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P52926

- HMGA2_HUMAN

UniProt

P52926 - HMGA2_HUMAN

Protein

High mobility group protein HMGI-C

Gene

HMGA2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi24 – 3411A.T hook 1Add
    BLAST
    DNA bindingi44 – 5411A.T hook 2Add
    BLAST
    DNA bindingi71 – 8212A.T hook 3Add
    BLAST

    GO - Molecular functioni

    1. 5'-deoxyribose-5-phosphate lyase activity Source: UniProtKB
    2. AT DNA binding Source: UniProtKB
    3. C2H2 zinc finger domain binding Source: UniProtKB
    4. cAMP response element binding Source: UniProtKB
    5. core promoter binding Source: UniProtKB
    6. DNA-(apurinic or apyrimidinic site) lyase activity Source: UniProtKB
    7. DNA binding Source: UniProtKB
    8. DNA binding, bending Source: UniProtKB
    9. DNA-dependent protein kinase activity Source: UniProtKB
    10. MH1 domain binding Source: UniProtKB
    11. MH2 domain binding Source: UniProtKB
    12. nucleosomal DNA binding Source: UniProtKB
    13. protein binding Source: UniProtKB
    14. regulatory region DNA binding Source: UniProtKB
    15. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: UniProtKB
    16. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: UniProtKB
    17. SMAD binding Source: UniProtKB
    18. transcription factor binding Source: UniProtKB

    GO - Biological processi

    1. adrenal gland development Source: Ensembl
    2. base-excision repair Source: UniProtKB
    3. cell proliferation in forebrain Source: Ensembl
    4. chondrocyte differentiation Source: UniProtKB
    5. chondrocyte proliferation Source: UniProtKB
    6. chromatin organization Source: UniProtKB
    7. chromosome breakage Source: UniProtKB
    8. chromosome condensation Source: UniProtKB-KW
    9. DNA catabolic process, endonucleolytic Source: GOC
    10. DNA damage response, detection of DNA damage Source: UniProtKB
    11. endodermal cell differentiation Source: UniProtKB
    12. epithelial to mesenchymal transition Source: UniProtKB
    13. fat cell differentiation Source: UniProtKB
    14. fat pad development Source: Ensembl
    15. heterochromatin assembly Source: UniProtKB
    16. histone H2A-S139 phosphorylation Source: UniProtKB
    17. male gonad development Source: Ensembl
    18. mesenchymal cell differentiation Source: UniProtKB
    19. mesodermal cell differentiation Source: UniProtKB
    20. mesodermal-endodermal cell signaling Source: UniProtKB
    21. mitotic G2 DNA damage checkpoint Source: UniProtKB
    22. mitotic nuclear division Source: UniProtKB-KW
    23. multicellular organismal development Source: ProtInc
    24. negative regulation by host of viral transcription Source: UniProtKB
    25. negative regulation of apoptotic process Source: UniProtKB
    26. negative regulation of astrocyte differentiation Source: Ensembl
    27. negative regulation of DNA binding Source: UniProtKB
    28. negative regulation of double-strand break repair via nonhomologous end joining Source: UniProtKB
    29. negative regulation of intracellular steroid hormone receptor signaling pathway Source: Ensembl
    30. negative regulation of JAK-STAT cascade Source: Ensembl
    31. negative regulation of single stranded viral RNA replication via double stranded DNA intermediate Source: UniProtKB
    32. negative regulation of transcription, DNA-templated Source: UniProtKB
    33. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    34. oncogene-induced cell senescence Source: UniProtKB
    35. pituitary gland development Source: Ensembl
    36. positive regulation of apoptotic process Source: UniProtKB
    37. positive regulation of cell cycle arrest Source: UniProtKB
    38. positive regulation of cellular response to X-ray Source: UniProtKB
    39. positive regulation of cellular senescence Source: UniProtKB
    40. positive regulation of gene expression Source: UniProtKB
    41. positive regulation of multicellular organism growth Source: Ensembl
    42. positive regulation of response to DNA damage stimulus Source: UniProtKB
    43. positive regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
    44. positive regulation of stem cell proliferation Source: UniProtKB
    45. positive regulation of transcription, DNA-templated Source: UniProtKB
    46. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    47. positive regulation of transcription regulatory region DNA binding Source: UniProtKB
    48. regulation of cell cycle process Source: UniProtKB
    49. regulation of cellular response to drug Source: UniProtKB
    50. regulation of growth hormone secretion Source: Ensembl
    51. regulation of stem cell maintenance Source: UniProtKB
    52. regulation of transcription, DNA-templated Source: UniProtKB
    53. response to virus Source: UniProtKB
    54. senescence-associated heterochromatin focus assembly Source: UniProtKB
    55. signal transduction Source: Ensembl
    56. somatic stem cell maintenance Source: Ensembl
    57. spermatogenesis Source: Ensembl
    58. stem cell differentiation Source: UniProtKB

