRCLIKSP 850 860 870 880 890 900 DRLADINYEG RLEAVSRKQG AQFKEYRPET GSWVFKVSHF SKYGLQDSDE EEEEHPSKTS 910 920 930 TKKLKTAPLP PASQTTPLQM ALNGKPAPPP QVEKKGQ « Hide
Isoform 4 [UniParc]. Checksum: 129DABAFB69253AD Show »	FASTA	920	96,075
10 20 30 40 50 60 MFNKSFGTPF GGGTGGFGTT STFGQNTGFG TTSGGAFGTS AFGSSNNTGG LFGNSQTKPG 70 80 90 100 110 120 GLFGTSSFSQ PATSTSTGFG FGTSTGTANT LFGTASTGTS LFSSQNNAFA QNKPTGFGNF 130 140 150 160 170 180 GTSTSSGGLF GTTNTTSNPF GSTSGSLFGP SSFTAAPTGT TIKFNPPTGT DTMVKAGVST 190 200 210 220 230 240 NISTKHQCIT AMKEYESKSL EELRLEDYQA NRKGPQNQVG AGTTTGLFGS SPATSSATGL 250 260 270 280 290 300 FSSSTTNSGF AYGQNKTAFG TSTTGFGTNP GGLFGQQNQQ TTSLFSKPFG QATTTQNTGF 310 320 330 340 350 360 SFGNTSTIGQ PSTNTMGLFG VTQASQPGGL FGTATNTSTG TAFGTGTGLF GQTNTGFGAV 370 380 390 400 410 420 GSTLFGNNKL TTFGSSTTSA PSFGTTSGGL FGFGTNTSGN SIFGSKPAPG TLGTGLGAGF 430 440 450 460 470 480 GTALGAGQAS LFGNNQPKIG GPLGTGAFGA PGFNTTTATL GFGAPQAPVA LTDPNASAAQ 490 500 510 520 530 540 QAVLQQHINS LTYSPFGDSP LFRNPMSDPK KKEERLKPTN PAAQKALTTP THYKLTPRPA 550 560 570 580 590 600 TRVRPKALQT TGTAKSHLFD GLDDDEPSLA NGAFMPKKSI KKLVLKNLNN SNLFSPVNRD 610 620 630 640 650 660 SENLASPSEY PENGERFSFL SKPVDENHQQ DGDEDSLVSH FYTNPIAKPI PQTPESAGNK 670 680 690 700 710 720 HSNSNSVDDT IVALNMRAAL RNGLEGSSEE TSFHDESLQD DREEIENNSY HMHPAGIILT 730 740 750 760 770 780 KVGYYTIPSM DDLAKITNEK GECIVSDFTI GRKGYGSIYF EGDVNLTNLN LDDIVHIRRK 790 800 810 820 830 840 EVVVYLDDNQ KPPVGEGLNR KAEVTLDGVW PTDKTSRCLI KSPDRLADIN YEGRLEAVSR 850 860 870 880 890 900 KQGAQFKEYR PETGSWVFKV SHFSKYGLQD SDEEEEEHPS KTSTKKLKTA PLPPASQTTP 910 920 LQMALNGKPA PPPQVEKKGQ « Hide
Isoform 5 (Nup196) (ADIR2) [UniParc]. Checksum: 4BCA483C2E9E1A8E Show »	FASTA	1,800	195,817
10 20 30 40 50 60 MFNKSFGTPF GGGTGGFGTT STFGQNTGFG TTSGGAFGTS AFGSSNNTGG LFGNSQTKPG 70 80 90 100 110 120 GLFGTSSFSQ PATSTSTGFG FGTSTGTANT LFGTASTGTS LFSSQNNAFA QNKPTGFGNF 130 140 150 160 170 180 GTSTSSGGLF GTTNTTSNPF GSTSGSLFGP SSFTAAPTGT TIKFNPPTGT DTMVKAGVST 190 200 210 220 230 240 NISTKHQCIT AMKEYESKSL EELRLEDYQA NRKGPQNQVG AGTTTGLFGS SPATSSATGL 250 260 270 280 290 300 FSSSTTNSGF AYGQNKTAFG TSTTGFGTNP GGLFGQQNQQ TTSLFSKPFG QATTTQNTGF 310 320 330 340 350 360 SFGNTSTIGQ PSTNTMGLFG VTQASQPGGL FGTATNTSTG TAFGTGTGLF GQTNTGFGAV 370 380 390 400 410 420 GSTLFGNNKL TTFGSSTTSA PSFGTTSGGL FGFGTNTSGN SIFGSKPAPG TLGTGLGAGF 430 440 450 460 470 480 GTALGAGQAS LFGNNQPKIG GPLGTGAFGA PGFNTTTATL GFGAPQAPVA LTDPNASAAQ 490 500 510 520 530 540 QAVLQQHINS LTYSPFGDSP LFRNPMSDPK KKEERLKPTN PAAQKALTTP THYKLTPRPA 550 560 570 580 590 600 TRVRPKALQT TGTAKSHLFD GLDDDEPSLA NGAFMPKKSI KKLVLKNLNN SNLFSPVNRD 610 620 630 640 650 660 SENLASPSEY PENGERFSFL SKPVDENHQQ DGDEDSLVSH FYTNPIAKPI PQTPESAGNK 670 680 690 700 710 720 HSNSNSVDDT IVALNMRAAL RNGLEGSSEE TSFHDESLQD DREEIENNSY HMHPAGIILT 730 740 750 760 770 780 KVGYYTIPSM DDLAKITNEK GECIVSDFTI GRKGYGSIYF EGDVNLTNLN LDDIVHIRRK 790 800 810 820 830 840 EVVVYLDDNQ KPPVGEGLNR KAEVTLDGVW PTDKTSRCLI KSPDRLADIN YEGRLEAVSR 850 860 870 880 890 900 KQGAQFKEYR PETGSWVFKV SHFSKYGLQD SDEEEEEHPS KTSTKKLKTA PLPPASQTTP 910 920 930 940 950 960 LQMALNGKPA PPPQSQSPEV