ID PDX1_HUMAN Reviewed; 283 AA. AC P52945; O60594; Q5VYW2; DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1996, sequence version 1. DT 27-MAR-2024, entry version 213. DE RecName: Full=Pancreas/duodenum homeobox protein 1; DE Short=PDX-1; DE AltName: Full=Glucose-sensitive factor; DE Short=GSF; DE AltName: Full=Insulin promoter factor 1; DE Short=IPF-1; DE AltName: Full=Insulin upstream factor 1; DE Short=IUF-1; DE AltName: Full=Islet/duodenum homeobox-1; DE Short=IDX-1; DE AltName: Full=Somatostatin-transactivating factor 1; DE Short=STF-1; GN Name=PDX1; Synonyms=IPF1, STF1; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=7590740; DOI=10.1006/geno.1995.1120; RA Stoffel M., Stein R., Wright C.V., Espinosa R. III, le Beau M.M., RA Bell G.I.; RT "Localization of human homeodomain transcription factor insulin promoter RT factor 1 (IPF1) to chromosome band 13q12.1."; RL Genomics 28:125-126(1995). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC TISSUE=Pancreatic islet; RX PubMed=8635654; DOI=10.2337/diab.45.6.789; RA Inoue H., Riggs A.C., Tanizawa Y., Ueda K., Kuwano A., Liu L., RA Donis-Keller H., Permutt M.A.; RT "Isolation, characterization, and chromosomal mapping of the human insulin RT promoter factor 1 (IPF-1) gene."; RL Diabetes 45:789-794(1996). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Pancreatic islet; RA Hiroshi I.; RL Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Pancreatic islet; RA Marshak S., Totary H., Cerasi E., Melloul D.; RL Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RA Hara M., Lindner T.H., Paz V.P., Wang X., Iwasaki N., Bell G.I.; RL Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases. RN [6] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Pancreatic islet; RX PubMed=9252422; DOI=10.1074/jbc.272.33.20936; RA Macfarlane W.M., Smith S.B., James R.F., Clifton A.D., Doza Y.N., Cohen P., RA Docherty K.; RT "The p38/reactivating kinase mitogen-activated protein kinase cascade RT mediates the activation of the transcription factor insulin upstream factor RT 1 and insulin gene transcription by high glucose in pancreatic beta- RT cells."; RL J. Biol. Chem. 272:20936-20944(1997). RN [7] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15057823; DOI=10.1038/nature02379; RA Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., RA Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., RA Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., RA Ambrose K.D., Andrews D.T., Ashwell R.I.S., Babbage A.K., Bagguley C.L., RA Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., RA Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., RA Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., RA Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., RA Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., RA Frankish A.G., Frankland J., French L., Garner P., Garnett J., RA Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., RA Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., RA Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., RA Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., RA Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., RA Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., RA Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., RA Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., RA Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., RA Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., RA Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., RA Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., RA Rogers J., Ross M.T.; RT "The DNA sequence and analysis of human chromosome 13."; RL Nature 428:522-528(2004). RN [8] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [9] RP INVOLVEMENT IN PAGEN1. RX PubMed=8988180; DOI=10.1038/ng0197-106; RA Stoffers D.A., Zinkin N.T., Stanojevic V., Clarke W.L., Habener J.F.; RT "Pancreatic agenesis attributable to a single nucleotide deletion in the RT human IPF1 gene coding sequence."; RL Nat. Genet. 