    Keywords - Biological processi

    Cell cycle, Cell division, DNA condensation, Growth regulation, Mitosis, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_169121. Formation of Senescence-Associated Heterochromatin Foci (SAHF).
    SignaLinkiP52926.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    High mobility group protein HMGI-C
    Alternative name(s):
    High mobility group AT-hook protein 2
    Gene namesi
    Name:HMGA2
    Synonyms:HMGIC
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:5009. HMGA2.

    Subcellular locationi

    GO - Cellular componenti

    1. nuclear chromosome Source: UniProtKB
    2. nucleoplasm Source: Reactome
    3. nucleus Source: UniProtKB
    4. protein-DNA complex Source: UniProtKB
    5. senescence-associated heterochromatin focus Source: UniProtKB
    6. SMAD protein complex Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    A chromosomal aberration involving HMGA2 is associated with a subclass of benign mesenchymal tumors known as lipomas. Translocation t(3;12)(q27-q28;q13-q15) with LPP is shown in lipomas. HMGA2 is also fused with a number of other genes in lipomas.
    A chromosomal aberration involving HMGA2 is associated with pulmonary chondroid hamartomas. Translocation t(3;12)(q27-q28;q14-q15) with LPP is detected in pulmonary chondroid hamartomas.
    A chromosomal aberration involving HMGA2 is associated with parosteal lipomas. Translocation t(3;12)(q28;q14) with LPP is also shown in one parosteal lipoma.
    A chromosomal aberration involving HMGA2 is found in uterine leiomyoma. Translocation t(12;14)(q15;q23-24) with RAD51B. Chromosomal rearrangements involving HMGA2 do not seem to be the principle pathobiological mechanism in uterine leiomyoma.

    Keywords - Diseasei

    Proto-oncogene

    Organism-specific databases

    MIMi150699. phenotype.
    611547. phenotype.
    Orphaneti94063. 12q14 microdeletion syndrome.
    99970. Dedifferentiated liposarcoma.
    99971. Well-differentiated liposarcoma.
    PharmGKBiPA35093.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed2 Publications
    Chaini2 – 109108High mobility group protein HMGI-CPRO_0000206711Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine2 Publications
    Modified residuei40 – 401Phosphothreonine1 Publication
    Modified residuei44 – 441Phosphoserine1 Publication
    Modified residuei105 – 1051Phosphoserine1 Publication

    Post-translational modificationi

    Regulated by cell cycle-dependent phosphorylation which alters its DNA binding affinity. Phosphorylated by NEK2 By similarity.By similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiP52926.
    PaxDbiP52926.
    PRIDEiP52926.

    PTM databases

    PhosphoSiteiP52926.

    Expressioni

    Developmental stagei

    Expressed predominantly during embryogenesis.

    Gene expression databases

    ArrayExpressiP52926.
    BgeeiP52926.
    CleanExiHS_HMGA2.
    GenevestigatoriP52926.

    Organism-specific databases

    HPAiCAB017809.

    Interactioni

    Subunit structurei

    Interacts with E4F1. Interacts with NEK2 By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    PRMT6Q96LA82EBI-912511,EBI-912440

    Protein-protein interaction databases

    BioGridi113763. 19 interactions.
    IntActiP52926. 2 interactions.
    STRINGi9606.ENSP00000384026.

    Structurei

    3D structure databases

    ProteinModelPortaliP52926.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni44 – 6320Interaction with E4F1Add
    BLAST

    Sequence similaritiesi

    Belongs to the HMGA family.Curated
    Contains 3 A.T hook DNA-binding domains.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG295015.
    HOGENOMiHOG000076308.
    HOVERGENiHBG051913.
    KOiK09283.
    OMAiNSIKRSH.
    OrthoDBiEOG7QRQXW.
    PhylomeDBiP52926.
    TreeFamiTF351623.

    Family and domain databases

    InterProiIPR020478. AT_hook-like.
    IPR017956. AT_hook_DNA-bd_motif.
    IPR000116. HMGI/HMGY.
    IPR000637. HMGI/Y_DNA-bd_CS.
    [Graphical view]
    PfamiPF02178. AT_hook. 3 hits.
    [Graphical view]
    PRINTSiPR00929. ATHOOK.
    PR00930. HIGHMOBLTYIY.
    SMARTiSM00384. AT_hook. 3 hits.
    [Graphical view]
    PROSITEiPS00354. HMGI_Y. 2 hits.
    [Graphical view]

    Sequences (6)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 6 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms seem to exist.

