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P52943

- CRIP2_HUMAN

UniProt

P52943 - CRIP2_HUMAN

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Protein
Cysteine-rich protein 2
Gene
CRIP2, CRP2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. zinc ion binding Source: ProtInc

GO - Biological processi

  1. hemopoiesis Source: Ensembl
  2. positive regulation of cell proliferation Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine-rich protein 2
Short name:
CRP-2
Alternative name(s):
Protein ESP1
Gene namesi
Name:CRIP2
Synonyms:CRP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:2361. CRIP2.

Subcellular locationi

GO - Cellular componenti

  1. cell cortex Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26879.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 208208Cysteine-rich protein 2
PRO_0000075710Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei23 – 231N6-acetyllysine By similarity
Modified residuei138 – 1381N6-acetyllysine1 Publication
Modified residuei144 – 1441N6-acetyllysine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP52943.
PaxDbiP52943.
PeptideAtlasiP52943.
PRIDEiP52943.

PTM databases

PhosphoSiteiP52943.

Expressioni

Tissue specificityi

Widespread tissue expression; highest levels in the heart.

Gene expression databases

ArrayExpressiP52943.
BgeeiP52943.
CleanExiHS_CRIP2.
GenevestigatoriP52943.

Organism-specific databases

HPAiHPA042664.

Interactioni

Subunit structurei

Interacts with TGFB1I1 By similarity.

Protein-protein interaction databases

BioGridi107787. 12 interactions.
DIPiDIP-49905N.
IntActiP52943. 10 interactions.
MINTiMINT-2857785.
STRINGi9606.ENSP00000328521.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni6 – 83
Turni14 – 163
Beta strandi17 – 204
Beta strandi23 – 264
Turni27 – 293
Beta strandi33 – 353
Beta strandi45 – 473
Beta strandi50 – 523
Turni54 – 563
Helixi57 – 615

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CU8NMR-A1-63[»]
ProteinModelPortaliP52943.
SMRiP52943. Positions 1-63, 126-184.

Miscellaneous databases

EvolutionaryTraceiP52943.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 5753LIM zinc-binding 1
Add
BLAST
Domaini126 – 17853LIM zinc-binding 2
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi63 – 7311Gly-rich
Add
BLAST
Compositional biasi180 – 19415Gly-rich
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

eggNOGiNOG246818.
HOGENOMiHOG000111234.
HOVERGENiHBG051143.
InParanoidiP52943.
OMAiIEGQTAP.
OrthoDBiEOG7CK39M.
PhylomeDBiP52943.
TreeFamiTF313758.

Family and domain databases

Gene3Di2.10.110.10. 2 hits.
InterProiIPR001781. Znf_LIM.
[Graphical view]
PfamiPF00412. LIM. 2 hits.
[Graphical view]
SMARTiSM00132. LIM. 2 hits.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P52943-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MASKCPKCDK TVYFAEKVSS LGKDWHKFCL KCERCSKTLT PGGHAEHDGK    50
PFCHKPCYAT LFGPKGVNIG GAGSYIYEKP LAEGPQVTGP IEVPAARAEE 100
RKASGPPKGP SRASSVTTFT GEPNTCPRCS KKVYFAEKVT SLGKDWHRPC 150
LRCERCGKTL TPGGHAEHDG QPYCHKPCYG ILFGPKGVNT GAVGSYIYDR 200
DPEGKVQP 208
Length:208
Mass (Da):22,493
Last modified:October 1, 1996 - v1
Checksum:iD32B99F98D51D3B0
GO
Isoform 2 (identifier: P52943-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: MASKCPKCDKTVYF → MPPHHLLPWL...TCLVHQAEGT

Show »
Length:282
Mass (Da):30,221
Checksum:iFF8BB75C7912BE75
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1414MASKC…KTVYF → MPPHHLLPWLAQVPSAEGEL VRLVSRAGGRGACFWPAVTM EMAVAAGCVCKGGGCCHREP SQDHHESQEHRGPLVGSQTC LVHQAEGT in isoform 2.
VSP_047074Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D42123 mRNA. Translation: BAA07703.1.
U36190 mRNA. Translation: AAB03194.1.
BT019911 mRNA. Translation: AAV38714.1.
AK300092 mRNA. Translation: BAH13206.1.
AK315757 mRNA. Translation: BAG38110.1.
AL928654 Genomic DNA. No translation available.
BC000434 mRNA. Translation: AAH00434.1.
BC001931 mRNA. Translation: AAH01931.1.
BC034151 mRNA. Translation: AAH34151.1.
BC128101 mRNA. Translation: AAI28102.1.
CCDSiCCDS10003.1. [P52943-1]
CCDS59246.1. [P52943-2]
PIRiG02090.
RefSeqiNP_001257766.1. NM_001270837.1. [P52943-2]
NP_001257770.1. NM_001270841.1.
NP_001303.1. NM_001312.3. [P52943-1]
UniGeneiHs.534309.