15:106-110(1997). RN [10] RP INVOLVEMENT IN MODY4. RX PubMed=9326926; DOI=10.1038/ng1097-138; RA Stoffers D.A., Ferrer J., Clarke W.L., Habener J.F.; RT "Early-onset type-II diabetes mellitus (MODY4) linked to IPF1."; RL Nat. Genet. 17:138-139(1997). RN [11] RP INTERACTION WITH SETD7. RX PubMed=16141209; DOI=10.1074/jbc.m505741200; RA Francis J., Chakrabarti S.K., Garmey J.C., Mirmira R.G.; RT "Pdx-1 links histone H3-Lys-4 methylation to RNA polymerase II elongation RT during activation of insulin transcription."; RL J. Biol. Chem. 280:36244-36253(2005). RN [12] RP PHOSPHORYLATION AT SER-268 BY HIPK2. RX PubMed=20637728; DOI=10.1016/j.bbrc.2010.07.035; RA An R., da Silva Xavier G., Semplici F., Vakhshouri S., Hao H.X., Rutter J., RA Pagano M.A., Meggio F., Pinna L.A., Rutter G.A.; RT "Pancreatic and duodenal homeobox 1 (PDX1) phosphorylation at serine-269 is RT HIPK2-dependent and affects PDX1 subnuclear localization."; RL Biochem. Biophys. Res. Commun. 399:155-161(2010). RN [13] RP VARIANTS ARG-18; ASN-76 AND HIS-197, AND INVOLVEMENT IN T2D. RX PubMed=10545530; DOI=10.1172/jci7449; RA Macfarlane W.M., Frayling T.M., Ellard S., Evans J.C., Allen L.I., RA Bulman M.P., Ayres S., Shepherd M., Clark P., Millward A., Demaine A., RA Wilkin T., Docherty K., Hattersley A.T.; RT "Missense mutations in the insulin promoter factor-1 gene predispose to RT type 2 diabetes."; RL J. Clin. Invest. 104:R33-R39(1999). RN [14] RP VARIANTS LEU-59; ASN-76 AND PRO-243 INS, AND INVOLVEMENT IN T2D. RX PubMed=10545531; DOI=10.1172/jci7469; RA Hani E.H., Stoffers D.A., Chevre J.-C., Durand E., Stanojevic V., Dina C., RA Habener J.F., Froguel P.; RT "Defective mutations in the insulin promoter factor-1 (IPF-1) gene in late- RT onset type 2 diabetes mellitus."; RL J. Clin. Invest. 104:R41-R48(1999). CC -!- FUNCTION: Activates insulin, somatostatin, glucokinase, islet amyloid CC polypeptide and glucose transporter type 2 gene transcription. CC Particularly involved in glucose-dependent regulation of insulin gene CC transcription. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic CC acinar cells is involved in the transcriptional activation of the ELA1 CC enhancer; the complex binds to the enhancer B element and cooperates CC with the transcription factor 1 complex (PTF1) bound to the enhancer A CC element. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During CC development, specifies the early pancreatic epithelium, permitting its CC proliferation, branching and subsequent differentiation. At adult CC stage, required for maintaining the hormone-producing phenotype of the CC beta-cell. CC -!- SUBUNIT: Interacts with the basic helix-loop-helix domains of TCF3(E47) CC and NEUROD1 and with HMG-I(Y). Interacts with SPOP (By similarity). CC Interacts with the methyltransferase SETD7. Part of a PDX1:PBX1b:MEIS2b CC complex. {ECO:0000250, ECO:0000269|PubMed:16141209}. CC -!- SUBCELLULAR LOCATION: Nucleus. Cytoplasm, cytosol {ECO:0000250}. CC -!- TISSUE SPECIFICITY: Duodenum and pancreas (Langerhans islet beta cells CC and small subsets of endocrine non-beta-cells, at low levels in acinar CC cells). CC -!- DOMAIN: The Antp-type hexapeptide mediates heterodimerization with PBX CC on a regulatory element of the somatostatin promoter. {ECO:0000250}. CC -!- DOMAIN: The homeodomain, which contains the nuclear localization CC signal, not only mediates DNA-binding, but also acts as a protein- CC protein interaction domain for TCF3(E47), NEUROD1 and HMG-I(Y). CC {ECO:0000250}. CC -!