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P52924

- COS10_YEAST

UniProt

P52924 - COS10_YEAST

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Protein

Protein COS10

Gene

COS10

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. endocytosis Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-33379-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein COS10
Gene namesi
Name:COS10
Ordered Locus Names:YNR075W
ORF Names:N3820
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIV

Organism-specific databases

CYGDiYNR075w.
SGDiS000005358. COS10.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 374374Protein COS10PRO_0000207521Add
BLAST

Proteomic databases

PaxDbiP52924.

Expressioni

Gene expression databases

GenevestigatoriP52924.

Interactioni

Protein-protein interaction databases

BioGridi35901. 11 interactions.
DIPiDIP-4249N.
IntActiP52924. 1 interaction.
MINTiMINT-544382.
STRINGi4932.YNR075W.

Structurei

3D structure databases

ProteinModelPortaliP52924.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3636CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini60 – 623ExtracellularSequence Analysis
Topological domaini86 – 374289CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei37 – 5923HelicalSequence AnalysisAdd
BLAST
Transmembranei63 – 8523HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the DUP/COS family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG293470.
GeneTreeiENSGT00390000009322.
HOGENOMiHOG000000864.
InParanoidiP52924.
OMAiCQRIRIS.
OrthoDBiEOG74TX82.

Family and domain databases

InterProiIPR001142. DUP.
[Graphical view]
PfamiPF00674. DUP. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P52924-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGEEIRLLSS KGLETHSSFC LPEDIFRNRL TWLCSEIRNS GFWIWSLSWL
60 70 80 90 100
PLAVWWGMAS TWFYPLLTSV VLILALIAIL PVVQIQYSKY TLSNQLTQLS
110 120 130 140 150
KEIIKSAPGA YSADWDAVAI HFNSYLYENK AWKTAHFFFN GTDCQEAFRK
160 170 180 190 200
TILEPAVLRR QNEDPRFSSI EILVPYTEDA VQVYFTKVNA QWRLIHGKKE
210 220 230 240 250
CKLTMLENVK LPKETYRCKL AWSCQRIRIS FSPLDFLPDM SDFFICANLS
260 270 280 290 300
PACLVSYWLI DIFFRMIDDF QNIRPKSMKV DDKMQYLSDI INEQGASPEK
310 320 330 340 350
WDTIARKTNT RLFEKRVWKN EEFFFDGTDC QAFFERNFSS LLFSKKSASP
360 370
RSLNVELWKY IQEAQLSCNY EPLP
Length:374
Mass (Da):43,867
Last modified:October 1, 1996 - v1
Checksum:i7A7195A782065B5F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X86790 Genomic DNA. Translation: CAA60488.1.
Z71690 Genomic DNA. Translation: CAA96359.1.
BK006947 Genomic DNA. Translation: DAA10616.1.
PIRiS54057.
RefSeqiNP_014473.1. NM_001183252.1.

Genome annotation databases

EnsemblFungiiYNR075W; YNR075W; YNR075W.
GeneIDi855812.
KEGGisce:YNR075W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X86790 Genomic DNA. Translation: CAA60488.1 .
Z71690 Genomic DNA. Translation: CAA96359.1 .
BK006947 Genomic DNA. Translation: DAA10616.1 .
PIRi S54057.
RefSeqi NP_014473.1. NM_001183252.1.

3D structure databases

ProteinModelPortali P52924.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35901. 11 interactions.
DIPi DIP-4249N.
IntActi P52924. 1 interaction.
MINTi MINT-544382.
STRINGi 4932.YNR075W.

Proteomic databases

PaxDbi P52924.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YNR075W ; YNR075W ; YNR075W .
GeneIDi 855812.
KEGGi sce:YNR075W.

Organism-specific databases

CYGDi YNR075w.
SGDi S000005358. COS10.

Phylogenomic databases

eggNOGi NOG293470.
GeneTreei ENSGT00390000009322.
HOGENOMi HOG000000864.
InParanoidi P52924.
OMAi CQRIRIS.
OrthoDBi EOG74TX82.

Enzyme and pathway databases

BioCyci YEAST:G3O-33379-MONOMER.

Miscellaneous databases

NextBioi 980342.

Gene expression databases

Genevestigatori P52924.

Family and domain databases

InterProi IPR001142. DUP.
[Graphical view ]
Pfami PF00674. DUP. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequencing of a 9.2 kb telomeric fragment from the right arm of Saccharomyces cerevisiae chromosome XIV."
    Levesque H., Lepingle A., Nicaud J.-M., Gaillardin C.
    Yeast 12:289-295(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
    Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J.
    , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
    Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  5. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.

Entry informationi

Entry nameiCOS10_YEAST
AccessioniPrimary (citable) accession number: P52924
Secondary accession number(s): D6W1Q0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2370 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

External Data

Dasty 3