P52943 (CRIP2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cysteine-rich protein 2
Short name=CRP-2

Alternative name(s):
Protein ESP1

Gene names

Name:	CRIP2
Synonyms:	CRP2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	208 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Interacts with TGFB1I1 By similarity.
Tissue specificity	Widespread tissue expression; highest levels in the heart.
Sequence similarities	Contains 2 LIM zinc-binding domains.

Ontologies

Keywords
Domain	LIM domain Repeat
Ligand	Metal-binding Zinc
PTM	Acetylation
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	hemopoiesis Inferred from electronic annotation. Source: Compara positive regulation of cell proliferation Inferred from electronic annotation. Source: Compara
Cellular_component	cell cortex Inferred from electronic annotation. Source: Compara
Molecular_function	zinc ion binding Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 208

208

Cysteine-rich protein 2

PRO_0000075710

Regions

Domain

5 – 57

53

LIM zinc-binding 1

Domain

126 – 178

53

LIM zinc-binding 2

Compositional bias

63 – 73

11

Gly-rich

Compositional bias

180 – 194

15

Gly-rich

Amino acid modifications

Modified residue

138

1

N6-acetyllysine Ref.8

Secondary structure

1

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208

Helix Strand Turn

Details...

Turn

6 – 8

3

Turn

14 – 16

3

Beta strand

17 – 20

4

Beta strand

23 – 26

4

Turn

27 – 29

3

Beta strand

33 – 35

3

Beta strand

45 – 47

3

Beta strand

50 – 52

3

Turn

54 – 56

3

Helix

57 – 61

5

Sequences

	Sequence		Length	Mass (Da)
	P52943 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: D32B99F98D51D3B0	FASTA	208	22,493
	10 20 30 40 50 60 MASKCPKCDK TVYFAEKVSS LGKDWHKFCL KCERCSKTLT PGGHAEHDGK PFCHKPCYAT 70 80 90 100 110 120 LFGPKGVNIG GAGSYIYEKP LAEGPQVTGP IEVPAARAEE RKASGPPKGP SRASSVTTFT 130 140 150 160 170 180 GEPNTCPRCS KKVYFAEKVT SLGKDWHRPC LRCERCGKTL TPGGHAEHDG QPYCHKPCYG 190 200 ILFGPKGVNT GAVGSYIYDR DPEGKVQP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human ESP1/CRP2, a member of the LIM domain protein family: characterization of the cDNA and assignment of the gene locus to chromosome 14q32.3." Karim M.A., Ohta K., Egashira M., Jinno Y., Niikawa N., Matsuda I., Indo Y. Genomics 31:167-176(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"A novel cDNA encoding for a LIM domain protein located at human chromosome 14q32 as a candidate for leukemic translocation." Tsui S.K.W., Chan P.P.K., Cheuk C.W., Liew C.C., Waye M.M.Y., Fung K.P., Lee C.Y. Biochem. Mol. Biol. Int. 39:747-754(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Heart.
[3]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[6]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[7]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Leukemic T-cell.
[8]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-138, MASS SPECTROMETRY.
[9]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[10]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[11]	"Solution structure of the LIM domain of human cysteine-rich protein 2." RIKEN structural genomics initiative (RSGI) Submitted (JAN-2006) to the PDB data bank Cited for: STRUCTURE BY NMR OF 1-63.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

D42123 mRNA. Translation: BAA07703.1.
U36190 mRNA. Translation: AAB03194.1.
BT019911 mRNA. Translation: AAV38714.1.
AK315757 mRNA. Translation: BAG38110.1.
BC000434 mRNA. Translation: AAH00434.1.
BC001931 mRNA. Translation: AAH01931.1.
BC034151 mRNA. Translation: AAH34151.1.
BC128101 mRNA. Translation: AAI28102.1.

IPI

IPI00006034.

PIR

G02090.

RefSeq

NP_001257766.1. NM_001270837.1.
NP_001257770.1. NM_001270841.1.
NP_001303.1. NM_001312.3.

UniGene

Hs.534309.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2CU8	NMR	-	A	1-63	[»]

ProteinModelPortal

P52943.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-49905N.

IntAct

P52943. 2 interactions.

MINT

MINT-2857785.

STRING

9606.ENSP00000328521.

PTM databases

PhosphoSite

P52943.

Polymorphism databases

DMDM

1706133.

Proteomic databases

PaxDb

P52943.

PeptideAtlas

P52943.

PRIDE

P52943.

Protocols and materials databases

DNASU

1397.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000329146; ENSP00000328521; ENSG00000182809.

GeneID

1397.

KEGG

hsa:1397.

UCSC

uc001yrd.1. human.

Organism-specific databases

CTD

1397.

GeneCards

GC14P105939.

HGNC

HGNC:2361. CRIP2.

HPA

HPA042664.

MIM

601183. gene.

neXtProt

NX_P52943.

PharmGKB

PA26879.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG246818.

HOGENOM

HOG000111234.

HOVERGEN

HBG051143.

InParanoid

P52943.

PhylomeDB

P52943.

Gene expression databases

ArrayExpress

P52943.

Bgee

P52943.

CleanEx

HS_CRIP2.

Genevestigator

P52943.

GermOnline

ENSG00000182809. Homo sapiens.

Family and domain databases

Gene3D

2.10.110.10. 2 hits.

InterPro

IPR001781. Znf_LIM.
[Graphical view]

Pfam

PF00412. LIM. 2 hits.
[Graphical view]

SMART

SM00132. LIM. 2 hits.
[Graphical view]

PROSITE

PS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

CRIP2. human.

EvolutionaryTrace

P52943.

GenomeRNAi

1397.

NextBio

5717.

SOURCE

Search...

Entry information

Entry name

CRIP2_HUMAN

Accession

Primary (citable) accession number: P52943
Secondary accession number(s): A1A4U1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	May 1, 2013
This is version 112 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.