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P52927

- HMGA2_MOUSE

UniProt

P52927 - HMGA2_MOUSE

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Protein
High mobility group protein HMGI-C
Gene
Hmga2, Hmgic
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi24 – 3411A.T hook 1
Add
BLAST
DNA bindingi44 – 5411A.T hook 2
Add
BLAST
DNA bindingi71 – 8212A.T hook 3
Add
BLAST

GO - Molecular functioni

  1. 5'-deoxyribose-5-phosphate lyase activity Source: UniProtKB
  2. AT DNA binding Source: UniProtKB
  3. C2H2 zinc finger domain binding Source: UniProtKB
  4. DNA binding, bending Source: UniProtKB
  5. DNA-(apurinic or apyrimidinic site) lyase activity Source: UniProtKB
  6. DNA-dependent protein kinase activity Source: UniProtKB
  7. MH1 domain binding Source: UniProtKB
  8. MH2 domain binding Source: UniProtKB
  9. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: UniProtKB
  10. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: MGI
  11. cAMP response element binding Source: UniProtKB
  12. core promoter binding Source: UniProtKB
  13. nucleosomal DNA binding Source: UniProtKB
  14. protein binding Source: IntAct
  15. protein binding transcription factor activity Source: Ensembl
  16. regulatory region DNA binding Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. DNA catabolic process, endonucleolytic Source: GOC
  2. DNA damage response, detection of DNA damage Source: UniProtKB
  3. adipose tissue development Source: MGI
  4. adrenal gland development Source: MGI
  5. base-excision repair Source: UniProtKB
  6. cell proliferation Source: MGI
  7. cell proliferation in forebrain Source: MGI
  8. chondrocyte differentiation Source: UniProtKB
  9. chondrocyte proliferation Source: UniProtKB
  10. chromosome breakage Source: UniProtKB
  11. chromosome condensation Source: UniProtKB-KW
  12. endodermal cell differentiation Source: UniProtKB
  13. epithelial to mesenchymal transition Source: UniProtKB
  14. fat cell differentiation Source: UniProtKB
  15. fat pad development Source: MGI
  16. heterochromatin assembly Source: UniProtKB
  17. histone H2A-S139 phosphorylation Source: UniProtKB
  18. male gonad development Source: MGI
  19. meiotic nuclear division Source: UniProtKB-KW
  20. mesenchymal cell differentiation Source: UniProtKB
  21. mesodermal cell differentiation Source: UniProtKB
  22. mesodermal-endodermal cell signaling Source: UniProtKB
  23. mitotic G2 DNA damage checkpoint Source: UniProtKB
  24. mitotic nuclear division Source: UniProtKB-KW
  25. negative regulation by host of viral transcription Source: UniProtKB
  26. negative regulation of DNA binding Source: UniProtKB
  27. negative regulation of JAK-STAT cascade Source: Ensembl
  28. negative regulation of apoptotic process Source: UniProtKB
  29. negative regulation of astrocyte differentiation Source: MGI
  30. negative regulation of double-strand break repair via nonhomologous end joining Source: UniProtKB
  31. negative regulation of intracellular steroid hormone receptor signaling pathway Source: Ensembl
  32. negative regulation of single stranded viral RNA replication via double stranded DNA intermediate Source: UniProtKB
  33. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  34. negative regulation of transcription, DNA-templated Source: UniProtKB
  35. oncogene-induced cell senescence Source: UniProtKB
  36. pituitary gland development Source: MGI
  37. positive regulation of apoptotic process Source: UniProtKB
  38. positive regulation of cell cycle arrest Source: UniProtKB
  39. positive regulation of cell proliferation Source: MGI
  40. positive regulation of cellular response to X-ray Source: UniProtKB
  41. positive regulation of cellular senescence Source: UniProtKB
  42. positive regulation of gene expression Source: UniProtKB
  43. positive regulation of multicellular organism growth Source: MGI
  44. positive regulation of response to DNA damage stimulus Source: UniProtKB
  45. positive regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
  46. positive regulation of stem cell proliferation Source: UniProtKB
  47. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  48. positive regulation of transcription regulatory region DNA binding Source: UniProtKB
  49. regulation of cell cycle process Source: UniProtKB
  50. regulation of cellular response to drug Source: UniProtKB
  51. regulation of growth hormone secretion Source: MGI
  52. regulation of peptide hormone secretion Source: MGI
  53. regulation of stem cell maintenance Source: UniProtKB
  54. regulation of transcription, DNA-templated Source: UniProtKB
  55. response to virus Source: Ensembl
  56. senescence-associated heterochromatin focus assembly Source: UniProtKB
  57. signal transduction Source: Ensembl
  58. somatic stem cell maintenance Source: MGI
  59. spermatogenesis Source: MGI
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, DNA condensation, Growth regulation, Meiosis, Mitosis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_209428. Formation of Senescence-Associated Heterochromatin Foci (SAHF).

