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P52926

- HMGA2_HUMAN

UniProt

P52926 - HMGA2_HUMAN

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Protein
High mobility group protein HMGI-C
Gene
HMGA2, HMGIC
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi24 – 3411A.T hook 1
Add
BLAST
DNA bindingi44 – 5411A.T hook 2
Add
BLAST
DNA bindingi71 – 8212A.T hook 3
Add
BLAST

GO - Molecular functioni

  1. 5'-deoxyribose-5-phosphate lyase activity Source: UniProtKB
  2. AT DNA binding Source: UniProtKB
  3. C2H2 zinc finger domain binding Source: UniProtKB
  4. DNA binding Source: UniProtKB
  5. DNA binding, bending Source: UniProtKB
  6. DNA-(apurinic or apyrimidinic site) lyase activity Source: UniProtKB
  7. DNA-dependent protein kinase activity Source: UniProtKB
  8. MH1 domain binding Source: UniProtKB
  9. MH2 domain binding Source: UniProtKB
  10. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: UniProtKB
  11. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: UniProtKB
  12. SMAD binding Source: UniProtKB
  13. cAMP response element binding Source: UniProtKB
  14. core promoter binding Source: UniProtKB
  15. nucleosomal DNA binding Source: UniProtKB
  16. protein binding Source: UniProtKB
  17. regulatory region DNA binding Source: UniProtKB
  18. transcription factor binding Source: UniProtKB

GO - Biological processi

  1. DNA catabolic process, endonucleolytic Source: GOC
  2. DNA damage response, detection of DNA damage Source: UniProtKB
  3. adrenal gland development Source: Ensembl
  4. base-excision repair Source: UniProtKB
  5. cell proliferation in forebrain Source: Ensembl
  6. chondrocyte differentiation Source: UniProtKB
  7. chondrocyte proliferation Source: UniProtKB
  8. chromatin organization Source: UniProtKB
  9. chromosome breakage Source: UniProtKB
  10. chromosome condensation Source: UniProtKB-KW
  11. endodermal cell differentiation Source: UniProtKB
  12. epithelial to mesenchymal transition Source: UniProtKB
  13. fat cell differentiation Source: UniProtKB
  14. fat pad development Source: Ensembl
  15. heterochromatin assembly Source: UniProtKB
  16. histone H2A-S139 phosphorylation Source: UniProtKB
  17. male gonad development Source: Ensembl
  18. mesenchymal cell differentiation Source: UniProtKB
  19. mesodermal cell differentiation Source: UniProtKB
  20. mesodermal-endodermal cell signaling Source: UniProtKB
  21. mitotic G2 DNA damage checkpoint Source: UniProtKB
  22. mitotic nuclear division Source: UniProtKB-KW
  23. multicellular organismal development Source: ProtInc
  24. negative regulation by host of viral transcription Source: UniProtKB
  25. negative regulation of DNA binding Source: UniProtKB
  26. negative regulation of JAK-STAT cascade Source: Ensembl
  27. negative regulation of apoptotic process Source: UniProtKB
  28. negative regulation of astrocyte differentiation Source: Ensembl
  29. negative regulation of double-strand break repair via nonhomologous end joining Source: UniProtKB
  30. negative regulation of intracellular steroid hormone receptor signaling pathway Source: Ensembl
  31. negative regulation of single stranded viral RNA replication via double stranded DNA intermediate Source: UniProtKB
  32. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  33. negative regulation of transcription, DNA-templated Source: UniProtKB
  34. oncogene-induced cell senescence Source: UniProtKB
  35. pituitary gland development Source: Ensembl
  36. positive regulation of apoptotic process Source: UniProtKB
  37. positive regulation of cell cycle arrest Source: UniProtKB
  38. positive regulation of cellular response to X-ray Source: UniProtKB
  39. positive regulation of cellular senescence Source: UniProtKB
  40. positive regulation of gene expression Source: UniProtKB
  41. positive regulation of multicellular organism growth Source: Ensembl
  42. positive regulation of response to DNA damage stimulus Source: UniProtKB
  43. positive regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
  44. positive regulation of stem cell proliferation Source: UniProtKB
  45. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  46. positive regulation of transcription regulatory region DNA binding Source: UniProtKB
  47. positive regulation of transcription, DNA-templated Source: UniProtKB
  48. regulation of cell cycle process Source: UniProtKB
  49. regulation of cellular response to drug Source: UniProtKB
  50. regulation of growth hormone secretion Source: Ensembl
  51. regulation of stem cell maintenance Source: UniProtKB
  52. regulation of transcription, DNA-templated Source: UniProtKB
  53. response to virus Source: UniProtKB
  54. senescence-associated heterochromatin focus assembly Source: UniProtKB
  55. signal transduction Source: Ensembl
  56. somatic stem cell maintenance Source: Ensembl
  57. spermatogenesis Source: Ensembl
  58. stem cell differentiation Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, DNA condensation, Growth regulation, Mitosis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_169121. Formation of Senescence-Associated Heterochromatin Foci (SAHF).
SignaLinkiP52926.

