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P52945

- PDX1_HUMAN

UniProt

P52945 - PDX1_HUMAN

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Protein

Pancreas/duodenum homeobox protein 1

Gene

PDX1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi146 – 20560HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. chromatin binding Source: Ensembl
  2. core promoter sequence-specific DNA binding Source: Ensembl
  3. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: Ensembl
  4. sequence-specific DNA binding transcription factor activity Source: BHF-UCL

GO - Biological processi

  1. central nervous system development Source: Ensembl
  2. detection of glucose Source: BHF-UCL
  3. digestive tract development Source: Ensembl
  4. endocrine pancreas development Source: Reactome
  5. exocrine pancreas development Source: Ensembl
  6. generation of precursor metabolites and energy Source: ProtInc
  7. glucose homeostasis Source: Ensembl
  8. glucose metabolic process Source: Ensembl
  9. insulin secretion Source: BHF-UCL
  10. liver development Source: Ensembl
  11. morphogenesis of embryonic epithelium Source: Ensembl
  12. negative regulation of cell proliferation Source: Ensembl
  13. negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway Source: Ensembl
  14. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  15. negative regulation of type B pancreatic cell apoptotic process Source: Ensembl
  16. nitric oxide mediated signal transduction Source: BHF-UCL
  17. organ morphogenesis Source: ProtInc
  18. organ regeneration Source: Ensembl
  19. organ senescence Source: Ensembl
  20. positive regulation of cell death Source: Ensembl
  21. positive regulation of cell proliferation Source: Ensembl
  22. positive regulation of DNA binding Source: Ensembl
  23. positive regulation of insulin secretion Source: Ensembl
  24. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  25. response to chlorate Source: Ensembl
  26. response to cytokine Source: Ensembl
  27. response to drug Source: Ensembl
  28. response to fatty acid Source: Ensembl
  29. response to glucocorticoid Source: Ensembl
  30. response to iron(II) ion Source: Ensembl
  31. response to leucine Source: Ensembl
  32. response to nicotine Source: Ensembl
  33. response to vitamin Source: Ensembl
  34. response to wounding Source: Ensembl
  35. smoothened signaling pathway Source: Ensembl
  36. stem cell differentiation Source: Ensembl
  37. transcription from RNA polymerase II promoter Source: ProtInc
  38. transdifferentiation Source: Ensembl
  39. type B pancreatic cell differentiation Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_13778. Regulation of gene expression in early pancreatic precursor cells.
REACT_13819. Regulation of gene expression in beta cells.
SignaLinkiP52945.

Names & Taxonomyi

Protein namesi
Recommended name:
Pancreas/duodenum homeobox protein 1
Short name:
PDX-1
Alternative name(s):
Glucose-sensitive factor
Short name:
GSF
Insulin promoter factor 1
Short name:
IPF-1
Insulin upstream factor 1
Short name:
IUF-1
Islet/duodenum homeobox-1
Short name:
IDX-1
Somatostatin-transactivating factor 1
Short name:
STF-1
Gene namesi
Name:PDX1
Synonyms:IPF1, STF1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 13

Organism-specific databases

HGNCiHGNC:6107. PDX1.

Subcellular locationi

Nucleus. Cytoplasmcytosol By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Involvement in diseasei

Pancreatic agenesis 1 (PAGEN1) [MIM:260370]: A disease characterized by isolated hypoplasia or agenesis of the pancreas, pancreatic beta-cell failure resulting in neonatal insulin-dependent diabetes mellitus, and exocrine pancreatic insufficiency.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.
Diabetes mellitus, non-insulin-dependent (NIDDM) [MIM:125853]: A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.
Maturity-onset diabetes of the young 4 (MODY4) [MIM:606392]: A form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.2 Publications
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti18 – 181C → R in MODY4. 1 Publication
VAR_009309
Natural varianti59 – 591Q → L in MODY4. 1 Publication
VAR_009310
Natural varianti76 – 761D → N in MODY4; unknown pathological significance. 2 Publications
VAR_009311
Natural varianti197 – 1971R → H in MODY4. 1 Publication
VAR_009312
Natural varianti243 – 2431P → PP in MODY4. 1 Publication
VAR_009313

Keywords - Diseasei

Diabetes mellitus, Disease mutation

Organism-specific databases

MIMi125853. phenotype.
260370. phenotype.
606392. phenotype.
Orphaneti552. MODY syndrome.
2805. Partial pancreatic agenesis.
99885. Permanent neonatal diabetes mellitus.
PharmGKBiPA162399173.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 283283Pancreas/duodenum homeobox protein 1PRO_0000049147Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei151 – 1511Phosphothreonine; by PASKBy similarity
Modified residuei268 – 2681Phosphoserine; by HIPK21 Publication

Post-translational modificationi

Phosphorylated by the SAPK2 pathway at high intracellular glucose concentration. Phosphorylated by HIPK2 on Ser-268 upon glucose accumulation. This phoyphorylation mediates subnuclear localization shifting. Phosphorylation by PASK may lead to translocation into the cytosol (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP52945.
PRIDEiP52945.