    Isoform 1 (identifier: P52926-1) [UniParc]FASTAAdd to Basket

    Also known as: HMGA2a

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSARGEGAGQ PSTSAQGQPA APAPQKRGRG RPRKQQQEPT GEPSPKRPRG    50
    RPKGSKNKSP SKAAQKKAEA TGEKRPRGRP RKWPQQVVQK KPAQEETEET 100
    SSQESAEED 109
    Length:109
    Mass (Da):11,832
    Last modified:October 1, 1996 - v1
    Checksum:iF36BABE623DA4615
    GO
    Isoform 2 (identifier: P52926-2) [UniParc]FASTAAdd to Basket

    Also known as: HMGA2f

    The sequence of this isoform differs from the canonical sequence as follows:
         84-109: PQQVVQKKPAQEETEETSSQESAEED → DNLLPRTSSKKKTSLGNSTKRSH

    Show »
    Length:106
    Mass (Da):11,456
    Checksum:i0596B200B4B660B6
    GO
    Isoform 3 (identifier: P52926-3) [UniParc]FASTAAdd to Basket

    Also known as: HMGA2d'

    The sequence of this isoform differs from the canonical sequence as follows:
         84-109: PQQVVQKKPAQEETEETSSQESAEED → LQN

    Show »
    Length:86
    Mass (Da):9,273
    Checksum:i18F9DE5C08244EFE
    GO
    Isoform 4 (identifier: P52926-4) [UniParc]FASTAAdd to Basket

    Also known as: HMGA2d

    The sequence of this isoform differs from the canonical sequence as follows:
         84-109: PQQVVQKKPAQEETEETSSQESAEED → WLLMKSPCW

    Show »
    Length:92
    Mass (Da):10,063
    Checksum:i5095EAC51787CB88
    GO
    Isoform 5 (identifier: P52926-5) [UniParc]FASTAAdd to Basket

    Also known as: HMGA2c'

    The sequence of this isoform differs from the canonical sequence as follows:
         84-109: PQQVVQKKPAQEETEETSSQESAEED → LRAQALDSDGLGSNSGPSLS

    Show »
    Length:103
    Mass (Da):10,845
    Checksum:iCBBAAB6286C8BB91
    GO
    Isoform 6 (identifier: P52926-6) [UniParc]FASTAAdd to Basket

    Also known as: HMGA2c

    The sequence of this isoform differs from the canonical sequence as follows:
         84-109: PQQVVQKKPAQEETEETSSQESAEED → EEFYIAA

    Show »
    Length:90
    Mass (Da):9,742
    Checksum:i606D74FA0564126C
    GO

    Polymorphismi

    Genetic variations in HMGA2 define the stature quantitative trait locus 9 (STQTL9) [MIMi:611547]. Human height is a classic, highly heritable quantitative trait.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei84 – 10926PQQVV…SAEED → DNLLPRTSSKKKTSLGNSTK RSH in isoform 2. 1 PublicationVSP_042564Add
    BLAST
    Alternative sequencei84 – 10926PQQVV…SAEED → LQN in isoform 3. 1 PublicationVSP_047772Add
    BLAST
    Alternative sequencei84 – 10926PQQVV…SAEED → WLLMKSPCW in isoform 4. 1 PublicationVSP_047773Add
    BLAST
    Alternative sequencei84 – 10926PQQVV…SAEED → LRAQALDSDGLGSNSGPSLS in isoform 5. 1 PublicationVSP_047774Add
    BLAST
    Alternative sequencei84 – 10926PQQVV…SAEED → EEFYIAA in isoform 6. 1 PublicationVSP_047775Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z31595 mRNA. Translation: CAA83472.1.
    U28749 mRNA. Translation: AAA68613.1.
    U28754
    , U28750, U28751, U28752, U28753 Genomic DNA. Translation: AAA68614.1.
    L46353, L41044, L44578 Genomic DNA. Translation: AAA96484.1.
    X92518 mRNA. Translation: CAA63295.1.
    AY601861 mRNA. Translation: AAU43851.1.
    AY601862 mRNA. Translation: AAU43852.1.
    AY601863 mRNA. Translation: AAU43853.1.
    AY601864 mRNA. Translation: AAU43854.1.
    AY601867 mRNA. Translation: AAU43857.1.
    AC090673 Genomic DNA. No translation available.
    AC107308 Genomic DNA. No translation available.
    CCDSiCCDS31854.1. [P52926-2]
    CCDS44936.1. [P52926-1]
    PIRiJC2232.
    RefSeqiNP_003474.1. NM_003483.4. [P52926-1]
    NP_003475.1. NM_003484.1. [P52926-2]
    UniGeneiHs.505924.

