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Protein

Cysteine-rich protein 2

Gene

CRIP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • zinc ion binding Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

SIGNORiP52943.

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine-rich protein 2
Short name:
CRP-2
Alternative name(s):
Protein ESP1
Gene namesi
Name:CRIP2
Synonyms:CRP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:2361. CRIP2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi1397.
OpenTargetsiENSG00000182809.
PharmGKBiPA26879.

Polymorphism and mutation databases

DMDMi1706133.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000757101 – 208Cysteine-rich protein 2Add BLAST208

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei23N6-acetyllysineBy similarity1
Modified residuei104PhosphoserineCombined sources1
Modified residuei138N6-acetyllysineCombined sources1
Modified residuei144N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP52943.
MaxQBiP52943.
PaxDbiP52943.
PeptideAtlasiP52943.
PRIDEiP52943.

PTM databases

iPTMnetiP52943.
PhosphoSitePlusiP52943.

Expressioni

Tissue specificityi

Widespread tissue expression; highest levels in the heart.

Gene expression databases

BgeeiENSG00000182809.
CleanExiHS_CRIP2.
ExpressionAtlasiP52943. baseline and differential.
GenevisibleiP52943. HS.

Organism-specific databases

HPAiHPA042664.

Interactioni

Subunit structurei

Interacts with TGFB1I1.By similarity

Protein-protein interaction databases

BioGridi107787. 19 interactors.
DIPiDIP-49905N.
IntActiP52943. 13 interactors.
MINTiMINT-2857785.
STRINGi9606.ENSP00000328521.

Structurei

Secondary structure

1208
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni6 – 8Combined sources3
Turni14 – 16Combined sources3
Beta strandi17 – 20Combined sources4
Beta strandi23 – 26Combined sources4
Turni27 – 29Combined sources3
Beta strandi33 – 35Combined sources3
Beta strandi45 – 47Combined sources3
Beta strandi50 – 52Combined sources3
Turni54 – 56Combined sources3
Helixi57 – 61Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CU8NMR-A1-63[»]
ProteinModelPortaliP52943.
SMRiP52943.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP52943.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 57LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST53
Domaini126 – 178LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi63 – 73Gly-richAdd BLAST11
Compositional biasi180 – 194Gly-richAdd BLAST15

Sequence similaritiesi

Contains 2 LIM zinc-binding domains.PROSITE-ProRule annotation

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

eggNOGiENOG410KDR6. Eukaryota.
ENOG410XUEW. LUCA.
GeneTreeiENSGT00550000074548.
HOGENOMiHOG000111234.
HOVERGENiHBG051143.
InParanoidiP52943.
OMAiHESQEHR.
OrthoDBiEOG091G11RX.
PhylomeDBiP52943.
TreeFamiTF313758.

Family and domain databases

Gene3Di2.10.110.10. 2 hits.
InterProiIPR001781. Znf_LIM.
[Graphical view]
PfamiPF00412. LIM. 2 hits.
[Graphical view]
SMARTiSM00132. LIM. 2 hits.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P52943-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASKCPKCDK TVYFAEKVSS LGKDWHKFCL KCERCSKTLT PGGHAEHDGK
60 70 80 90 100
PFCHKPCYAT LFGPKGVNIG GAGSYIYEKP LAEGPQVTGP IEVPAARAEE
110 120 130 140 150
RKASGPPKGP SRASSVTTFT GEPNTCPRCS KKVYFAEKVT SLGKDWHRPC
160 170 180 190 200
LRCERCGKTL TPGGHAEHDG QPYCHKPCYG ILFGPKGVNT GAVGSYIYDR

DPEGKVQP
Length:208
Mass (Da):22,493
Last modified:October 1, 1996 - v1
Checksum:iD32B99F98D51D3B0
GO
Isoform 2 (identifier: P52943-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: MASKCPKCDKTVYF → MPPHHLLPWL...TCLVHQAEGT

Show »
Length:282
Mass (Da):30,221
Checksum:iFF8BB75C7912BE75
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0470741 – 14MASKC…KTVYF → MPPHHLLPWLAQVPSAEGEL VRLVSRAGGRGACFWPAVTM EMAVAAGCVCKGGGCCHREP SQDHHESQEHRGPLVGSQTC LVHQAEGT in isoform 2. 1 PublicationAdd BLAST14

