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P52924

- COS10_YEAST

UniProt

P52924 - COS10_YEAST

Protein

Protein COS10

Gene

COS10

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. endocytosis Source: SGD

    Enzyme and pathway databases

    BioCyciYEAST:G3O-33379-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein COS10
    Gene namesi
    Name:COS10
    Ordered Locus Names:YNR075W
    ORF Names:N3820
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XIV

    Organism-specific databases

    CYGDiYNR075w.
    SGDiS000005358. COS10.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 374374Protein COS10PRO_0000207521Add
    BLAST

    Proteomic databases

    PaxDbiP52924.

    Expressioni

    Gene expression databases

    GenevestigatoriP52924.

    Interactioni

    Protein-protein interaction databases

    BioGridi35901. 11 interactions.
    DIPiDIP-4249N.
    IntActiP52924. 1 interaction.
    MINTiMINT-544382.
    STRINGi4932.YNR075W.

    Structurei

    3D structure databases

    ProteinModelPortaliP52924.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3636CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini60 – 623ExtracellularSequence Analysis
    Topological domaini86 – 374289CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei37 – 5923HelicalSequence AnalysisAdd
    BLAST
    Transmembranei63 – 8523HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the DUP/COS family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG293470.
    GeneTreeiENSGT00390000009322.
    HOGENOMiHOG000000864.
    OMAiCQRIRIS.
    OrthoDBiEOG74TX82.

    Family and domain databases

    InterProiIPR001142. DUP.
    [Graphical view]
    PfamiPF00674. DUP. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P52924-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGEEIRLLSS KGLETHSSFC LPEDIFRNRL TWLCSEIRNS GFWIWSLSWL    50
    PLAVWWGMAS TWFYPLLTSV VLILALIAIL PVVQIQYSKY TLSNQLTQLS 100
    KEIIKSAPGA YSADWDAVAI HFNSYLYENK AWKTAHFFFN GTDCQEAFRK 150
    TILEPAVLRR QNEDPRFSSI EILVPYTEDA VQVYFTKVNA QWRLIHGKKE 200
    CKLTMLENVK LPKETYRCKL AWSCQRIRIS FSPLDFLPDM SDFFICANLS 250
    PACLVSYWLI DIFFRMIDDF QNIRPKSMKV DDKMQYLSDI INEQGASPEK 300
    WDTIARKTNT RLFEKRVWKN EEFFFDGTDC QAFFERNFSS LLFSKKSASP 350
    RSLNVELWKY IQEAQLSCNY EPLP 374
    Length:374
    Mass (Da):43,867
    Last modified:October 1, 1996 - v1
    Checksum:i7A7195A782065B5F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X86790 Genomic DNA. Translation: CAA60488.1.
    Z71690 Genomic DNA. Translation: CAA96359.1.
    BK006947 Genomic DNA. Translation: DAA10616.1.
    PIRiS54057.
    RefSeqiNP_014473.1. NM_001183252.1.

    Genome annotation databases

    EnsemblFungiiYNR075W; YNR075W; YNR075W.
    GeneIDi855812.
    KEGGisce:YNR075W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X86790 Genomic DNA. Translation: CAA60488.1 .
    Z71690 Genomic DNA. Translation: CAA96359.1 .
    BK006947 Genomic DNA. Translation: DAA10616.1 .
    PIRi S54057.
    RefSeqi NP_014473.1. NM_001183252.1.

    3D structure databases

    ProteinModelPortali P52924.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 35901. 11 interactions.
    DIPi DIP-4249N.
    IntActi P52924. 1 interaction.
    MINTi MINT-544382.
    STRINGi 4932.YNR075W.

    Proteomic databases

    PaxDbi P52924.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YNR075W ; YNR075W ; YNR075W .
    GeneIDi 855812.
    KEGGi sce:YNR075W.

    Organism-specific databases

    CYGDi YNR075w.
    SGDi S000005358. COS10.

    Phylogenomic databases

    eggNOGi NOG293470.
    GeneTreei ENSGT00390000009322.
    HOGENOMi HOG000000864.
    OMAi CQRIRIS.
    OrthoDBi EOG74TX82.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-33379-MONOMER.

    Miscellaneous databases

    NextBioi 980342.

    Gene expression databases

    Genevestigatori P52924.

    Family and domain databases

    InterProi IPR001142. DUP.
    [Graphical view ]
    Pfami PF00674. DUP. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequencing of a 9.2 kb telomeric fragment from the right arm of Saccharomyces cerevisiae chromosome XIV."
      Levesque H., Lepingle A., Nicaud J.-M., Gaillardin C.
      Yeast 12:289-295(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
      Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J.
      , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
      Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    5. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
      Kim H., Melen K., Oesterberg M., von Heijne G.
      Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
      Strain: ATCC 208353 / W303-1A.

    Entry informationi

    Entry nameiCOS10_YEAST
    AccessioniPrimary (citable) accession number: P52924
    Secondary accession number(s): D6W1Q0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 2370 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XIV
      Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

    External Data

    Dasty 3