Names & Taxonomyi

Protein namesi
Recommended name:
High mobility group protein HMGI-C
Alternative name(s):
High mobility group AT-hook protein 2
Gene namesi
Name:Hmga2
Synonyms:Hmgic
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:101761. Hmga2.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. SMAD protein complex Source: UniProtKB
  2. nuclear chromosome Source: MGI
  3. nucleus Source: UniProtKB
  4. protein-DNA complex Source: UniProtKB
  5. senescence-associated heterochromatin focus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 108107High mobility group protein HMGI-C
PRO_0000206712Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine By similarity
Modified residuei40 – 401Phosphothreonine By similarity
Modified residuei44 – 441Phosphoserine By similarity
Modified residuei104 – 1041Phosphoserine1 Publication

Post-translational modificationi

Regulated by cell cycle-dependent phosphorylation which alters its DNA binding affinity. Phosphorylated by NEK2.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP52927.
PRIDEiP52927.

PTM databases

PhosphoSiteiP52927.

Expressioni

Tissue specificityi

Expressed in mitotic spermatogonia, meiotic spermatocytes, and postmeiotic round spermatids (at protein level).1 Publication

Developmental stagei

Expressed predominantly during embryogenesis.

Gene expression databases

BgeeiP52927.
CleanExiMM_HMGA2.
GenevestigatoriP52927.

Interactioni

Subunit structurei

Interacts with E4F1 By similarity. Interacts with NEK2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
RB1P064005EBI-912574,EBI-491274From a different organism.

Protein-protein interaction databases

BioGridi200341. 7 interactions.
IntActiP52927. 5 interactions.
MINTiMINT-1847926.
STRINGi10090.ENSMUSP00000072556.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni44 – 6320Interaction with E4F1 By similarity
Add
BLAST

Sequence similaritiesi

Belongs to the HMGA family.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG295015.
GeneTreeiENSGT00730000111387.
HOGENOMiHOG000076308.
HOVERGENiHBG051913.
InParanoidiP52927.
KOiK09283.
OMAiNSIKRSH.
OrthoDBiEOG7QRQXW.
PhylomeDBiP52927.
TreeFamiTF351623.

Family and domain databases

InterProiIPR020478. AT_hook-like.
IPR017956. AT_hook_DNA-bd_motif.
IPR000116. HMGI/HMGY.
[Graphical view]
PfamiPF02178. AT_hook. 3 hits.
[Graphical view]
PRINTSiPR00929. ATHOOK.
PR00930. HIGHMOBLTYIY.
SMARTiSM00384. AT_hook. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P52927-1 [UniParc]FASTAAdd to Basket

« Hide

MSARGEGAGQ PSTSAQGQPA APVPQKRGRG RPRKQQQEPT CEPSPKRPRG    50
RPKGSKNKSP SKAAQKKAET IGEKRPRGRP RKWPQQVVQK KPAQETEETS 100
SQESAEED 108
Length:108
Mass (Da):11,819
Last modified:October 1, 1996 - v1
Checksum:i40A3E38F62268C09
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L41621
, L41617, L41618, L41619, L41620 Genomic DNA. Translation: AAC69244.1.
X58380 mRNA. Translation: CAA41270.1.
X99915
, X99916, X99917, X99918, X99919 Genomic DNA. Translation: CAA68187.1.
AK028346 mRNA. Translation: BAC25896.1.
AK142059 mRNA. Translation: BAE24928.1.
BC052158 mRNA. Translation: AAH52158.1.
BC085085 mRNA. Translation: AAH85085.1.
CCDSiCCDS36073.1.
PIRiJC4575.
RefSeqiNP_034571.1. NM_010441.2.
UniGeneiMm.157190.