- PTM: Phosphorylated by the SAPK2 pathway at high intracellular glucose CC concentration. Phosphorylated by HIPK2 on Ser-268 upon glucose CC accumulation. This phosphorylation mediates subnuclear localization CC shifting. Phosphorylation by PASK may lead to translocation into the CC cytosol (By similarity). {ECO:0000250}. CC -!- DISEASE: Pancreatic agenesis 1 (PAGEN1) [MIM:260370]: A disease CC characterized by isolated hypoplasia or agenesis of the pancreas, CC pancreatic beta-cell failure resulting in neonatal insulin-dependent CC diabetes mellitus, and exocrine pancreatic insufficiency. CC {ECO:0000269|PubMed:8988180}. Note=The disease is caused by variants CC affecting the gene represented in this entry. CC -!- DISEASE: Type 2 diabetes mellitus (T2D) [MIM:125853]: A multifactorial CC disorder of glucose homeostasis caused by a lack of sensitivity to the CC body's own insulin. Affected individuals usually have an obese body CC habitus and manifestations of a metabolic syndrome characterized by CC diabetes, insulin resistance, hypertension and hypertriglyceridemia. CC The disease results in long-term complications that affect the eyes, CC kidneys, nerves, and blood vessels. {ECO:0000269|PubMed:10545530, CC ECO:0000269|PubMed:10545531}. Note=Disease susceptibility is associated CC with variants affecting the gene represented in this entry. CC -!- DISEASE: Maturity-onset diabetes of the young 4 (MODY4) [MIM:606392]: A CC form of diabetes that is characterized by an autosomal dominant mode of CC inheritance, onset in childhood or early adulthood (usually before 25 CC years of age), a primary defect in insulin secretion and frequent CC insulin-independence at the beginning of the disease. CC {ECO:0000269|PubMed:9326926}. Note=The disease is caused by variants CC affecting the gene represented in this entry. CC -!- MISCELLANEOUS: According to PubMed:16141209, it may be methylated by CC SETD7 in vitro. However, the relevance of methylation is unsure in CC vivo. {ECO:0000269|PubMed:16141209}. CC -!- SIMILARITY: Belongs to the Antp homeobox family. IPF1/XlHbox-8 CC subfamily. {ECO:0000305}. CC -!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and CC Haematology; CC URL="https://atlasgeneticsoncology.org/gene/43921/PDX1"; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U35632; AAA88820.1; -; mRNA. DR EMBL; S82178; AAB47101.1; -; Genomic_DNA. DR EMBL; S82168; AAB47101.1; JOINED; Genomic_DNA. DR EMBL; U30329; AAA74012.1; -; mRNA. DR EMBL; X99894; CAA68169.1; -; mRNA. DR EMBL; AF035260; AAB88463.1; -; Genomic_DNA. DR EMBL; AF035259; AAB88463.1; JOINED; Genomic_DNA. DR EMBL; AF049893; AAC05157.1; -; mRNA. DR EMBL; AL353195; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471075; EAX08420.1; -; Genomic_DNA. DR CCDS; CCDS9327.1; -. DR PIR; G01926; G01926. DR RefSeq; NP_000200.1; NM_000209.3. DR PDB; 6F8F; X-ray; 2.00 A; G=223-233. DR PDB; 7KPK; X-ray; 1.71 A; B=265-283. DR PDBsum; 6F8F; -. DR PDBsum; 7KPK; -. DR AlphaFoldDB; P52945; -. DR BMRB; P52945; -. DR SMR; P52945; -. DR BioGRID; 109860; 17. DR ELM; P52945; -. DR IntAct; P52945; 2. DR MINT; P52945; -. DR STRING; 9606.ENSP00000370421; -. DR iPTMnet; P52945; -. DR PhosphoSitePlus; P52945; -. DR BioMuta; PDX1; -. DR DMDM; 1708540; -. DR jPOST; P52945; -. DR MassIVE; P52945; -. DR PaxDb; 9606-ENSP00000370421; -. DR PeptideAtlas; P52945; -. DR ProteomicsDB; 56554; -. DR Pumba; P52945; -. DR Antibodypedia; 22687; 1005 antibodies from 39 providers. DR DNASU; 3651; -. DR Ensembl; ENST00000381033.5; ENSP00000370421.4; ENSG00000139515.6. DR GeneID; 3651; -. DR KEGG; hsa:3651; -. DR MANE-Select; ENST00000381033.5; ENSP00000370421.4; NM_000209.4; NP_000200.1. DR UCSC; uc001urt.3; human. DR AGR; HGNC:6107; -. DR CTD; 3651; -. DR DisGeNET; 3651; -. DR GeneCards; PDX1; -. DR GeneReviews; PDX1; -. DR HGNC; HGNC:6107; PDX1. DR HPA; ENSG00000139515; Group enriched (intestine, pancreas). DR MalaCards; PDX1; -. DR MIM; 125853; phenotype. DR MIM; 260370; phenotype. DR MIM; 600733; gene. DR MIM; 606392; phenotype. DR neXtProt; NX_P52945; -. DR OpenTargets; ENSG00000139515; -. DR Orphanet; 99885; Isolated permanent neonatal diabetes mellitus. DR Orphanet; 552; MODY. DR Orphanet; 2805; Partial pancreatic agenesis. DR PharmGKB; PA162399173; -. DR VEuPathDB; HostDB:ENSG00000139515; -. DR eggNOG; KOG0489; Eukaryota. DR GeneTree; ENSGT00940000162542; -. DR HOGENOM; CLU_087401_0_0_1; -. DR InParanoid; P52945; -. DR OMA; HTWKGQW; -. DR OrthoDB; 728401at2759; -. DR PhylomeDB; P52945; -. DR TreeFam; TF326223; -. DR PathwayCommons; P52945; -. DR Reactome; R-HSA-210745; Regulation of gene expression in beta cells. DR Reactome; R-HSA-210747; Regulation of gene expression in early pancreatic precursor cells. DR SignaLink; P52945; -. DR SIGNOR; P52945; -. DR BioGRID-ORCS; 3651; 10 hits in 1167 CRISPR screens. DR ChiTaRS; PDX1; human. DR GeneWiki; PDX1; -. DR GenomeRNAi; 3651; -. DR Pharos; P52945; Tbio. DR PRO; PR:P52945; -. DR Proteomes; UP000005640; Chromosome 13. DR RNAct; P52945; Protein. DR Bgee; ENSG00000139515; Expressed in islet of Langerhans and 29 other cell types or tissues. DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB. DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell. DR GO; GO:0016607; C:nuclear speck; IEA:Ensembl. DR GO; GO:0005654; C:nucleoplasm; IDA:HPA. DR GO; GO:0005634; C:nucleus; IBA:GO_Central. DR GO; GO:0003700; F:DNA-binding transcription factor activity; TAS:BHF-UCL. DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB. DR GO; GO:1990841; F:promoter-specific chromatin binding; IEA:Ensembl. DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central. DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL. DR GO; GO:0009887; P:animal organ morphogenesis; TAS:ProtInc. DR GO; GO:0031100; P:animal organ regeneration; IEA:Ensembl. DR GO; GO:0048565; P:digestive tract development; IEA:Ensembl. DR GO; GO:0031017; P:exocrine pancreas development; IEA:Ensembl. DR GO; GO:0006091; P:generation of precursor metabolites and energy; TAS:ProtInc. DR GO; GO:0010255; P:glucose mediated signaling pathway; ISS:BHF-UCL. DR GO; GO:0006006; P:glucose metabolic process; IEA:Ensembl. DR GO; GO:0030073; P:insulin secretion; IDA:BHF-UCL. DR GO; GO:0070059; P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; IEA:Ensembl. DR GO; GO:0001889; P:liver development; IEA:Ensembl. DR GO; GO:0016331; P:morphogenesis of embryonic epithelium; IEA:Ensembl. DR GO; GO:1902236; P:negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; IEA:Ensembl. DR GO; GO:0050680; P:negative regulation of epithelial cell proliferation; IEA:Ensembl. DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl. DR GO; GO:2000675; P:negative regulation of type B pancreatic cell apoptotic process; IEA:Ensembl. DR GO; GO:0007263; P:nitric oxide mediated signal transduction; IDA:BHF-UCL. DR GO; GO:0032024; P:positive regulation of insulin secretion; ISS:UniProtKB. DR GO; GO:0035774; P:positive regulation of insulin secretion involved in cellular response to glucose stimulus; IEA:Ensembl. DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:BHF-UCL. DR GO; GO:1904692; P:positive regulation of type B pancreatic cell proliferation; IEA:Ensembl. DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central. DR GO; GO:0043279; P:response to alkaloid; IEA:Ensembl. DR GO; GO:0010157; P:response to chlorate; IEA:Ensembl. DR GO; GO:0034097; P:response to cytokine; IEA:Ensembl. DR GO; GO:0070542; P:response to fatty acid; IEA:Ensembl. DR GO; GO:0051384; P:response to glucocorticoid; IEA:Ensembl. DR GO; GO:0010040; P:response to iron(II) ion; IEA:Ensembl. DR GO; GO:0043201; P:response to leucine; IEA:Ensembl. DR GO; GO:0035094; P:response to