PTM databases

PhosphoSiteiP52945.

Expressioni

Tissue specificityi

Duodenum and pancreas (Langerhans islet beta cells and small subsets of endocrine non-beta-cells, at low levels in acinar cells).

Gene expression databases

BgeeiP52945.
CleanExiHS_PDX1.
GenevestigatoriP52945.

Organism-specific databases

HPAiCAB025873.

Interactioni

Subunit structurei

Interacts with the basic helix-loop-helix domains of TCF3(E47) and NEUROD1 and with HMG-I(Y). Interacts with SPOP (By similarity). Interacts with the methyltransferase SETD7. Part of a PDX1:PBX1b:MEIS2b complex.By similarity1 Publication

Protein-protein interaction databases

BioGridi109860. 10 interactions.
IntActiP52945. 2 interactions.
MINTiMINT-1894661.
STRINGi9606.ENSP00000370421.

Structurei

3D structure databases

ProteinModelPortaliP52945.
SMRiP52945. Positions 146-205.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni13 – 7361Transactivation domainBy similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi118 – 1236Antp-type hexapeptide
Motifi197 – 2037Nuclear localization signalBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi42 – 5110Poly-Pro
Compositional biasi216 – 2194Poly-Gly
Compositional biasi239 – 2446Poly-Pro

Domaini

The Antp-type hexapeptide mediates heterodimerization with PBX on a regulatory element of the somatostatin promoter.By similarity
The homeodomain, which contains the nuclear localization signal, not only mediates DNA-binding, but also acts as a protein-protein interaction domain for TCF3(E47), NEUROD1 and HMG-I(Y).By similarity

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG271681.
GeneTreeiENSGT00760000118940.
HOGENOMiHOG000115484.
HOVERGENiHBG004525.
InParanoidiP52945.
KOiK07594.
OMAiCLYMSRQ.
OrthoDBiEOG744TB4.
PhylomeDBiP52945.
TreeFamiTF326223.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017995. Homeobox_antennapedia.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P52945-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNGEEQYYAA TQLYKDPCAF QRGPAPEFSA SPPACLYMGR QPPPPPPHPF
60 70 80 90 100
PGALGALEQG SPPDISPYEV PPLADDPAVA HLHHHLPAQL ALPHPPAGPF
110 120 130 140 150
PEGAEPGVLE EPNRVQLPFP WMKSTKAHAW KGQWAGGAYA AEPEENKRTR
160 170 180 190 200
TAYTRAQLLE LEKEFLFNKY ISRPRRVELA VMLNLTERHI KIWFQNRRMK
210 220 230 240 250
WKKEEDKKRG GGTAVGGGGV AEPEQDCAVT SGEELLALPP PPPPGGAVPP
260 270 280
AAPVAAREGR LPPGLSASPQ PSSVAPRRPQ EPR
Length:283
Mass (Da):30,771
Last modified:October 1, 1996 - v1
Checksum:i5D48EC8D3289F72B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti56 – 561A → S in AAC05157. (PubMed:9252422)Curated
Sequence conflicti116 – 1161Q → H in AAC05157. (PubMed:9252422)Curated
Sequence conflicti210 – 2112GG → SS in AAC05157. (PubMed:9252422)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti18 – 181C → R in MODY4. 1 Publication
VAR_009309
Natural varianti59 – 591Q → L in MODY4. 1 Publication
VAR_009310
Natural varianti76 – 761D → N in MODY4; unknown pathological significance. 2 Publications
VAR_009311
Natural varianti197 – 1971R → H in MODY4. 1 Publication
VAR_009312
Natural varianti243 – 2431P → PP in MODY4. 1 Publication
VAR_009313

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U35632 mRNA. Translation: AAA88820.1.
S82178, S82168 Genomic DNA. Translation: AAB47101.1.
U30329 mRNA. Translation: AAA74012.1.
X99894 mRNA. Translation: CAA68169.1.
AF035260, AF035259 Genomic DNA. Translation: AAB88463.1.
AF049893 mRNA. Translation: AAC05157.1.
AL353195 Genomic DNA. Translation: CAH72544.1.
CH471075 Genomic DNA. Translation: EAX08420.1.
CCDSiCCDS9327.1.
PIRiG01926.
RefSeqiNP_000200.1. NM_000209.3.
UniGeneiHs.32938.

Genome annotation databases

EnsembliENST00000381033; ENSP00000370421; ENSG00000139515.
GeneIDi3651.
KEGGihsa:3651.
UCSCiuc001urt.2. human.

Polymorphism databases

DMDMi1708540.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U35632 mRNA. Translation: AAA88820.1 .
S82178 , S82168 Genomic DNA. Translation: AAB47101.1 .
U30329 mRNA. Translation: AAA74012.1 .
X99894 mRNA. Translation: CAA68169.1 .
AF035260 , AF035259 Genomic DNA. Translation: AAB88463.1 .
AF049893 mRNA. Translation: AAC05157.1 .
AL353195 Genomic DNA. Translation: CAH72544.1 .
CH471075 Genomic DNA. Translation: EAX08420.1 .
CCDSi CCDS9327.1.
PIRi G01926.
RefSeqi NP_000200.1. NM_000209.3.
UniGenei Hs.32938.

