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P52924 (COS10_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein COS10
Gene names
Name:COS10
Ordered Locus Names:YNR075W
ORF Names:N3820
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length374 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein.

Miscellaneous

Present with 2370 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the DUP/COS family.

Ontologies

Keywords
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processendocytosis

Inferred from mutant phenotype PubMed 11378903. Source: SGD

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 374374Protein COS10
PRO_0000207521

Regions

Topological domain1 – 3636Cytoplasmic Potential
Transmembrane37 – 5923Helical; Potential
Topological domain60 – 623Extracellular Potential
Transmembrane63 – 8523Helical; Potential
Topological domain86 – 374289Cytoplasmic Potential

Sequences

Sequence LengthMass (Da)Tools
P52924 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 7A7195A782065B5F

FASTA37443,867
        10         20         30         40         50         60 
MGEEIRLLSS KGLETHSSFC LPEDIFRNRL TWLCSEIRNS GFWIWSLSWL PLAVWWGMAS 

        70         80         90        100        110        120 
TWFYPLLTSV VLILALIAIL PVVQIQYSKY TLSNQLTQLS KEIIKSAPGA YSADWDAVAI 

       130        140        150        160        170        180 
HFNSYLYENK AWKTAHFFFN GTDCQEAFRK TILEPAVLRR QNEDPRFSSI EILVPYTEDA 

       190        200        210        220        230        240 
VQVYFTKVNA QWRLIHGKKE CKLTMLENVK LPKETYRCKL AWSCQRIRIS FSPLDFLPDM 

       250        260        270        280        290        300 
SDFFICANLS PACLVSYWLI DIFFRMIDDF QNIRPKSMKV DDKMQYLSDI INEQGASPEK 

       310        320        330        340        350        360 
WDTIARKTNT RLFEKRVWKN EEFFFDGTDC QAFFERNFSS LLFSKKSASP RSLNVELWKY 

       370 
IQEAQLSCNY EPLP 

« Hide

References

« Hide 'large scale' references
[1]"Sequencing of a 9.2 kb telomeric fragment from the right arm of Saccharomyces cerevisiae chromosome XIV."
Levesque H., Lepingle A., Nicaud J.-M., Gaillardin C.
Yeast 12:289-295(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J. expand/collapse author list , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[5]"A global topology map of the Saccharomyces cerevisiae membrane proteome."
Kim H., Melen K., Oesterberg M., von Heijne G.
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
Strain: ATCC 208353 / W303-1A.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X86790 Genomic DNA. Translation: CAA60488.1.
Z71690 Genomic DNA. Translation: CAA96359.1.
BK006947 Genomic DNA. Translation: DAA10616.1.
PIRS54057.
RefSeqNP_014473.1. NM_001183252.1.

3D structure databases

ProteinModelPortalP52924.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid35901. 11 interactions.
DIPDIP-4249N.
IntActP52924. 1 interaction.
MINTMINT-544382.
STRING4932.YNR075W.

Proteomic databases

PaxDbP52924.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYNR075W; YNR075W; YNR075W.
GeneID855812.
KEGGsce:YNR075W.

Organism-specific databases

CYGDYNR075w.
SGDS000005358. COS10.

Phylogenomic databases

eggNOGNOG293470.
GeneTreeENSGT00390000009322.
HOGENOMHOG000000864.
OMACQRIRIS.
OrthoDBEOG74TX82.

Enzyme and pathway databases

BioCycYEAST:G3O-33379-MONOMER.

Gene expression databases

GenevestigatorP52924.

Family and domain databases

InterProIPR001142. DUP.
[Graphical view]
PfamPF00674. DUP. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio980342.

Entry information

Entry nameCOS10_YEAST
AccessionPrimary (citable) accession number: P52924
Secondary accession number(s): D6W1Q0
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 14, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XIV

Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families