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D42123 mRNA. Translation: BAA07703.1.
U36190 mRNA. Translation: AAB03194.1.
BT019911 mRNA. Translation: AAV38714.1.
AK300092 mRNA. Translation: BAH13206.1.
AK315757 mRNA. Translation: BAG38110.1.
AL928654 Genomic DNA. No translation available.
BC000434 mRNA. Translation: AAH00434.1.
BC001931 mRNA. Translation: AAH01931.1.
BC034151 mRNA. Translation: AAH34151.1.
BC128101 mRNA. Translation: AAI28102.1.
CCDSiCCDS10003.1. [P52943-1]
CCDS59246.1. [P52943-2]
PIRiG02090.
RefSeqiNP_001257766.1. NM_001270837.1. [P52943-2]
NP_001257770.1. NM_001270841.1.
NP_001303.1. NM_001312.3. [P52943-1]
UniGeneiHs.534309.

Genome annotation databases

EnsembliENST00000329146; ENSP00000328521; ENSG00000182809. [P52943-1]
ENST00000483017; ENSP00000426119; ENSG00000182809. [P52943-2]
GeneIDi1397.
KEGGihsa:1397.
UCSCiuc001yrd.3. human. [P52943-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D42123 mRNA. Translation: BAA07703.1.
U36190 mRNA. Translation: AAB03194.1.
BT019911 mRNA. Translation: AAV38714.1.
AK300092 mRNA. Translation: BAH13206.1.
AK315757 mRNA. Translation: BAG38110.1.
AL928654 Genomic DNA. No translation available.
BC000434 mRNA. Translation: AAH00434.1.
BC001931 mRNA. Translation: AAH01931.1.
BC034151 mRNA. Translation: AAH34151.1.
BC128101 mRNA. Translation: AAI28102.1.
CCDSiCCDS10003.1. [P52943-1]
CCDS59246.1. [P52943-2]
PIRiG02090.
RefSeqiNP_001257766.1. NM_001270837.1. [P52943-2]
NP_001257770.1. NM_001270841.1.
NP_001303.1. NM_001312.3. [P52943-1]
UniGeneiHs.534309.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CU8NMR-A1-63[»]
ProteinModelPortaliP52943.
SMRiP52943.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107787. 19 interactors.
DIPiDIP-49905N.
IntActiP52943. 13 interactors.
MINTiMINT-2857785.
STRINGi9606.ENSP00000328521.

PTM databases

iPTMnetiP52943.
PhosphoSitePlusiP52943.

Polymorphism and mutation databases

DMDMi1706133.

Proteomic databases

EPDiP52943.
MaxQBiP52943.
PaxDbiP52943.
PeptideAtlasiP52943.
PRIDEiP52943.

Protocols and materials databases

DNASUi1397.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329146; ENSP00000328521; ENSG00000182809. [P52943-1]
ENST00000483017; ENSP00000426119; ENSG00000182809. [P52943-2]
GeneIDi1397.
KEGGihsa:1397.
UCSCiuc001yrd.3. human. [P52943-1]

Organism-specific databases

CTDi1397.
DisGeNETi1397.
GeneCardsiCRIP2.
HGNCiHGNC:2361. CRIP2.
HPAiHPA042664.
MIMi601183. gene.
neXtProtiNX_P52943.
OpenTargetsiENSG00000182809.
PharmGKBiPA26879.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KDR6. Eukaryota.
ENOG410XUEW. LUCA.
GeneTreeiENSGT00550000074548.
HOGENOMiHOG000111234.
HOVERGENiHBG051143.
InParanoidiP52943.
OMAiHESQEHR.
OrthoDBiEOG091G11RX.
PhylomeDBiP52943.
TreeFamiTF313758.

Enzyme and pathway databases

SIGNORiP52943.

Miscellaneous databases

ChiTaRSiCRIP2. human.
EvolutionaryTraceiP52943.
GeneWikiiCRIP2.
GenomeRNAii1397.
PROiP52943.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000182809.
CleanExiHS_CRIP2.
ExpressionAtlasiP52943. baseline and differential.
GenevisibleiP52943. HS.

Family and domain databases

Gene3Di2.10.110.10. 2 hits.
InterProiIPR001781. Znf_LIM.
[Graphical view]
PfamiPF00412. LIM. 2 hits.
[Graphical view]
SMARTiSM00132. LIM. 2 hits.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCRIP2_HUMAN
AccessioniPrimary (citable) accession number: P52943
Secondary accession number(s): A1A4U1, B7Z6C0, E9PD13
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 142 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.