Genome annotation databases

EnsembliENSMUST00000072777; ENSMUSP00000072556; ENSMUSG00000056758.
GeneIDi15364.
KEGGimmu:15364.
UCSCiuc007hfb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L41621
, L41617 , L41618 , L41619 , L41620 Genomic DNA. Translation: AAC69244.1 .
X58380 mRNA. Translation: CAA41270.1 .
X99915
, X99916 , X99917 , X99918 , X99919 Genomic DNA. Translation: CAA68187.1 .
AK028346 mRNA. Translation: BAC25896.1 .
AK142059 mRNA. Translation: BAE24928.1 .
BC052158 mRNA. Translation: AAH52158.1 .
BC085085 mRNA. Translation: AAH85085.1 .
CCDSi CCDS36073.1.
PIRi JC4575.
RefSeqi NP_034571.1. NM_010441.2.
UniGenei Mm.157190.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

BioGridi 200341. 7 interactions.
IntActi P52927. 5 interactions.
MINTi MINT-1847926.
STRINGi 10090.ENSMUSP00000072556.

PTM databases

PhosphoSitei P52927.

Proteomic databases

PaxDbi P52927.
PRIDEi P52927.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000072777 ; ENSMUSP00000072556 ; ENSMUSG00000056758 .
GeneIDi 15364.
KEGGi mmu:15364.
UCSCi uc007hfb.1. mouse.

Organism-specific databases

CTDi 8091.
MGIi MGI:101761. Hmga2.

Phylogenomic databases

eggNOGi NOG295015.
GeneTreei ENSGT00730000111387.
HOGENOMi HOG000076308.
HOVERGENi HBG051913.
InParanoidi P52927.
KOi K09283.
OMAi NSIKRSH.
OrthoDBi EOG7QRQXW.
PhylomeDBi P52927.
TreeFami TF351623.

Enzyme and pathway databases

Reactomei REACT_209428. Formation of Senescence-Associated Heterochromatin Foci (SAHF).

Miscellaneous databases

ChiTaRSi HMGA2. mouse.
NextBioi 287988.
PROi P52927.
SOURCEi Search...

Gene expression databases

Bgeei P52927.
CleanExi MM_HMGA2.
Genevestigatori P52927.

Family and domain databases

InterProi IPR020478. AT_hook-like.
IPR017956. AT_hook_DNA-bd_motif.
IPR000116. HMGI/HMGY.
[Graphical view ]
Pfami PF02178. AT_hook. 3 hits.
[Graphical view ]
PRINTSi PR00929. ATHOOK.
PR00930. HIGHMOBLTYIY.
SMARTi SM00384. AT_hook. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning of the HMGI-C phosphoprotein, a nuclear protein associated with neoplastic and undifferentiated phenotypes."
    Manfioletti G., Giancotti V., Bandiera A., Buratti E., Sautiere P., Cary P., Crane-Robinson C., Coles B., Goodwin G.H.
    Nucleic Acids Res. 19:6793-6797(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Isolation and characterization of the gene coding for murine high-mobility-group protein HMGI-C."
    Manfioletti G., Rustighi A., Mantovani F., Goodwin G.H., Giancotti V.
    Gene 167:249-253(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Genomic structure and expression of the murine Hmgi-c gene."
    Zhou X., Benson K.F., Przybysz K., Liu J., Hou Y., Cherath L., Chada K.
    Nucleic Acids Res. 24:4071-4077(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Eye.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo and Limb.
  6. "Phosphorylation of high-mobility group protein A2 by Nek2 kinase during the first meiotic division in mouse spermatocytes."
    Di Agostino S., Fedele M., Chieffi P., Fusco A., Rossi P., Geremia R., Sette C.
    Mol. Biol. Cell 15:1224-1232(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, PHOSPHORYLATION, INTERACTION WITH NEK2, TISSUE SPECIFICITY.
  7. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
    Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
    Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-104, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiHMGA2_MOUSE
AccessioniPrimary (citable) accession number: P52927
Secondary accession number(s): Q3UQW0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 3, 2014
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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