Genome annotation databases

EnsembliENST00000329146; ENSP00000328521; ENSG00000182809. [P52943-1]
ENST00000483017; ENSP00000426119; ENSG00000182809. [P52943-2]
ENST00000603102; ENSP00000474302; ENSG00000270931. [P52943-1]
ENST00000605799; ENSP00000474119; ENSG00000270931. [P52943-2]
GeneIDi1397.
KEGGihsa:1397.
UCSCiuc001yrd.2. human. [P52943-1]

Polymorphism databases

DMDMi1706133.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D42123 mRNA. Translation: BAA07703.1 .
U36190 mRNA. Translation: AAB03194.1 .
BT019911 mRNA. Translation: AAV38714.1 .
AK300092 mRNA. Translation: BAH13206.1 .
AK315757 mRNA. Translation: BAG38110.1 .
AL928654 Genomic DNA. No translation available.
BC000434 mRNA. Translation: AAH00434.1 .
BC001931 mRNA. Translation: AAH01931.1 .
BC034151 mRNA. Translation: AAH34151.1 .
BC128101 mRNA. Translation: AAI28102.1 .
CCDSi CCDS10003.1. [P52943-1 ]
CCDS59246.1. [P52943-2 ]
PIRi G02090.
RefSeqi NP_001257766.1. NM_001270837.1. [P52943-2 ]
NP_001257770.1. NM_001270841.1.
NP_001303.1. NM_001312.3. [P52943-1 ]
UniGenei Hs.534309.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2CU8 NMR - A 1-63 [» ]
ProteinModelPortali P52943.
SMRi P52943. Positions 1-63, 126-184.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107787. 12 interactions.
DIPi DIP-49905N.
IntActi P52943. 10 interactions.
MINTi MINT-2857785.
STRINGi 9606.ENSP00000328521.

PTM databases

PhosphoSitei P52943.

Polymorphism databases

DMDMi 1706133.

Proteomic databases

MaxQBi P52943.
PaxDbi P52943.
PeptideAtlasi P52943.
PRIDEi P52943.

Protocols and materials databases

DNASUi 1397.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000329146 ; ENSP00000328521 ; ENSG00000182809 . [P52943-1 ]
ENST00000483017 ; ENSP00000426119 ; ENSG00000182809 . [P52943-2 ]
ENST00000603102 ; ENSP00000474302 ; ENSG00000270931 . [P52943-1 ]
ENST00000605799 ; ENSP00000474119 ; ENSG00000270931 . [P52943-2 ]
GeneIDi 1397.
KEGGi hsa:1397.
UCSCi uc001yrd.2. human. [P52943-1 ]

Organism-specific databases

CTDi 1397.
GeneCardsi GC14P105939.
HGNCi HGNC:2361. CRIP2.
HPAi HPA042664.
MIMi 601183. gene.
neXtProti NX_P52943.
PharmGKBi PA26879.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG246818.
HOGENOMi HOG000111234.
HOVERGENi HBG051143.
InParanoidi P52943.
OMAi IEGQTAP.
OrthoDBi EOG7CK39M.
PhylomeDBi P52943.
TreeFami TF313758.

Miscellaneous databases

ChiTaRSi CRIP2. human.
EvolutionaryTracei P52943.
GeneWikii CRIP2.
GenomeRNAii 1397.
NextBioi 35479932.
PROi P52943.
SOURCEi Search...

Gene expression databases

ArrayExpressi P52943.
Bgeei P52943.
CleanExi HS_CRIP2.
Genevestigatori P52943.

Family and domain databases

Gene3Di 2.10.110.10. 2 hits.
InterProi IPR001781. Znf_LIM.
[Graphical view ]
Pfami PF00412. LIM. 2 hits.
[Graphical view ]
SMARTi SM00132. LIM. 2 hits.
[Graphical view ]
PROSITEi PS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human ESP1/CRP2, a member of the LIM domain protein family: characterization of the cDNA and assignment of the gene locus to chromosome 14q32.3."
    Karim M.A., Ohta K., Egashira M., Jinno Y., Niikawa N., Matsuda I., Indo Y.
    Genomics 31:167-176(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "A novel cDNA encoding for a LIM domain protein located at human chromosome 14q32 as a candidate for leukemic translocation."
    Tsui S.K.W., Chan P.P.K., Cheuk C.W., Liew C.C., Waye M.M.Y., Fung K.P., Lee C.Y.
    Biochem. Mol. Biol. Int. 39:747-754(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Heart.
  3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Lung and Pericardium.
  5. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  9. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-138, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "Solution structure of the LIM domain of human cysteine-rich protein 2."
    RIKEN structural genomics initiative (RSGI)
    Submitted (JAN-2006) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 1-63.

Entry informationi

Entry nameiCRIP2_HUMAN
AccessioniPrimary (citable) accession number: P52943
Secondary accession number(s): A1A4U1, B7Z6C0, E9PD13
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 9, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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