ID CRIP2_HUMAN Reviewed; 208 AA. AC P52943; A1A4U1; B7Z6C0; E9PD13; DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1996, sequence version 1. DT 27-MAR-2024, entry version 184. DE RecName: Full=Cysteine-rich protein 2; DE Short=CRP-2; DE AltName: Full=Protein ESP1; GN Name=CRIP2; Synonyms=CRP2; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). RX PubMed=8824798; DOI=10.1006/geno.1996.0028; RA Karim M.A., Ohta K., Egashira M., Jinno Y., Niikawa N., Matsuda I., RA Indo Y.; RT "Human ESP1/CRP2, a member of the LIM domain protein family: RT characterization of the cDNA and assignment of the gene locus to chromosome RT 14q32.3."; RL Genomics 31:167-176(1996). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). RC TISSUE=Heart; RX PubMed=8843343; DOI=10.1080/15216549600201831; RA Tsui S.K.W., Chan P.P.K., Cheuk C.W., Liew C.C., Waye M.M.Y., Fung K.P., RA Lee C.Y.; RT "A novel cDNA encoding for a LIM domain protein located at human chromosome RT 14q32 as a candidate for leukemic translocation."; RL Biochem. Mol. Biol. Int. 39:747-754(1996). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., RA Phelan M., Farmer A.; RT "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."; RL Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). RC TISSUE=Lung, and Pericardium; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=12508121; DOI=10.1038/nature01348; RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., RA Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., RA Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., RA Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., RA Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., RA Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., RA Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., RA Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., RA Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., RA Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., RA Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., RA Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., RA Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., RA Waterston R., Hood L., Weissenbach J.; RT "The DNA sequence and analysis of human chromosome 14."; RL Nature 421:601-607(2003). RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RC TISSUE=Lung; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [7] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma; RX PubMed=18669648; DOI=10.1073/pnas.0805139105; RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., RA Elledge S.J., Gygi S.P.; RT "A quantitative atlas of mitotic phosphorylation."; RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). RN [8] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Leukemic T-cell; RX PubMed=19690332; DOI=10.1126/scisignal.2000007; RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., RA Rodionov V., Han D.K.; RT "Quantitative phosphoproteomic analysis of T cell receptor signaling RT reveals system-wide modulation of protein-protein interactions."; RL Sci. Signal. 2:RA46-RA46(2009). RN [9] RP ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-138, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=19608861; DOI=10.1126/science.1175371; RA Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., RA Olsen J.V., Mann M.; RT "Lysine acetylation targets protein complexes and co-regulates major RT cellular functions."; RL Science 325:834-840(2009). RN [10] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma; RX PubMed=20068231; DOI=10.1126/scisignal.2000475; RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.; RT "Quantitative phosphoproteomics reveals widespread full phosphorylation RT site occupancy during mitosis."; RL Sci. Signal. 