EQLGRVVELD SDMVDITQEP VLDTMLEESM PEDQEPVSAS 970 980 990 1000 1010 1020 THIASSLGIN PHVLQIMKAS LLTDEEDVDM ALDQRFSRLP SKADTSQEIC SPRLPISASH 1030 1040 1050 1060 1070 1080 SSKTRSLVGG LLQSKFTSGA FLSPSVSVQE CRTPRAASLM NIPSTSSWSV PPPLTSVFTM 1090 1100 1110 1120 1130 1140 PSPAPEVPLK TVGTRRQLGL VPREKSVTYG KGKLLMDMAL FMGRSFRVGW GPNWTLANSG 1150 1160 1170 1180 1190 1200 EQLNGSHELE NHQIADSMEF GFLPNPVAVK PLTESPFKVH LEKLSLRQRK PDEDMKLYQT 1210 1220 1230 1240 1250 1260 PLELKLKHST VHVDELCPLI VPNLGVAVIH DYADWVKEAS GDLPEAQIVK HWSLTWTLCE 1270 1280 1290 1300 1310 1320 ALWGHLKELD SQLNEPREYI QILERRRAFS RWLSCTATPQ IEEEVSLTQK NSPVEAVFSY 1330 1340 1350 1360 1370 1380 LTGKRISEAC SLAQQSGDHR LALLLSQFVG SQSVRELLTM QLVDWHQLQA DSFIQDERLR 1390 1400 1410 1420 1430 1440 IFALLAGKPV WQLSEKKQIN VCSQLDWKRS LAIHLWYLLP PTASISRALS MYEEAFQNTS 1450 1460 1470 1480 1490 1500 DSDRYACSPL PSYLEGSGCV IAEEQNSQTP LRDVCFHLLK LYSDRHYDLN QLLEPRSITA 1510 1520 1530 1540 1550 1560 DPLDYRLSWH LWEVLRALNY THLSAQCEGV LQASYAGQLE SEGLWEWAIF VLLHIDNSGI 1570 1580 1590 1600 1610 1620 REKAVRELLT RHCQLLETPE SWAKETFLTQ KLRVPAKWIH EAKAVRAHME SDKHLEALCL 1630 1640 1650 1660 1670 1680 FKAEHWNRCH KLIIRHLASD AIINENYDYL KGFLEDLAPP ERSSLIQDWE TSGLVYLDYI 1690 1700 1710 1720 1730 1740 RVIEMLRHIQ QVDCSGNDLE QLHIKVTSLC SRIEQIQCYS AKDRLAQSDM AKRVANLLRV 1750 1760 1770 1780 1790 1800 VLSLHHPPDR TSDSTPDPQR VPLRLLAPHI GRLPMPEDYA MDELRSLTQS YLRELAVGSL « Hide
Isoform 6 [UniParc]. Checksum: 158300FBC47A0C0C Show »	FASTA	1,714	186,268
10 20 30 40 50 60 MFNKSFGTPF GGGTGGFGTT STFGQNTGFG TTSGGAFGTS AFGSSNNTGG LFGNSQTKPG 70 80 90 100 110 120 GLFGTSSFSQ PATSTSTGFG FGTSTGTANT LFGTASTGTS LFSSQNNAFA QNKPTGFGNF 130 140 150 160 170 180 GTSTSSGGLF GTTNTTSNPF GSTSGSLFGP SSFTAAPTGT TIKFNPPTGT DTMVKAGVST 190 200 210 220 230 240 NISTKHQCIT AMKEYESKSL EELRLEDYQA NRKGPQNQVG AGTTTGLFGS SPATSSATGL 250 260 270 280 290 300 FSSSTTNSGF AYGQNKTAFG TSTTGFGTNP GGLFGQQNQQ TTSLFSKPFG QATTTQNTGF 310 320 330 340 350 360 SFGNTSTIGQ PSTNTMGLFG VTQASQPGGL FGTATNTSTG TAFGTGTGLF GQTNTGFGAV 370 380 390 400 410 420 GSTLFGNNKL TTFGSSTTSA PSFGTTSGGL FGNKPTLTLG TNTNTSNFGF GTNTSGNSIF 430 440 450 460 470 480 GSKPAPGTLG TGLGAGFGTA LGAGQASLFG NNQPKIGGPL GTGAFGAPGF NTTTATLGFG 490 500 510 520 530 540 APQAPVALTD PNASAAQQAV LQQHINSLTY SPFGDSPLFR NPMSDPKKKE ERLKPTNPAA 550 560 570 580 590 600 QKALTTPTHY KLTPRPATRV RPKALQTTGT AKSHLFDGLD DDEPSLANGA FMPKKSIKKL 610 620 630 640 650 660 VLKNLNNSNL FSPVNRDSEN LASPSEYPEN GERFSFLSKP VDENHQQDGD EDSLVSHFYT 670 680 690 700 710 720 NPIAKPIPQT PESAGNKHSN SNSVDDTIVA LNMRAALRNG LEGSSEETSF HDESLQDDRE 730 740 750 760 770 780 EIENNSYHMH PAGIILTKVG YYTIPSMDDL AKITNEKGEC IVSDFTIGRK GYGSIYFEGD 790 800 810 820 830 840 VNLTNLNLDD IVHIRRKEVV VYLDDNQKPP VGEGLNRKAE VTLDGVWPTD KTSRCLIKSP 850 860 870 880 890 900 DRLADINYEG RLEAVSRKQG AQFKEYRPET GSWVFKVSHF SKYGLQDSDE EEEEHPSKTS 910 920 930 940 950 960 TKKLKTAPLP PASQTTPLQM ALNGKPAPPP QSQSPEVEQL GRVVELDSDM VDITQEPVLD 970 980 990 1000 1010 1020 TMLEESMPED QEPVSASTHI ASSLGINPHV LQIMKASLLT DEEDVDMALD QRFSRLPSKA 1030 1040 1050 1060 1070 1080 DTSQEICSPR LPISASHSSK TRSLVGGLLQ SKFTSGAFLS PSVSVQECRT PRAASLMNIP 