Names & Taxonomyi

Protein namesi
Recommended name:
High mobility group protein HMGI-C
Alternative name(s):
High mobility group AT-hook protein 2
Gene namesi
Name:HMGA2
Synonyms:HMGIC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:5009. HMGA2.

Subcellular locationi

GO - Cellular componenti

  1. SMAD protein complex Source: UniProtKB
  2. nuclear chromosome Source: UniProtKB
  3. nucleoplasm Source: Reactome
  4. nucleus Source: UniProtKB
  5. protein-DNA complex Source: UniProtKB
  6. senescence-associated heterochromatin focus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving HMGA2 is associated with a subclass of benign mesenchymal tumors known as lipomas. Translocation t(3;12)(q27-q28;q13-q15) with LPP is shown in lipomas. HMGA2 is also fused with a number of other genes in lipomas.
A chromosomal aberration involving HMGA2 is associated with pulmonary chondroid hamartomas. Translocation t(3;12)(q27-q28;q14-q15) with LPP is detected in pulmonary chondroid hamartomas.
A chromosomal aberration involving HMGA2 is associated with parosteal lipomas. Translocation t(3;12)(q28;q14) with LPP is also shown in one parosteal lipoma.
A chromosomal aberration involving HMGA2 is found in uterine leiomyoma. Translocation t(12;14)(q15;q23-24) with RAD51B. Chromosomal rearrangements involving HMGA2 do not seem to be the principle pathobiological mechanism in uterine leiomyoma.

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

MIMi150699. phenotype.
611547. phenotype.
Orphaneti94063. 12q14 microdeletion syndrome.
99970. Dedifferentiated liposarcoma.
99971. Well-differentiated liposarcoma.
PharmGKBiPA35093.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 109108High mobility group protein HMGI-C
PRO_0000206711Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine2 Publications
Modified residuei40 – 401Phosphothreonine1 Publication
Modified residuei44 – 441Phosphoserine1 Publication
Modified residuei105 – 1051Phosphoserine1 Publication

Post-translational modificationi

Regulated by cell cycle-dependent phosphorylation which alters its DNA binding affinity. Phosphorylated by NEK2 By similarity.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP52926.
PaxDbiP52926.
PRIDEiP52926.

PTM databases

PhosphoSiteiP52926.

Expressioni

Developmental stagei

Expressed predominantly during embryogenesis.

Gene expression databases

ArrayExpressiP52926.
BgeeiP52926.
CleanExiHS_HMGA2.
GenevestigatoriP52926.

Organism-specific databases

HPAiCAB017809.

Interactioni

Subunit structurei

Interacts with E4F1. Interacts with NEK2 By similarity.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PRMT6Q96LA82EBI-912511,EBI-912440

Protein-protein interaction databases

BioGridi113763. 19 interactions.
IntActiP52926. 2 interactions.
STRINGi9606.ENSP00000384026.

Structurei

3D structure databases

ProteinModelPortaliP52926.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni44 – 6320Interaction with E4F1
Add
BLAST

Sequence similaritiesi

Belongs to the HMGA family.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG295015.
HOGENOMiHOG000076308.
HOVERGENiHBG051913.
KOiK09283.
OMAiNSIKRSH.
OrthoDBiEOG7QRQXW.
PhylomeDBiP52926.
TreeFamiTF351623.