3:RA3-RA3(2010). RN [11] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., RA Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [12] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma; RX PubMed=23186163; DOI=10.1021/pr300630k; RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., RA Mohammed S.; RT "Toward a comprehensive characterization of a human cancer cell RT phosphoproteome."; RL J. Proteome Res. 12:260-271(2013). RN [13] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-104, AND IDENTIFICATION BY RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., RA Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver RT phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [14] RP STRUCTURE BY NMR OF 1-63. RG RIKEN structural genomics initiative (RSGI); RT "Solution structure of the LIM domain of human cysteine-rich protein 2."; RL Submitted (JAN-2006) to the PDB data bank. CC -!- SUBUNIT: Interacts with TGFB1I1. {ECO:0000250}. CC -!- INTERACTION: CC P52943; Q04206: RELA; NbExp=2; IntAct=EBI-947590, EBI-73886; CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; CC IsoId=P52943-1; Sequence=Displayed; CC Name=2; CC IsoId=P52943-2; Sequence=VSP_047074; CC -!- TISSUE SPECIFICITY: Widespread tissue expression; highest levels in the CC heart. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; D42123; BAA07703.1; -; mRNA. DR EMBL; U36190; AAB03194.1; -; mRNA. DR EMBL; BT019911; AAV38714.1; -; mRNA. DR EMBL; AK300092; BAH13206.1; -; mRNA. DR EMBL; AK315757; BAG38110.1; -; mRNA. DR EMBL; AL928654; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC000434; AAH00434.1; -; mRNA. DR EMBL; BC001931; AAH01931.1; -; mRNA. DR EMBL; BC034151; AAH34151.1; -; mRNA. DR EMBL; BC128101; AAI28102.1; -; mRNA. DR CCDS; CCDS10003.1; -. [P52943-1] DR CCDS; CCDS59246.1; -. [P52943-2] DR PIR; G02090; G02090. DR RefSeq; NP_001257766.1; NM_001270837.1. [P52943-2] DR RefSeq; NP_001257770.1; NM_001270841.1. DR RefSeq; NP_001303.1; NM_001312.3. [P52943-1] DR PDB; 2CU8; NMR; -; A=1-63. DR PDBsum; 2CU8; -. DR AlphaFoldDB; P52943; -. DR SMR; P52943; -. DR BioGRID; 107787; 44. DR DIP; DIP-49905N; -. DR IntAct; P52943; 21. DR MINT; P52943; -. DR STRING; 9606.ENSP00000426119; -. DR GlyGen; P52943; 2 sites, 1 O-linked glycan (2 sites). DR iPTMnet; P52943; -. DR PhosphoSitePlus; P52943; -. DR SwissPalm; P52943; -. DR BioMuta; CRIP2; -. DR DMDM; 1706133; -. DR EPD; P52943; -. DR jPOST; P52943; -. DR MassIVE; P52943; -. DR MaxQB; P52943; -. DR PaxDb; 9606-ENSP00000426119; -. DR PeptideAtlas; P52943; -. DR ProteomicsDB; 56553; -. [P52943-1] DR ProteomicsDB; 6770; -. DR Pumba; P52943; -. DR Antibodypedia; 15064; 255 antibodies from 28 providers. DR DNASU; 1397; -. DR Ensembl; ENST00000329146.9; ENSP00000328521.5; ENSG00000182809.11. [P52943-1] DR Ensembl; ENST00000483017.7; ENSP00000426119.2; ENSG00000182809.11. [P52943-2] DR GeneID; 1397; -. DR KEGG; hsa:1397; -. DR MANE-Select; ENST00000329146.9; ENSP00000328521.5; NM_001312.4; NP_001303.1. DR UCSC; uc001yrd.3; human. [P52943-1] DR AGR; HGNC:2361; -. DR CTD; 1397; -. DR DisGeNET; 1397; -. DR GeneCards; CRIP2; -. DR HGNC; HGNC:2361; CRIP2. DR