1090 1100 1110 1120 1130 1140 STSSCLTESP FKVHLEKLSL RQRKPDEDMK LYQTPLELKL KHSTVHVDEL CPLIVPNLGV 1150 1160 1170 1180 1190 1200 AVIHDYADWV KEASGDLPEA QIVKHWSLTW TLCEALWGHL KELDSQLNEP REYIQILERR 1210 1220 1230 1240 1250 1260 RAFSRWLSCT ATPQIEEEVS LTQKNSPVEA VFSYLTGKRI SEACSLAQQS GDHRLALLLS 1270 1280 1290 1300 1310 1320 QFVGSQSVRE LLTMQLVDWH QLQADSFIQD ERLRIFALLA GKPVWQLSEK KQINVCSQLD 1330 1340 1350 1360 1370 1380 WKRSLAIHLW YLLPPTASIS RALSMYEEAF QNTSDSDRYA CSPLPSYLEG SGCVIAEEQN 1390 1400 1410 1420 1430 1440 SQTPLRDVCF HLLKLYSDRH YDLNQLLEPR SITADPLDYR LSWHLWEVLR ALNYTHLSAQ 1450 1460 1470 1480 1490 1500 CEGVLQASYA GQLESEGLWE WAIFVLLHID NSGIREKAVR ELLTRHCQLL ETPESWAKET 1510 1520 1530 1540 1550 1560 FLTQKLRVPA KWIHEAKAVR AHMESDKHLE ALCLFKAEHW NRCHKLIIRH LASDAIINEN 1570 1580 1590 1600 1610 1620 YDYLKGFLED LAPPERSSLI QDWETSGLVY LDYIRVIEML RHIQQVDCSG NDLEQLHIKV 1630 1640 1650 1660 1670 1680 TSLCSRIEQI QCYSAKDRLA QSDMAKRVAN LLRVVLSLHH PPDRTSDSTP DPQRVPLRLL 1690 1700 1710 APHIGRLPMP EDYAMDELRS LTQSYLRELA VGSL « Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9." Borrow J., Shearman A.M., Stanton V.P., Becher R., Collins T., Williams A.J., Dube I., Katz F., Kwong Y.L., Morris C., Ohyashiki K., Toyama K., Rowley J., Housman D.E. Nat. Genet. 12:159-167(1996) [PubMed: 8563754] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), CHROMOSOMAL TRANSLOCATION WITH HOXA9.
[2]	"Molecular analysis of the chromosomal breakpoints and identification of the repetitive sequences near the breakpoints of NUP98 in therapy-related leukemia with inv(11)(p15q22)." Arai Y., Kaneko Y., Kubo T., Arai K., Hosoda F., Ohki M. Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
[3]	"A conserved biogenesis pathway for nucleoporins: proteolytic processing of a 186-kilodalton precursor generates Nup98 and the novel nucleoporin, Nup96." Fontoura B.M.A., Blobel G., Matunis M.J. J. Cell Biol. 144:1097-1112(1999) [PubMed: 10087256] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), PROTEIN SEQUENCE OF 1648-1664.
[4]	"An alternative splice form of NUP98 encodes a 196kDa NUP196 isoform." Borrow J., Housman D.E. Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5).
[5]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. Sakaki Y. Nature 440:497-500(2006) [PubMed: 16554811] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 963-1817 (ISOFORM 6). Tissue: Lung carcinoma.
[7]	Xu Y.H., Guo B.C., Yu Y.L. Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1176-1817 (ISOFORM 5). Tissue: Liver.
[8]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1212-1817 (ISOFORM 5).
[9]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1227-1817 (ISOFORM 5). Tissue: Testis.
[10]	"The t(11;20)(p15;q11) chromosomal translocation associated with therapy-related myelodysplastic syndrome results in an NUP98-TOP1 fusion." Ahuja H.G., Felix C.A., Aplan P.D. Blood 94:3258-3261(1999) [PubMed: 10556215] [Abstract] Cited for: CHROMOSOMAL TRANSLOCATION WITH TOP1.