    Genome annotation databases

    EnsembliENST00000354636; ENSP00000346658; ENSG00000149948. [P52926-2]
    ENST00000393578; ENSP00000377206; ENSG00000149948. [P52926-6]
    ENST00000403681; ENSP00000384026; ENSG00000149948. [P52926-1]
    ENST00000425208; ENSP00000407306; ENSG00000149948. [P52926-4]
    ENST00000537275; ENSP00000437747; ENSG00000149948. [P52926-5]
    ENST00000537429; ENSP00000443372; ENSG00000149948. [P52926-3]
    GeneIDi8091.
    KEGGihsa:8091.
    UCSCiuc001ssv.3. human. [P52926-2]
    uc001ssx.3. human. [P52926-1]

    Polymorphism databases

    DMDMi1708263.

    Keywords - Coding sequence diversityi

    Alternative splicing, Chromosomal rearrangement

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z31595 mRNA. Translation: CAA83472.1 .
    U28749 mRNA. Translation: AAA68613.1 .
    U28754
    , U28750 , U28751 , U28752 , U28753 Genomic DNA. Translation: AAA68614.1 .
    L46353 , L41044 , L44578 Genomic DNA. Translation: AAA96484.1 .
    X92518 mRNA. Translation: CAA63295.1 .
    AY601861 mRNA. Translation: AAU43851.1 .
    AY601862 mRNA. Translation: AAU43852.1 .
    AY601863 mRNA. Translation: AAU43853.1 .
    AY601864 mRNA. Translation: AAU43854.1 .
    AY601867 mRNA. Translation: AAU43857.1 .
    AC090673 Genomic DNA. No translation available.
    AC107308 Genomic DNA. No translation available.
    CCDSi CCDS31854.1. [P52926-2 ]
    CCDS44936.1. [P52926-1 ]
    PIRi JC2232.
    RefSeqi NP_003474.1. NM_003483.4. [P52926-1 ]
    NP_003475.1. NM_003484.1. [P52926-2 ]
    UniGenei Hs.505924.

    3D structure databases

    ProteinModelPortali P52926.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113763. 19 interactions.
    IntActi P52926. 2 interactions.
    STRINGi 9606.ENSP00000384026.

    PTM databases

    PhosphoSitei P52926.

    Polymorphism databases

    DMDMi 1708263.

    Proteomic databases

    MaxQBi P52926.
    PaxDbi P52926.
    PRIDEi P52926.

    Protocols and materials databases

    DNASUi 8091.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000354636 ; ENSP00000346658 ; ENSG00000149948 . [P52926-2 ]
    ENST00000393578 ; ENSP00000377206 ; ENSG00000149948 . [P52926-6 ]
    ENST00000403681 ; ENSP00000384026 ; ENSG00000149948 . [P52926-1 ]
    ENST00000425208 ; ENSP00000407306 ; ENSG00000149948 . [P52926-4 ]
    ENST00000537275 ; ENSP00000437747 ; ENSG00000149948 . [P52926-5 ]
    ENST00000537429 ; ENSP00000443372 ; ENSG00000149948 . [P52926-3 ]
    GeneIDi 8091.
    KEGGi hsa:8091.
    UCSCi uc001ssv.3. human. [P52926-2 ]
    uc001ssx.3. human. [P52926-1 ]

    Organism-specific databases

    CTDi 8091.
    GeneCardsi GC12P066218.
    HGNCi HGNC:5009. HMGA2.
    HPAi CAB017809.
    MIMi 150699. phenotype.
    600698. gene.
    611547. phenotype.
    neXtProti NX_P52926.
    Orphaneti 94063. 12q14 microdeletion syndrome.
    99970. Dedifferentiated liposarcoma.
    99971. Well-differentiated liposarcoma.
    PharmGKBi PA35093.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG295015.
    HOGENOMi HOG000076308.
    HOVERGENi HBG051913.
    KOi K09283.
    OMAi NSIKRSH.
    OrthoDBi EOG7QRQXW.
    PhylomeDBi P52926.
    TreeFami TF351623.