nicotine; IEA:Ensembl. DR GO; GO:0033273; P:response to vitamin; IEA:Ensembl. DR GO; GO:0009410; P:response to xenobiotic stimulus; IEA:Ensembl. DR GO; GO:0007224; P:smoothened signaling pathway; IEA:Ensembl. DR GO; GO:0048863; P:stem cell differentiation; IEA:Ensembl. DR GO; GO:0006366; P:transcription by RNA polymerase II; TAS:ProtInc. DR GO; GO:0060290; P:transdifferentiation; IEA:Ensembl. DR GO; GO:0097050; P:type B pancreatic cell apoptotic process; IEA:Ensembl. DR GO; GO:0003309; P:type B pancreatic cell differentiation; IDA:BHF-UCL. DR GO; GO:0044342; P:type B pancreatic cell proliferation; IEA:Ensembl. DR CDD; cd00086; homeodomain; 1. DR DisProt; DP01597; -. DR Gene3D; 1.10.10.60; Homeodomain-like; 1. DR InterPro; IPR009057; Homeobox-like_sf. DR InterPro; IPR017995; Homeobox_antennapedia. DR InterPro; IPR017970; Homeobox_CS. DR InterPro; IPR001356; Homeobox_dom. DR InterPro; IPR020479; Homeobox_metazoa. DR PANTHER; PTHR45664:SF12; PANCREAS_DUODENUM HOMEOBOX PROTEIN 1; 1. DR PANTHER; PTHR45664; PROTEIN ZERKNUELLT 1-RELATED; 1. DR Pfam; PF00046; Homeodomain; 1. DR PRINTS; PR00025; ANTENNAPEDIA. DR PRINTS; PR00024; HOMEOBOX. DR SMART; SM00389; HOX; 1. DR SUPFAM; SSF46689; Homeodomain-like; 1. DR PROSITE; PS00027; HOMEOBOX_1; 1. DR PROSITE; PS50071; HOMEOBOX_2; 1. DR Genevisible; P52945; HS. PE 1: Evidence at protein level; KW 3D-structure; Activator; Cytoplasm; Developmental protein; KW Diabetes mellitus; Disease variant; DNA-binding; Homeobox; Nucleus; KW Phosphoprotein; Reference proteome; Transcription; KW Transcription regulation. FT CHAIN 1..283 FT /note="Pancreas/duodenum homeobox protein 1" FT /id="PRO_0000049147" FT DNA_BIND 146..205 FT /note="Homeobox" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108" FT REGION 13..73 FT /note="Transactivation domain" FT /evidence="ECO:0000250" FT REGION 34..71 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 201..283 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT MOTIF 118..123 FT /note="Antp-type hexapeptide" FT MOTIF 197..203 FT /note="Nuclear localization signal" FT /evidence="ECO:0000250" FT COMPBIAS 37..52 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 236..250 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT MOD_RES 151 FT /note="Phosphothreonine; by PASK" FT /evidence="ECO:0000250|UniProtKB:P52946" FT MOD_RES 268 FT /note="Phosphoserine; by HIPK2" FT /evidence="ECO:0000269|PubMed:20637728" FT VARIANT 18 FT /note="C -> R (risk factor for type 2 diabetes; FT dbSNP:rs137852785)" FT /evidence="ECO:0000269|PubMed:10545530" FT /id="VAR_009309" FT VARIANT 59 FT /note="Q -> L (risk factor for type 2 diabetes; FT dbSNP:rs137852784)" FT /evidence="ECO:0000269|PubMed:10545531" FT /id="VAR_009310" FT VARIANT 76 FT /note="D -> N (risk factor for type 2 diabetes; FT dbSNP:rs137852783)" FT /evidence="ECO:0000269|PubMed:10545530, FT ECO:0000269|PubMed:10545531" FT /id="VAR_009311" FT VARIANT 197 FT /note="R -> H (risk factor for type 2 diabetes; FT dbSNP:rs137852786)" FT /evidence="ECO:0000269|PubMed:10545530" FT /id="VAR_009312" FT VARIANT 243 FT /note="P -> PP (risk factor for type 2 diabetes)" FT /evidence="ECO:0000269|PubMed:10545531" FT /id="VAR_009313" FT CONFLICT 56 FT /note="A -> S (in Ref. 6; AAC05157)" FT /evidence="ECO:0000305" FT CONFLICT 116 FT /note="Q -> H (in Ref. 6; AAC05157)" FT /evidence="ECO:0000305" FT CONFLICT 210..211 FT /note="GG -> SS (in Ref. 6; AAC05157)" FT /evidence="ECO:0000305" SQ SEQUENCE 283 AA; 30771 MW; 5D48EC8D3289F72B CRC64; MNGEEQYYAA TQLYKDPCAF QRGPAPEFSA SPPACLYMGR QPPPPPPHPF PGALGALEQG SPPDISPYEV PPLADDPAVA HLHHHLPAQL ALPHPPAGPF PEGAEPGVLE EPNRVQLPFP WMKSTKAHAW KGQWAGGAYA AEPEENKRTR TAYTRAQLLE LEKEFLFNKY ISRPRRVELA VMLNLTERHI KIWFQNRRMK WKKEEDKKRG GGTAVGGGGV AEPEQDCAVT SGEELLALPP PPPPGGAVPP AAPVAAREGR LPPGLSASPQ PSSVAPRRPQ EPR //