[11]	"RAE1 is a shuttling mRNA export factor that binds to a GLEBS-like NUP98 motif at the nuclear pore complex through multiple domains." Pritchard C.E., Fornerod M., Kasper L.H., van Deursen J.M. J. Cell Biol. 145:237-254(1999) [PubMed: 10209021] [Abstract] Cited for: INTERACTION WITH RAE1.
[12]	"Vesicular stomatitis virus matrix protein inhibits host cell gene expression by targeting the nucleoporin Nup98." von Kobbe C., van Deursen J.M., Rodrigues J.P., Sitterlin D., Bachi A., Wu X., Wilm M., Carmo-Fonseca M., Izaurralde E. Mol. Cell 6:1243-1252(2000) [PubMed: 11106761] [Abstract] Cited for: INTERACTION WITH VESICULAR STOMATITIS VIRUS PROTEIN M.
[13]	"A novel gene, NSD1, is fused to NUP98 in the t(5;11)(q35;p15.5) in de novo childhood acute myeloid leukemia." Jaju R.J., Fidler C., Haas O.A., Strickson A.J., Watkins F., Clark K., Cross N.C., Cheng J.F., Aplan P.D., Kearney L., Boultwood J., Wainscoat J.S. Blood 98:1264-1267(2001) [PubMed: 11493482] [Abstract] Cited for: CHROMOSOMAL TRANSLOCATION WITH NSD1.
[14]	"Novel vertebrate nucleoporins Nup133 and Nup160 play a role in mRNA export." Vasu S., Shah S., Orjalo A., Park M., Fischer W.H., Forbes D.J. J. Cell Biol. 155:339-354(2001) [PubMed: 11684705] [Abstract] Cited for: SUBUNIT.
[15]	"NUP98 is fused to the NSD3 gene in acute myeloid leukemia associated with t(8;11)(p11.2;p15)." Rosati R., La Starza R., Veronese A., Aventin A., Schwienbacher C., Vallespi T., Negrini M., Martelli M.F., Mecucci C. Blood 99:3857-3860(2002) [PubMed: 11986249] [Abstract] Cited for: CHROMOSOMAL TRANSLOCATION WITH WHSC1L1.
[16]	"Large-scale characterization of HeLa cell nuclear phosphoproteins." Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004) [PubMed: 15302935] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-623, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[17]	"t(9;11)(p22;p15) with NUP98-LEDGF fusion gene in pediatric acute myeloid leukemia." Morerio C., Acquila M., Rosanda C., Rapella A., Tassano E., Micalizzi C., Panarello C. Leuk. Res. 29:467-470(2005) [PubMed: 15725483] [Abstract] Cited for: CHROMOSOMAL TRANSLOCATION WITH PSIP1/LEDGF.
[18]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-608; SER-612; SER-623; SER-839 AND SER-888, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[19]	"NUP98 rearrangements in hematopoietic malignancies: a study of the Groupe Francophone de Cytogenetique Hematologique." Romana S.P., Radford-Weiss I., Ben Abdelali R., Schluth C., Petit A., Dastugue N., Talmant P., Bilhou-Nabera C., Mugneret F., Lafage-Pochitaloff M., Mozziconacci M.-J., Andrieu J., Lai J.-L., Terre C., Rack K., Cornillet-Lefebvre P., Luquet I., Nadal N. Berger R. Leukemia 20:696-706(2006) [PubMed: 16467868] [Abstract] Cited for: CHROMOSOMAL TRANSLOCATION WITH LNP1.
[20]	"A probability-based approach for high-throughput protein phosphorylation analysis and site localization." Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P. Nat. Biotechnol. 24:1285-1292(2006) [PubMed: 16964243] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-608; SER-612; SER-623; SER-1028 AND SER-1060, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[21]	"Phosphoproteome analysis of the human mitotic spindle." Nousiainen M., Sillje H.H.W., Sauer G., Nigg E.A., Koerner R. Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006) [PubMed: 16565220] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-888, MASS SPECTROMETRY. Tissue: Cervix adenocarcinoma.