Family and domain databases

InterProiIPR020478. AT_hook-like.
IPR017956. AT_hook_DNA-bd_motif.
IPR000116. HMGI/HMGY.
IPR000637. HMGI/Y_DNA-bd_CS.
[Graphical view]
PfamiPF02178. AT_hook. 3 hits.
[Graphical view]
PRINTSiPR00929. ATHOOK.
PR00930. HIGHMOBLTYIY.
SMARTiSM00384. AT_hook. 3 hits.
[Graphical view]
PROSITEiPS00354. HMGI_Y. 2 hits.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: P52926-1) [UniParc]FASTAAdd to Basket

Also known as: HMGA2a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSARGEGAGQ PSTSAQGQPA APAPQKRGRG RPRKQQQEPT GEPSPKRPRG    50
RPKGSKNKSP SKAAQKKAEA TGEKRPRGRP RKWPQQVVQK KPAQEETEET 100
SSQESAEED 109
Length:109
Mass (Da):11,832
Last modified:October 1, 1996 - v1
Checksum:iF36BABE623DA4615
GO
Isoform 2 (identifier: P52926-2) [UniParc]FASTAAdd to Basket

Also known as: HMGA2f

The sequence of this isoform differs from the canonical sequence as follows:
     84-109: PQQVVQKKPAQEETEETSSQESAEED → DNLLPRTSSKKKTSLGNSTKRSH

Show »
Length:106
Mass (Da):11,456
Checksum:i0596B200B4B660B6
GO
Isoform 3 (identifier: P52926-3) [UniParc]FASTAAdd to Basket

Also known as: HMGA2d'

The sequence of this isoform differs from the canonical sequence as follows:
     84-109: PQQVVQKKPAQEETEETSSQESAEED → LQN

Show »
Length:86
Mass (Da):9,273
Checksum:i18F9DE5C08244EFE
GO
Isoform 4 (identifier: P52926-4) [UniParc]FASTAAdd to Basket

Also known as: HMGA2d

The sequence of this isoform differs from the canonical sequence as follows:
     84-109: PQQVVQKKPAQEETEETSSQESAEED → WLLMKSPCW

Show »
Length:92
Mass (Da):10,063
Checksum:i5095EAC51787CB88
GO
Isoform 5 (identifier: P52926-5) [UniParc]FASTAAdd to Basket

Also known as: HMGA2c'

The sequence of this isoform differs from the canonical sequence as follows:
     84-109: PQQVVQKKPAQEETEETSSQESAEED → LRAQALDSDGLGSNSGPSLS

Show »
Length:103
Mass (Da):10,845
Checksum:iCBBAAB6286C8BB91
GO
Isoform 6 (identifier: P52926-6) [UniParc]FASTAAdd to Basket

Also known as: HMGA2c

The sequence of this isoform differs from the canonical sequence as follows:
     84-109: PQQVVQKKPAQEETEETSSQESAEED → EEFYIAA

Show »
Length:90
Mass (Da):9,742
Checksum:i606D74FA0564126C
GO

Polymorphismi

Genetic variations in HMGA2 define the stature quantitative trait locus 9 (STQTL9) [MIMi:611547]. Human height is a classic, highly heritable quantitative trait.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei84 – 10926PQQVV…SAEED → DNLLPRTSSKKKTSLGNSTK RSH in isoform 2.
VSP_042564Add
BLAST
Alternative sequencei84 – 10926PQQVV…SAEED → LQN in isoform 3.
VSP_047772Add
BLAST
Alternative sequencei84 – 10926PQQVV…SAEED → WLLMKSPCW in isoform 4.
VSP_047773Add
BLAST
Alternative sequencei84 – 10926PQQVV…SAEED → LRAQALDSDGLGSNSGPSLS in isoform 5.
VSP_047774Add
BLAST
Alternative sequencei84 – 10926PQQVV…SAEED → EEFYIAA in isoform 6.
VSP_047775Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z31595 mRNA. Translation: CAA83472.1.
U28749 mRNA. Translation: AAA68613.1.
U28754
, U28750, U28751, U28752, U28753 Genomic DNA. Translation: AAA68614.1.
L46353, L41044, L44578 Genomic DNA. Translation: AAA96484.1.
X92518 mRNA. Translation: CAA63295.1.
AY601861 mRNA. Translation: AAU43851.1.
AY601862 mRNA. Translation: AAU43852.1.
AY601863 mRNA. Translation: AAU43853.1.
AY601864 mRNA. Translation: AAU43854.1.
AY601867 mRNA. Translation: AAU43857.1.
AC090673 Genomic DNA. No translation available.
AC107308 Genomic DNA. No translation available.
CCDSiCCDS31854.1. [P52926-2]
CCDS44936.1. [P52926-1]
PIRiJC2232.
RefSeqiNP_003474.1. NM_003483.4. [P52926-1]
NP_003475.1. NM_003484.1. [P52926-2]
UniGeneiHs.505924.