3D structure databases

ProteinModelPortali P52945.
SMRi P52945. Positions 146-205.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109860. 10 interactions.
IntActi P52945. 2 interactions.
MINTi MINT-1894661.
STRINGi 9606.ENSP00000370421.

PTM databases

PhosphoSitei P52945.

Polymorphism databases

DMDMi 1708540.

Proteomic databases

PaxDbi P52945.
PRIDEi P52945.

Protocols and materials databases

DNASUi 3651.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000381033 ; ENSP00000370421 ; ENSG00000139515 .
GeneIDi 3651.
KEGGi hsa:3651.
UCSCi uc001urt.2. human.

Organism-specific databases

CTDi 3651.
GeneCardsi GC13P028494.
GeneReviewsi PDX1.
HGNCi HGNC:6107. PDX1.
HPAi CAB025873.
MIMi 125853. phenotype.
260370. phenotype.
600733. gene.
606392. phenotype.
neXtProti NX_P52945.
Orphaneti 552. MODY syndrome.
2805. Partial pancreatic agenesis.
99885. Permanent neonatal diabetes mellitus.
PharmGKBi PA162399173.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG271681.
GeneTreei ENSGT00760000118940.
HOGENOMi HOG000115484.
HOVERGENi HBG004525.
InParanoidi P52945.
KOi K07594.
OMAi CLYMSRQ.
OrthoDBi EOG744TB4.
PhylomeDBi P52945.
TreeFami TF326223.

Enzyme and pathway databases

Reactomei REACT_13778. Regulation of gene expression in early pancreatic precursor cells.
REACT_13819. Regulation of gene expression in beta cells.
SignaLinki P52945.

Miscellaneous databases

GeneWikii PDX1.
GenomeRNAii 3651.
NextBioi 14279.
PROi P52945.
SOURCEi Search...

Gene expression databases

Bgeei P52945.
CleanExi HS_PDX1.
Genevestigatori P52945.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017995. Homeobox_antennapedia.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Localization of human homeodomain transcription factor insulin promoter factor 1 (IPF1) to chromosome band 13q12.1."
    Stoffel M., Stein R., Wright C.V., Espinosa R. III, le Beau M.M., Bell G.I.
    Genomics 28:125-126(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Isolation, characterization, and chromosomal mapping of the human insulin promoter factor 1 (IPF-1) gene."
    Inoue H., Riggs A.C., Tanizawa Y., Ueda K., Kuwano A., Liu L., Donis-Keller H., Permutt M.A.
    Diabetes 45:789-794(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Pancreatic islet.
  3. Hiroshi I.
    Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Pancreatic islet.
  4. Marshak S., Totary H., Cerasi E., Melloul D.
    Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Pancreatic islet.
  5. Hara M., Lindner T.H., Paz V.P., Wang X., Iwasaki N., Bell G.I.
    Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  6. "The p38/reactivating kinase mitogen-activated protein kinase cascade mediates the activation of the transcription factor insulin upstream factor 1 and insulin gene transcription by high glucose in pancreatic beta-cells."
    Macfarlane W.M., Smith S.B., James R.F., Clifton A.D., Doza Y.N., Cohen P., Docherty K.
    J. Biol. Chem. 272:20936-20944(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Pancreatic islet.
  7. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence."
    Stoffers D.A., Zinkin N.T., Stanojevic V., Clarke W.L., Habener J.F.
    Nat. Genet. 15:106-110(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN PAGEN1.
  10. "Pdx-1 links histone H3-Lys-4 methylation to RNA polymerase II elongation during activation of insulin transcription."
    Francis J., Chakrabarti S.K., Garmey J.C., Mirmira R.G.
    J. Biol. Chem. 280:36244-36253(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SETD7.
  11. "Pancreatic and duodenal homeobox 1 (PDX1) phosphorylation at serine-269 is HIPK2-dependent and affects PDX1 subnuclear localization."
    An R., da Silva Xavier G., Semplici F., Vakhshouri S., Hao H.X., Rutter J., Pagano M.A., Meggio F., Pinna L.A., Rutter G.A.
    Biochem. Biophys. Res. Commun. 399:155-161(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-268 BY HIPK2.
  12. Cited for: VARIANTS MODY4 ARG-18; ASN-76 AND HIS-197.
  13. "Defective mutations in the insulin promoter factor-1 (IPF-1) gene in late-onset type 2 diabetes mellitus."
    Hani E.H., Stoffers D.A., Chevre J.-C., Durand E., Stanojevic V., Dina C., Habener J.F., Froguel P.
    J. Clin. Invest. 104:R41-R48(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS MODY4 LEU-59; ASN-76 AND PRO-243 INS.

Entry informationi

Entry nameiPDX1_HUMAN
AccessioniPrimary (citable) accession number: P52945
Secondary accession number(s): O60594, Q5VYW2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 148 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

According to PubMed:16141209, it may be methylated by SETD7 in vitro. However, the relevance of methylation is unsure in vivo.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3