[22]	"A novel NUP98-PHF23 fusion resulting from a cryptic translocation t(11;17)(p15;p13) in acute myeloid leukemia." Reader J.C., Meekins J.S., Gojo I., Ning Y. Leukemia 21:842-844(2007) [PubMed: 17287853] [Abstract] Cited for: CHROMOSOMAL TRANSLOCATION WITH PHF23. Tissue: Peripheral blood.
[23]	"Evaluation of the low-specificity protease elastase for large-scale phosphoproteome analysis." Wang B., Malik R., Nigg E.A., Korner R. Anal. Chem. 80:9526-9533(2008) [PubMed: 19007248] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-623; SER-888; SER-934; SER-1023 AND SER-1028, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[24]	"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column." Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y. Anal. Sci. 24:161-166(2008) [PubMed: 18187866] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-623, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[25]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed: 18220336] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-608; SER-612; SER-1060 AND SER-1064, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[26]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-888 AND SER-934, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[27]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-608; SER-612; SER-623; SER-839; SER-888; SER-934; THR-1000; SER-1023; SER-1028; SER-1043; SER-1060 AND THR-1070, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[28]	"Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography." Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J. Proteomics 8:1346-1361(2008) [PubMed: 18318008] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-888, MASS SPECTROMETRY. Tissue: Liver.
[29]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-608; SER-612; SER-623; THR-670; SER-673; SER-888; THR-916; SER-1023; SER-1028 AND SER-1060, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[30]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-608; SER-612; SER-618; SER-623; SER-625 AND SER-888, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[31]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed: 19608861] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-603, MASS SPECTROMETRY.
[32]	"The three-dimensional structure of the autoproteolytic, nuclear pore-targeting domain of the human nucleoporin Nup98." Hodel A.E., Hodel M.R., Griffis E.R., Hennig K.A., Ratner G.A., Xu S., Powers M.A. Mol. Cell 10:347-358(2002) [PubMed: 12191480] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 710-870 OF NUP98, INTERACTION WITH NUP96.
[33]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. Velculescu V.E. Science 314:268-274(2006) [PubMed: 16959974] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] VAL-1669.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

