P52924 (COS10_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein COS10

Gene names

Name:	COS10
Ordered Locus Names:	YNR075W
ORF Names:	N3820

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	374 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein.
Miscellaneous	Present with 2370 molecules/cell in log phase SD medium.
Sequence similarities	Belongs to the DUP/COS family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	endocytosis Inferred from mutant phenotype PubMed 11378903. Source: SGD
Cellular_component	endoplasmic reticulum Inferred from direct assay PubMed 11914276PubMed 14562095. Source: SGD integral to membrane Inferred from sequence model PubMed 12192589. Source: SGD nuclear envelope Inferred from direct assay PubMed 11914276. Source: SGD
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
AGP1	P25376	1	EBI-4995,EBI-2357

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 374	374	Protein COS10		PRO_0000207521
Regions
	Topological domain	1 – 36	36	Cytoplasmic Potential
	Transmembrane	37 – 59	23	Helical; Potential
	Topological domain	60 – 62	3	Extracellular Potential
	Transmembrane	63 – 85	23	Helical; Potential
	Topological domain	86 – 374	289	Cytoplasmic Potential

Sequences

	Sequence		Length	Mass (Da)
	P52924 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 7A7195A782065B5F	FASTA	374	43,867
	10 20 30 40 50 60 MGEEIRLLSS KGLETHSSFC LPEDIFRNRL TWLCSEIRNS GFWIWSLSWL PLAVWWGMAS 70 80 90 100 110 120 TWFYPLLTSV VLILALIAIL PVVQIQYSKY TLSNQLTQLS KEIIKSAPGA YSADWDAVAI 130 140 150 160 170 180 HFNSYLYENK AWKTAHFFFN GTDCQEAFRK TILEPAVLRR QNEDPRFSSI EILVPYTEDA 190 200 210 220 230 240 VQVYFTKVNA QWRLIHGKKE CKLTMLENVK LPKETYRCKL AWSCQRIRIS FSPLDFLPDM 250 260 270 280 290 300 SDFFICANLS PACLVSYWLI DIFFRMIDDF QNIRPKSMKV DDKMQYLSDI INEQGASPEK 310 320 330 340 350 360 WDTIARKTNT RLFEKRVWKN EEFFFDGTDC QAFFERNFSS LLFSKKSASP RSLNVELWKY 370 IQEAQLSCNY EPLP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequencing of a 9.2 kb telomeric fragment from the right arm of Saccharomyces cerevisiae chromosome XIV." Levesque H., Lepingle A., Nicaud J.-M., Gaillardin C. Yeast 12:289-295(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[2]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications." Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J. , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J. Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[4]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[5]	"A global topology map of the Saccharomyces cerevisiae membrane proteome." Kim H., Melen K., Oesterberg M., von Heijne G. Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract] Cited for: TOPOLOGY [LARGE SCALE ANALYSIS]. Strain: ATCC 208353 / W303-1A.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X86790 Genomic DNA. Translation: CAA60488.1. Z71690 Genomic DNA. Translation: CAA96359.1. BK006947 Genomic DNA. Translation: DAA10616.1.
PIR	S54057.
RefSeq	NP_014473.1. NM_001183252.1.
3D structure databases
ProteinModelPortal	P52924.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-4249N.
IntAct	P52924. 1 interaction.
MINT	MINT-544382.
STRING	4932.YNR075W.
Proteomic databases
PaxDb	P52924.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YNR075W; YNR075W; YNR075W.
GeneID	855812.
KEGG	sce:YNR075W.
Organism-specific databases
CYGD	YNR075w.
SGD	S000005358. COS10.
Phylogenomic databases
eggNOG	NOG293470.
GeneTree	ENSGT00390000009322.
HOGENOM	HOG000000864.
OrthoDB	EOG4578J4.
Gene expression databases
Genevestigator	P52924.
GermOnline	YNR075W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR001142. DUP. [Graphical view]
Pfam	PF00674. DUP. 2 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	980342.

Entry information

Entry name

COS10_YEAST

Accession

Primary (citable) accession number: P52924
Secondary accession number(s): D6W1Q0

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	April 3, 2013
This is version 92 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program