HPA; ENSG00000182809; Tissue enriched (heart). DR MIM; 601183; gene. DR neXtProt; NX_P52943; -. DR OpenTargets; ENSG00000182809; -. DR PharmGKB; PA26879; -. DR VEuPathDB; HostDB:ENSG00000182809; -. DR eggNOG; KOG1700; Eukaryota. DR GeneTree; ENSGT00940000158683; -. DR HOGENOM; CLU_054591_2_0_1; -. DR InParanoid; P52943; -. DR OMA; CEAQSHH; -. DR OrthoDB; 7294at2759; -. DR PhylomeDB; P52943; -. DR TreeFam; TF313758; -. DR PathwayCommons; P52943; -. DR SignaLink; P52943; -. DR SIGNOR; P52943; -. DR BioGRID-ORCS; 1397; 13 hits in 1150 CRISPR screens. DR ChiTaRS; CRIP2; human. DR EvolutionaryTrace; P52943; -. DR GeneWiki; CRIP2; -. DR GenomeRNAi; 1397; -. DR Pharos; P52943; Tbio. DR PRO; PR:P52943; -. DR Proteomes; UP000005640; Chromosome 14. DR RNAct; P52943; Protein. DR Bgee; ENSG00000182809; Expressed in apex of heart and 183 other cell types or tissues. DR ExpressionAtlas; P52943; baseline and differential. DR GO; GO:0005938; C:cell cortex; IEA:Ensembl. DR GO; GO:0008270; F:zinc ion binding; TAS:ProtInc. DR GO; GO:0030097; P:hemopoiesis; IEA:Ensembl. DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl. DR CDD; cd09476; LIM1_TLP; 2. DR Gene3D; 2.10.110.10; Cysteine Rich Protein; 2. DR InterPro; IPR001781; Znf_LIM. DR PANTHER; PTHR46074:SF2; CYSTEINE-RICH PROTEIN 2; 1. DR PANTHER; PTHR46074; CYSTEINE-RICH PROTEIN CRIP FAMILY MEMBER; 1. DR Pfam; PF00412; LIM; 2. DR SMART; SM00132; LIM; 2. DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 4. DR PROSITE; PS00478; LIM_DOMAIN_1; 2. DR PROSITE; PS50023; LIM_DOMAIN_2; 2. DR Genevisible; P52943; HS. PE 1: Evidence at protein level; KW 3D-structure; Acetylation; Alternative splicing; LIM domain; Metal-binding; KW Phosphoprotein; Reference proteome; Repeat; Zinc. FT CHAIN 1..208 FT /note="Cysteine-rich protein 2" FT /id="PRO_0000075710" FT DOMAIN 5..57 FT /note="LIM zinc-binding 1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125" FT DOMAIN 126..178 FT /note="LIM zinc-binding 2" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125" FT REGION 98..119 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT MOD_RES 23 FT /note="N6-acetyllysine" FT /evidence="ECO:0000250|UniProtKB:Q9DCT8" FT MOD_RES 104 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:24275569" FT MOD_RES 138 FT /note="N6-acetyllysine" FT /evidence="ECO:0007744|PubMed:19608861" FT MOD_RES 144 FT /note="N6-acetyllysine" FT /evidence="ECO:0000250|UniProtKB:Q9DCT8" FT VAR_SEQ 1..14 FT /note="MASKCPKCDKTVYF -> MPPHHLLPWLAQVPSAEGELVRLVSRAGGRGACF FT WPAVTMEMAVAAGCVCKGGGCCHREPSQDHHESQEHRGPLVGSQTCLVHQAEGT (in FT isoform 2)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_047074" FT TURN 6..8 FT /evidence="ECO:0007829|PDB:2CU8" FT TURN 14..16 FT /evidence="ECO:0007829|PDB:2CU8" FT STRAND 17..20 FT /evidence="ECO:0007829|PDB:2CU8" FT STRAND 23..26 FT /evidence="ECO:0007829|PDB:2CU8" FT TURN 27..29 FT /evidence="ECO:0007829|PDB:2CU8" FT STRAND 33..35 FT /evidence="ECO:0007829|PDB:2CU8" FT STRAND 45..47 FT /evidence="ECO:0007829|PDB:2CU8" FT STRAND 50..52 FT /evidence="ECO:0007829|PDB:2CU8" FT TURN 54..56 FT /evidence="ECO:0007829|PDB:2CU8" FT HELIX 57..61 FT /evidence="ECO:0007829|PDB:2CU8" SQ SEQUENCE 208 AA; 22493 MW; D32B99F98D51D3B0 CRC64; MASKCPKCDK TVYFAEKVSS LGKDWHKFCL KCERCSKTLT PGGHAEHDGK PFCHKPCYAT LFGPKGVNIG GAGSYIYEKP LAEGPQVTGP IEVPAARAEE RKASGPPKGP SRASSVTTFT GEPNTCPRCS KKVYFAEKVT SLGKDWHRPC LRCERCGKTL TPGGHAEHDG QPYCHKPCYG ILFGPKGVNT GAVGSYIYDR DPEGKVQP //