U41815 mRNA. Translation: AAC50366.1.
AB040538 mRNA. Translation: BAB18537.1.
AF071076 mRNA. Translation: AAD22395.1. Sequence problems.
AF071077 mRNA. Translation: AAD22396.1. Sequence problems.
AF231130 mRNA. Translation: AAL56659.1.
AC060812 Genomic DNA. No translation available.
AC090587 Genomic DNA. No translation available.
BC041136 mRNA. Translation: AAH41136.1.
BC012906 mRNA. Translation: AAH12906.2.
AF116074 mRNA. Translation: AAF19342.1. Sequence problems.
BT007349 mRNA. Translation: AAP36013.1.
AL133601 mRNA. Translation: CAB63736.1.
AL137613 mRNA. Translation: CAB70842.1.

IPI

IPI00006038.
IPI00216688.
IPI00337395.
IPI00337397.
IPI00936708.
IPI00953181.

PIR

T43443.

RefSeq

NP_005378.4. NM_005387.5.
NP_057404.2. NM_016320.4.
NP_624357.1. NM_139131.3.
NP_624358.2. NM_139132.3.

UniGene

Hs.524750.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1KO6	X-ray	3.00	A/C	695-880	[»]
			B/D	881-931	[»]
2Q5X	X-ray	1.90	A	733-887	[»]
2Q5Y	X-ray	2.30	A/C	729-880	[»]
3MMY	X-ray	1.65	B/D/F/H	158-213	[»]

ProteinModelPortal

P52948.

SMR

P52948. Positions 158-213, 729-880.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-32484N.

IntAct

P52948. 11 interactions.

MINT

MINT-121544.

STRING

P52948.

Protein family/group databases

MEROPS

S59.001.

PTM databases

PhosphoSite

P52948.

Polymorphism databases

DMDM

308153660.

Proteomic databases

PRIDE

P52948.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000359171; ENSP00000352091; ENSG00000110713.

GeneID

4928.

KEGG

hsa:4928.

UCSC

uc001lyh.1. human.
uc001lyi.1. human.
uc001lyk.1. human.

Organism-specific databases

CTD

4928.

GeneCards

GC11M003696.

HGNC

HGNC:8068. NUP98.

MIM

601021. gene.

neXtProt

NX_P52948.

PharmGKB

PA31856.

GenAtlas

Search...

Phylogenomic databases

eggNOG

prNOG07907.

HOVERGEN

HBG052702.

OMA

DWVKEAS.

PhylomeDB

P52948.

Enzyme and pathway databases

Reactome

REACT_152. Cell Cycle, Mitotic.
REACT_15518. Transmembrane transport of small molecules.
REACT_383. DNA Replication.
REACT_474. Metabolism of carbohydrates.
REACT_6185. HIV Infection.

Gene expression databases

ArrayExpress

P52948.

Bgee

P52948.

Genevestigator

P52948.

GermOnline

ENSG00000110713. Homo sapiens.

Family and domain databases

InterPro

IPR021967. Nup96.
IPR007230. Peptidase_S59.
[Graphical view]

KO

K14297.

Pfam

PF04096. Nucleoporin2. 1 hit.
PF12110. Nup96. 1 hit.
[Graphical view]

SUPFAM

SSF82215. Peptidase_S59. 1 hit.

PROSITE

PS51434. NUP_C. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

NextBio

18979.

PMAP-CutDB

P52948.

SOURCE

Search...

Entry information

Entry name

NUP98_HUMAN

Accession

Primary (citable) accession number: P52948
Secondary accession number(s): Q8IUT2

Q9Y6J5

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 5, 2010
Last modified:	January 25, 2012
This is version 133 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.