    Enzyme and pathway databases

    Reactomei REACT_169121. Formation of Senescence-Associated Heterochromatin Foci (SAHF).
    SignaLinki P52926.

    Miscellaneous databases

    ChiTaRSi HMGA2. human.
    GeneWikii HMGA2.
    GenomeRNAii 8091.
    NextBioi 30727.
    PROi P52926.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P52926.
    Bgeei P52926.
    CleanExi HS_HMGA2.
    Genevestigatori P52926.

    Family and domain databases

    InterProi IPR020478. AT_hook-like.
    IPR017956. AT_hook_DNA-bd_motif.
    IPR000116. HMGI/HMGY.
    IPR000637. HMGI/Y_DNA-bd_CS.
    [Graphical view ]
    Pfami PF02178. AT_hook. 3 hits.
    [Graphical view ]
    PRINTSi PR00929. ATHOOK.
    PR00930. HIGHMOBLTYIY.
    SMARTi SM00384. AT_hook. 3 hits.
    [Graphical view ]
    PROSITEi PS00354. HMGI_Y. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Hepatoma.
    2. "Recurrent rearrangements in the high mobility group protein gene, HMGI-C, in benign mesenchymal tumours."
      Schoenmakers E.F.P.M., Wanschura S., Mols R., Bullerdiek J., van den Berghe H., van de Ven W.J.M.
      Nat. Genet. 10:436-444(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
    3. "The gene for the human architectural transcription factor HMGI-C consists of five exons each coding for a distinct functional element."
      Chau K.-Y., Patel U.A., Lee K.-L.D., Lam H.-Y.P., Crane-Robinson C.
      Nucleic Acids Res. 23:4262-4266(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "Genomic characterization of human HMGIC, a member of the accessory transcription factor family found at translocation breakpoints in lipomas."
      Ashar H.R., Cherath L., Przysybz K., Chada K.
      Genomics 31:207-214(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    5. "Extensive expression studies revealed a complex alternative splicing pattern of the HMGA2 gene."
      Hauke S., Leopold S., Schlueter C., Flohr A.M., Murua Escobar H., Rogalla P., Bullerdiek J.
      Biochim. Biophys. Acta 1729:24-31(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3; 4; 5 AND 6), ALTERNATIVE SPLICING.
      Tissue: Fibroblast.
    6. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Bienvenut W.V., Fleming J., Leug H.Y.
      Submitted (JAN-2010) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 2-27, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Hepatoma.
    8. "Expression of reciprocal fusion transcripts of the HMGIC and LPP genes in parosteal lipoma."
      Petit M.M., Swarts S., Bridge J.A., Van de Ven W.J.M.
      Cancer Genet. Cytogenet. 106:18-23(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHROMOSOMAL TRANSLOCATION WITH LPP.
    9. "Allelic knockout of novel splice variants of human recombination repair gene RAD51B in t(12;14) uterine leiomyomas."
      Schoenmakers E.F.P.M., Huysmans C., Van de Ven W.J.M.
      Cancer Res. 59:19-23(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHROMOSOMAL TRANSLOCATION WITH RAD51B.
    10. "An identical HMGIC-LPP fusion transcript is consistently expressed in pulmonary chondroid hamartomas with t(3;12)(q27-28;q14-15)."
      Rogalla P., Lemke I., Kazmierczak B., Bullerdiek J.
      Genes Chromosomes Cancer 29:363-366(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHROMOSOMAL TRANSLOCATION WITH LPP.
    11. "Fusion transcripts involving HMGA2 are not a common molecular mechanism in uterine leiomyomata with rearrangements in 12q15."
      Quade B.J., Weremowicz S., Neskey D.M., Vanni R., Ladd C., Dal Cin P., Morton C.C.
      Cancer Res. 63:1351-1358(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHROMOSOMAL TRANSLOCATION WITH RAD51B.
    12. "Transcriptional activation of the cyclin A gene by the architectural transcription factor HMGA2."
      Tessari M.A., Gostissa M., Altamura S., Sgarra R., Rustighi A., Salvagno C., Caretti G., Imbriano C., Mantovani R., Del Sal G., Giancotti V., Manfioletti G.
      Mol. Cell. Biol. 23:9104-9116(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH E4F1.
    13. Cited for: INVOLVEMENT IN STQTL9.
    14. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    16. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-40; SER-44 AND SER-105, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiHMGA2_HUMAN
    AccessioniPrimary (citable) accession number: P52926
    Secondary accession number(s): E7EP85
    , E7EWA2, Q1M182, Q1M185, Q1M186, Q1M187, Q1M188
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 144 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3