Genome annotation databases

EnsembliENST00000354636; ENSP00000346658; ENSG00000149948. [P52926-2]
ENST00000393578; ENSP00000377206; ENSG00000149948. [P52926-6]
ENST00000403681; ENSP00000384026; ENSG00000149948. [P52926-1]
ENST00000425208; ENSP00000407306; ENSG00000149948. [P52926-4]
ENST00000537275; ENSP00000437747; ENSG00000149948. [P52926-5]
ENST00000537429; ENSP00000443372; ENSG00000149948. [P52926-3]
GeneIDi8091.
KEGGihsa:8091.
UCSCiuc001ssv.3. human. [P52926-2]
uc001ssx.3. human. [P52926-1]

Polymorphism databases

DMDMi1708263.

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z31595 mRNA. Translation: CAA83472.1 .
U28749 mRNA. Translation: AAA68613.1 .
U28754
, U28750 , U28751 , U28752 , U28753 Genomic DNA. Translation: AAA68614.1 .
L46353 , L41044 , L44578 Genomic DNA. Translation: AAA96484.1 .
X92518 mRNA. Translation: CAA63295.1 .
AY601861 mRNA. Translation: AAU43851.1 .
AY601862 mRNA. Translation: AAU43852.1 .
AY601863 mRNA. Translation: AAU43853.1 .
AY601864 mRNA. Translation: AAU43854.1 .
AY601867 mRNA. Translation: AAU43857.1 .
AC090673 Genomic DNA. No translation available.
AC107308 Genomic DNA. No translation available.
CCDSi CCDS31854.1. [P52926-2 ]
CCDS44936.1. [P52926-1 ]
PIRi JC2232.
RefSeqi NP_003474.1. NM_003483.4. [P52926-1 ]
NP_003475.1. NM_003484.1. [P52926-2 ]
UniGenei Hs.505924.

3D structure databases

ProteinModelPortali P52926.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113763. 19 interactions.
IntActi P52926. 2 interactions.
STRINGi 9606.ENSP00000384026.

PTM databases

PhosphoSitei P52926.

Polymorphism databases

DMDMi 1708263.

Proteomic databases

MaxQBi P52926.
PaxDbi P52926.
PRIDEi P52926.

Protocols and materials databases

DNASUi 8091.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000354636 ; ENSP00000346658 ; ENSG00000149948 . [P52926-2 ]
ENST00000393578 ; ENSP00000377206 ; ENSG00000149948 . [P52926-6 ]
ENST00000403681 ; ENSP00000384026 ; ENSG00000149948 . [P52926-1 ]
ENST00000425208 ; ENSP00000407306 ; ENSG00000149948 . [P52926-4 ]
ENST00000537275 ; ENSP00000437747 ; ENSG00000149948 . [P52926-5 ]
ENST00000537429 ; ENSP00000443372 ; ENSG00000149948 . [P52926-3 ]
GeneIDi 8091.
KEGGi hsa:8091.
UCSCi uc001ssv.3. human. [P52926-2 ]
uc001ssx.3. human. [P52926-1 ]

Organism-specific databases

CTDi 8091.
GeneCardsi GC12P066218.
HGNCi HGNC:5009. HMGA2.
HPAi CAB017809.
MIMi 150699. phenotype.
600698. gene.
611547. phenotype.
neXtProti NX_P52926.
Orphaneti 94063. 12q14 microdeletion syndrome.
99970. Dedifferentiated liposarcoma.
99971. Well-differentiated liposarcoma.
PharmGKBi PA35093.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG295015.
HOGENOMi HOG000076308.
HOVERGENi HBG051913.
KOi K09283.
OMAi NSIKRSH.
OrthoDBi EOG7QRQXW.
PhylomeDBi P52926.
TreeFami TF351623.

Enzyme and pathway databases

Reactomei REACT_169121. Formation of Senescence-Associated Heterochromatin Foci (SAHF).
SignaLinki P52926.

Miscellaneous databases

ChiTaRSi HMGA2. human.
GeneWikii HMGA2.
GenomeRNAii 8091.
NextBioi 30727.
PROi P52926.
SOURCEi Search...

