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Protein

Protein COS10

Gene

COS10

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

Present with 2370 molecules/cell in log phase SD medium.1 Publication

GO - Biological processi

  • endocytosis Source: SGD
  • protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway Source: SGD

Enzyme and pathway databases

BioCyciYEAST:G3O-33379-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Protein COS10
Gene namesi
Name:COS10
Ordered Locus Names:YNR075W
ORF Names:N3820
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNR075W
SGDiS000005358 COS10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 36CytoplasmicSequence analysisAdd BLAST36
Transmembranei37 – 59HelicalSequence analysisAdd BLAST23
Topological domaini60 – 62ExtracellularSequence analysis3
Transmembranei63 – 85HelicalSequence analysisAdd BLAST23
Topological domaini86 – 374CytoplasmicSequence analysisAdd BLAST289

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002075211 – 374Protein COS10Add BLAST374

Proteomic databases

PaxDbiP52924
PRIDEiP52924

Interactioni

Protein-protein interaction databases

BioGridi35901, 26 interactors
DIPiDIP-4249N
IntActiP52924, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliP52924
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DUP/COS family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000009322
HOGENOMiHOG000000864
InParanoidiP52924
OMAiCQRIRIS
OrthoDBiEOG092C2BGY

Family and domain databases

InterProiView protein in InterPro
IPR001142 DUP/COS
PfamiView protein in Pfam
PF00674 DUP, 2 hits

Sequencei

Sequence statusi: Complete.

P52924-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEEIRLLSS KGLETHSSFC LPEDIFRNRL TWLCSEIRNS GFWIWSLSWL
60 70 80 90 100
PLAVWWGMAS TWFYPLLTSV VLILALIAIL PVVQIQYSKY TLSNQLTQLS
110 120 130 140 150
KEIIKSAPGA YSADWDAVAI HFNSYLYENK AWKTAHFFFN GTDCQEAFRK
160 170 180 190 200
TILEPAVLRR QNEDPRFSSI EILVPYTEDA VQVYFTKVNA QWRLIHGKKE
210 220 230 240 250
CKLTMLENVK LPKETYRCKL AWSCQRIRIS FSPLDFLPDM SDFFICANLS
260 270 280 290 300
PACLVSYWLI DIFFRMIDDF QNIRPKSMKV DDKMQYLSDI INEQGASPEK
310 320 330 340 350
WDTIARKTNT RLFEKRVWKN EEFFFDGTDC QAFFERNFSS LLFSKKSASP
360 370
RSLNVELWKY IQEAQLSCNY EPLP
Length:374
Mass (Da):43,867
Last modified:October 1, 1996 - v1
Checksum:i7A7195A782065B5F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X86790 Genomic DNA Translation: CAA60488.1
Z71690 Genomic DNA Translation: CAA96359.1
BK006947 Genomic DNA Translation: DAA10616.1
PIRiS54057
RefSeqiNP_014473.1, NM_001183252.1

Genome annotation databases

EnsemblFungiiYNR075W; YNR075W; YNR075W
GeneIDi855812
KEGGisce:YNR075W

Similar proteinsi

Entry informationi

Entry nameiCOS10_YEAST
AccessioniPrimary (citable) accession number: P52924
Secondary accession number(s): D6W1Q0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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