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Protein

Stage 0 sporulation protein A

Gene

spo0A

Organism
Bacillus anthracis
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with Spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. Repressor of abrB, activator of the spoIIa operon. Binds the DNA sequence 5'-TGNCGAA-3' (0A box) (By similarity).By similarity

Cofactori

Ca2+By similarityNote: Binds 1 Ca2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi10CalciumBy similarity1
Metal bindingi11CalciumBy similarity1
Metal bindingi56CalciumBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi196 – 215H-T-H motifSequence analysisAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Sporulation, Transcription, Transcription regulation, Two-component regulatory system

Keywords - Ligandi

Calcium, DNA-binding, Metal-binding

Enzyme and pathway databases

BioCyciANTHRA:SPO0A-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Stage 0 sporulation protein A
Gene namesi
Name:spo0A
Ordered Locus Names:BA_4394, GBAA_4394, BAS4076
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000594 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000812261 – 264Stage 0 sporulation protein AAdd BLAST264

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei564-aspartylphosphatePROSITE-ProRule annotation1

Post-translational modificationi

Phosphorylated by KinA and KinB.By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi198094.BA_4394.

Structurei

3D structure databases

ProteinModelPortaliP52928.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 123Response regulatoryPROSITE-ProRule annotationAdd BLAST119

Sequence similaritiesi

Contains 1 response regulatory domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4107QQR. Bacteria.
COG0784. LUCA.
HOGENOMiHOG000057639.
KOiK07699.
OMAiTKELYPM.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR014879. Spo0A_C.
IPR012052. Spore_0_A.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00072. Response_reg. 1 hit.
PF08769. Spo0A_C. 1 hit.
[Graphical view]
PIRSFiPIRSF002937. Res_reg_Spo0A. 1 hit.
ProDomiPD010908. Spo0A_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00448. REC. 1 hit.
[Graphical view]
SUPFAMiSSF46894. SSF46894. 1 hit.
SSF52172. SSF52172. 1 hit.
TIGRFAMsiTIGR02875. spore_0_A. 1 hit.
PROSITEiPS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P52928-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKIKVCLVD DNKELVSMLE SYVAAQDDME VIGTAYNGQE CLNLLKDKQP
60 70 80 90 100
DVLVLDIIMP HLDGLAVLEK MRHIERLRQP SVIMLTAFGQ EDVTKKAVDL
110 120 130 140 150
GASYFILKPF DMENLTSHIR QVSGKANATI KRPLPSFRSA TTVDGKPKNL
160 170 180 190 200
DASITSIIHE IGVPAHIKGY MYLREAISMV YNDIELLGSI TKVLYPDIAK
210 220 230 240 250
KYNTTASRVE RAIRHAIEVA WSRGNIDSIS SLFGYTVSMS KAKPTNSEFI
260
AMVADKLRLE HKAS
Length:264
Mass (Da):29,440
Last modified:June 21, 2004 - v2
Checksum:i62F8155B55739D63
GO

Sequence cautioni

The sequence AAT56377 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti22Y → C in AAA18871 (PubMed:7885226).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP28110.1.
AE017334 Genomic DNA. Translation: AAT33514.2.
AE017225 Genomic DNA. Translation: AAT56377.1. Different initiation.
U09970 Genomic DNA. Translation: AAA18871.1.
PIRiS60868.
RefSeqiNP_846624.1. NC_003997.3.
WP_003161566.1. NZ_LHUO01000006.1.

Genome annotation databases

EnsemblBacteriaiAAP28110; AAP28110; BA_4394.
AAT33514; AAT33514; GBAA_4394.
AAT56377; AAT56377; BAS4076.
GeneIDi1087648.
KEGGiban:BA_4394.
bar:GBAA_4394.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP28110.1.
AE017334 Genomic DNA. Translation: AAT33514.2.
AE017225 Genomic DNA. Translation: AAT56377.1. Different initiation.
U09970 Genomic DNA. Translation: AAA18871.1.
PIRiS60868.
RefSeqiNP_846624.1. NC_003997.3.
WP_003161566.1. NZ_LHUO01000006.1.

3D structure databases

ProteinModelPortaliP52928.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi198094.BA_4394.

Protocols and materials databases

DNASUi1087648.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAP28110; AAP28110; BA_4394.
AAT33514; AAT33514; GBAA_4394.
AAT56377; AAT56377; BAS4076.
GeneIDi1087648.
KEGGiban:BA_4394.
bar:GBAA_4394.

Phylogenomic databases

eggNOGiENOG4107QQR. Bacteria.
COG0784. LUCA.
HOGENOMiHOG000057639.
KOiK07699.
OMAiTKELYPM.

Enzyme and pathway databases

BioCyciANTHRA:SPO0A-MONOMER.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR014879. Spo0A_C.
IPR012052. Spore_0_A.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00072. Response_reg. 1 hit.
PF08769. Spo0A_C. 1 hit.
[Graphical view]
PIRSFiPIRSF002937. Res_reg_Spo0A. 1 hit.
ProDomiPD010908. Spo0A_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00448. REC. 1 hit.
[Graphical view]
SUPFAMiSSF46894. SSF46894. 1 hit.
SSF52172. SSF52172. 1 hit.
TIGRFAMsiTIGR02875. spore_0_A. 1 hit.
PROSITEiPS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSP0A_BACAN
AccessioniPrimary (citable) accession number: P52928
Secondary accession number(s): Q6HTL2, Q6KMV2, Q81M59
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: June 21, 2004
Last modified: November 2, 2016
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.