Gene expression databases

ArrayExpressi P52926.
Bgeei P52926.
CleanExi HS_HMGA2.
Genevestigatori P52926.

Family and domain databases

InterProi IPR020478. AT_hook-like.
IPR017956. AT_hook_DNA-bd_motif.
IPR000116. HMGI/HMGY.
IPR000637. HMGI/Y_DNA-bd_CS.
[Graphical view ]
Pfami PF02178. AT_hook. 3 hits.
[Graphical view ]
PRINTSi PR00929. ATHOOK.
PR00930. HIGHMOBLTYIY.
SMARTi SM00384. AT_hook. 3 hits.
[Graphical view ]
PROSITEi PS00354. HMGI_Y. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Hepatoma.
  2. "Recurrent rearrangements in the high mobility group protein gene, HMGI-C, in benign mesenchymal tumours."
    Schoenmakers E.F.P.M., Wanschura S., Mols R., Bullerdiek J., van den Berghe H., van de Ven W.J.M.
    Nat. Genet. 10:436-444(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
  3. "The gene for the human architectural transcription factor HMGI-C consists of five exons each coding for a distinct functional element."
    Chau K.-Y., Patel U.A., Lee K.-L.D., Lam H.-Y.P., Crane-Robinson C.
    Nucleic Acids Res. 23:4262-4266(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Genomic characterization of human HMGIC, a member of the accessory transcription factor family found at translocation breakpoints in lipomas."
    Ashar H.R., Cherath L., Przysybz K., Chada K.
    Genomics 31:207-214(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  5. "Extensive expression studies revealed a complex alternative splicing pattern of the HMGA2 gene."
    Hauke S., Leopold S., Schlueter C., Flohr A.M., Murua Escobar H., Rogalla P., Bullerdiek J.
    Biochim. Biophys. Acta 1729:24-31(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3; 4; 5 AND 6), ALTERNATIVE SPLICING.
    Tissue: Fibroblast.
  6. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Bienvenut W.V., Fleming J., Leug H.Y.
    Submitted (JAN-2010) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2-27, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Hepatoma.
  8. "Expression of reciprocal fusion transcripts of the HMGIC and LPP genes in parosteal lipoma."
    Petit M.M., Swarts S., Bridge J.A., Van de Ven W.J.M.
    Cancer Genet. Cytogenet. 106:18-23(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHROMOSOMAL TRANSLOCATION WITH LPP.
  9. "Allelic knockout of novel splice variants of human recombination repair gene RAD51B in t(12;14) uterine leiomyomas."
    Schoenmakers E.F.P.M., Huysmans C., Van de Ven W.J.M.
    Cancer Res. 59:19-23(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHROMOSOMAL TRANSLOCATION WITH RAD51B.
  10. "An identical HMGIC-LPP fusion transcript is consistently expressed in pulmonary chondroid hamartomas with t(3;12)(q27-28;q14-15)."
    Rogalla P., Lemke I., Kazmierczak B., Bullerdiek J.
    Genes Chromosomes Cancer 29:363-366(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHROMOSOMAL TRANSLOCATION WITH LPP.
  11. "Fusion transcripts involving HMGA2 are not a common molecular mechanism in uterine leiomyomata with rearrangements in 12q15."
    Quade B.J., Weremowicz S., Neskey D.M., Vanni R., Ladd C., Dal Cin P., Morton C.C.
    Cancer Res. 63:1351-1358(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHROMOSOMAL TRANSLOCATION WITH RAD51B.
  12. "Transcriptional activation of the cyclin A gene by the architectural transcription factor HMGA2."
    Tessari M.A., Gostissa M., Altamura S., Sgarra R., Rustighi A., Salvagno C., Caretti G., Imbriano C., Mantovani R., Del Sal G., Giancotti V., Manfioletti G.
    Mol. Cell. Biol. 23:9104-9116(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH E4F1.
  13. Cited for: INVOLVEMENT IN STQTL9.
  14. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  16. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-40; SER-44 AND SER-105, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiHMGA2_HUMAN
AccessioniPrimary (citable) accession number: P52926
Secondary accession number(s): E7EP85
, E7EWA2, Q1M182, Q1M185, Q1M186, Q1M187, Q1M188
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 3, 2014
This is version 143 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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